array:25 [
  "pii" => "S2341287920302520"
  "issn" => "23412879"
  "doi" => "10.1016/j.anpede.2020.03.009"
  "estado" => "S300"
  "fechaPublicacion" => "2021-02-01"
  "aid" => "2822"
  "copyright" => "Asociación Española de Pediatría"
  "copyrightAnyo" => "2020"
  "documento" => "simple-article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "crp"
  "cita" => "An Pediatr (Barc). 2021;94:107-9"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "Traduccion" => array:1 [
    "es" => array:20 [
      "pii" => "S1695403320301363"
      "issn" => "16954033"
      "doi" => "10.1016/j.anpedi.2020.03.008"
      "estado" => "S300"
      "fechaPublicacion" => "2021-02-01"
      "aid" => "2822"
      "copyright" => "Asociación Española de Pediatría"
      "documento" => "simple-article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "crp"
      "cita" => "An Pediatr (Barc). 2021;94:107-9"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "es" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fica</span>"
        "titulo" => "Tratamiento insul&#237;nico&#44; requerimientos de insulina y resultados perinatales en una cohorte de embarazadas con diabetes tipo 1"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "107"
            "paginaFinal" => "109"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Insulin treatment&#44; insulin requirements and perinatal outcomes in a pregnancy cohort with type 1 diabetes"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "M&#46; Pilar Bah&#237;llo-Curieses, Vanesa Mat&#237;as del Pozo, Cristina &#193;lvarez Colomo, Gonzalo D&#237;az-Soto"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "M&#46; Pilar"
                "apellidos" => "Bah&#237;llo-Curieses"
              ]
              1 => array:2 [
                "nombre" => "Vanesa"
                "apellidos" => "Mat&#237;as del Pozo"
              ]
              2 => array:2 [
                "nombre" => "Cristina"
                "apellidos" => "&#193;lvarez Colomo"
              ]
              3 => array:2 [
                "nombre" => "Gonzalo"
                "apellidos" => "D&#237;az-Soto"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2341287920302520"
          "doi" => "10.1016/j.anpede.2020.03.009"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2341287920302520?idApp=UINPBA00005H"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403320301363?idApp=UINPBA00005H"
      "url" => "/16954033/0000009400000002/v2_202102090634/S1695403320301363/v2_202102090634/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S234128792030260X"
    "issn" => "23412879"
    "doi" => "10.1016/j.anpede.2020.03.010"
    "estado" => "S300"
    "fechaPublicacion" => "2021-02-01"
    "aid" => "2819"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "crp"
    "cita" => "An Pediatr &#40;Barc&#41;. 2021;94:109-11"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>"
      "titulo" => "Optimisation of the management of tick bites&#58; a pre-post intervention study"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "109"
          "paginaFinal" => "111"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Optimizaci&#243;n del manejo de la mordedura de garrapata&#58; estudio pre-post-intervenci&#243;n"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 2369
              "Ancho" => 3167
              "Tamanyo" => 389680
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "at0020"
              "detalle" => "Figure "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Geographical distribution of the 19 tick bite cases included in the prospective analysis and microbiological identification of the involved tick&#46; In cases of confirmed diagnosis of tick-borne disease&#44; the reported genus was assumed without prior microbiological identification&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Miguel Garc&#237;a-Boyano, Asier Oliver Olid, Miguel &#193;ngel Molina Guti&#233;rrez, Virginia Santana Rojo, Milagros Garc&#237;a L&#243;pez Hortelano"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "Miguel"
              "apellidos" => "Garc&#237;a-Boyano"
            ]
            1 => array:2 [
              "nombre" => "Asier"
              "apellidos" => "Oliver Olid"
            ]
            2 => array:2 [
              "nombre" => "Miguel &#193;ngel"
              "apellidos" => "Molina Guti&#233;rrez"
            ]
            3 => array:2 [
              "nombre" => "Virginia"
              "apellidos" => "Santana Rojo"
            ]
            4 => array:2 [
              "nombre" => "Milagros"
              "apellidos" => "Garc&#237;a L&#243;pez Hortelano"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S234128792030260X?idApp=UINPBA00005H"
    "url" => "/23412879/0000009400000002/v1_202102100701/S234128792030260X/v1_202102100701/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2341287920302647"
    "issn" => "23412879"
    "doi" => "10.1016/j.anpede.2020.03.014"
    "estado" => "S300"
    "fechaPublicacion" => "2021-02-01"
    "aid" => "2827"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "An Pediatr &#40;Barc&#41;. 2021;94:99-106"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
      "titulo" => "Relationship between parental stress and psychological distress and emotional and behavioural problems in pre-school children with autistic spectrum disorder"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "99"
          "paginaFinal" => "106"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Relaci&#243;n entre estr&#233;s y malestar psicol&#243;gico de los padres y problemas emocionales y conductuales en ni&#241;os preescolares con trastorno del espectro autista"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Marina Romero, Ester Mar&#237;n, Jose Guzm&#225;n-Parra, Patricia Navas, Juan Manuel Aguilar, J&#46; Pablo Lara, Miguel &#193;ngel Barbancho"
          "autores" => array:7 [
            0 => array:2 [
              "nombre" => "Marina"
              "apellidos" => "Romero"
            ]
            1 => array:2 [
              "nombre" => "Ester"
