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vomiting and watery stools with fresh blood of three days&#8217; duration&#44; with asthenia and oligoanuria in the previous 48<span class="elsevierStyleHsp" style=""></span>h&#46; The relevant findings of urgent laboratory testing were&#58; haemoglobin&#44; 9<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#59; platelets&#44; 67&#44;000&#47;&#956;L&#59; creatinine&#44; 3&#46;9<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#59; urea&#44; 162<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; uric acid&#44; 15&#46;9<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#59; lactate dehydrogenase &#40;LDH&#41;&#44; 5397<span class="elsevierStyleHsp" style=""></span>IU&#47;L&#59; and 4&#8211;5 schistocytes per high-power field in the peripheral blood smear&#46; The patient was admitted to the paediatric intensive care unit for suspected HUS&#44; and her persistent anuria required initiation of continuous venovenous haemodiafiltration&#44; which was followed by peritoneal dialysis for a total of 21 days of blood purification&#46; The complement levels were decreased at diagnosis &#40;C3&#44; 62&#46;1<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#59; C4&#44; 10&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41; and had normalised three days later&#44; including properdin &#40;28&#46;6<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41; and CH100 &#40;1&#46;125<span class="elsevierStyleHsp" style=""></span>U&#47;mL&#41; values&#46; The detection of anti-ADAMTS13 antibodies was positive &#40;43&#46;9<span class="elsevierStyleHsp" style=""></span>AU&#47;mL&#41;&#44; although ADAMTS13 activity was normal &#40;64&#46;5&#37;&#41;&#46; The investigation was completed with a stool culture that was negative for enterohaemorrhagic <span class="elsevierStyleItalic">E&#46; coli</span>&#46; Due to this result&#44; the sample was analysed by PCR and found to be positive for verotoxigenic <span class="elsevierStyleItalic">E&#46; coli</span>&#44; and genetic characterisation and serotyping identified the isolate as strain O26H&#58;11&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">E&#46; coli</span> strain O26&#58;H11 has been an emergent pathogen in Europe since it was first isolated in Germany in 1990&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> It has been increasingly isolated in cases of HUS to eventually become the second most frequent cause &#40;15&#8211;19&#37;&#41; following serotype O157&#58;H7&#44; even surpassing this serotype in some countries between 2008 and 2012&#46; It can also produce two types of Stx&#44; of which Stx2a is strongly associated with the development of HUS&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> Furthermore&#44; there is evidence that children are more frequently infected by <span class="elsevierStyleItalic">stx</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">2a</span></span>-harbouring strains&#44; and thus are more likely to develop HUS&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The detection of enterohaemorrhagic <span class="elsevierStyleItalic">E&#46; coli</span> O26&#58;H11 by PCR in our patient constitutes the first time that this strain is found in a child with HUS in Spain&#46; This serotype is associated with infection in younger children&#44; and the form of HUS that it causes may have a similar severity and clinical course to the form produced by O157&#58;H7&#46; The patient was kept in isolation during the early weeks of hospitalisation&#44; and is currently awaiting negative stool culture results to resume her schooling&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Our patient did not receive antibiotic therapy&#44; as it is not indicated for HUS&#59; furthermore&#44; antibiotic use has been associated with an increased risk of developing HUS in enteroinvasive diarrhoeas&#44;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> and experimental studies have shown that it may induce the expression and release of Stx&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">We have only found references to other two cases of diarrhoea-associated HUS<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> with presence of anti-ADAMTS13 antibodies and preserved normal ADAMTS13 activity&#44; as observed in our patient&#46; The role of these antibodies in these patients has not been clearly established&#44; so their presence alone would not indicate a specific intervention insofar as activity continues to be normal&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Our patient only required one red blood cell transfusion after her haemoglobin level had reached a minimum of 5&#46;7<span class="elsevierStyleHsp" style=""></span>g&#47;dL four days after admission&#59; the platelet levels dropped to 64&#44;000 in the first 24<span class="elsevierStyleHsp" style=""></span>h and then increased gradually from the fifth day of hospitalisation&#46; The concentration of haptoglobin at diagnosis was less than 10<span class="elsevierStyleHsp" style=""></span>mg&#47;dL and the LDH levels were reduced by half in the first three days&#44; normalising two weeks later&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">We should also note the absence of neurologic manifestations in our patient &#40;save for mild confusion&#41;&#44; the presence of which is variable in the early stages of HUS&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Our purpose in presenting this case is to emphasise&#44; on one hand&#44; that a high degree of suspicion is essential&#44; as this disease can cause severe sequelae or even death in 5&#37; to 10&#37; of the cases&#44; and on the other&#44; that an exhaustive microbiological diagnosis is imperative&#44; promptly submitting samples for the early identification of emerging strains so that appropriate preventive measures can be implemented&#46; This requires the support of reference centres&#44; which in our case was the Centro Nacional de Microbiolog&#237;a &#40;Instituto de Salud Carlos III&#41;&#46;</p></span>"
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Journal Information
Vol. 84. Issue 3.
Pages 171-172 (1 March 2016)
Vol. 84. Issue 3.
Pages 171-172 (1 March 2016)
Scientific Letter
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Typical haemolytic uraemic syndrome: Report of the first case due to Escherichia coli O26:H11 in Spain
Síndrome hemolítico urémico típico: comunicación del primer caso producido por Escherichia coli O26:H11 en España
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E.J. Bardón Canchoa,
Corresponding author
edubc15@hotmail.com

