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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Congenital lung malformations &#40;CLMs&#41; constitute a heterogeneous group of lung anomalies involving the airways&#44; parenchyma and blood vessels&#46; Historically&#44; they have been considered infrequent&#44; as their annual incidence has been documented to be of 1 case per 10&#44;000&#8211;35&#44;000 pregnancies<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> or about 30&#8211;42 cases per 100&#44;000 inhabitants in the general population&#46; There are also authors that assert that their diagnosis has improved considerably with the introduction of routine prenatal ultrasound examinations&#44;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> but few studies have analysed how their incidence has actually been changing in recent times&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">In order to establish the incidence of CLMs in the autonomous community of Cantabria &#40;Spain&#41;&#44; we conducted a retrospective descriptive study of all cases of CLM managed in the Department of Paediatrics of the Hospital Universitario Marqu&#233;s de Valdecilla in Santander&#44; &#40;Cantabria&#44; Spain&#41;&#44; specifically in the Units of Paediatric Pulmonology and Paediatric Surgery&#44; in the period between January 2007 and December 2017&#46; Our hospital is the tertiary care hospital that manages all complicated pregnancies in Cantabria&#44; and we identified the patients using information obtained from the Department of Admissions and Clinical Records&#46; In addition&#44; we obtained data on the number of births during this period from the Instituto C&#225;ntabro de Estad&#237;stica &#40;Statistical Institute of Cantabria&#41; and the Instituto Nacional de Estad&#237;stica &#40;National Institute of Statistics&#41;&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">A total of 16 cases of CLM were diagnosed during the period under study&#44; corresponding to 9 female patients and 7 male patients&#46; The diagnosis was prenatal in 15 cases &#40;93&#46;7&#37;&#41;&#44; with the defect identified in the ultrasound examination performed at 22 weeks&#8217; gestation&#46; All of these patients were evaluated with a chest radiograph and a chest ultrasound examination within 24<span class="elsevierStyleHsp" style=""></span>h from birth&#44; and these imaging tests confirmed the presence of a CLM in the patients whose second trimester ultrasound examination had been positive&#46; In the remaining patient&#44; treated in 2007&#44; the CLM was diagnosed at age 4 months by means of a chest radiograph and a computed tomography angiogram&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> presents the data on the annual incidence of CLM&#46; The mean annual incidence was of 2&#46;05 cases per 10&#44;000 births &#40;standard deviation&#44; 3&#46;26&#41; and the median was 1&#46;98 cases &#40;interquartile range&#44; 6&#46;79&#41;&#44; calculated with data through December 2016&#46; We could not calculate the incidence for 2017 because at the time of this writing there is no published data on the number of births in Cantabria during this year&#46; We ought to highlight the considerable variability between years&#44; as 2 cases were diagnosed in a total of 31&#44;137 children born between 2007 and 2012&#44; compared to 12 cases diagnosed in a total of 17&#44;710 children born between 2013 and 2016&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">These data are consistent with the findings of a study by Stocker et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> who also found a significant interannual variability and reported an incidence of 1&#46;27 cases per 10&#44;000 births between 1994 and 1998 and an incidence that was nearly triple of 4&#46;15 cases per 10&#44;000 births between 2008 and 2012&#46; Given the increase in the number of CLMs in recent years&#44; we need to consider whether this results from an actual increase in incidence or improvements in diagnostic techniques&#46; Stocker et al&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> favour the hypothesis of an increased incidence&#44; which is also supported by data in the EUROCAT registry&#44; which shows an increase of 6&#46;5&#37; in some CLMs &#40;95&#37; CI&#44; 3&#46;5&#37;&#8211;9&#46;4&#37;&#41;&#44; a phenomenon for which there is currently no plausible explanation&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">A salient finding in our study was the predominance of the female sex&#44; contrary to previous studies&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> which have historically reported a predominance of the male sex&#46; This fact&#44; along with the significant interannual variability&#44; suggests that further studies with a longer follow-up are required to establish the current actual incidence of CLMs&#44; which will also require the participation of a larger number of hospitals to increase the number of cases included in the analyses&#46; Establishing the incidence of CLMs more accurately is relevant for the purpose of improving the management of these patients&#44; as the increase in the number of cases diagnosed prenatally has raised controversy regarding the correct approach to the management of asymptomatic patients&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a></p></span>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Annual incidence of congenital lung malformations in Cantabria&#44; 2007&#8211;2016&#46;</p>"
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Journal Information
Vol. 91. Issue 1.
Pages 53-54 (1 July 2019)
Vol. 91. Issue 1.
Pages 53-54 (1 July 2019)
Scientific Letter
Open Access
Does the incidence of congenital pulmonary malformations vary? 11 years of experience
¿Varía la incidencia de las malformaciones pulmonares congénitas?: 11 años de experiencia
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Rocío Sancho Gutiérreza, Elena Pérez Belmontea, Ernesto de Diego Garcíab, Antonia Jesús López Lópezb, María Jesús Cabero Péreza,
Corresponding author
mariajesuscabero@gmail.com

Corresponding author.
a Servicio de Pediatría, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain
b Cirugía Pediátrica, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain
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Table 1. Annual incidence of congenital lung malformations in Cantabria, 2007–2016.
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Dear Editor:

Congenital lung malformations (CLMs) constitute a heterogeneous group of lung anomalies involving the airways, parenchyma and blood vessels. Historically, they have been considered infrequent, as their annual incidence has been documented to be of 1 case per 10,000–35,000 pregnancies1 or about 30–42 cases per 100,000 inhabitants in the general population. There are also authors that assert that their diagnosis has improved considerably with the introduction of routine prenatal ultrasound examinations,2 but few studies have analysed how their incidence has actually been changing in recent times.