              "apellidos" => "Mar&#237;n"
            ]
            2 => array:2 [
              "nombre" => "Jose"
              "apellidos" => "Guzm&#225;n-Parra"
            ]
            3 => array:2 [
              "nombre" => "Patricia"
              "apellidos" => "Navas"
            ]
            4 => array:2 [
              "nombre" => "Juan Manuel"
              "apellidos" => "Aguilar"
            ]
            5 => array:2 [
              "nombre" => "J&#46; Pablo"
              "apellidos" => "Lara"
            ]
            6 => array:2 [
              "nombre" => "Miguel &#193;ngel"
              "apellidos" => "Barbancho"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1695403320301417"
        "doi" => "10.1016/j.anpedi.2020.03.012"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403320301417?idApp=UINPBA00005H"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2341287920302647?idApp=UINPBA00005H"
    "url" => "/23412879/0000009400000002/v1_202102100701/S2341287920302647/v1_202102100701/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>"
    "titulo" => "Insulin treatment&#44; insulin requirements and perinatal outcomes in a pregnancy cohort with type 1 diabetes"
    "tieneTextoCompleto" => true
    "saludo" => "To the Editor&#58;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "107"
        "paginaFinal" => "109"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "M&#46; Pilar Bah&#237;llo-Curieses, Vanesa Mat&#237;as del Pozo, Cristina &#193;lvarez Colomo, Gonzalo D&#237;az-Soto"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "M&#46; Pilar"
            "apellidos" => "Bah&#237;llo-Curieses"
            "email" => array:1 [
              0 => "mpbahillo@saludcastillayleon.es"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Vanesa"
            "apellidos" => "Mat&#237;as del Pozo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Cristina"
            "apellidos" => "&#193;lvarez Colomo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Gonzalo"
            "apellidos" => "D&#237;az-Soto"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Servicio de Pediatr&#237;a&#44; Hospital Cl&#237;nico Universitario Valladolid&#44; Valladolid&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Obstetricia y Ginecolog&#237;a&#44; Hospital Cl&#237;nico Universitario Valladolid&#44; Valladolid&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Servicio de Endocrinolog&#237;a&#44; Hospital Cl&#237;nico Universitario Valladolid&#44; Valladolid&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Tratamiento insul&#237;nico&#44; requerimientos de insulina y resultados perinatales en una cohorte de embarazadas con diabetes tipo 1"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Pregestational type 1 diabetes &#40;T1D&#41; is a risk factor for maternal and foetal complications related to pregestational and gestational glycaemic control&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Optimal control in the first trimester of pregnancy is associated with improved obstetric outcomes&#44; a lower incidence of congenital malformations and a reduction in perinatal mortality&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> However&#44; maintenance of strict glycaemic control throughout pregnancy is very difficult&#44; as insulin requirements are continuously changing during this period&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We conducted a retrospective study in pregnant women with pregestational T1D and their newborn infants in the 2010&#8211;2018 period on the occasion of the opening of the pregestational diabetes clinic in our hospital&#46; We collected data on glycaemic control&#44; obstetric and perinatal complications in both treatment groups&#44; and weekly insulin requirements exclusively in the group treated with continuous subcutaneous insulin infusion &#40;CSII&#41;&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The sample included 39 pregnant women &#40;18 treated with CSII&#44; 21 with multiple dose injection &#91;MDI&#93; therapy&#41;&#46; Of this total&#44; 56&#46;4&#37; had received preconception care&#44; and their glycaemic control was considered adequate for pregnancy based on the criteria established in the consensus guidelines of the Spanish Group on Diabetes and Gestation&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> We compared baseline characteristics and maternal and infant outcomes in both groups &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; There were no instances of hospital admission due to acute decompensation secondary to T1D&#46; The caesarean delivery rate was higher in both groups compared to the overall rate for our hospital &#40;24&#46;8&#37;&#41;&#44; and there was a significantly higher incidence of intrauterine growth restriction and preeclampsia in the CSII group&#46; We did not find any other significant differences in metabolic&#44; obstetric or perinatal variables based on the treatment received&#44; the duration of T1D or maternal body mass index&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">When we compared the immediate pregestational period with the first trimester of gestation in patients treated with CSII&#44; we observed a significant increase in the daily capillary blood glucose levels measured in the first trimester &#40;4&#46;1&#8239;&#177;&#8239;1&#46;1 vs 7&#46;1&#8239;&#177;&#8239;1&#46;3&#59; <span class="elsevierStyleItalic">P</span>&#8239;&#60;&#8239;&#46;05&#41; and the number of correction boluses administered per day &#40;3&#46;5 &#177; 1&#46;1 vs 5&#46;2 &#177; 0&#46;9&#59; <span class="elsevierStyleItalic">P</span>&#8239;&#60;&#8239;&#46;05&#41;&#46; We also found increases in insulin requirements &#40;in absolute terms and per kg of body weight&#41; from week 1 to week 10 of gestation&#44; followed by decreases between weeks 11 and 18 and increases from week 18 to delivery &#40;<span class="elsevierStyleItalic">P</span>&#8239;&#60;&#8239;&#46;001&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">In addition&#44; pregnant women managed with CSII that had infants