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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Ureaplasma urealyticum</span> se asocia a afecci&#243;n respiratoria en el reci&#233;n nacido y prematuro&#46; Sin embargo&#44; pocos estudios abordan esta asociaci&#243;n en el per&#237;odo del lactante o en la primera infancia&#46; Por ello&#44; se ha realiza do una valoraci&#243;n cl&#237;nica de los pacientes que presentaban tos pertusoide y aislamiento en el aspirado nasofar&#237;ngeo de <span class="elsevierStyleItalic">U&#46; urealyticum</span></p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Durante un per&#237;odo de 11 a&#241;os se procesaron 1&#46;063 muestras de aspirado nasofar&#237;ngeo de 905 ni&#241;os con s&#237;ndrome pertusoide&#44; investig&#225;ndose la presencia de <span class="elsevierStyleItalic">Bordetella</span> spp&#46;&#44; otras bacterias&#44; virus y micoplasmas&#46; Se revisaron las historias cl&#237;nicas de los pacientes con cultivo positivo a <span class="elsevierStyleItalic">U&#46; urealyticum</span> seg&#250;n un protocolo preestablecido</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">U&#46; urealyticum</span> se aislo del aspirado nasofaringeo en 26 pacientes con una mediana de edad de 5 meses &#40;rango&#58; 23 dias-22 meses&#41;&#46; La edad gestacional en 9 pacientes fue inferior a las 37 semanas&#46; Todos los pacientes fueron hospitalizados con un cuadro de tos pertusoide&#44; que se asocio a dificultad respiratoria con broncospasmo en 18 ninos &#40;69&#44;2&#37;&#41;&#46; Doce pacientes &#40;46&#44;1&#37;&#41; tuvieron fiebre y 15 &#40;57&#44;7&#37;&#41; linfocitosis &#40;media&#58; 8&#46;635l&#41;&#46; La radiografia simple de torax estaba alterada en 18 pacientes &#40;69&#44;2&#37;&#41;&#44; que presentaron hiperinsuflacion aerea con o sin atelectasias&#46; Todos los pacientes evolucionaron favorablemente&#46; <span class="elsevierStyleItalic">U&#46; urealyticum</span> se asocio a otro microorganismo en 16 pacientes &#40;61&#44;5&#37;&#41;&#58; en 9 a bacterias &#40;<span class="elsevierStyleItalic">H&#46; influenzae&#44; S&#46; pneumoniae&#44; B&#46; pertussis</span> y <span class="elsevierStyleItalic">M&#46; catarrhalis</span>&#41;&#44; en 5 a virus &#40;virus respiratorio sincitial&#44; citomegalovirus&#44; adenovirus y enterovirus&#41; y en 2 muestras a ambos &#40;virus respiratorio sincitial con <span class="elsevierStyleItalic">S&#46; pneumoniae</span> y <span class="elsevierStyleItalic">B&#46; pertussis</span>&#44; respecivamente&#41;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">No creemos que <span class="elsevierStyleItalic">U&#46; urealyticum</span> pueda ser considerado claramente como agente etiol&#243;gico en el s&#237;ndrome pertusoide&#44; ya que en el 61&#44;5&#37; de los pacientes su aislamiento coincidi&#243; con otros microorganismos primaria o potencialmente pat&#243;genos&#46; Ser&#237;an necesarios nuevos estudios que permitan establecer la patogenicidad de este microorganismo fuera del per&#237;odo neonatal</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Ureaplasma urealyticum</span> is associated with respiratory pathology in the neonates and preterm neonates&#46; However&#44; this association has been poorly studied in infants and during early infancy&#46; To address this issue&#44; a clinic evaluation of patients with whooping cough and isolation of <span class="elsevierStyleItalic">U&#46; urealyticum</span> in their nasopharyngeal aspirates has been done</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Over a period of 11 years&#44; 1063 nasopharyngeal aspirates from 905 infants were studied&#46; Clinical samples were cultured for <span class="elsevierStyleItalic">Bordetella</span> spp&#46;&#44; other bacteria&#44; viruses and mycoplasma&#46; Data of patients with positive cultures for <span class="elsevierStyleItalic">U&#46; urealyticum</span> were obtained from clinical records</p> <span class="elsevierStyleSectionTitle">Result</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">U&#46; urealyticum</span> was isolated from 26 patients with a median age of 5 months &#40;range&#58; 23 days-22 months&#41;&#46; The gestational age of 9 patients &#40;34&#46;6&#37;&#41; was less than 37 weeks&#46; All the patients were hospitalised because of pertussis- like syndrome&#44; which was associated with respiratory distress due to bronchospasm in 18 patients &#40;69&#46;2&#37;&#41;&#46; Twelve patients &#40;46&#46;1&#37;&#41; had fever and 15 &#40;57&#46;7&#37;&#41; showed lymphocytosis&#46; The chest roentgenogram was abnormal in 18 patients &#40;69&#46;2&#37;&#41;&#58; pulmonary hiperaeration&#44; with or without atelectasis&#46; Clinical evolution was good in all patients&#46; In 16 patients &#40;61&#46;5&#37;&#41; U&#46; urealyticum was isolated together with other microorganisms&#58; in 9 samples with bacteria &#40;<span class="elsevierStyleItalic">H&#46; influenzae&#44; S&#46; pneumoniae&#44; B&#46; pertussis&#44; M&#46;catarrhalis</span>&#41;&#44; in 5 with viruses &#40;respiratory syncytial virus&#44; cytomegalovirus&#44; adenovirus&#44; enterovirus&#41; and in 2 samples with respiratory syncitial virus and <span class="elsevierStyleItalic">S&#46; pneumoniae</span> and <span class="elsevierStyleItalic">B&#46; pertussis</span> respectively</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Likely <span class="elsevierStyleItalic">U&#46; urealyticum</span> cannot be considered clearly as the etiologic agent of whooping cough&#44; mainly because in the 61&#46;5&#37; of patients <span class="elsevierStyleItalic">U&#46; urealyticum</span> has been isolated together with other microorganisms considered pathogens or potentially pathogens&#46; Future studies would be necessary in order to establish the pathogenic role of <span class="elsevierStyleItalic">U&#46; urealyticum</span> after the neonatal period</p>"
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Vol. 52. Núm. 3.
Páginas 238-241 (marzo 2000)
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Vol. 52. Núm. 3.
Páginas 238-241 (marzo 2000)
Acceso a texto completo
Ureaplasma urealyticum y síndrome pertusoide
Ureaplasma Urealyticum And Pertussis-Like Syndrome
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12473
A. Ferrer Marcellesa,*, F.A. Moraga-Llopb, A. Andreu Domingoa, M.T. Martín Gómeza
a Servicios de Microbiología Universitat Autònoma de Barcelona
b Servicios de Pediatría.Hospitals Vall d'Hebron. Universitat Autònoma de Barcelona
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Estadísticas
Objetivo

