array:23 [
  "pii" => "S1695403300773632"
  "issn" => "16954033"
  "doi" => "10.1016/S1695-4033(00)77363-2"
  "estado" => "S300"
  "fechaPublicacion" => "2000-04-01"
  "aid" => "77363"
  "copyright" => "Asociación Española de Pediatría"
  "copyrightAnyo" => "2000"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "sco"
  "cita" => "An Pediatr (Barc). 2000;52:381-4"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 8030
    "formatos" => array:3 [
      "EPUB" => 78
      "HTML" => 7349
      "PDF" => 603
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1695403300773644"
    "issn" => "16954033"
    "doi" => "10.1016/S1695-4033(00)77364-4"
    "estado" => "S300"
    "fechaPublicacion" => "2000-04-01"
    "aid" => "77364"
    "copyright" => "Asociación Española de Pediatría"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "sco"
    "cita" => "An Pediatr (Barc). 2000;52:385-8"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2651
      "formatos" => array:3 [
        "EPUB" => 62
        "HTML" => 1823
        "PDF" => 766
      ]
    ]
    "es" => array:7 [
      "idiomaDefecto" => true
      "titulo" => "Síndrome de West asociado a displasia frontal calcificada. Evolución favorable"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "385"
          "paginaFinal" => "388"
        ]
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "E. Fernández-Romero, R. Camino León, A. Arjona Padillo, J.M. Barcia Ruiz"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "E."
              "apellidos" => "Fernández-Romero"
            ]
            1 => array:2 [
              "nombre" => "R."
              "apellidos" => "Camino León"
            ]
            2 => array:2 [
              "nombre" => "A."
              "apellidos" => "Arjona Padillo"
            ]
            3 => array:2 [
              "nombre" => "J.M."
              "apellidos" => "Barcia Ruiz"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403300773644?idApp=UINPBA00005H"
    "url" => "/16954033/0000005200000004/v1_201307051457/S1695403300773644/v1_201307051457/es/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S1695403300773620"
    "issn" => "16954033"
    "doi" => "10.1016/S1695-4033(00)77362-0"
    "estado" => "S300"
    "fechaPublicacion" => "2000-04-01"
    "aid" => "77362"
    "copyright" => "Asociación Española de Pediatría"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "sco"
    "cita" => "An Pediatr (Barc). 2000;52:377-80"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 3069
      "formatos" => array:3 [
        "EPUB" => 71
        "HTML" => 2298
        "PDF" => 700
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Un caso de paludismo neonatal en España"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "377"
          "paginaFinal" => "380"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "A case of neonatal malaria in Spain"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Juana María Romero Urbano, Rosario Vázquez López, Antonio Jurado Ortiz, Antonio Martínez Valverde"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Juana"
              "apellidos" => "María Romero Urbano"
            ]
            1 => array:2 [
              "nombre" => "Rosario"
              "apellidos" => "Vázquez López"
            ]
            2 => array:2 [
              "nombre" => "Antonio"
              "apellidos" => "Jurado Ortiz"
            ]
            3 => array:2 [
              "nombre" => "Antonio"
              "apellidos" => "Martínez Valverde"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403300773620?idApp=UINPBA00005H"
    "url" => "/16954033/0000005200000004/v1_201307051457/S1695403300773620/v1_201307051457/es/main.assets"
  ]
  "es" => array:10 [
    "idiomaDefecto" => true
    "titulo" => "Eficacia terapéutica del ketoconazol en el síndrome de Cushing"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "381"
        "paginaFinal" => "384"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "F. Carral San Laureano, J.L. Lechuga Campoy, J. Merino López, J. Caro Contreras, M. Aguilar Diosdado"
        "autores" => array:5 [
          0 => array:3 [
            "nombre" => "F."