with macrosomia had higher insulin requirements &#40;absolute and per kg of body weight&#41; throughout pregnancy &#40;<span class="elsevierStyleItalic">P</span>&#8239;&#60;&#8239;&#46;05&#41;&#46; We did not find any differences in the mean glucose level &#40;&#177;SD&#41; or the percentage of blood glucose measurements outside the target range programmed in the CSII pump&#46; Lastly&#44; mothers managed with CSII whose babies had neonatal hypoglycaemia had greater insulin requirements &#40;absolute and per kg of body weight&#41; throughout pregnancy &#40;<span class="elsevierStyleItalic">P</span>&#8239;&#60;&#8239;&#46;05&#41;&#44; and a higher mean baseline blood glucose level &#40;&#177;SD&#41;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">In women with T1D&#44; pregnancy causes rapid changes in insulin requirements that make it difficult to maintain good glycaemic control&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Treatment with CSII offers greater flexibility to adapt in response to these changes&#44; and its use is recommended by some authors&#44; especially in the first trimester of pregnancy&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> In this regard&#44; we ought to highlight the high percentage of women managed with CSII in our study cohort &#40;46&#46;1&#37;&#41;&#44; which exceeded the percentages reported for the general population and in studies specifically focused on women with pregestational T1D&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Pregestational glycaemic control is essential to achieve the best possible maternal and foetal outcomes&#46; In our cohort&#44; with a mean pregestational glycated haemoglobin &#40;HbA1c&#41; concentration of 7&#46;30&#37;&#44; and despite improvements during gestation and the absence of severe acute decompensations of T1D&#44; we still found a high incidence of complications during pregnancy and in the perinatal period &#40;especially macrosomia&#41;&#44; although it was similar to those reported in previous studies<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> and these outcomes need to be interpreted in the context of the limitations intrinsic to the small sample size and retrospective design of our study&#46; On the other hand&#44; we found that glycaemic control was similar in both treatment groups&#44; although the duration of diabetes was greater in the group of patients managed with CSII&#46; While pregnant women managed with CSII had better baseline HbA1c values&#44; these differences diminished and eventually disappeared in subsequent trimesters&#46; In addition&#44; the incidence of intrauterine growth restriction and preeclampsia was greater in the CSII group&#46; This difference may seem contradictory in the context of a treatment method that allows better glycaemic control&#44; but it has been described in the past in association with a greater difficulty in maintaining glycaemic control&#44; duration of diabetes and complications in patients treated with CSII&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The observed changes in insulin requirements&#44; with a succession of increases and decreases&#44; have been described in the previous literature&#44;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> but not in a group exclusively treated with CSII&#44; which makes our findings more precise and reliable&#46; Last of all&#44; the greater insulin requirements observed in mothers treated with CSII of infants with macrosomia could be explained by greater difficulties maintaining glycaemic control and more frequent need of correction boluses&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">In conclusion&#44; despite the creation of specific management units and the use of CSII in pregestational T1D&#44; the incidence of maternal and foetal complications remains high&#46; New methods need to be developed to improve metabolic control in these patients&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Bah&#237;llo-Curieses MP&#44; Mat&#237;as del Pozo V&#44; &#193;lvarez Colomo C&#44; D&#237;az-Soto G&#46; Tratamiento insul&#237;nico&#44; requerimientos de insulina y resultados perinatales en una cohorte de embarazadas con diabetes tipo 1&#46; An Pediatr &#40;Barc&#41;&#46; 2021&#59;94&#58;107&#8211;109&#46;</p>"
      ]
    ]
    "multimedia" => array:2 [
      0 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0005"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">BMI&#44; body mass index&#59; CSII&#44; continuous subcutaneous insulin infusion&#59; DM&#44; diabetes mellitus&#59; HbA1c&#44; glycated haemoglobin&#59; IUGR&#44; intrauterine growth restriction&#59; MDI&#58; multiple dose injection&#59; NS&#44; not significant&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">CSII&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">MDI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mean&#8239;&#177;&#8239;standard deviation</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Maternal age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31&#46;23&#8239;&#177;&#8239;4&#46;31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30&#46;31&#8239;&#177;&#8239;5&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Maternal BMI &#40;kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24&#8239;&#177;&#8239;2&#46;31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&#8239;&#177;&#8239;1&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Maternal weight gain &#40;kg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#46;6&#8239;&#177;&#8239;2&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#46;4&#8239;&#177;&#8239;2&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Duration of DM &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;65&#8239;&#177;&#8239;8&#46;36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#46;73&#8239;&#177;&#8239;8&#46;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HbA1c&#44; baseline &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#46;0&#8239;&#177;&#8239;1&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#46;5&#8239;&#177;&#8239;1&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HbA1c&#44; 