array:25 [
  "pii" => "S2341287918302047"
  "issn" => "23412879"
  "doi" => "10.1016/j.anpede.2018.01.016"
  "estado" => "S300"
  "fechaPublicacion" => "2019-01-01"
  "aid" => "2381"
  "copyright" => "Asociación Española de Pediatría"
  "copyrightAnyo" => "2017"
  "documento" => "simple-article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "crp"
  "cita" => "An Pediatr (Barc). 2019;90:51-2"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 1523
    "formatos" => array:3 [
      "EPUB" => 113
      "HTML" => 1121
      "PDF" => 289
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:20 [
      "pii" => "S1695403318300341"
      "issn" => "16954033"
      "doi" => "10.1016/j.anpedi.2018.01.015"
      "estado" => "S300"
      "fechaPublicacion" => "2019-01-01"
      "aid" => "2381"
      "copyright" => "Asociación Española de Pediatría"
      "documento" => "simple-article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "crp"
      "cita" => "An Pediatr (Barc). 2019;90:51-2"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 3558
        "formatos" => array:3 [
          "EPUB" => 149
          "HTML" => 2445
          "PDF" => 964
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fica</span>"
        "titulo" => "<span class="elsevierStyleItalic">Arthroderma benhamiae</span> en pacientes con cobayas"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "51"
            "paginaFinal" => "52"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "<span class="elsevierStyleItalic">Arthroderma benhamiae</span> in patients with guinea pigs"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 1200
                "Ancho" => 800
                "Tamanyo" => 151456
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Querion de Celso&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Tania Mart&#237;n-Pe&#241;aranda, Jos&#233; Miguel Lera Imbuluzqueta, Miriam Alkorta Gurrutxaga"
            "autores" => array:3 [
              0 => array:2 [
                "nombre" => "Tania"
                "apellidos" => "Mart&#237;n-Pe&#241;aranda"
              ]
              1 => array:2 [
                "nombre" => "Jos&#233; Miguel"
                "apellidos" => "Lera Imbuluzqueta"
              ]
              2 => array:2 [
                "nombre" => "Miriam"
                "apellidos" => "Alkorta Gurrutxaga"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2341287918302047"
          "doi" => "10.1016/j.anpede.2018.01.016"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2341287918302047?idApp=UINPBA00005H"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403318300341?idApp=UINPBA00005H"
      "url" => "/16954033/0000009000000001/v1_201901020605/S1695403318300341/v1_201901020605/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2341287918300553"
    "issn" => "23412879"
    "doi" => "10.1016/j.anpede.2018.03.001"
    "estado" => "S300"
    "fechaPublicacion" => "2019-01-01"
    "aid" => "2400"
    "documento" => "simple-article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "crp"
    "cita" => "An Pediatr &#40;Barc&#41;. 2019;90:52-3"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2143
      "formatos" => array:3 [
        "EPUB" => 135
        "HTML" => 968
        "PDF" => 1040
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>"
      "titulo" => "Cow&#39;s milk protein intolerance imitating septic shock in a young infant"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "52"
          "paginaFinal" => "53"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Intolerancia a la prote&#237;na de la leche de vaca simulando shock s&#233;ptico en un lactante peque&#241;o"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Sylvia Jacob, Artur Bonito Vitor"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "Sylvia"
              "apellidos" => "Jacob"
            ]
            1 => array:2 [
              "nombre" => "Artur Bonito"
              "apellidos" => "Vitor"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1695403318301139"
        "doi" => "10.1016/j.anpedi.2018.01.020"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403318301139?idApp=UINPBA00005H"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2341287918300553?idApp=UINPBA00005H"
    "url" => "/23412879/0000009000000001/v1_201901020610/S2341287918300553/v1_201901020610/en/main.assets"
  ]
  "itemAnterior" => array:20 [
    "pii" => "S2341287918302035"
    "issn" => "23412879"
    "doi" => "10.1016/j.anpede.2018.03.005"
    "estado" => "S300"
    "fechaPublicacion" => "2019-01-01"
    "aid" => "2406"
    "copyright" => "Asociaci&#243;n Espa&#241;ola de Pediatr&#237;a"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "An Pediatr &#40;Barc&#41;. 2019;90:42-50"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1152
      "formatos" => array:3 [
        "EPUB" => 108
        "HTML" => 796
        "PDF" => 248
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
      "titulo" => "Health and socio-educational needs of the families and children with rare metabolic diseases&#58; Qualitative study in a tertiary hospital"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "42"
          "paginaFinal" => "50"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Necesidades sanitarias y socioeducativas de ni&#241;os con enfermedades raras de tipo metab&#243;lico y sus familias&#58; estudio cualitativo en un hospital de tercer nivel"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1018
              "Ancho" => 1659
              "Tamanyo" => 86445
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Prevalence of the different diagnoses in paediatric patients with inborn errors of metabolism managed at the Metabolic Disease Unit of a tertiary care hospital &#40;<span class="elsevierStyleItalic">N</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>65&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Eva Mar&#237;a Tejada-Ortigosa, Katherine Flores-Rojas, Laura Moreno-Quintana, Mar&#237;a Carmen Mu&#241;oz-Villanueva, Juan Luis P&#233;rez-Navero, Mercedes Gil-Campos"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "Eva Mar&#237;a"
              "apellidos" => "Tejada-Ortigosa"
            ]
            1 => array:2 [
              "nombre" => "Katherine"
              "apellidos" => "Flores-Rojas"
            ]
            2 => array:2 [
              "nombre" => "Laura"
              "apellidos" => "Moreno-Quintana"
            ]
            3 => array:2 [
              "nombre" => "Mar&#237;a Carmen"
              "apellidos" => "Mu&#241;oz-Villanueva"
            ]
            4 => array:2 [
              "nombre" => "Juan Luis"
