array:23 [
  "pii" => "S1695403300775011"
  "issn" => "16954033"
  "doi" => "10.1016/S1695-4033(00)77501-1"
  "estado" => "S300"
  "fechaPublicacion" => "2000-12-01"
  "aid" => "77501"
  "copyright" => "Asociación Española de Pediatría"
  "copyrightAnyo" => "2000"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "sco"
  "cita" => "An Pediatr (Barc). 2000;53:573-9"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 3801
    "formatos" => array:3 [
      "EPUB" => 62
      "HTML" => 3146
      "PDF" => 593
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1695403300775023"
    "issn" => "16954033"
    "doi" => "10.1016/S1695-4033(00)77502-3"
    "estado" => "S300"
    "fechaPublicacion" => "2000-12-01"
    "aid" => "77502"
    "copyright" => "Asociación Española de Pediatría"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "sco"
    "cita" => "An Pediatr (Barc). 2000;53:580-5"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 16400
      "formatos" => array:3 [
        "EPUB" => 89
        "HTML" => 9251
        "PDF" => 7060
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Uso del chupete: beneficios y riesgos"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "580"
          "paginaFinal" => "585"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Pacifier use. Risks and benefits"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "L. Martínez Sánchez, E.P. Díaz González, S. García-Tornel Florensa, J. Gaspà Martí"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "L."
              "apellidos" => "Martínez Sánchez"
            ]
            1 => array:2 [
              "nombre" => "E.P."
              "apellidos" => "Díaz González"
            ]
            2 => array:2 [
              "nombre" => "S."
              "apellidos" => "García-Tornel Florensa"
            ]
            3 => array:2 [
              "nombre" => "J."
              "apellidos" => "Gaspà Martí"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403300775023?idApp=UINPBA00005H"
    "url" => "/16954033/0000005300000006/v1_201307051530/S1695403300775023/v1_201307051530/es/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S169540330077500X"
    "issn" => "16954033"
    "doi" => "10.1016/S1695-4033(00)77500-X"
    "estado" => "S300"
    "fechaPublicacion" => "2000-12-01"
    "aid" => "77500"
    "copyright" => "Asociación Española de Pediatría"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "An Pediatr (Barc). 2000;53:567-72"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 18989
      "formatos" => array:3 [
        "EPUB" => 79
        "HTML" => 16696
        "PDF" => 2214
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Celulitis orbitaria y periorbitaria. Revisión de 107 casos"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "567"
          "paginaFinal" => "572"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Orbital and periorbital cellulitis. Report of 107 cases"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "L. Rodríguez Ferran, R. Puigarnau Vallhonrat, W. Fasheh Youssef, J.L. Ribó Aristazábal, C. Luaces Cubells, J. Pou Fernández"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "L."
              "apellidos" => "Rodríguez Ferran"
            ]
            1 => array:2 [
              "nombre" => "R."
              "apellidos" => "Puigarnau Vallhonrat"
            ]
            2 => array:2 [
              "nombre" => "W."
              "apellidos" => "Fasheh Youssef"
            ]
            3 => array:2 [
              "nombre" => "J.L."
              "apellidos" => "Ribó Aristazábal"
            ]
            4 => array:2 [
              "nombre" => "C."
              "apellidos" => "Luaces Cubells"
            ]
            5 => array:2 [
              "nombre" => "J."
              "apellidos" => "Pou Fernández"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S169540330077500X?idApp=UINPBA00005H"
    "url" => "/16954033/0000005300000006/v1_201307051530/S169540330077500X/v1_201307051530/es/main.assets"
  ]
  "es" => array:14 [
    "idiomaDefecto" => true
    "titulo" => "Consenso sobre diagnóstico y tratamiento de las alteraciones del metabolismo hidrocarbonado en la fibrosis quística"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "573"
        "paginaFinal" => "579"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "R. Barrio Castellanos, A. Cos Blanco, E. García García, M. Gussinyé Cañadell, J.F. Merino Torres, M.T. Muñoz Calvo"
        "autores" => array:6 [
          0 => array:4 [
            "nombre" => "R."