1<span class="elsevierStyleSup">st</span> trimester &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;6&#8239;&#177;&#8239;0&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#46;2&#8239;&#177;&#8239;1&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HbA1c&#44; 2<span class="elsevierStyleSup">nd</span> trimester &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;2&#8239;&#177;&#8239;0&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;5&#8239;&#177;&#8239;0&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HbA1c&#44; 3<span class="elsevierStyleSup">rd</span> trimester &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;2&#8239;&#177;&#8239;0&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;4&#8239;&#177;&#8239;0&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Duration of pregnancy &#40;weeks&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36&#46;71&#8239;&#177;&#8239;1&#46;61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36&#46;55&#8239;&#177;&#8239;3&#46;34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Percentage</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Macrosomia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46&#46;2&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Retinopathy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&#46;3&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&#46;3&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Caesarean delivery&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">64&#46;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">59&#46;1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Polyhydramnios&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;9&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Preeclampsia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&#46;2&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#46;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; &#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Preterm birth&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&#46;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31&#46;8&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IUGR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&#46;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; &#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Neonatal hypoglycaemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35&#46;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&#46;0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Neonatal hypocalcaemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#46;1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Neonatal jaundice&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&#46;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44&#46;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Neonatal respiratory distress&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35&#46;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&#46;3&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Admission to neonatal unit at birth&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">68&#46;8&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">61&#46;1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2516874.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Characteristics and obstetric and perinatal outcomes in the 2 groups under study&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0010"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">SD&#44; standard deviation&#59; wk&#44; week&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Absolute requirement increase&#58; mean&#8239;&#177;&#8239;SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Relative &#40;&#37;&#41; requirement increase&#58; mean&#8239;&#177;&#8239;SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Insulin requirement &#40;IU&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#60; week 10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;73&#8239;&#177;&#8239;3&#46;81&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;53&#8239;&#177;&#8239;10&#46;32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Week 11-18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;68&#8239;&#177;&#8239;3&#46;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;39&#8239;&#177;&#8239;7&#46;71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Week 19-delivery&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;25&#8239;&#177;&#8239;6&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31&#46;3&#8239;&#177;&#8239;8&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Insulin requirement&#47;kg body weight &#40;IU&#47;kg&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#60; week 10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0238&#8239;&#177;&#8239;0&#46;055&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;46&#8239;&#177;&#8239;10&#46;31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Week 11-18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;0063&#8239;&#177;&#8239;0&#46;042&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;2&#46;08&#8239;&#177;&#8239;8&#46;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Week 19-delivery&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;2031&#8239;&#177;&#8239;0&#46;08&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&#46;22&#8239;&#177;&#8239;9&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2516873.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Insulin requirements during pregnancy&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:7 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Continuous glucose monitoring in pregnant women with type 1 diabetes &#40;CONCEPTT&#41;&#58; a multicentre international randomized controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;S&#46; Feig"
                            1 => "L&#46;E&#46; Donovan"
                            2 => "R&#46; Corcoy"
