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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Determinar si par&#225;metros bioqu&#237;micos&#44; utilizados en el adulto como indicadores del dep&#243;sito de grasa intraabdominal &#40;alanina aminotransferasa &#91;ALT&#93;&#41;&#44; colinesterasa &#91;ChE&#93;&#44; gamma glutamiltransferasa &#91;&#47;GT&#93;&#44; aspartato aminotransferasa &#91;AST&#93;&#41;&#44; est&#225;n o no elevados en obesos prep&#250;-beres&#44; as&#237; como valorar su posible correlaci&#243;n con valores basales de insulina e &#237;ndices antropom&#233;tricos&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio de casos y controles en ni&#241;os de ambos sexos &#40;46 obesos y 49 no obesos&#41; de 6 a 9 a&#241;os&#46; A todos los ni&#241;os se les determin&#243; el &#237;ndice de masa corporal &#40;IMC&#41;&#44; &#237;ndice cintura&#47;cadera e &#237;ndice cintura&#47;muslo&#46; Se cuantific&#243;&#58; glucosa e insulina basal&#44; &#237;ndice insulina&#47;glucosa&#44; ALT&#44; AST&#44; gGT y ChE&#46; La comparaci&#243;n de medias se realiz&#243; por la t de Student&#46; La correlaci&#243;n entre variables se evalu&#243; por el coeficiente de correlaci&#243;n de Pearson&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Los grupos fueron homog&#233;neos&#44; no presentaron diferencias significativas en la edad ni en el sexo&#46; La concentraci&#243;n de glucosa fue similar en ambos grupos&#44; en tanto que la de insulina&#44; ALT&#44; ChE&#44; gGT e &#237;ndice ALT&#47;AST fueron significativamente superiores en el grupo de obesos&#46; La concentraci&#243;n de ALT y de ChE se correlacionaron positivamente con la insulina&#44; el &#237;ndice insulina&#47;glucosa&#44; as&#237; como con el IMC e &#237;ndice cintura&#47;cadera&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Par&#225;metros bioqu&#237;micos como la ALT y la ChE pueden ser de utilidad en el ni&#241;o obeso como medida indirecta del dep&#243;sito de grasa&#46; El aumento de estos par&#225;metros depende&#44; a esta edad&#44; tanto de la concentraci&#243;n de insulina como del grado de obesidad y distribuci&#243;n de la grasa&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To determine whether biochemical parameters&#44; used in adult to indicate intraabdominal fat deposits &#91;alanine aminotransferase &#40;ALT&#41;&#44; cholinesterase &#40;ChE&#41;&#44; gamma-glutamyltransferase &#40;&#63;-GT&#41;&#44; and aspartate aminotransferase &#40;AST&#41;&#93; are increased in obese pre-pubertal children and to evaluate their possible correlation with basal insulin levels and anthropometric measures&#46;</p> <span class="elsevierStyleSectionTitle">Patients and method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Study of obese pediatric patients and controls of both sexes &#40;46 obese and 49 not obese&#41; aged between 6 and 9 years&#46; Body mass index &#40;BMI&#41;&#44; waist&#47;hip and waist&#47;thigh ratio were determined in all children&#46; Glucose and basal insulin concentrations&#44; the insulin&#47;glucose index&#44; ALT&#44; AST&#44; &#35;yGT and ChE were quantified in all children&#46; Student&#39;s t-test was used to perform the mean comparison and Pearson&#39;s correlation coefficient was used to evaluate the correlation between variables&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The groups were homogeneous&#44; presenting no significant differences in age or sex&#46; Glucose concentrations were similar in both groups&#44; while those of insulin&#44; ALT&#44; ChE&#44; &#35;yGT and the ALT&#47;AST index were significantly higher in the group of obese children&#46; Concentrations of ALT and ChE were positively correlated with insulin and the insulin&#47;glucose index&#44; BMI&#44; and waist&#47;hip ratio&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Biochemical parameters such as ALT and ChE may be useful as indirect measure of fat deposits in obese children&#46; In this age group&#44; an increase in these parameters depends on insulin concentration as well as on the degree of obesity and fat distribution&#46;</p>"
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Valores elevados de alanina aminotransferasa y colinesterasa en niños obesos prepúberes: correlación con la concentración de insulina basal e índices antropométricos
High levels of alanine aminotransferase and cholinesterase in obese pre-pubertal children: correlation with basal insulin concentration and anthropometric measures
R. Martos Estepa
Autor para correspondencia
labpozo@mx3.redestb.es

Correspondencia: Manuel Fuentes Bocanegra, 19, 6.° 1 a 14005 Córdoba.
Zona Básica de Salud Palma del Río Hospital Comarcal Valle de los Pedroches. Córdoba.