            "apellidos" => "Barrio Castellanos"
            "email" => array:1 [
              0 => "rbarrio@hrc.insalud.es"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "A&#46;"
            "apellidos" => "Cos Blanco"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "E&#46;"
            "apellidos" => "Garc&#237;a Garc&#237;a"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "M&#46;"
            "apellidos" => "Gussiny&#233; Ca&#241;adell"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "J&#46;F&#46;"
            "apellidos" => "Merino Torres"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">e</span>"
                "identificador" => "aff0025"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "M&#46;T&#46;"
            "apellidos" => "Mu&#241;oz Calvo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">f</span>"
                "identificador" => "aff0030"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:6 [
          0 => array:3 [
            "entidad" => "Servicios de Pediatr&#237; Hospital Ram&#243;n y Cajal Hospital La Paz&#44; Madrid&#46;"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Hospital La Paz&#44; Madrid&#46;"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Hospital Carlos Haya&#44; M&#225;laga&#46;"
            "etiqueta" => "<span class="elsevierStyleSup">c</span>"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Hospital Vall d&#8217;Hebron&#44; Barcelona&#46;"
            "etiqueta" => "<span class="elsevierStyleSup">d</span>"
            "identificador" => "aff0020"
          ]
          4 => array:3 [
            "entidad" => "Hospital La Fe&#44; Valencia&#46;"
            "etiqueta" => "<span class="elsevierStyleSup">e</span>"
            "identificador" => "aff0025"
          ]
          5 => array:3 [
            "entidad" => "Hospital Ni&#241;o Jes&#250;s&#44; Madrid"
            "etiqueta" => "<span class="elsevierStyleSup">f</span>"
            "identificador" => "aff0030"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#42;"
            "correspondencia" => "Correspondencia&#58; Unidad de Diabetes Pedi&#225;trica&#46; Servicio de Pediatr&#237;a&#46; Hospital Ram&#243;n y Cajal&#46; Crta&#46; Colmenar Viejo km 9&#44;4&#46; 28034 Madrid"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Consensus on the diagnosis and management of cystic fibrosis related diabetes"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2000-09-30"
    "fechaAceptado" => "2000-09-30"
    "PalabrasClave" => array:2 [
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec186527"
          "palabras" => array:4 [
            0 => "Fibrosis qu&#237;stica"
            1 => "Diabetes relacionada con fibrosis qu&#237;stica &#40;DRFQ&#41;"
            2 => "Diabetes mellitus"
            3 => "Alteraci&#243;n de la tolerancia a la glucosa"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec186526"
          "palabras" => array:4 [
            0 => "Cystic fibrosis"
            1 => "Diabetes mellitus"
            2 => "Impaired glucose tolerance"
            3 => "Cystic fibrosis related diabetes mellitus"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:1 [
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La alteraci&#243;n del metabolismo hidrocarbonado es una complicaci&#243;n frecuente de la fibrosis qu&#237;stica&#46; La diabetes relacionada con fibrosis qu&#237;stica &#40;DRFQ&#41; se debe a una disminuci&#243;n en la secreci&#243;n de la insulina secundaria a la insuficiencia pancre&#225;tica&#46; Los pacientes con fibrosis qu&#237;stica y diabetes presentan mayor morbilidad y mortalidad y el mismo riesgo de las complicaciones cr&#243;nicas de la diabetes que los pacientes con diabetes tipo 1o 2&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El diagn&#243;stico precoz y el tratamiento adecuado de la diabetes de estos pacientes es imprescindible&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">En mayo de 2000 tuvo lugar en Madrid una conferencia de consenso sobre DRFQ para definir las pautas para su diagn&#243;stico y tratamiento&#46;</p>"
      ]
      "en" => array:1 [
        "resumen" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Abnormal glucose tolerance and diabetes mellitus are a common complication of cystic fibrosis &#40;CF&#41;&#46; Cystic fibrosis related diabetes &#40;CFRD&#41; is due to decreased insulin secretion&#44; secondary to pancreatic insufficiency&#46; Patients with CFRD have increased morbidity and mortality and are subject to the same microvascular complications as patients with other types of diabetes&#46; Prompt diagnosis and aggressive management of CFRD is important&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">A consensus conference on CFRD was held in Madrid in May 2000 to define the current standards for the diagnosis and management of this disease in Spain&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:17 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagnosis&#44; screening and management of cystic fibrosis related diabetes mellitus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Moran"
                            1 => "D&#46; Hardin"
                            2 => "D&#46; Rodman"
                            3 => "H&#46;F&#46; Allen"
                            4 => "R&#46;J&#46; Beall"
                            5 => "D&#46; Borowitz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "A consensus conference report&#46; Diabetes Res Clin Pract"
                        "fecha" => "1999"
                        "volumen" => "45"
                        "paginaInicial" => "61"
                        "paginaFinal" => "73"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10499886"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Glucose tolerance in adults with CF&#58; phenotype-genotype correlations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46;K&#46; Stewart"
                            1 => "M&#46; Hanna"
                            2 => "J&#46; Corey"