                            3 => "K&#46;E&#46; Murphy"
                            4 => "S&#46;A&#46; Amiel"
                            5 => "K&#46;F&#46; Kunt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(17)32400-5"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2017"
                        "volumen" => "390"
                        "paginaInicial" => "2347"
                        "paginaFinal" => "2359"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28923465"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Risk factors for large-for-gestational age infants in pregnant women with type 1 diabetes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; orrens"
                            1 => "J&#46; Verhaeghe"
                            2 => "C&#46; Vanhole"
                            3 => "R&#46; Devlieger"
                            4 => "C&#46; Mathieu"
                            5 => "K&#46; Benhalima"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/s12884-016-0958-0"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Pregnancy Childbirth"
                        "fecha" => "2016"
                        "volumen" => "16"
                        "paginaInicial" => "162"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27421257"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pre-pregnancy care for women with pregestational diabetes mellitus&#58; a systematic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46;A&#46; Wahabi"
                            1 => "R&#46;A&#46; Alzeidan"
                            2 => "S&#46;A&#46; Esmaeil"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "BMC Public Health"
                        "fecha" => "2012"
                        "volumen" => "12"
                        "paginaInicial" => "792"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Insulin requirements throughout pregnancy in women with type 1 diabetes mellitus&#58; three changes of direction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Garc&#237;a-Patterson"
                            1 => "I&#46; Gich"
                            2 => "S&#46;B&#46; Amini"
                            3 => "P&#46;M&#46; Catalano"
                            4 => "A&#46; de Leiva"
                            5 => "R&#46; Corcoy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00125-009-1633-z"
                      "Revista" => array:6 [
                        "tituloSerie" => "Diabetolog&#237;a"
                        "fecha" => "2010"
                        "volumen" => "53"
                        "paginaInicial" => "446"
                        "paginaFinal" => "451"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20013109"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Asistencia a la gestante con diabetes&#46; Gu&#237;a de Pr&#225;ctica Cl&#237;nica actualizada en 2014"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "Grupo Espa&#241;ol de Diabetes y Embarazo &#40;GEDE&#41;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Av Diabetol"
                        "fecha" => "2015"
                        "volumen" => "31"
                        "paginaInicial" => "45"
                        "paginaFinal" => "59"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Continuous subcutaneous insulin infusion vs multiple daily injections in pregnant women with type 1 diabetes mellitus&#58; a systematic review and meta-analysis of randomized controlled trials and observational studies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P&#46;M&#46; Rys"
                            1 => "A&#46;H&#46; Ludwig-Slomczynska"
                            2 => "K&#46; Cyganek"
                            3 => "M&#46;T&#46; Malecki"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1530/EJE-17-0804"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Endocrinol"
                        "fecha" => "2018"
                        "volumen" => "178"
                        "paginaInicial" => "545"
                        "paginaFinal" => "563"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29545258"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pump or multiple daily injections in pregnancy involving type 1 diabetes&#58; a prespecified analysis of the CONCEPTT randomized controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;S&#46; Feig"
                            1 => "R&#46; Corcoy"
                            2 => "L&#46;E&#46; Donovan"
                            3 => "K&#46;E&#46; Murphy"
                            4 => "J&#46;F&#46;R&#46; Barrett"
                            5 => "J&#46;J&#46; S&#225;nchez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Diabetes Care"
                        "fecha" => "2018"
                        "volumen" => "41"
                        "paginaInicial" => "2471"
                        "paginaFinal" => "2479"
                        "itemHostRev" => array:3 [
                          "pii" => "S1878875016311093"
                          "estado" => "S300"
                          "issn" => "18788750"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/23412879/0000009400000002/v1_202102100701/S2341287920302520/v1_202102100701/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "38181"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Scientific letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/23412879/0000009400000002/v1_202102100701/S2341287920302520/v1_202102100701/en/main.pdf?idApp=UINPBA00005H&text.app=https://analesdepediatria.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2341287920302520?idApp=UINPBA00005H"
]
Share
Journal Information
Vol. 94. Issue 2.
Pages 107-109 (1 February 2021)
Vol. 94. Issue 2.
Pages 107-109 (1 February 2021)
Scientific Letter
Open Access
Insulin treatment, insulin requirements and perinatal outcomes in a pregnancy cohort with type 1 diabetes
Tratamiento insulínico, requerimientos de insulina y resultados perinatales en una cohorte de embarazadas con diabetes tipo 1
Visits
3033
M. Pilar Bahíllo-Curiesesa,
Corresponding author
mpbahillo@saludcastillayleon.es