Corresponding author.
, L. Butragueño Laisecab, O. Álvarez Blancoa, A.J. Alcaraz Romerob, A.B. Martínez Lópeza
a Servicio de Nefrología Pediátrica, Hospital Materno-Infantil, Hospital General Universitario Gregorio Marañón, Madrid, Spain
b Unidad de Cuidados Intensivos Pediátricos, Hospital Materno-Infantil, Hospital General Universitario Gregorio Marañón, Madrid, Spain
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Dear Editor:

Haemolytic uraemic syndrome (HUS), while rare, is one of the main causes of acute renal failure in the paediatric age group. It is characterised by the development of haemolytic anaemia, thrombocytopenia and acute renal failure.1 Most cases present with diarrhoea (so-called typical HUS), with Shiga toxin (Stx)-producing Escherichia coli (E. coli), especially serotype O157:H7, being the most frequent aetiological agent. We are presenting a case caused by the O26:H11 strain of enterohaemorrhagic E. coli.

The patient was a girl aged 2 years presenting with fever, vomiting and watery stools with fresh blood of three days’ duration, with asthenia and oligoanuria in the previous 48h. The relevant findings of urgent laboratory testing were: haemoglobin, 9g/dL; platelets, 67,000/μL; creatinine, 3.9mg/dL; urea, 162mg/dL, uric acid, 15.9mg/dL; lactate dehydrogenase (LDH), 5397IU/L; and 4–5 schistocytes per high-power field in the peripheral blood smear. The patient was admitted to the paediatric intensive care unit for suspected HUS, and her persistent anuria required initiation of continuous venovenous haemodiafiltration, which was followed by peritoneal dialysis for a total of 21 days of blood purification. The complement levels were decreased at diagnosis (C3, 62.1mg/dL; C4, 10.5mg/dL) and had normalised three days later, including properdin (28.6mg/dL) and CH100 (1.125U/mL) values. The detection of anti-ADAMTS13 antibodies was positive (43.9AU/mL), although ADAMTS13 activity was normal (64.5%). The investigation was completed with a stool culture that was negative for enterohaemorrhagic E. coli. Due to this result, the sample was analysed by PCR and found to be positive for verotoxigenic E. coli, and genetic characterisation and serotyping identified the isolate as strain O26H:11.