                            3 => "J&#46; Zielenski"
                            4 => "L&#46;C&#46; Tsui"
                            5 => "P&#46;B&#46; Durie"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Pediatr Pulmonol"
                        "fecha" => "1997"
                        "volumen" => "14"
                        "paginaInicial" => "361"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diabetes mellitus in cystic fibrosis&#58; effect of insulin therapy on lung function and infections"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46; Lanng"
                            1 => "B&#46; Thorsteinsson"
                            2 => "J&#46; Nerup"
                            3 => "C&#46; Kock"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Paediatr"
                        "fecha" => "1994"
                        "volumen" => "83"
                        "paginaInicial" => "849"
                        "paginaFinal" => "885"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7981562"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "titulo" => "Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus"
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Diabetes Care"
                        "fecha" => "1997"
                        "volumen" => "20"
                        "paginaInicial" => "1183"
                        "paginaFinal" => "1197"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9203460"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genetic determination of diabetes mellitus in patients with cystic fibrosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46; Rosenecker"
                            1 => "I&#46; Eichler"
                            2 => "L&#46; Kuhn"
                            3 => "H&#46;K&#46; Harms"
                            4 => "J&#46; Von der Hardt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pediatr"
                        "fecha" => "1995"
                        "volumen" => "127"
                        "paginaInicial" => "441"
                        "paginaFinal" => "443"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7658279"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "1998"
                        "editorial" => "MD"
                        "editorialLocalizacion" => "Bethesda"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Abnormal glucose metabolism in cystic fibrosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Moran"
                            1 => "L&#46; Doherty"
                            2 => "L&#46; Wang"
                            3 => "W&#46; Thomas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pediat"
                        "fecha" => "1998"
                        "volumen" => "133"
                        "paginaInicial" => "10"
                        "paginaFinal" => "16"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9672504"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pancreatic endocrine function in cystic fibrosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46; Moran"
                            1 => "P&#46; Diem"
                            2 => "D&#46;J&#46; Klein"
                            3 => "M&#46;D&#46; Levitt"
                            4 => "R&#46;P&#46; Robertson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pediatr"
                        "fecha" => "1991"
                        "volumen" => "118"
                        "paginaInicial" => "715"
                        "paginaFinal" => "772"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2019925"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pancreas and gut hormones responses to oral glucose and intravenous glucagon in cystic fibrosis patients with normal&#44; impaired&#44; and diabetic glucose tolerance"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46; Lanng"
                            1 => "B&#46; Thorsteinsson"
                            2 => "M&#46;E&#46; Roder"
                            3 => "C&#46; Orskov"
                            4 => "J&#46; Holst"
                            5 => "J&#46; Nerup"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Endocrinol"
                        "fecha" => "1993"
                        "volumen" => "128"
                        "paginaInicial" => "207"
                        "paginaFinal" => "214"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8480468"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Selective preservation of somatostatin secretion in CF patients with diabetes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "L&#46;R&#46; Meacham"
                            1 => "L&#46;P&#46; McKean"
                            2 => "C&#46;N&#46; Buchanan"
                            3 => "D&#46;B&#46; Caplan"
                            4 => "R&#46;W&#46; Pfaffle"
                            5 => "J&#46;S&#46; Parks"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Pediatr Pulmonol"
                        "fecha" => "1991"
                        "volumen" => "6"
                        "paginaInicial" => "333"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CF associated islet changes may provide a basis for diabetes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Lohr"
                            1 => "P&#46; Goertchem"
                            2 => "H&#46; Nizze"
                            3 => "N&#46;S&#46; Gould"
                            4 => "V&#46;E&#46; Gould"
                            5 => "M&#46; Oberholzer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Virchows Arch A Pathol Anat"
                        "fecha" => "1989"
                        "volumen" => "414"
                        "paginaInicial" => "179"
                        "paginaFinal" => "185"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diabetes mellitus associated with cystic fibrosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46;M&#46; Finkelstein"