            "apellidos" => "Carral San Laureano"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          1 => array:4 [
            "nombre" => "J&#46;L&#46;"
            "apellidos" => "Lechuga Campoy"
            "email" => array:1 [
              0 => "joseluislechuga&#64;comcadiz&#46;es"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "J&#46;"
            "apellidos" => "Merino L&#243;pez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "J&#46;"
            "apellidos" => "Caro Contreras"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "M&#46;"
            "apellidos" => "Aguilar Diosdado"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Secci&#243;n de Endocrinolog&#237;a&#46; Hospital Universitario Puerta del Mar&#46; C&#225;diz&#46;"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Pediatr&#237;a&#46; Hospital Universitario Puerta del Mar&#46; C&#225;diz&#46;"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#42;"
            "correspondencia" => "Correspondencia&#58; Secci&#243;n de Endocrinolog&#237;a &#40;8&#46;<span class="elsevierStyleSup">a</span> planta&#41;&#46; Hospital Puerta del Mar&#46; Ana de Viya&#44; 21&#46; 11009 C&#225;diz&#46;"
          ]
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "1999-04-30"
    "fechaAceptado" => "1999-10-31"
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:20 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cushing&#39;s syndrome in children and adolescents&#58; presentation&#44; diagnosis&#44; and therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;A&#46; Magiakou"
                            1 => "G&#46; Mastorakos"
                            2 => "E&#46;H&#46; Olfield"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199409083311002"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1994"
                        "volumen" => "331"
                        "paginaInicial" => "629"
                        "paginaFinal" => "636"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8052272"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cushing syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46;N&#46; Orth"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1995"
                        "volumen" => "12"
                        "paginaInicial" => "791"
                        "paginaFinal" => "803"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The adrenal cortex"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "W&#46;L&#46; Miller"
                            1 => "J&#46;B&#46; Tyrrell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Endocrinology and metabolism"
                        "paginaInicial" => "659"
                        "paginaFinal" => "711"
                        "serieFecha" => "1995"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cushing&#39;s disease in children"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46;C&#46; Leinung"
                            1 => "D&#46; Zimmerman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Endocrinol Metab Clin North Am"
                        "fecha" => "1994"
                        "volumen" => "23"
                        "paginaInicial" => "629"
                        "paginaFinal" => "639"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7805659"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Biochemical and radiologic diagnosis of Cushing&#39;s syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;W&#46; Findling"
                            1 => "J&#46;L&#46; Doppman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Endocrinol Metab Clin North Am"
                        "fecha" => "1994"
                        "volumen" => "23"
                        "paginaInicial" => "511"
                        "paginaFinal" => "537"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7805651"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The desmopressin stimulation test in the differencial diagnosis of Cushing&#39;s syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46;A&#46; Malerbi"
                            1 => "B&#46;B&#46; Mendo&#231;a"
                            2 => "B&#46; Liberman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clin Endocrinol"
                        "fecha" => "1993"
                        "volumen" => "38"
                        "paginaInicial" => "463"
                        "paginaFinal" => "472"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The desmopressin test and Cushing&#39;s syndrome&#58; Current state of play"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46; Newell-Price"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clin Endocrinol"
                        "fecha" => "1997"
                        "volumen" => "47"
                        "paginaInicial" => "173"
                        "paginaFinal" => "174"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Investigation&#44; management and therapeutic outcome in 12 cases of childhood and adolescent Cushing&#39;s syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Weber"
                            1 => "P&#46;J&#46; Trainer"
                            2 => "A&#46;B&#46; Grossman"
                            3 => "F&#46; Afshar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clin Endocrinol"
                        "fecha" => "1995"
                        "volumen" => "43"
                        "paginaInicial" => "19"
                        "paginaFinal" => "28"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Transnasal microsurgery in children and adolescents with Cushing&#39;s disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "U&#46;J&#46; Knappe"
                            1 => "D&#46;K&#46; L&#252;decke"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurosurgery"
                        "fecha" => "1996"
                        "volumen" => "39"
                        "paginaInicial" => "484"
                        "paginaFinal" => "493"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8875478"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Petrosal sinus sampling with and without corticotropin-releasing hormone for the differential diagnosis of Cushing&#39;s syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46;H&#46; Oldfield"
                            1 => "J&#46;L&#46; Doppman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199109263251301"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1991"
                        "volumen" => "325"
                        "paginaInicial" => "897"
                        "paginaFinal" => "905"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1652686"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Long term follow-up of transphenoidal surgery for the treatment of Cushing&#39;s disease in childhood"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46;C&#46; Leinung"
                            1 => "L&#46;A&#46; Kane"
                            2 => "B&#46;W&#46; Scheithauer"
                            3 => "P&#46;C&#46; Carpenter"
