¿Trombofilia y enfermedad de Perthes?
Thrombophilia and perthes' disease¿
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"apellidos" => "Cedó Rigalt" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403300774054?idApp=UINPBA00005H" "url" => "/16954033/0000005300000001/v1_201307051509/S1695403300774054/v1_201307051509/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "¿Trombofilia y enfermedad de Perthes?" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "12" "paginaFinal" => "16" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J.M. Tusell Puigbert, C. Aulesa Martínez, M. Aguirre Canyadell, I. Nicolau Fusté, P. Valentín Valentín, J.J. Ortega Aramburu" "autores" => array:6 [ 0 => array:3 [ "nombre" => "J.M." "apellidos" => "Tusell Puigbert" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "C." "apellidos" => "Aulesa Martínez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "M." "apellidos" => "Aguirre Canyadell" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "I." "apellidos" => "Nicolau Fusté" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "P." "apellidos" => "Valentín Valentín" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "J.J." "apellidos" => "Ortega Aramburu" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Hospital Materno-Infantil" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Hospital General Vall d'Hebron. Barcelona." "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Servicio de Hemato-Oncología. Hospital Materno-Infantil Vall d'Hebron. P.° Vall d'Hebron 119-129. 08035 Barcelona.Este estudio ha sido financiado por el CAPI (Centro de Ayudas y Promoción para la Investigación)del Hospital Materno-Infantil Vall d'Hebron de Barcelona. Beca n.° CAPI:PR-MI-98-69." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Thrombophilia and perthes' disease¿" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2000-01-31" "fechaAceptado" => "2000-04-30" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec186383" "palabras" => array:3 [ 0 => "Enfermedad de Perthes" 1 => "Niños" 2 => "Trombofilia" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec186384" "palabras" => array:3 [ 0 => "Perthes' disease" 1 => "Children" 2 => "Thrombophilia" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se ha postulado que la causa de la enfermedad de Perthespueda ser una trombosis intravascular condicionadapor un potencial trastorno congénito de la hemostasia queconduciría a situaciones de trombofilia o hipofibrinólisis.</p> <span class="elsevierStyleSectionTitle">Pacientes y método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Un estudio completo de la hemostasia, que incluya factoresde coagulación, estudio de la trombofilia y de la fibrinólisisen un grupo de niños con enfermedad de Perthes,podría determinar la prevalencia de trastornos de lahemostasia y fibrinólisis en este colectivo. Un grupo de25 pacientes con edades comprendidas entre 5 y 25 añosen el momento del estudio, anteriormente diagnosticadosde enfermedad de Perthes, fueron sometidos a análisis dela hemostasia y trombofilia, comparando los resultadoscon los de un grupo control.