              "apellidos" => "P&#233;rez-Navero"
            ]
            5 => array:2 [
              "nombre" => "Mercedes"
              "apellidos" => "Gil-Campos"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S169540331830119X"
        "doi" => "10.1016/j.anpedi.2018.03.003"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S169540331830119X?idApp=UINPBA00005H"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2341287918302035?idApp=UINPBA00005H"
    "url" => "/23412879/0000009000000001/v1_201901020610/S2341287918302035/v1_201901020610/en/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>"
    "titulo" => "<span class="elsevierStyleItalic">Arthroderma benhamiae</span> in patients with guinea pigs"
    "tieneTextoCompleto" => true
    "saludo" => "<span class="elsevierStyleItalic">Dear Editor&#58;</span>"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "51"
        "paginaFinal" => "52"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Tania Mart&#237;n-Pe&#241;aranda, Jos&#233; Miguel Lera Imbuluzqueta, Miriam Alkorta Gurrutxaga"
        "autores" => array:3 [
          0 => array:4 [
            "nombre" => "Tania"
            "apellidos" => "Mart&#237;n-Pe&#241;aranda"
            "email" => array:1 [
              0 => "TANIA&#46;MARTINPENARANDA&#64;osakidetza&#46;eus"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Jos&#233; Miguel"
            "apellidos" => "Lera Imbuluzqueta"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Miriam"
            "apellidos" => "Alkorta Gurrutxaga"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Microbiolog&#237;a&#44; Hospital Universitario de Donostia&#44; Donostia&#44; Guip&#250;zcoa&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital Universitario de Donostia&#44; Donostia&#44; Guip&#250;zcoa&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "<span class="elsevierStyleItalic">Arthroderma benhamiae</span> en pacientes con cobayas"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1200
            "Ancho" => 800
            "Tamanyo" => 151456
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Kerion celsi&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Arthroderma benhamiae</span> is the teleomorph of a zoonotic dermatophytic fungus that belongs to the <span class="elsevierStyleItalic">Trichophyton mentagrophytes</span> species complex&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">1</span></a> Small rodents are its main reservoir&#44; especially guinea pigs&#44; in which it can cause an inflammatory cutaneous infection&#46; It has also been isolated from larger animals&#44; such as dogs and cats&#46; In recent years&#44; the incidence of infection by this fungus has increased due to the increase in the number of guinea pigs and other small rodents that are household pets&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">2&#44;3</span></a> This dermatophyte can cause tinea corporis&#44; tinea faciei and in some cases kerion celsi&#46; Onychomycosis has been reported in very rare cases&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">2</span></a> It is characterised by highly inflammatory lesions&#44; especially in children&#44; who frequently develop kerion celsi&#46; Besides children&#44; it is frequently isolated from adolescents and immunosuppressed individuals&#46; In the early stage of infection&#44; the skin lesions may be confused with impetigo&#44; which delays diagnosis&#46; We now proceed to present 2 cases diagnosed in our microbiology laboratory in the span of 3 months&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Girl aged 3 years that presented with an inflammatory and suppurative lesion with onset 2 months prior that was diagnosed as kerion celsi&#46; At onset&#44; the patient developed lesions in the mouth and nose that were treated with topical antibiotics due to suspected impetigo&#46; Subsequently&#44; the patient developed additional erythematous plaques with a honey-coloured crust in the parieto-occipital region&#44; which were treated with topical mupirocin and oral amoxicillin-clavulanic acid&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Due to the unfavourable response to treatment&#44; she was referred to the dermatology department&#44; where she received a diagnosis of tinea capitis and started topical treatment with a terbinafine cream and a sertaconazole nitrate gel&#46; The relevant findings of the history were a past episode of tinea corporis in the father and the presence of a pet guinea pig in the household that also had skin lesions&#46; Two weeks later&#44; the lesions had progressed into abscesses &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The abscesses were actively drained every 48<span class="elsevierStyleHsp" style=""></span>h&#44; with collection of a sample of the exudate and dystrophic hairs for submission to the microbiology laboratory&#46; The patient received a prescription for a new course of treatment with oral itraconazole &#40;62&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#41; and a miconazole&#47;hydrocortisone cream for 3 weeks&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Girl aged 8 years referred to the dermatology department for assessment of a bald plaque in the scalp more than 1 month after onset of symptoms &#40;lesions initially developed in the left breast and spread to the scalp over time&#41;&#46; During the history taking&#44; she reported that her pet guinea pigs had developed bald patches before she contracted the disease&#46; A sample was collected for culture and the patient received treatment with terbinafine at a dose of 125<span class="elsevierStyleHsp" style=""></span>mg&#47;day for 1 month combined with topical administration of a terbinafine cream in the morning and a mometasone furoate and acetylsalicylic acid cream at night&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The microbiology laboratory processed the samples of both patients &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; In both cases&#44; 15 days after submission the laboratory report indicated the presence of a fungus initially identified as a <span class="elsevierStyleItalic">Trichophyton</span> species&#46; The definitive identification as <span class="elsevierStyleItalic">Arthroderma benhamiae</span> was achieved by the analysis of the sequence of the internal transcribed spacer &#40;ITS&#41; region of ribosomal RNA&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Arthroderma benhamiae</span> usually causes mild infections that respond to topical treatment with ciclopirox&#44; imidazole or terbinafine&#46; However&#44; cases