                            4 => "E&#46;R&#46; Laws"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jcem.80.8.7629245"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "1995"
                        "volumen" => "80"
                        "paginaInicial" => "2475"
                        "paginaFinal" => "2479"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7629245"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Long-term outcome in children and adolescents after transsphenoidal surgery for Cushing&#39;s disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46;J&#46; Devoe"
                            1 => "W&#46;L&#46; Miller"
                            2 => "F&#46;A&#46; Conte"
                            3 => "S&#46;L&#46; Kaplan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jcem.82.10.4290"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "1997"
                        "volumen" => "82"
                        "paginaInicial" => "3196"
                        "paginaFinal" => "3202"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9329338"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Results of treating childhood Cushing&#39;s disease with pituitary iradiation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;S&#46; Jennings"
                            1 => "G&#46;W&#46; Liddle"
                            2 => "D&#46;N&#46; Orth"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "N Engl J"
                        "fecha" => "1977"
                        "volumen" => "297"
                        "paginaInicial" => "958"
                        "paginaFinal" => "962"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The long-term outcome of pituitary irradiation after unsuccessful transsphenoidal surgery in Cushing&#39;s disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46; Estrada"
                            1 => "M&#46; Boronat"
                            2 => "M&#46; Mielgo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199701163360303"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1997"
                        "volumen" => "336"
                        "paginaInicial" => "172"
                        "paginaFinal" => "177"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8988897"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The medical treatment of Cushing&#39;s syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;W&#46; Miller"
                            1 => "L&#46; Crapo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/edrv-14-4-443"
                      "Revista" => array:6 [
                        "tituloSerie" => "Endocr Rev"
                        "fecha" => "1993"
                        "volumen" => "14"
                        "paginaInicial" => "443"
                        "paginaFinal" => "458"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7693447"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ketokonazol treatment in Cushing&#39;s syndrome&#58; experience in 34 patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "N&#46; Sonino"
                            1 => "M&#46; Boscaro"
                            2 => "A&#46; Paoletta"
                            3 => "F&#46; Mantero"
                            4 => "D&#46; Ziliotto"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clin Endocrinol"
                        "fecha" => "1991"
                        "volumen" => "35"
                        "paginaInicial" => "347"
                        "paginaFinal" => "352"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The use of ketokonazole as an inhibitor of steroid production"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "N&#46; Sonino"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM198709243171307"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1987"
                        "volumen" => "317"
                        "paginaInicial" => "812"
                        "paginaFinal" => "818"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3306384"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Use of ketoconazole in the treatment of Cushing&#39;s syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46; Loli"
                            1 => "M&#46;E&#46; Berselli"
                            2 => "M&#46;A&#46; Tagliaferri"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Clin Endo Metab"
                        "fecha" => "1986"
                        "volumen" => "63"
                        "paginaInicial" => "1365"
                        "paginaFinal" => "1371"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical experience with ketoconazole as a therapy for patiens with Cushing&#39;s syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46;R&#46; McCance"
                            1 => "D&#46;R&#46; Hadden"
                            2 => "L&#46; Kennedy"
                            3 => "B&#46; Sheridan"
                            4 => "A&#46;B&#46; Atkinson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clin Endocrinol"
                        "fecha" => "1987"
                        "volumen" => "27"
                        "paginaInicial" => "593"
                        "paginaFinal" => "599"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Use of ketokonazole in the treatment of Cushing&#39;s disease and ectopic ACTH syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Tabarin"
                            1 => "A&#46; Navarrenne"
                            2 => "J&#46; Gu&#233;rin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clin Endocrinol"
                        "fecha" => "1991"
                        "volumen" => "34"
                        "paginaInicial" => "63"
                        "paginaFinal" => "69"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/16954033/0000005200000004/v1_201307051457/S1695403300773632/v1_201307051457/es/main.assets"
  "Apartado" => array:4 [
    "identificador" => "14441"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Notas cl&#237;nicas"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/16954033/0000005200000004/v1_201307051457/S1695403300773632/v1_201307051457/es/main.pdf?idApp=UINPBA00005H&text.app=https://analesdepediatria.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403300773632?idApp=UINPBA00005H"
]
Compartir
Información de la revista
Vol. 52. Núm. 4.
Páginas 381-384 (abril 2000)
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Vol. 52. Núm. 4.
Páginas 381-384 (abril 2000)
Acceso a texto completo
Eficacia terapéutica del ketoconazol en el síndrome de Cushing
Visitas
12415
F. Carral San Laureanoa, J.L. Lechuga Campoyb,
Autor para correspondencia
joseluislechuga@comcadiz.es

Correspondencia: Sección de Endocrinología (8.a planta). Hospital Puerta del Mar. Ana de Viya, 21. 11009 Cádiz.
, J. Merino Lópezb, J. Caro Contrerasb, M. Aguilar Diosdadoa
a Sección de Endocrinología. Hospital Universitario Puerta del Mar. Cádiz.
b Servicio de Pediatría. Hospital Universitario Puerta del Mar. Cádiz.