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se detectaron alteraciones en la trombofilia en un solopaciente con un déficit moderado-leve de proteína S,siendo los demás casos considerados dentro de la normalidaden relación a la edad de los pacientes.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Los datos clínicos, epidemiológicos y de laboratorio deeste grupo de pacientes pediátricos, comparados con losde un grupo control estudiado, no abonan la hipótesis deun defecto en la trombogénesis, como causante de la necrosisavascular de la cabeza del fémur en nuestro medio.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">It has been suggested that the cause of Perthes diseasemay be intravascular thrombosis induced by a potentialcongenital hemostatic disorder leading to conditions ofthrombophilia or hyperfibrinolysis.</p> <span class="elsevierStyleSectionTitle">Patients and method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Complete study of hemostasis with coagulation and antithrombinfactors as well as study of thrombophilia andfibrinolysis in these patients could determine the prevalenceof hemostasis and fibrinolysis in this group of patients.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Alterations in hemostasis and thrombosis were detectedin one patient who had moderate-to-light protein Sdeficiency. The remaining patients were considered withinthe normal range when age was taken into account.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Epidemiological and laboratory data from this group ofpediatric patients and from the control group do not supportthe hypothesis that a thrombogenesis defect couldbe the underlying cause of avascular necrosis of the hipjoint.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:41 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Disorders of hemostasis in childhood: risk factors for venous thromboembolism." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.J. 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| 2024 Junio | 38 | 71 | 109 |
| 2024 Mayo | 51 | 66 | 117 |
| 2024 Abril | 32 | 37 | 69 |
| 2024 Marzo | 39 | 39 | 78 |
| 2024 Febrero | 43 | 50 | 93 |
| 2024 Enero | 41 | 39 | 80 |
| 2023 Diciembre | 37 | 21 | 58 |
| 2023 Noviembre | 48 | 40 | 88 |
| 2023 Octubre | 55 | 44 | 99 |
| 2023 Septiembre | 29 | 27 | 56 |
| 2023 Agosto | 31 | 26 | 57 |
| 2023 Julio | 35 | 43 | 78 |
| 2023 Junio | 55 | 30 | 85 |
| 2023 Mayo | 37 | 26 | 63 |
| 2023 Abril | 26 | 20 | 46 |
| 2023 Marzo | 30 | 35 | 65 |
| 2023 Febrero | 32 | 18 | 50 |
| 2023 Enero | 19 | 33 | 52 |
| 2022 Diciembre | 42 | 29 | 71 |
| 2022 Noviembre | 39 | 62 | 101 |
| 2022 Octubre | 22 | 69 | 91 |
| 2022 Septiembre | 26 | 50 | 76 |
| 2022 Agosto | 21 | 58 | 79 |
| 2022 Julio | 19 | 52 | 71 |
| 2022 Junio | 22 | 45 | 67 |
| 2022 Mayo | 29 | 53 | 82 |
| 2022 Abril | 27 | 58 | 85 |
| 2022 Marzo | 42 | 66 | 108 |
| 2022 Febrero | 29 | 56 | 85 |
| 2022 Enero | 41 | 86 | 127 |
| 2021 Diciembre | 42 | 62 | 104 |
| 2021 Noviembre | 36 | 49 | 85 |
| 2021 Octubre | 45 | 73 | 118 |
| 2021 Septiembre | 28 | 60 | 88 |
| 2021 Agosto | 40 | 47 | 87 |
| 2021 Julio | 30 | 48 | 78 |
| 2021 Junio | 44 | 62 | 106 |