with more extensive involvement and tinea capitis require treatment with oral antifungals&#46; In patients with kerion celsi&#44; early diagnosis and prompt initiation of treatment are of the essence due to the risk of scarring hair loss&#46; There are few studies on the use of different antifungals to treat infections by this fungus&#46; Most authors report use of terbinafine&#44; griseofulvin&#44; itraconazole or fluconazole for a minimum of 4&#8211;6 weeks&#44;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">4</span></a> with favourable outcomes&#46; Epidemiological data&#44; such as the presence of pets&#44; especially guinea pigs&#44; are important clues for suspecting and correctly diagnosing this fungal skin infection&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Mart&#237;n-Pe&#241;aranda T&#44; Lera Imbuluzqueta JM&#44; Alkorta Gurrutxaga M&#46; <span class="elsevierStyleItalic">Arthroderma benhamiae</span> en pacientes con cobayas&#46; An Pediatr &#40;Barc&#41;&#46; 2019&#59;90&#58;51&#8211;52&#46;</p>"
      ]
    ]
    "multimedia" => array:2 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1200
            "Ancho" => 800
            "Tamanyo" => 151456
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Kerion celsi&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 718
            "Ancho" => 800
            "Tamanyo" => 57965
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Appearance of <span class="elsevierStyleItalic">Arthroderma benhamiae</span> growth in Sabouraud agar plate&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:4 [
            0 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:3 [
                  "comentario" => "Available in&#58; <a class="elsevierStyleInterRef" target="_blank" id="intr0010" href="https://doi.org/10.4067/S0716-10182015000400009">https&#58;&#47;&#47;doi&#46;org&#47;10&#46;4067&#47;S0716-10182015000400009</a>"
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Complejo <span class="elsevierStyleItalic">Trichophyton mentagrophytes</span>"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "L&#46; Rivas"
                            1 => "M&#46; M&#252;hlhauser"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4067/S0716-10182015000400009"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Chilena Infectol"
                        "fecha" => "2015"
                        "volumen" => "32"
                        "paginaInicial" => "319"
                        "paginaFinal" => "320"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26230438"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:3 [
                  "comentario" => "Available in&#58; <a class="elsevierStyleInterRef" target="_blank" id="intr0015" href="https://www.ncbi.nlm.nih.gov/pubmed/24981469">https&#58;&#47;&#47;www&#46;ncbi&#46;nlm&#46;nih&#46;gov&#47;pubmed&#47;24981469</a>"
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Trichophyton species of <span class="elsevierStyleItalic">Arthroderma benhamiae</span> &#8211; a new infectious agent in dermatology"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Nenoff"
                            1 => "S&#46; Uhrla&#223;"
                            2 => "C&#46; Kr&#252;ger"
                            3 => "M&#46; Erhard"
                            4 => "U&#46;C&#46; Hipler"
                            5 => "F&#46; Seyfarth"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/ddg.12390"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dtsch Dermatol Ges"
                        "fecha" => "2014"
                        "volumen" => "12"
                        "paginaInicial" => "571"
                        "paginaFinal" => "581"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24981469"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tinea faciei caused by <span class="elsevierStyleItalic">Trichophyton mentagrophytes</span> &#40;molecular type <span class="elsevierStyleItalic">Arthroderma benhamiae</span>&#41; mimics impetigo&#58; a case report and literature review of cases in Japan"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "U&#46; Kimura"
                            1 => "K&#46; Yokoyama"
                            2 => "M&#46; Hiruma"
                            3 => "R&#46; Kano"
                            4 => "K&#46; Takamori"
                            5 => "Y&#46; Suga"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3314/mmj.56.E1"
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Mycol J"
                        "fecha" => "2015"
                        "volumen" => "56"
                        "paginaInicial" => "E1"
                        "paginaFinal" => "E5"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25855021"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Trichophyton species of <span class="elsevierStyleItalic">Arthroderma benhamiae&#58;</span> clinical therapeutic aspects of a new pathogen in dermatology"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Hiernickel"
                            1 => "C&#46; Wiegand"
                            2 => "S&#46; Schliemann"
                            3 => "F&#46; Seyfarth"
                            4 => "K&#46; Jung"
                            5 => "P&#46; Elsner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Dtsch Dermatol Ges"
                        "fecha" => "2016"
                        "volumen" => "67"
                        "paginaInicial" => "706"
                        "paginaFinal" => "711"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/23412879/0000009000000001/v1_201901020610/S2341287918302047/v1_201901020610/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "38181"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Scientific letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/23412879/0000009000000001/v1_201901020610/S2341287918302047/v1_201901020610/en/main.pdf?idApp=UINPBA00005H&text.app=https://analesdepediatria.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2341287918302047?idApp=UINPBA00005H"
]
Share
Journal Information
Vol. 90. Issue 1.
Pages 51-52 (1 January 2019)
Vol. 90. Issue 1.
Pages 51-52 (1 January 2019)
Scientific Letter
Open Access
Arthroderma benhamiae in patients with guinea pigs
Arthroderma benhamiae en pacientes con cobayas
Visits
7923
Tania Martín-Peñarandaa,
Corresponding author
, José Miguel Lera Imbuluzquetab, Miriam Alkorta Gurrutxagaa,b
a Servicio de Microbiología, Hospital Universitario de Donostia, Donostia, Guipúzcoa, Spain
b Servicio de Dermatología, Hospital Universitario de Donostia, Donostia, Guipúzcoa, Spain
This item has received