                            1 => "C&#46;L&#46; Wielinski"
                            2 => "G&#46;R&#46; Elliot"
                            3 => "W&#46;J&#46; Warwick"
                            4 => "J&#46; Barbosa"
                            5 => "S&#46;C&#46; Wu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pediatr"
                        "fecha" => "1988"
                        "volumen" => "112"
                        "paginaInicial" => "373"
                        "paginaFinal" => "377"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3346774"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral glucosa tolerance testing in cystic fibrosis&#58; correlations with clinical parameters and glycosilated hemoglobin determinations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; DeSchepper"
                            1 => "I&#46; Dab"
                            2 => "M&#46;P&#46; Derde"
                            3 => "H&#46; Loeb"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Pediatr"
                        "fecha" => "1991"
                        "volumen" => "150"
                        "paginaInicial" => "403"
                        "paginaFinal" => "406"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2040347"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sulfonylurea in the treatment of CFRD&#46; A 15 years experience"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46;M&#46; Bertele-Harms"
                            1 => "H&#46;K&#46; Harms"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Pediatr Pulmonol"
                        "fecha" => "1996"
                        "volumen" => "13"
                        "paginaInicial" => "380"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nutritional assessment and management in cystic fibrosis&#58; a consensus report"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "B&#46;W&#46; Ramsey"
                            1 => "P&#46; Farrell"
                            2 => "P&#46;B&#46; Pencharz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Clin Nutr"
                        "fecha" => "1992"
                        "volumen" => "55"
                        "paginaInicial" => "71"
                        "paginaFinal" => "75"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "American Diabetes Association&#46; Clinical practice recommendation&#46; Diabetes Care 1998&#59; S1"
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A longitudinal study of the effects of pregnancy in 325 women with CF"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46;C&#46; Fitz Simmons"
                            1 => "S&#46; Fitzpatrick"
                            2 => "B&#46; Thompson"
                            3 => "M&#46; Aitkin"
                            4 => "S&#46; Fiel"
                            5 => "G&#46; Winnie"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Pediatr Pulmonol"
                        "fecha" => "1996"
                        "volumen" => "13"
                        "paginaInicial" => "99"
                        "paginaFinal" => "101"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/16954033/0000005300000006/v1_201307051530/S1695403300775011/v1_201307051530/es/main.assets"
  "Apartado" => array:4 [
    "identificador" => "14284"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Art&#237;culo especial"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/16954033/0000005300000006/v1_201307051530/S1695403300775011/v1_201307051530/es/main.pdf?idApp=UINPBA00005H&text.app=https://analesdepediatria.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403300775011?idApp=UINPBA00005H"
]
Compartir
Información de la revista
Vol. 53. Núm. 6.
Páginas 573-579 (diciembre 2000)
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Vol. 53. Núm. 6.
Páginas 573-579 (diciembre 2000)
Acceso a texto completo
Consenso sobre diagnóstico y tratamiento de las alteraciones del metabolismo hidrocarbonado en la fibrosis quística
Consensus on the diagnosis and management of cystic fibrosis related diabetes
Visitas
12991
R. Barrio Castellanosa,
Autor para correspondencia
rbarrio@hrc.insalud.es

Correspondencia: Unidad de Diabetes Pediátrica. Servicio de Pediatría. Hospital Ramón y Cajal. Crta. Colmenar Viejo km 9,4. 28034 Madrid
, A. Cos Blancob, E. García Garcíac, M. Gussinyé Cañadelld, J.F. Merino Torrese, M.T. Muñoz Calvof
a Servicios de Pediatrí Hospital Ramón y Cajal Hospital La Paz, Madrid.
b Hospital La Paz, Madrid.
c Hospital Carlos Haya, Málaga.
d Hospital Vall d’Hebron, Barcelona.
e Hospital La Fe, Valencia.
f Hospital Niño Jesús, Madrid
Este artículo ha recibido
Información del artículo
Resumen
Bibliografía
Descargar PDF
Estadísticas

La alteración del metabolismo hidrocarbonado es una complicación frecuente de la fibrosis quística. La diabetes relacionada con fibrosis quística (DRFQ) se debe a una disminución en la secreción de la insulina secundaria a la insuficiencia pancreática. Los pacientes con fibrosis quística y diabetes presentan mayor morbilidad y mortalidad y el mismo riesgo de las complicaciones crónicas de la diabetes que los pacientes con diabetes tipo 1o 2.

El diagnóstico precoz y el tratamiento adecuado de la diabetes de estos pacientes es imprescindible.

En mayo de 2000 tuvo lugar en Madrid una conferencia de consenso sobre DRFQ para definir las pautas para su diagnóstico y tratamiento.

Palabras clave:
Fibrosis quística
Diabetes relacionada con fibrosis quística (DRFQ)
Diabetes mellitus
Alteración de la tolerancia a la glucosa

Abnormal glucose tolerance and diabetes mellitus are a common complication of cystic fibrosis (CF). Cystic fibrosis related diabetes (CFRD) is due to decreased insulin secretion, secondary to pancreatic insufficiency. Patients with CFRD have increased morbidity and mortality and are subject to the same microvascular complications as patients with other types of diabetes. Prompt diagnosis and aggressive management of CFRD is important.

