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Journal Information
Vol. 100. Issue 5.
Pages e12-e13 (1 May 2024)
Vol. 100. Issue 5.
Pages e12-e13 (1 May 2024)
Images in Paediatrics
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Vulvar necrotic lesion. An uncommon diagnosis
Lesión necrótica vulvar. Un diagnóstico infrecuente
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Paula Manuel Vieira
Corresponding author
paula@pvieira.net

Corresponding author.
, Juliana da Silva Cardoso, Carla Teixeira, Isabel Couto Guerra
Centro Materno-Infantil do Norte Albino Aroso, Centro Hospitalar Universitário do Porto, Oporto, Portugal
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A previously healthy girl aged 15 months with no family history of interest who attended a childcare facility received a diagnosis of lobar pneumonia that responded favourably to treatment with amoxicillin at a dose of 90mg/kg/day. On day 10 of treatment, the fever recurred. A hard mass with an erythematous base and a necrotic central area with a bullous lesion was detected in the genitals (Fig. 1). There was also a small, purplish necrotic lesion in the anal margin. Both lesions worsened over the next 24hours. The laboratory tests revealed severe neutropenia (420/μL) and elevation of liver enzymes (AST/ALT, 43/102 U/L) and C-reactive protein (244.6mg/L). This led to diagnosis of ecthyma gangrenosum and initiation of antibiotherapy with ceftazidime, amikacin and vancomycin. Pseudomonas aeruginosa was isolated from culture of a sample of the cutaneous lesion, and there was no growth in the blood culture. Treatment with ceftazidime and amikacin continued for a total of 21 days. The response was favourable, with full resolution of the genital lesion and re-epithelialization of the necrotic area. The neutrophil count normalised, and there has been no evidence of immunodeficiency to date (normal respiratory burst and immunophenotyping of peripheral lymphocytes).

Figure 1.

Typical ecthyma gangrenosum lesion: well-demarcated bullous lesion with a central necrotic area and a swollen, erythematous base in the genitals. Small necrotic lesion in the anal margin (arrow).

(0.05MB).

Ecthyma gangrenosum is an infrequent infectious disease manifesting with a papular or nodular lesion that progresses rapidly to necrotic ulceration with a black central crust.1,2 It is typically associated with infection by P. aeruginosa, although other aetiological agents may be involved, chiefly Staphylococcus aureus.2,3 Early detection and initiation of antibiotherapy are key prognostic factors.1 This disease is frequently associated with neutropenia and immunodeficiencies, so their presence must always be ruled out.1,3

References
[1]
S. Biscaye, D. Demonchy, M. Afanetti, A. Dupont, H. Haas, A. Tran, et al.
Ecthyma gangrenosum, a skin manifestation of Pseudomonas aeruginosa sepsis in a previously healthy child: a case report.
Medicine (Baltimore), 96 (2017), pp. e5507
[2]
A. Pathak, P. Singh, Y. Yadav, M. Dhaneria.
Ecthyma gangrenosum in a neonate: not always pseudomonas.
BMJ Case Rep, 2013 (2013),
[3]
E. Torres, B. Marques, J. Gil, M.J. Virtuoso, A.B. Sousa, I. Esteves, et al.
Ectima gangrenoso: um alerta para imunodeficiência.
Acta Pediátra Port, 47 (2016), pp. 172-176
Copyright © 2021. Asociación Española de Pediatría
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