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        "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se ha postulado que la causa de la enfermedad de Perthespueda ser una trombosis intravascular condicionadapor un potencial trastorno cong&#233;nito de la hemostasia queconducir&#237;a a situaciones de trombofilia o hipofibrin&#243;lisis&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Un estudio completo de la hemostasia&#44; que incluya factoresde coagulaci&#243;n&#44; estudio de la trombofilia y de la fibrin&#243;lisisen un grupo de ni&#241;os con enfermedad de Perthes&#44;podr&#237;a determinar la prevalencia de trastornos de lahemostasia y fibrin&#243;lisis en este colectivo&#46; Un grupo de25 pacientes con edades comprendidas entre 5 y 25 a&#241;osen el momento del estudio&#44; anteriormente diagnosticadosde enfermedad de Perthes&#44; fueron sometidos a an&#225;lisis dela hemostasia y trombofilia&#44; comparando los resultadoscon los de un grupo control&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se detectaron alteraciones en la trombofilia en un solopaciente con un d&#233;ficit moderado-leve de prote&#237;na S&#44;siendo los dem&#225;s casos considerados dentro de la normalidaden relaci&#243;n a la edad de los pacientes&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Los datos cl&#237;nicos&#44; epidemiol&#243;gicos y de laboratorio deeste grupo de pacientes pedi&#225;tricos&#44; comparados con losde un grupo control estudiado&#44; no abonan la hip&#243;tesis deun defecto en la trombog&#233;nesis&#44; como causante de la necrosisavascular de la cabeza del f&#233;mur en nuestro medio&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">It has been suggested that the cause of Perthes diseasemay be intravascular thrombosis induced by a potentialcongenital hemostatic disorder leading to conditions ofthrombophilia or hyperfibrinolysis&#46;</p> <span class="elsevierStyleSectionTitle">Patients and method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Complete study of hemostasis with coagulation and antithrombinfactors as well as study of thrombophilia andfibrinolysis in these patients could determine the prevalenceof hemostasis and fibrinolysis in this group of patients&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Alterations in hemostasis and thrombosis were detectedin one patient who had moderate-to-light protein Sdeficiency&#46; The remaining patients were considered withinthe normal range when age was taken into account&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Epidemiological and laboratory data from this group ofpediatric patients and from the control group do not supportthe hypothesis that a thrombogenesis defect couldbe the underlying cause of avascular necrosis of the hipjoint&#46;</p>"
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Vol. 53. Núm. 1.
Páginas 12-16 (julio 2000)
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Vol. 53. Núm. 1.
Páginas 12-16 (julio 2000)
Acceso a texto completo
¿Trombofilia y enfermedad de Perthes?
Thrombophilia and perthes' disease¿
Visitas
9811
J.M. Tusell Puigberta,*, C. Aulesa Martíneza, M. Aguirre Canyadella, I. Nicolau Fustéb, P. Valentín Valentínb, J.J. Ortega Aramburua
a Hospital Materno-Infantil
b Hospital General Vall d'Hebron. Barcelona.
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Resumen
Bibliografía
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Estadísticas
Fundamento

Se ha postulado que la causa de la enfermedad de Perthespueda ser una trombosis intravascular condicionadapor un potencial trastorno congénito de la hemostasia queconduciría a situaciones de trombofilia o hipofibrinólisis.

Pacientes y método

Un estudio completo de la hemostasia, que incluya factoresde coagulación, estudio de la trombofilia y de la fibrinólisisen un grupo de niños con enfermedad de Perthes,podría determinar la prevalencia de trastornos de lahemostasia y fibrinólisis en este colectivo. Un grupo de25 pacientes con edades comprendidas entre 5 y 25 añosen el momento del estudio, anteriormente diagnosticadosde enfermedad de Perthes, fueron sometidos a análisis dela hemostasia y trombofilia, comparando los resultadoscon los de un grupo control.

Resultados

Se detectaron alteraciones en la trombofilia en un solopaciente con un déficit moderado-leve de proteína S,siendo los demás casos considerados dentro de la normalidaden relación a la edad de los pacientes.

Conclusiones

Los datos clínicos, epidemiológicos y de laboratorio deeste grupo de pacientes pediátricos, comparados con losde un grupo control estudiado, no abonan la hipótesis deun defecto en la trombogénesis, como causante de la necrosisavascular de la cabeza del fémur en nuestro medio.

Palabras clave:
Enfermedad de Perthes
Niños
Trombofilia
Background

It has been suggested that the cause of Perthes diseasemay be intravascular thrombosis induced by a potentialcongenital hemostatic disorder leading to conditions ofthrombophilia or hyperfibrinolysis.

Patients and method

Complete study of hemostasis with coagulation and antithrombinfactors as well as study of thrombophilia andfibrinolysis in these patients could determine the prevalenceof hemostasis and fibrinolysis in this group of patients.

Results

Alterations in hemostasis and thrombosis were detectedin one patient who had moderate-to-light protein Sdeficiency. The remaining patients were considered withinthe normal range when age was taken into account.

Conclusions

Epidemiological and laboratory data from this group ofpediatric patients and from the control group do not supportthe hypothesis that a thrombogenesis defect couldbe the underlying cause of avascular necrosis of the hipjoint.

Key words:
Perthes' disease
Children
Thrombophilia
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