Under a Creative Commons license
Article information
Full Text
Bibliography
Download PDF
Statistics
Figures (2)
Full Text
Dear Editor:

Arthroderma benhamiae is the teleomorph of a zoonotic dermatophytic fungus that belongs to the Trichophyton mentagrophytes species complex.1 Small rodents are its main reservoir, especially guinea pigs, in which it can cause an inflammatory cutaneous infection. It has also been isolated from larger animals, such as dogs and cats. In recent years, the incidence of infection by this fungus has increased due to the increase in the number of guinea pigs and other small rodents that are household pets.2,3 This dermatophyte can cause tinea corporis, tinea faciei and in some cases kerion celsi. Onychomycosis has been reported in very rare cases.2 It is characterised by highly inflammatory lesions, especially in children, who frequently develop kerion celsi. Besides children, it is frequently isolated from adolescents and immunosuppressed individuals. In the early stage of infection, the skin lesions may be confused with impetigo, which delays diagnosis. We now proceed to present 2 cases diagnosed in our microbiology laboratory in the span of 3 months.

Girl aged 3 years that presented with an inflammatory and suppurative lesion with onset 2 months prior that was diagnosed as kerion celsi. At onset, the patient developed lesions in the mouth and nose that were treated with topical antibiotics due to suspected impetigo. Subsequently, the patient developed additional erythematous plaques with a honey-coloured crust in the parieto-occipital region, which were treated with topical mupirocin and oral amoxicillin-clavulanic acid.