In order to establish the incidence of CLMs in the autonomous community of Cantabria (Spain), we conducted a retrospective descriptive study of all cases of CLM managed in the Department of Paediatrics of the Hospital Universitario Marqués de Valdecilla in Santander, (Cantabria, Spain), specifically in the Units of Paediatric Pulmonology and Paediatric Surgery, in the period between January 2007 and December 2017. Our hospital is the tertiary care hospital that manages all complicated pregnancies in Cantabria, and we identified the patients using information obtained from the Department of Admissions and Clinical Records. In addition, we obtained data on the number of births during this period from the Instituto Cántabro de Estadística (Statistical Institute of Cantabria) and the Instituto Nacional de Estadística (National Institute of Statistics).

A total of 16 cases of CLM were diagnosed during the period under study, corresponding to 9 female patients and 7 male patients. The diagnosis was prenatal in 15 cases (93.7%), with the defect identified in the ultrasound examination performed at 22 weeks’ gestation. All of these patients were evaluated with a chest radiograph and a chest ultrasound examination within 24h from birth, and these imaging tests confirmed the presence of a CLM in the patients whose second trimester ultrasound examination had been positive. In the remaining patient, treated in 2007, the CLM was diagnosed at age 4 months by means of a chest radiograph and a computed tomography angiogram.

Table 1 presents the data on the annual incidence of CLM. The mean annual incidence was of 2.05 cases per 10,000 births (standard deviation, 3.26) and the median was 1.98 cases (interquartile range, 6.79), calculated with data through December 2016. We could not calculate the incidence for 2017 because at the time of this writing there is no published data on the number of births in Cantabria during this year. We ought to highlight the considerable variability between years, as 2 cases were diagnosed in a total of 31,137 children born between 2007 and 2012, compared to 12 cases diagnosed in a total of 17,710 children born between 2013 and 2016.

Table 1.

Annual incidence of congenital lung malformations in Cantabria, 2007–2016.

Year  Births  Congenital lung malformations  Incidence per 10,000 births 
2007  4873  2.05 
2008  5060  0.00 
2009  5518  0.00 
2010  5480  0.00 
2011  5240  1.90 
2012  4966  0.00 
2013  4725  6.34 
2014  4470  6.71 
2015  4280  7.00 
2016  4235  7.08 
2017  a  – 
a

We have not included data for 2017 because at the time of this writing the Instituto Nacional de Estadística has not yet published the total number of births in Cantabria.

These data are consistent with the findings of a study by Stocker et al.,3 who also found a significant interannual variability and reported an incidence of 1.27 cases per 10,000 births between 1994 and 1998 and an incidence that was nearly triple of 4.15 cases per 10,000 births between 2008 and 2012. Given the increase in the number of CLMs in recent years, we need to consider whether this results from an actual increase in incidence or improvements in diagnostic techniques. Stocker et al.3 favour the hypothesis of an increased incidence, which is also supported by data in the EUROCAT registry, which shows an increase of 6.5% in some CLMs (95% CI, 3.5%–9.4%), a phenomenon for which there is currently no plausible explanation.4

A salient finding in our study was the predominance of the female sex, contrary to previous studies,5 which have historically reported a predominance of the male sex. This fact, along with the significant interannual variability, suggests that further studies with a longer follow-up are required to establish the current actual incidence of CLMs, which will also require the participation of a larger number of hospitals to increase the number of cases included in the analyses. Establishing the incidence of CLMs more accurately is relevant for the purpose of improving the management of these patients, as the increase in the number of cases diagnosed prenatally has raised controversy regarding the correct approach to the management of asymptomatic patients.6

References
[1]
M. Saavedra, M. Guelfand.
Enfoque actual de las malformaciones pulmonares.
Rev Med Clin Condes, 28 (2017), pp. 29-36
[2]
J. Wall, A. Coates.
Prenatal imaging and postnatal presentation, diagnosis and management of congenital lung malformations.
Curr Opin Pediatr, 26 (2014), pp. 315-319
[3]
L.J. Stocker, D.G. Wellesley, M.P. Stanton, R. Parasuraman, D.T. Howe.
The increasing incidence of foetal echogenic congenital lung malformations: an observational study.
Prenat Diagn, 35 (2015), pp. 148-153
[4]
J.K. Morris, A.L. Springett, R. Greenlees, M. Loane, M.C. Addor, L. Arriola, et al.
Trends in congenital anomalies in Europe from 1980 to 2012.
PLOS ONE, 13 (2018), pp. e0194986
[5]
I. Ruchonnet-Metrailler, E. Leroy-Terquem, J. Stirnemann, P. Cros, H. Ducoin, A. Hadchouel, et al.
Neonatal outcomes of prenatally diagnosed congenital pulmonary malformations.
Pediatrics, 133 (2014), pp. e1285-e1291
[6]
C.N. Criss, N. Musili, N. Matusko, S. Baker, J.D. Geiger, S.M. Kunisaki.
Asymptomatic congenital lung malformations: is nonoperative management a viable alternative?.
J Pediatr Surg, 53 (2018), pp. 1092-1097

Please cite this article as: Sancho Gutiérrez R, Pérez Belmonte E, de Diego García E, López López AJ, Cabero Pérez MJ. ¿Varía la incidencia de las malformaciones pulmonares congénitas?: 11 años de experiencia. An Pediatr (Barc). 2019;91:53–54.

Copyright © 2019. Asociación Española de Pediatría
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