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An uncommon diagnosis" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "e12" "paginaFinal" => "e13" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Paula Manuel Vieira, Juliana da Silva Cardoso, Carla Teixeira, Isabel Couto Guerra" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Paula Manuel" "apellidos" => "Vieira" "email" => array:1 [ 0 => "paula@pvieira.net" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Juliana" "apellidos" => "da Silva Cardoso" ] 2 => array:2 [ "nombre" => "Carla" "apellidos" => "Teixeira" ] 3 => array:2 [ "nombre" => "Isabel Couto" "apellidos" => "Guerra" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Centro Materno-Infantil do Norte Albino Aroso, Centro Hospitalar Universitário do Porto, Oporto, Portugal" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Lesión necrótica vulvar. Un diagnóstico infrecuente" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 839 "Ancho" => 600 "Tamanyo" => 51391 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0135" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Typical ecthyma gangrenosum lesion: well-demarcated bullous lesion with a central necrotic area and a swollen, erythematous base in the genitals. Small necrotic lesion in the anal margin (arrow).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A previously healthy girl aged 15 months with no family history of interest who attended a childcare facility received a diagnosis of lobar pneumonia that responded favourably to treatment with amoxicillin at a dose of 90<span class="elsevierStyleHsp" style=""></span>mg/kg/day. On day 10 of treatment, the fever recurred. A hard mass with an erythematous base and a necrotic central area with a bullous lesion was detected in the genitals (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). There was also a small, purplish necrotic lesion in the anal margin. Both lesions worsened over the next 24<span class="elsevierStyleHsp" style=""></span>hours. The laboratory tests revealed severe neutropenia (420/μL) and elevation of liver enzymes (AST/ALT, 43/102 U/L) and C-reactive protein (244.6<span class="elsevierStyleHsp" style=""></span>mg/L). This led to diagnosis of ecthyma gangrenosum and initiation of antibiotherapy with ceftazidime, amikacin and vancomycin. <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> was isolated from culture of a sample of the cutaneous lesion, and there was no growth in the blood culture. Treatment with ceftazidime and amikacin continued for a total of 21 days. The response was favourable, with full resolution of the genital lesion and re-epithelialization of the necrotic area. The neutrophil count normalised, and there has been no evidence of immunodeficiency to date (normal respiratory burst and immunophenotyping of peripheral lymphocytes).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Ecthyma gangrenosum is an infrequent infectious disease manifesting with a papular or nodular lesion that progresses rapidly to necrotic ulceration with a black central crust.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a> It is typically associated with infection by <span class="elsevierStyleItalic">P. aeruginosa</span>, although other aetiological agents may be involved, chiefly <span class="elsevierStyleItalic">Staphylococcus aureus.</span><a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,3</span></a> Early detection and initiation of antibiotherapy are key prognostic factors.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> This disease is frequently associated with neutropenia and immunodeficiencies, so their presence must always be ruled out.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,3</span></a></p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2021-09-10" "fechaAceptado" => "2021-11-09" "multimedia" => array:1 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 839 "Ancho" => 600 "Tamanyo" => 51391 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0135" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Typical ecthyma gangrenosum lesion: well-demarcated bullous lesion with a central necrotic area and a swollen, erythematous base in the genitals. Small necrotic lesion in the anal margin (arrow).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:3 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ecthyma gangrenosum, a skin manifestation of <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> sepsis in a previously healthy child: a case report" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Biscaye" 1 => "D. Demonchy" 2 => "M. Afanetti" 3 => "A. Dupont" 4 => "H. Haas" 5 => "A. 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Esteves" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Acta Pediátra Port" "fecha" => "2016" "volumen" => "47" "paginaInicial" => "172" "paginaFinal" => "176" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/23412879/0000010000000005/v1_202405192134/S2341287924000747/v1_202405192134/en/main.assets" "Apartado" => array:4 [ "identificador" => "77701" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Images in Paediatrics" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/23412879/0000010000000005/v1_202405192134/S2341287924000747/v1_202405192134/en/main.pdf?idApp=UINPBA00005H&text.app=https://analesdepediatria.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2341287924000747?idApp=UINPBA00005H" ]
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