F.J. Ruz Rodrígueza, M. Valle Jiménezb, F. Gascón Lunab, F. Bermudo Guitarteb, Ramón Cañete Estradac
a Hinojosa del Duque. Córdoba. Hospital Comarcal Valle de los Pedroches. Córdoba.
b Servicio de Laboratorio Clínico. Hospital Comarcal Valle de los Pedroches. Córdoba.
c Unidad de Endocrinología Pediátrica. Hospital Reina Sofia. Córdoba
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      "en" => array:1 [
        "titulo" => "High levels of alanine aminotransferase and cholinesterase in obese pre-pubertal children&#58; correlation with basal insulin concentration and anthropometric measures"
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    "fechaRecibido" => "2000-01-31"
    "fechaAceptado" => "2000-06-30"
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            0 => "Ni&#241;os prep&#250;beres"
            1 => "Obesidad"
            2 => "Alanina aminotransferasa"
            3 => "Colinesterasa"
            4 => "Grasa intraabdominal"
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            0 => "Pre-puberal children"
            1 => "Obesity"
            2 => "Alanine aminotransfera-se"
            3 => "Cholinesterase"
            4 => "Intraabdominal fat"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Determinar si par&#225;metros bioqu&#237;micos&#44; utilizados en el adulto como indicadores del dep&#243;sito de grasa intraabdominal &#40;alanina aminotransferasa &#91;ALT&#93;&#41;&#44; colinesterasa &#91;ChE&#93;&#44; gamma glutamiltransferasa &#91;&#47;GT&#93;&#44; aspartato aminotransferasa &#91;AST&#93;&#41;&#44; est&#225;n o no elevados en obesos prep&#250;-beres&#44; as&#237; como valorar su posible correlaci&#243;n con valores basales de insulina e &#237;ndices antropom&#233;tricos&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio de casos y controles en ni&#241;os de ambos sexos &#40;46 obesos y 49 no obesos&#41; de 6 a 9 a&#241;os&#46; A todos los ni&#241;os se les determin&#243; el &#237;ndice de masa corporal &#40;IMC&#41;&#44; &#237;ndice cintura&#47;cadera e &#237;ndice cintura&#47;muslo&#46; Se cuantific&#243;&#58; glucosa e insulina basal&#44; &#237;ndice insulina&#47;glucosa&#44; ALT&#44; AST&#44; gGT y ChE&#46; La comparaci&#243;n de medias se realiz&#243; por la t de Student&#46; La correlaci&#243;n entre variables se evalu&#243; por el coeficiente de correlaci&#243;n de Pearson&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Los grupos fueron homog&#233;neos&#44; no presentaron diferencias significativas en la edad ni en el sexo&#46; La concentraci&#243;n de glucosa fue similar en ambos grupos&#44; en tanto que la de insulina&#44; ALT&#44; ChE&#44; gGT e &#237;ndice ALT&#47;AST fueron significativamente superiores en el grupo de obesos&#46; La concentraci&#243;n de ALT y de ChE se correlacionaron positivamente con la insulina&#44; el &#237;ndice insulina&#47;glucosa&#44; as&#237; como con el IMC e &#237;ndice cintura&#47;cadera&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Par&#225;metros bioqu&#237;micos como la ALT y la ChE pueden ser de utilidad en el ni&#241;o obeso como medida indirecta del dep&#243;sito de grasa&#46; El aumento de estos par&#225;metros depende&#44; a esta edad&#44; tanto de la concentraci&#243;n de insulina como del grado de obesidad y distribuci&#243;n de la grasa&#46;</p>"
      ]
      "en" => array:1 [
        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To determine whether biochemical parameters&#44; used in adult to indicate intraabdominal fat deposits &#91;alanine aminotransferase &#40;ALT&#41;&#44; cholinesterase &#40;ChE&#41;&#44; gamma-glutamyltransferase &#40;&#63;-GT&#41;&#44; and aspartate aminotransferase &#40;AST&#41;&#93; are increased in obese pre-pubertal children and to evaluate their possible correlation with basal insulin levels and anthropometric measures&#46;</p> <span class="elsevierStyleSectionTitle">Patients and method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Study of obese pediatric patients and controls of both sexes &#40;46 obese and 49 not obese&#41; aged between 6 and 9 years&#46; Body mass index &#40;BMI&#41;&#44; waist&#47;hip and waist&#47;thigh ratio were determined in all children&#46; Glucose and basal insulin concentrations&#44; the insulin&#47;glucose index&#44; ALT&#44; AST&#44; &#35;yGT and ChE were quantified in all children&#46; Student&#39;s t-test was used to perform the mean comparison and Pearson&#39;s correlation coefficient was used to evaluate the correlation between variables&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The groups were homogeneous&#44; presenting no significant differences in age or sex&#46; Glucose concentrations were similar in both groups&#44; while those of insulin&#44; ALT&#44; ChE&#44; &#35;yGT and the ALT&#47;AST index were significantly higher in the group of obese children&#46; Concentrations of ALT and ChE were positively correlated with insulin and the insulin&#47;glucose index&#44; BMI&#44; and waist&#47;hip ratio&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Biochemical parameters such as ALT and ChE may be useful as indirect measure of fat deposits in obese children&#46; In this age group&#44; an increase in these parameters depends on insulin concentration as well as on the degree of obesity and fat distribution&#46;</p>"
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    "NotaPie" => array:1 [
      0 => array:1 [
        "nota" => "<p class="elsevierStyleNotepara">Este trabajo recoge datos preliminares del proyecto &#34;Estudio metab&#243;lico en ni&#241;os obesos&#46; Relaci&#243;n entre &#237;ndice antropom&#233;trico y factores de riesgo cardiovascular&#34;&#44; financiado con una ayuda del Fondo de Investigaciones Sanitarias de la Seguridad Social &#40;FIS 183&#47;1997&#41;</p>"
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Información del artículo
ISSN: 16954033
Idioma original: Español
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