Corresponding author.
, Vanesa Matías del Pozoa, Cristina Álvarez Colomob, Gonzalo Díaz-Sotoc
a Servicio de Pediatría, Hospital Clínico Universitario Valladolid, Valladolid, Spain
b Servicio de Obstetricia y Ginecología, Hospital Clínico Universitario Valladolid, Valladolid, Spain
c Servicio de Endocrinología, Hospital Clínico Universitario Valladolid, Valladolid, Spain
This item has received

Under a Creative Commons license
Article information
Full Text
Bibliography
Download PDF
Statistics
Tables (2)
Table 1. Characteristics and obstetric and perinatal outcomes in the 2 groups under study.
Table 2. Insulin requirements during pregnancy.
Show moreShow less
Full Text
To the Editor:

Pregestational type 1 diabetes (T1D) is a risk factor for maternal and foetal complications related to pregestational and gestational glycaemic control.1 Optimal control in the first trimester of pregnancy is associated with improved obstetric outcomes, a lower incidence of congenital malformations and a reduction in perinatal mortality.2,3 However, maintenance of strict glycaemic control throughout pregnancy is very difficult, as insulin requirements are continuously changing during this period.4

We conducted a retrospective study in pregnant women with pregestational T1D and their newborn infants in the 2010–2018 period on the occasion of the opening of the pregestational diabetes clinic in our hospital. We collected data on glycaemic control, obstetric and perinatal complications in both treatment groups, and weekly insulin requirements exclusively in the group treated with continuous subcutaneous insulin infusion (CSII).