Este artículo ha recibido
Información del artículo
El Texto completo está disponible en PDF
Bibliografía
[1.]
M.A. Magiakou, G. Mastorakos, E.H. Olfield.
Cushing's syndrome in children and adolescents: presentation, diagnosis, and therapy.
N Engl J Med, 331 (1994), pp. 629-636
[2.]
D.N. Orth.
Cushing syndrome.
N Engl J Med, 12 (1995), pp. 791-803
[3.]
W.L. Miller, J.B. Tyrrell.
The adrenal cortex.
Endocrinology and metabolism, pp. 659-711
[4.]
M.C. Leinung, D. Zimmerman.
Cushing's disease in children.
Endocrinol Metab Clin North Am, 23 (1994), pp. 629-639
[5.]
J.W. Findling, J.L. Doppman.
Biochemical and radiologic diagnosis of Cushing's syndrome.
Endocrinol Metab Clin North Am, 23 (1994), pp. 511-537
[6.]
D.A. Malerbi, B.B. Mendoça, B. Liberman.
The desmopressin stimulation test in the differencial diagnosis of Cushing's syndrome.
Clin Endocrinol, 38 (1993), pp. 463-472
[7.]
J. Newell-Price.
The desmopressin test and Cushing's syndrome: Current state of play.
Clin Endocrinol, 47 (1997), pp. 173-174
[8.]
A. Weber, P.J. Trainer, A.B. Grossman, F. Afshar.
Investigation, management and therapeutic outcome in 12 cases of childhood and adolescent Cushing's syndrome.
Clin Endocrinol, 43 (1995), pp. 19-28
[9.]
U.J. Knappe, D.K. Lüdecke.
Transnasal microsurgery in children and adolescents with Cushing's disease.
Neurosurgery, 39 (1996), pp. 484-493
[10.]
E.H. Oldfield, J.L. Doppman.
Petrosal sinus sampling with and without corticotropin-releasing hormone for the differential diagnosis of Cushing's syndrome.
N Engl J Med, 325 (1991), pp. 897-905
[11.]
M.C. Leinung, L.A. Kane, B.W. Scheithauer, P.C. Carpenter, E.R. Laws.
Long term follow-up of transphenoidal surgery for the treatment of Cushing's disease in childhood.
J Clin Endocrinol Metab, 80 (1995), pp. 2475-2479
[12.]
D.J. Devoe, W.L. Miller, F.A. Conte, S.L. Kaplan.
Long-term outcome in children and adolescents after transsphenoidal surgery for Cushing's disease.
J Clin Endocrinol Metab, 82 (1997), pp. 3196-3202
[13.]
A.S. Jennings, G.W. Liddle, D.N. Orth.
Results of treating childhood Cushing's disease with pituitary iradiation.
N Engl J, 297 (1977), pp. 958-962
[14.]
J. Estrada, M. Boronat, M. Mielgo.
The long-term outcome of pituitary irradiation after unsuccessful transsphenoidal surgery in Cushing's disease.
N Engl J Med, 336 (1997), pp. 172-177
[15.]
J.W. Miller, L. Crapo.
The medical treatment of Cushing's syndrome.
Endocr Rev, 14 (1993), pp. 443-458
[16.]
N. Sonino, M. Boscaro, A. Paoletta, F. Mantero, D. Ziliotto.
Ketokonazol treatment in Cushing's syndrome: experience in 34 patients.
Clin Endocrinol, 35 (1991), pp. 347-352
[17.]
N. Sonino.
The use of ketokonazole as an inhibitor of steroid production.
N Engl J Med, 317 (1987), pp. 812-818
[18.]
P. Loli, M.E. Berselli, M.A. Tagliaferri.
Use of ketoconazole in the treatment of Cushing's syndrome.
J Clin Endo Metab, 63 (1986), pp. 1365-1371
[19.]
D.R. McCance, D.R. Hadden, L. Kennedy, B. Sheridan, A.B. Atkinson.
Clinical experience with ketoconazole as a therapy for patiens with Cushing's syndrome.
Clin Endocrinol, 27 (1987), pp. 593-599
[20.]
A. Tabarin, A. Navarrenne, J. Guérin.
Use of ketokonazole in the treatment of Cushing's disease and ectopic ACTH syndrome.
Clin Endocrinol, 34 (1991), pp. 63-69
Copyright © 2000. Asociación Española de Pediatría
Descargar PDF
Idiomas
Anales de Pediatría
Opciones de artículo
Herramientas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?