| 2021 Mayo | 36 | 63 | 99 |
| 2021 Abril | 99 | 86 | 185 |
| 2021 Marzo | 61 | 39 | 100 |
| 2021 Febrero | 75 | 34 | 109 |
| 2021 Enero | 49 | 31 | 80 |
| 2020 Diciembre | 36 | 18 | 54 |
| 2020 Noviembre | 30 | 13 | 43 |
| 2020 Octubre | 29 | 16 | 45 |
| 2020 Septiembre | 28 | 32 | 60 |
| 2020 Agosto | 22 | 43 | 65 |
| 2020 Julio | 23 | 36 | 59 |
| 2020 Junio | 29 | 33 | 62 |
| 2020 Mayo | 35 | 55 | 90 |
| 2020 Abril | 27 | 23 | 50 |
| 2020 Marzo | 30 | 17 | 47 |
| 2020 Febrero | 37 | 48 | 85 |
| 2020 Enero | 68 | 27 | 95 |
| 2019 Diciembre | 41 | 32 | 73 |
| 2019 Noviembre | 23 | 21 | 44 |
| 2019 Octubre | 22 | 18 | 40 |
| 2019 Septiembre | 32 | 30 | 62 |
| 2019 Agosto | 32 | 20 | 52 |
| 2019 Julio | 32 | 22 | 54 |
| 2019 Junio | 46 | 46 | 92 |
| 2019 Mayo | 123 | 57 | 180 |
| 2019 Abril | 64 | 81 | 145 |
| 2019 Marzo | 26 | 19 | 45 |
| 2019 Febrero | 15 | 13 | 28 |
| 2019 Enero | 18 | 13 | 31 |
| 2018 Diciembre | 28 | 19 | 47 |
| 2018 Noviembre | 25 | 25 | 50 |
| 2018 Octubre | 26 | 16 | 42 |
| 2018 Septiembre | 18 | 3 | 21 |
| 2018 Julio | 1 | 0 | 1 |
| 2018 Junio | 2 | 0 | 2 |
| 2018 Mayo | 2 | 0 | 2 |
| 2018 Abril | 12 | 0 | 12 |
| 2018 Marzo | 6 | 0 | 6 |
| 2018 Febrero | 9 | 0 | 9 |
| 2018 Enero | 7 | 0 | 7 |
| 2017 Diciembre | 3 | 0 | 3 |
| 2017 Noviembre | 12 | 0 | 12 |
| 2017 Octubre | 9 | 0 | 9 |
| 2017 Septiembre | 15 | 0 | 15 |
| 2017 Agosto | 6 | 0 | 6 |
| 2017 Julio | 8 | 1 | 9 |
| 2017 Junio | 20 | 12 | 32 |
| 2017 Mayo | 18 | 12 | 30 |
| 2017 Abril | 25 | 11 | 36 |
| 2017 Marzo | 15 | 22 | 37 |
| 2017 Febrero | 8 | 6 | 14 |
| 2017 Enero | 16 | 5 | 21 |
| 2016 Diciembre | 26 | 14 | 40 |
| 2016 Noviembre | 71 | 12 | 83 |
| 2016 Octubre | 41 | 17 | 58 |
| 2016 Septiembre | 51 | 14 | 65 |
| 2016 Agosto | 35 | 12 | 47 |
| 2016 Julio | 16 | 10 | 26 |
| 2016 Junio | 1 | 0 | 1 |
| 2016 Mayo | 1 | 0 | 1 |
| 2016 Abril | 2 | 0 | 2 |
| 2016 Enero | 4 | 0 | 4 |
| 2015 Diciembre | 3 | 0 | 3 |
| 2015 Noviembre | 2 | 0 | 2 |
| 2015 Octubre | 2 | 11 | 13 |
| 2015 Septiembre | 6 | 0 | 6 |
| 2015 Agosto | 2 | 17 | 19 |
| 2015 Julio | 9 | 0 | 9 |
| 2015 Junio | 17 | 0 | 17 |
| 2015 Mayo | 14 | 0 | 14 |
| 2015 Abril | 10 | 0 | 10 |
| 2015 Marzo | 12 | 0 | 12 |
| 2015 Febrero | 13 | 0 | 13 |
| 2015 Enero | 3 | 0 | 3 |
| 2014 Diciembre | 7 | 1 | 8 |
| 2014 Noviembre | 8 | 0 | 8 |
| 2014 Octubre | 7 | 0 | 7 |
| 2014 Septiembre | 4 | 0 | 4 |
| 2014 Agosto | 9 | 2 | 11 |
| 2014 Julio | 12 | 1 | 13 |
| 2014 Junio | 16 | 0 | 16 |
| 2014 Mayo | 10 | 1 | 11 |
| 2014 Abril | 9 | 2 | 11 |
| 2014 Marzo | 9 | 7 | 16 |
| 2014 Febrero | 10 | 10 | 20 |
| 2014 Enero | 10 | 6 | 16 |
| 2013 Diciembre | 16 | 12 | 28 |
| 2013 Noviembre | 9 | 9 | 18 |
| 2013 Octubre | 16 | 7 | 23 |
| 2013 Septiembre | 16 | 8 | 24 |
| 2013 Agosto | 12 | 7 | 19 |
| 2013 Julio | 2 | 2 | 4 |
| 2013 Junio | 2 | 4 | 6 |
| 2013 Mayo | 2 | 3 | 5 |
| 2013 Abril | 0 | 3 | 3 |
| 2013 Marzo | 7 | 2 | 9 |
| 2013 Febrero | 17 | 2 | 19 |
| 2013 Enero | 8 | 2 | 10 |
| 2012 Diciembre | 7 | 1 | 8 |
| 2012 Noviembre | 4 | 2 | 6 |
| 2012 Octubre | 2 | 1 | 3 |
| 2012 Septiembre | 3 | 2 | 5 |
| 2000 Junio | 2866 | 0 | 2866 |
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