Ureaplasma urealyticum se asocia a afección respiratoria en el recién nacido y prematuro. Sin embargo, pocos estudios abordan esta asociación en el período del lactante o en la primera infancia. Por ello, se ha realiza do una valoración clínica de los pacientes que presentaban tos pertusoide y aislamiento en el aspirado nasofaríngeo de U. urealyticum

Métodos

Durante un período de 11 años se procesaron 1.063 muestras de aspirado nasofaríngeo de 905 niños con síndrome pertusoide, investigándose la presencia de Bordetella spp., otras bacterias, virus y micoplasmas. Se revisaron las historias clínicas de los pacientes con cultivo positivo a U. urealyticum según un protocolo preestablecido

Resultados

U. urealyticum se aislo del aspirado nasofaringeo en 26 pacientes con una mediana de edad de 5 meses (rango: 23 dias-22 meses). La edad gestacional en 9 pacientes fue inferior a las 37 semanas. Todos los pacientes fueron hospitalizados con un cuadro de tos pertusoide, que se asocio a dificultad respiratoria con broncospasmo en 18 ninos (69,2%). Doce pacientes (46,1%) tuvieron fiebre y 15 (57,7%) linfocitosis (media: 8.635l). La radiografia simple de torax estaba alterada en 18 pacientes (69,2%), que presentaron hiperinsuflacion aerea con o sin atelectasias. Todos los pacientes evolucionaron favorablemente. U. urealyticum se asocio a otro microorganismo en 16 pacientes (61,5%): en 9 a bacterias (H. influenzae, S. pneumoniae, B. pertussis y M. catarrhalis), en 5 a virus (virus respiratorio sincitial, citomegalovirus, adenovirus y enterovirus) y en 2 muestras a ambos (virus respiratorio sincitial con S. pneumoniae y B. pertussis, respecivamente)

Conclusiones

No creemos que U. urealyticum pueda ser considerado claramente como agente etiológico en el síndrome pertusoide, ya que en el 61,5% de los pacientes su aislamiento coincidió con otros microorganismos primaria o potencialmente patógenos. Serían necesarios nuevos estudios que permitan establecer la patogenicidad de este microorganismo fuera del período neonatal

Palabras clave:
U. urealyticum
Síndrome pertusoide
Background

Ureaplasma urealyticum is associated with respiratory pathology in the neonates and preterm neonates. However, this association has been poorly studied in infants and during early infancy. To address this issue, a clinic evaluation of patients with whooping cough and isolation of U. urealyticum in their nasopharyngeal aspirates has been done

Methods

Over a period of 11 years, 1063 nasopharyngeal aspirates from 905 infants were studied. Clinical samples were cultured for Bordetella spp., other bacteria, viruses and mycoplasma. Data of patients with positive cultures for U. urealyticum were obtained from clinical records

Result

U. urealyticum was isolated from 26 patients with a median age of 5 months (range: 23 days-22 months). The gestational age of 9 patients (34.6%) was less than 37 weeks. All the patients were hospitalised because of pertussis- like syndrome, which was associated with respiratory distress due to bronchospasm in 18 patients (69.2%). Twelve patients (46.1%) had fever and 15 (57.7%) showed lymphocytosis. The chest roentgenogram was abnormal in 18 patients (69.2%): pulmonary hiperaeration, with or without atelectasis. Clinical evolution was good in all patients. In 16 patients (61.5%) U. urealyticum was isolated together with other microorganisms: in 9 samples with bacteria (H. influenzae, S. pneumoniae, B. pertussis, M.catarrhalis), in 5 with viruses (respiratory syncytial virus, cytomegalovirus, adenovirus, enterovirus) and in 2 samples with respiratory syncitial virus and S. pneumoniae and B. pertussis respectively

Conclusions

Likely U. urealyticum cannot be considered clearly as the etiologic agent of whooping cough, mainly because in the 61.5% of patients U. urealyticum has been isolated together with other microorganisms considered pathogens or potentially pathogens. Future studies would be necessary in order to establish the pathogenic role of U. urealyticum after the neonatal period

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