The sample included 39 pregnant women (18 treated with CSII, 21 with multiple dose injection [MDI] therapy). Of this total, 56.4% had received preconception care, and their glycaemic control was considered adequate for pregnancy based on the criteria established in the consensus guidelines of the Spanish Group on Diabetes and Gestation.5 We compared baseline characteristics and maternal and infant outcomes in both groups (Table 1). There were no instances of hospital admission due to acute decompensation secondary to T1D. The caesarean delivery rate was higher in both groups compared to the overall rate for our hospital (24.8%), and there was a significantly higher incidence of intrauterine growth restriction and preeclampsia in the CSII group. We did not find any other significant differences in metabolic, obstetric or perinatal variables based on the treatment received, the duration of T1D or maternal body mass index.

Table 1.

Characteristics and obstetric and perinatal outcomes in the 2 groups under study.

  CSII  MDI  P 
  Mean ± standard deviation 
Maternal age (years)  31.23 ± 4.31  30.31 ± 5.3  NS 
Maternal BMI (kg/m224 ± 2.31  23 ± 1.9  NS 
Maternal weight gain (kg)  9.6 ± 2.3  9.4 ± 2.8  NS 
Duration of DM (years)  16.65 ± 8.36  13.73 ± 8.24  NS 
HbA1c, baseline (%)  7.0 ± 1.3  7.5 ± 1.3  NS 
HbA1c, 1st trimester (%)  6.6 ± 0.9  7.2 ± 1.2  NS 
HbA1c, 2nd trimester (%)  6.2 ± 0.4  6.5 ± 0.6  NS 
HbA1c, 3rd trimester (%)  6.2 ± 0.7  6.4 ± 0.7  NS 
Duration of pregnancy (weeks)  36.71 ± 1.61  36.55 ± 3.34  NS 
  Percentage 
Macrosomia  44%  46.2%  NS 
Retinopathy  33.3%  27.3%  NS 
Caesarean delivery  64.7%  59.1%  NS 
Polyhydramnios  5.9%  0%  NS 
Preeclampsia  23.2%  9.5%  < .05 
Preterm birth  27.7%  31.8%  NS 
IUGR  23.5%  0%  < .05 
Neonatal hypoglycaemia  35.7%  50.0%  NS 
Neonatal hypocalcaemia  7.1%  5.5%  NS 
Neonatal jaundice  21.4%  44.4%  NS 
Neonatal respiratory distress  35.7%  33.3%  NS 
Admission to neonatal unit at birth  68.8%  61.1%  NS 

BMI, body mass index; CSII, continuous subcutaneous insulin infusion; DM, diabetes mellitus; HbA1c, glycated haemoglobin; IUGR, intrauterine growth restriction; MDI: multiple dose injection; NS, not significant.

When we compared the immediate pregestational period with the first trimester of gestation in patients treated with CSII, we observed a significant increase in the daily capillary blood glucose levels measured in the first trimester (4.1 ± 1.1 vs 7.1 ± 1.3; P < .05) and the number of correction boluses administered per day (3.5 ± 1.1 vs 5.2 ± 0.9; P < .05). We also found increases in insulin requirements (in absolute terms and per kg of body weight) from week 1 to week 10 of gestation, followed by decreases between weeks 11 and 18 and increases from week 18 to delivery (P < .001) (Table 2).

Table 2.

Insulin requirements during pregnancy.

  Absolute requirement increase: mean ± SD  Relative (%) requirement increase: mean ± SD 
Insulin requirement (IU)
< week 10  1.73 ± 3.81  5.53 ± 10.32 
Week 11-18  −0.68 ± 3.12  −0.39 ± 7.71 
Week 19-delivery  16.25 ± 6.2  31.3 ± 8.9 
Insulin requirement/kg body weight (IU/kg)
< week 10  0.0238 ± 0.055  5.46 ± 10.31 
Week 11-18  −0.0063 ± 0.042  −2.08 ± 8.13 
Week 19-delivery  0.2031 ± 0.08  29.22 ± 9.1 

SD, standard deviation; wk, week.

In addition, pregnant women managed with CSII that had infants with macrosomia had higher insulin requirements (absolute and per kg of body weight) throughout pregnancy (P < .05). We did not find any differences in the mean glucose level (±SD) or the percentage of blood glucose measurements outside the target range programmed in the CSII pump. Lastly, mothers managed with CSII whose babies had neonatal hypoglycaemia had greater insulin requirements (absolute and per kg of body weight) throughout pregnancy (P < .05), and a higher mean baseline blood glucose level (±SD).

In women with T1D, pregnancy causes rapid changes in insulin requirements that make it difficult to maintain good glycaemic control.4 Treatment with CSII offers greater flexibility to adapt in response to these changes, and its use is recommended by some authors, especially in the first trimester of pregnancy.6 In this regard, we ought to highlight the high percentage of women managed with CSII in our study cohort (46.1%), which exceeded the percentages reported for the general population and in studies specifically focused on women with pregestational T1D.