A consensus conference on CFRD was held in Madrid in May 2000 to define the current standards for the diagnosis and management of this disease in Spain.

Key words:
Cystic fibrosis
Diabetes mellitus
Impaired glucose tolerance
Cystic fibrosis related diabetes mellitus
El Texto completo está disponible en PDF
Bibliografía
[1.]
A. Moran, D. Hardin, D. Rodman, H.F. Allen, R.J. Beall, D. Borowitz.
Diagnosis, screening and management of cystic fibrosis related diabetes mellitus.
A consensus conference report. Diabetes Res Clin Pract, 45 (1999), pp. 61-73
[2.]
A.K. Stewart, M. Hanna, J. Corey, J. Zielenski, L.C. Tsui, P.B. Durie.
Glucose tolerance in adults with CF: phenotype-genotype correlations.
Pediatr Pulmonol, 14 (1997), pp. 361
[3.]
S. Lanng, B. Thorsteinsson, J. Nerup, C. Kock.
Diabetes mellitus in cystic fibrosis: effect of insulin therapy on lung function and infections.
Acta Paediatr, 83 (1994), pp. 849-885
[4.]
Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus.
Diabetes Care, 20 (1997), pp. 1183-1197
[5.]
J. Rosenecker, I. Eichler, L. Kuhn, H.K. Harms, J. Von der Hardt.
Genetic determination of diabetes mellitus in patients with cystic fibrosis.
J Pediatr, 127 (1995), pp. 441-443
[6.]
MD, (1998),
[7.]
A. Moran, L. Doherty, L. Wang, W. Thomas.
Abnormal glucose metabolism in cystic fibrosis.
J Pediat, 133 (1998), pp. 10-16
[8.]
A. Moran, P. Diem, D.J. Klein, M.D. Levitt, R.P. Robertson.
Pancreatic endocrine function in cystic fibrosis.
J Pediatr, 118 (1991), pp. 715-772
[9.]
S. Lanng, B. Thorsteinsson, M.E. Roder, C. Orskov, J. Holst, J. Nerup.
Pancreas and gut hormones responses to oral glucose and intravenous glucagon in cystic fibrosis patients with normal, impaired, and diabetic glucose tolerance.
Acta Endocrinol, 128 (1993), pp. 207-214
[10.]
L.R. Meacham, L.P. McKean, C.N. Buchanan, D.B. Caplan, R.W. Pfaffle, J.S. Parks.
Selective preservation of somatostatin secretion in CF patients with diabetes.
Pediatr Pulmonol, 6 (1991), pp. 333
[11.]
M. Lohr, P. Goertchem, H. Nizze, N.S. Gould, V.E. Gould, M. Oberholzer.
CF associated islet changes may provide a basis for diabetes.
Virchows Arch A Pathol Anat, 414 (1989), pp. 179-185
[12.]
S.M. Finkelstein, C.L. Wielinski, G.R. Elliot, W.J. Warwick, J. Barbosa, S.C. Wu.
Diabetes mellitus associated with cystic fibrosis.
J Pediatr, 112 (1988), pp. 373-377
[13.]
J. DeSchepper, I. Dab, M.P. Derde, H. Loeb.
Oral glucosa tolerance testing in cystic fibrosis: correlations with clinical parameters and glycosilated hemoglobin determinations.
Eur J Pediatr, 150 (1991), pp. 403-406
[14.]
R.M. Bertele-Harms, H.K. Harms.
Sulfonylurea in the treatment of CFRD. A 15 years experience.
Pediatr Pulmonol, 13 (1996), pp. 380
[15.]
B.W. Ramsey, P. Farrell, P.B. Pencharz.
Nutritional assessment and management in cystic fibrosis: a consensus report.
Am J Clin Nutr, 55 (1992), pp. 71-75
[16.]
American Diabetes Association. Clinical practice recommendation. Diabetes Care 1998; S1
[17.]
S.C. Fitz Simmons, S. Fitzpatrick, B. Thompson, M. Aitkin, S. Fiel, G. Winnie.
A longitudinal study of the effects of pregnancy in 325 women with CF.
Pediatr Pulmonol, 13 (1996), pp. 99-101
Copyright © 2000. Asociación Española de Pediatría
Descargar PDF
Idiomas
Anales de Pediatría
Opciones de artículo
Herramientas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?