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Vol. 53. Núm. 4.
Páginas 330-334 (octubre 2000)
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Vol. 53. Núm. 4.
Páginas 330-334 (octubre 2000)
Acceso a texto completo
Valores elevados de alanina aminotransferasa y colinesterasa en niños obesos prepúberes: correlación con la concentración de insulina basal e índices antropométricos
High levels of alanine aminotransferase and cholinesterase in obese pre-pubertal children: correlation with basal insulin concentration and anthropometric measures
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labpozo@mx3.redestb.es

Correspondencia: Manuel Fuentes Bocanegra, 19, 6.° 1 a 14005 Córdoba.
Zona Básica de Salud Palma del Río Hospital Comarcal Valle de los Pedroches. Córdoba.
F.J. Ruz Rodrígueza, M. Valle Jiménezb, F. Gascón Lunab, F. Bermudo Guitarteb, Ramón Cañete Estradac
a Hinojosa del Duque. Córdoba. Hospital Comarcal Valle de los Pedroches. Córdoba.
b Servicio de Laboratorio Clínico. Hospital Comarcal Valle de los Pedroches. Córdoba.
c Unidad de Endocrinología Pediátrica. Hospital Reina Sofia. Córdoba
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Estadísticas
Objetivos

Determinar si parámetros bioquímicos, utilizados en el adulto como indicadores del depósito de grasa intraabdominal (alanina aminotransferasa [ALT]), colinesterasa [ChE], gamma glutamiltransferasa [/GT], aspartato aminotransferasa [AST]), están o no elevados en obesos prepú-beres, así como valorar su posible correlación con valores basales de insulina e índices antropométricos.

Pacientes y método

Estudio de casos y controles en niños de ambos sexos (46 obesos y 49 no obesos) de 6 a 9 años. A todos los niños se les determinó el índice de masa corporal (IMC), índice cintura/cadera e índice cintura/muslo. Se cuantificó: glucosa e insulina basal, índice insulina/glucosa, ALT, AST, gGT y ChE. La comparación de medias se realizó por la t de Student. La correlación entre variables se evaluó por el coeficiente de correlación de Pearson.

Resultados

Los grupos fueron homogéneos, no presentaron diferencias significativas en la edad ni en el sexo. La concentración de glucosa fue similar en ambos grupos, en tanto que la de insulina, ALT, ChE, gGT e índice ALT/AST fueron significativamente superiores en el grupo de obesos. La concentración de ALT y de ChE se correlacionaron positivamente con la insulina, el índice insulina/glucosa, así como con el IMC e índice cintura/cadera.

Conclusiones

Parámetros bioquímicos como la ALT y la ChE pueden ser de utilidad en el niño obeso como medida indirecta del depósito de grasa. El aumento de estos parámetros depende, a esta edad, tanto de la concentración de insulina como del grado de obesidad y distribución de la grasa.

Palabras clave:
Niños prepúberes
Obesidad
Alanina aminotransferasa
Colinesterasa
Grasa intraabdominal
Keywords:
Pre-puberal children
Obesity
Alanine aminotransfera-se
Cholinesterase
Intraabdominal fat
Objective

To determine whether biochemical parameters, used in adult to indicate intraabdominal fat deposits [alanine aminotransferase (ALT), cholinesterase (ChE), gamma-glutamyltransferase (?-GT), and aspartate aminotransferase (AST)] are increased in obese pre-pubertal children and to evaluate their possible correlation with basal insulin levels and anthropometric measures.

Patients and method

Study of obese pediatric patients and controls of both sexes (46 obese and 49 not obese) aged between 6 and 9 years. Body mass index (BMI), waist/hip and waist/thigh ratio were determined in all children. Glucose and basal insulin concentrations, the insulin/glucose index, ALT, AST, #yGT and ChE were quantified in all children. Student's t-test was used to perform the mean comparison and Pearson's correlation coefficient was used to evaluate the correlation between variables.

Results

The groups were homogeneous, presenting no significant differences in age or sex. Glucose concentrations were similar in both groups, while those of insulin, ALT, ChE, #yGT and the ALT/AST index were significantly higher in the group of obese children. Concentrations of ALT and ChE were positively correlated with insulin and the insulin/glucose index, BMI, and waist/hip ratio.

Conclusions

Biochemical parameters such as ALT and ChE may be useful as indirect measure of fat deposits in obese children. In this age group, an increase in these parameters depends on insulin concentration as well as on the degree of obesity and fat distribution.

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Este trabajo recoge datos preliminares del proyecto "Estudio metabólico en niños obesos. Relación entre índice antropométrico y factores de riesgo cardiovascular", financiado con una ayuda del Fondo de Investigaciones Sanitarias de la Seguridad Social (FIS 183/1997)

Copyright © 2002. Asociación Española de Pediatría
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