Due to the unfavourable response to treatment, she was referred to the dermatology department, where she received a diagnosis of tinea capitis and started topical treatment with a terbinafine cream and a sertaconazole nitrate gel. The relevant findings of the history were a past episode of tinea corporis in the father and the presence of a pet guinea pig in the household that also had skin lesions. Two weeks later, the lesions had progressed into abscesses (Fig. 1). The abscesses were actively drained every 48h, with collection of a sample of the exudate and dystrophic hairs for submission to the microbiology laboratory. The patient received a prescription for a new course of treatment with oral itraconazole (62.5mg/day) and a miconazole/hydrocortisone cream for 3 weeks.

Figure 1.

Kerion celsi.

(0.14MB).

Girl aged 8 years referred to the dermatology department for assessment of a bald plaque in the scalp more than 1 month after onset of symptoms (lesions initially developed in the left breast and spread to the scalp over time). During the history taking, she reported that her pet guinea pigs had developed bald patches before she contracted the disease. A sample was collected for culture and the patient received treatment with terbinafine at a dose of 125mg/day for 1 month combined with topical administration of a terbinafine cream in the morning and a mometasone furoate and acetylsalicylic acid cream at night.

The microbiology laboratory processed the samples of both patients (Fig. 2). In both cases, 15 days after submission the laboratory report indicated the presence of a fungus initially identified as a Trichophyton species. The definitive identification as Arthroderma benhamiae was achieved by the analysis of the sequence of the internal transcribed spacer (ITS) region of ribosomal RNA.

Figure 2.

Appearance of Arthroderma benhamiae growth in Sabouraud agar plate.

(0.06MB).

Arthroderma benhamiae usually causes mild infections that respond to topical treatment with ciclopirox, imidazole or terbinafine. However, cases with more extensive involvement and tinea capitis require treatment with oral antifungals. In patients with kerion celsi, early diagnosis and prompt initiation of treatment are of the essence due to the risk of scarring hair loss. There are few studies on the use of different antifungals to treat infections by this fungus. Most authors report use of terbinafine, griseofulvin, itraconazole or fluconazole for a minimum of 4–6 weeks,4 with favourable outcomes. Epidemiological data, such as the presence of pets, especially guinea pigs, are important clues for suspecting and correctly diagnosing this fungal skin infection.

References
[1]
L. Rivas, M. Mühlhauser.
Complejo Trichophyton mentagrophytes.
[2]
P. Nenoff, S. Uhrlaß, C. Krüger, M. Erhard, U.C. Hipler, F. Seyfarth, et al.
Trichophyton species of Arthroderma benhamiae – a new infectious agent in dermatology.
J Dtsch Dermatol Ges, 12 (2014), pp. 571-581
[3]
U. Kimura, K. Yokoyama, M. Hiruma, R. Kano, K. Takamori, Y. Suga.
Tinea faciei caused by Trichophyton mentagrophytes (molecular type Arthroderma benhamiae) mimics impetigo: a case report and literature review of cases in Japan.
Med Mycol J, 56 (2015), pp. E1-E5
[4]
C. Hiernickel, C. Wiegand, S. Schliemann, F. Seyfarth, K. Jung, P. Elsner, et al.
Trichophyton species of Arthroderma benhamiae: clinical therapeutic aspects of a new pathogen in dermatology.
J Dtsch Dermatol Ges, 67 (2016), pp. 706-711

Please cite this article as: Martín-Peñaranda T, Lera Imbuluzqueta JM, Alkorta Gurrutxaga M. Arthroderma benhamiae en pacientes con cobayas. An Pediatr (Barc). 2019;90:51–52.

Copyright © 2017. Asociación Española de Pediatría
Download PDF
Idiomas
Anales de Pediatría (English Edition)
Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?