E. coli strain O26:H11 has been an emergent pathogen in Europe since it was first isolated in Germany in 1990.2 It has been increasingly isolated in cases of HUS to eventually become the second most frequent cause (15–19%) following serotype O157:H7, even surpassing this serotype in some countries between 2008 and 2012. It can also produce two types of Stx, of which Stx2a is strongly associated with the development of HUS.3 Furthermore, there is evidence that children are more frequently infected by stx2a-harbouring strains, and thus are more likely to develop HUS.2

The detection of enterohaemorrhagic E. coli O26:H11 by PCR in our patient constitutes the first time that this strain is found in a child with HUS in Spain. This serotype is associated with infection in younger children, and the form of HUS that it causes may have a similar severity and clinical course to the form produced by O157:H7. The patient was kept in isolation during the early weeks of hospitalisation, and is currently awaiting negative stool culture results to resume her schooling.

Our patient did not receive antibiotic therapy, as it is not indicated for HUS; furthermore, antibiotic use has been associated with an increased risk of developing HUS in enteroinvasive diarrhoeas,4 and experimental studies have shown that it may induce the expression and release of Stx.

We have only found references to other two cases of diarrhoea-associated HUS5 with presence of anti-ADAMTS13 antibodies and preserved normal ADAMTS13 activity, as observed in our patient. The role of these antibodies in these patients has not been clearly established, so their presence alone would not indicate a specific intervention insofar as activity continues to be normal.

Our patient only required one red blood cell transfusion after her haemoglobin level had reached a minimum of 5.7g/dL four days after admission; the platelet levels dropped to 64,000 in the first 24h and then increased gradually from the fifth day of hospitalisation. The concentration of haptoglobin at diagnosis was less than 10mg/dL and the LDH levels were reduced by half in the first three days, normalising two weeks later.

We should also note the absence of neurologic manifestations in our patient (save for mild confusion), the presence of which is variable in the early stages of HUS.

Our purpose in presenting this case is to emphasise, on one hand, that a high degree of suspicion is essential, as this disease can cause severe sequelae or even death in 5% to 10% of the cases, and on the other, that an exhaustive microbiological diagnosis is imperative, promptly submitting samples for the early identification of emerging strains so that appropriate preventive measures can be implemented. This requires the support of reference centres, which in our case was the Centro Nacional de Microbiología (Instituto de Salud Carlos III).

References
[1]
A. Kaur, L. Kerecuk.
Haemolytic uraemic syndrome.
Paediatr Child Health, 22 (2012), pp. 332-336
[2]
M. Bielaszewska, A. Mellmann, S. Bletz, W. Zhang, R. Köck, A. Kossow, et al.
Enterohemorrhagic Escherichia coli O26:H11/H-: a new virulent clone emerges in Europe.
Clin Infect Dis, 56 (2013), pp. 1373-1381
[3]
M. Marejková, K. Bláhová, J. Janda, A. Fruth, P. Petráš.
Enterohemorrhagic Escherichia coli as causes of hemolytic uremic syndrome in the Czech Republic.
[4]
C.S. Wong, J.C. Mooney, J.R. Brandt, A.O. Staples, S. Jelacic, D.R. Boster, et al.
Risk factors for the hemolytic uremic syndrome in children infected with Escherichia coli O157:H7: a multivariable analysis.
Clin Infect Dis, 55 (2012), pp. 33-41
[5]
M. Rieger, P.M. Mannucci, J.A. Kremer Hovinga, A. Herzog, G. Gerstenbauer, C. Konetschny, et al.
ADAMTS13 autoantibodies in patients with thrombotic microangiopathies and other immunomediated diseases.
Blood, 106 (2005), pp. 1262-1267

Please cite this article as: Bardón Cancho EJ, Butragueño Laiseca L, Álvarez Blanco O, Alcaraz Romero AJ, Martínez López AB. Síndrome hemolítico urémico típico: comunicación del primer caso producido por Escherichia coli O26:H11 en España. An Pediatr (Barc). 2016;84:171–172.

Copyright © 2015. Asociación Española de Pediatría
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