Pregestational glycaemic control is essential to achieve the best possible maternal and foetal outcomes. In our cohort, with a mean pregestational glycated haemoglobin (HbA1c) concentration of 7.30%, and despite improvements during gestation and the absence of severe acute decompensations of T1D, we still found a high incidence of complications during pregnancy and in the perinatal period (especially macrosomia), although it was similar to those reported in previous studies3 and these outcomes need to be interpreted in the context of the limitations intrinsic to the small sample size and retrospective design of our study. On the other hand, we found that glycaemic control was similar in both treatment groups, although the duration of diabetes was greater in the group of patients managed with CSII. While pregnant women managed with CSII had better baseline HbA1c values, these differences diminished and eventually disappeared in subsequent trimesters. In addition, the incidence of intrauterine growth restriction and preeclampsia was greater in the CSII group. This difference may seem contradictory in the context of a treatment method that allows better glycaemic control, but it has been described in the past in association with a greater difficulty in maintaining glycaemic control, duration of diabetes and complications in patients treated with CSII.7

The observed changes in insulin requirements, with a succession of increases and decreases, have been described in the previous literature,4 but not in a group exclusively treated with CSII, which makes our findings more precise and reliable. Last of all, the greater insulin requirements observed in mothers treated with CSII of infants with macrosomia could be explained by greater difficulties maintaining glycaemic control and more frequent need of correction boluses.

In conclusion, despite the creation of specific management units and the use of CSII in pregestational T1D, the incidence of maternal and foetal complications remains high. New methods need to be developed to improve metabolic control in these patients.

References
[1]
D.S. Feig, L.E. Donovan, R. Corcoy, K.E. Murphy, S.A. Amiel, K.F. Kunt, et al.
Continuous glucose monitoring in pregnant women with type 1 diabetes (CONCEPTT): a multicentre international randomized controlled trial.
Lancet, 390 (2017), pp. 2347-2359
[2]
A. orrens, J. Verhaeghe, C. Vanhole, R. Devlieger, C. Mathieu, K. Benhalima.
Risk factors for large-for-gestational age infants in pregnant women with type 1 diabetes.
BMC Pregnancy Childbirth, 16 (2016), pp. 162
[3]
H.A. Wahabi, R.A. Alzeidan, S.A. Esmaeil.
Pre-pregnancy care for women with pregestational diabetes mellitus: a systematic review and meta-analysis.
BMC Public Health, 12 (2012), pp. 792
[4]
A. García-Patterson, I. Gich, S.B. Amini, P.M. Catalano, A. de Leiva, R. Corcoy.
Insulin requirements throughout pregnancy in women with type 1 diabetes mellitus: three changes of direction.
Diabetología, 53 (2010), pp. 446-451
[5]
Grupo Español de Diabetes y Embarazo (GEDE).
Asistencia a la gestante con diabetes. Guía de Práctica Clínica actualizada en 2014.
Av Diabetol, 31 (2015), pp. 45-59
[6]
P.M. Rys, A.H. Ludwig-Slomczynska, K. Cyganek, M.T. Malecki.
Continuous subcutaneous insulin infusion vs multiple daily injections in pregnant women with type 1 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials and observational studies.
Eur J Endocrinol, 178 (2018), pp. 545-563
[7]
D.S. Feig, R. Corcoy, L.E. Donovan, K.E. Murphy, J.F.R. Barrett, J.J. Sánchez, et al.
Pump or multiple daily injections in pregnancy involving type 1 diabetes: a prespecified analysis of the CONCEPTT randomized controlled trial.
Diabetes Care, 41 (2018), pp. 2471-2479

Please cite this article as: Bahíllo-Curieses MP, Matías del Pozo V, Álvarez Colomo C, Díaz-Soto G. Tratamiento insulínico, requerimientos de insulina y resultados perinatales en una cohorte de embarazadas con diabetes tipo 1. An Pediatr (Barc). 2021;94:107–109.

Copyright © 2020. Asociación Española de Pediatría
Download PDF
Idiomas
Anales de Pediatría (English Edition)
Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?