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and 2 probable cases with isolation from non-sterile sites&#41; and TSS was caused by <span class="elsevierStyleItalic">S&#46; aureus</span> in only one patient&#46; The portal of entry was the pharynx in 7 cases&#44; the skin in 6 &#40;3 due to superinfection of lesions caused by varicella&#41; and unknown in 1&#46; All patients developed fever&#44; hypotension and failure of 2 or more organs &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#44; 8 &#40;57&#46;1&#37;&#41; had decreased level of consciousness or lethargy&#44; and 21&#46;4&#37; had gastrointestinal symptoms&#46; Exanthema developed in 64&#46;3&#37; of the patients &#40;generalised erythematous rash in 6&#44; and macular morbilliform rash in 3&#41;&#44; with delayed desquamation in 7 patients&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Ten patients &#40;71&#46;4&#37;&#41; required vasoactive support&#44; including administration of vasopressors in 5 patients for a mean of 6&#46;2 days &#40;2&#8211;12&#41;&#44; and with a mean vasoactive-inotropic score of 42&#46; Nine out of the 14 patients required ventilatory support&#44; 7 with intubation &#40;mean duration&#44; 10 days&#59; range&#44; 6&#8211;25&#41; and 2 with noninvasive mechanical ventilation &#40;mean duration&#44; 2&#46;5 days&#41;&#46; Some of the findings compatible with multiple organ failure were&#58; thrombocytopenia and&#47;or coagulopathy as well as abnormal liver function test results in 11 patients &#40;78&#46;6&#37;&#41;&#59; hypocalcaemia in 5 &#40;35&#46;7&#37;&#41;&#59; acute kidney injury in 10 &#40;71&#46;4&#37;&#41;&#44; 2 of whom required renal replacement therapy for a mean of 4 days&#46; Three patients developed soft-tissue necrosis in the form of necrotising fasciitis or pyomyositis that required surgical debridement&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">In 12 out of the 13 cases of streptococcal TSS&#44; clindamycin was added to the initial treatment with cefotaxime&#46; Four patients received immunoglobulin therapy &#40;3 with necrotising fasciitis or pyomyositis&#41; and 2 received steroid therapy&#46; The patient with staphylococcal infection initially received cefotaxime&#44; followed by cloxacillin&#46; All patients had favourable outcomes&#44; and none died&#46; Close contacts and household members did not receive prophylactic antibiotherapy in any case&#44; and there was no documentation of any associated events&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Our study reflects the severity of the illness developed by these patients&#44; with a large proportion requiring advanced haemodynamic and respiratory support&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> Most patients were less than 2 years of age&#44; which was consistent with other series&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> The most frequent portals of entry were the pharynx and the skin&#44; and varicella infection was a significant risk factor&#44; consistent with the literature&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> Ninety-three percent of cases were caused by <span class="elsevierStyleItalic">S&#46; pyogenes</span>&#44; which diverges from previous studies conducted in Spain and recent international publications&#44; in which <span class="elsevierStyleItalic">S&#46; aureus</span> continues to be the most prevalent causative agent&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Although streptococcal TSS is associated with a high mortality of up to 30&#8211;60&#37; compared to 5&#37; in staphylococcal TSS&#44;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;3&#8211;5</span></a> there were no deaths in our case series&#44; probably due to the early initiation of treatment&#46; The administration of prophylactic antibiotics to close contacts remains controversial&#44; and is recommended in a few countries&#44; such as Canada&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">It is crucial that this condition is detected early and the patient referred to a facility with intensive care services&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;5</span></a> When TSS is suspected&#44; the patient should be placed on life support&#44; as would be done in cases of septic shock&#44; with the addition of antitoxin treatment &#40;antimicrobials such as clindamycin&#41;&#44; surgical debridement&#44; and administration of immunoglobulin to enhance plasma neutralising activity against toxins&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a></p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Butrague&#241;o Laiseca L&#44; Garc&#237;a Mor&#237;n M&#44; Barredo Valderrama E&#44; Alcaraz Romero AJ&#46; S&#237;ndrome de <span class="elsevierStyleItalic">shock</span> t&#243;xico en una unidad de cuidados intensivos pedi&#225;tricos en los &#250;ltimos 15 a&#241;os&#46; An Pediatr &#40;Barc&#41;&#46; 2017&#59;87&#58;111&#8211;113&#46;</p>"
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          "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">IMV&#44; invasive mechanical ventilation&#59; IVIG&#44; intravenous immunoglobulin&#59; PICU&#44; paediatric intensive care unit&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Case&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Aetiologic agent&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Portal of entry&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Microbiological specimen collection site&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">IMV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Inotropic&#47;vasopressor agents&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Length of PICU stay in days&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Kidney failure&#47;renal replacement therapy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Antitoxin treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Complications&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;08&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">S&#46; pyogenes</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pharynx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pharynx&#44; pleura&#44; bronchial aspirate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&#47;yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&#47;yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Clindamycin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pneumonia with pleural effusion&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">S&#46; pyogenes</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Skin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Abscess and soft tissue biopsy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&#47;yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&#47;no&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IVIG&#47;clindamycin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Necrotising fasciitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">S&#46; pyogenes</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pharynx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pharynx&#44; blood culture&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&#47;no&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&#47;no&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Convulsive seizures&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">19&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">S&#46; pyogenes</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pharynx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pharynx&#44; blood culture&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&#47;no&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&#47;no&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Clindamycin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pneumonia with pleural effusion&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">S&#46; pyogenes</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pharynx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pharynx&#44; pleura&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&#47;no&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&#47;no&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Clindamycin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pneumonia with pleural effusion&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">S&#46; pyogenes</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Skin &#40;chickenpox&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pharynx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&#47;no&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&#47;no&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Clindamycin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">S&#46; pyogenes</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Skin &#40;chickenpox&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Perianal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&#47;yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&#47;no&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Clindamycin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Necrotising fasciitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">S&#46; pyogenes</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Unknown&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pleura&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&#47;no&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&#47;no&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Clindamycin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pneumonia with pleural effusion&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">S&#46; pyogenes</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pharynx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pharynx&#44; blood culture&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&#47;yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&#47;no&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IVIG&#47;Clindamycin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pneumonia with pleural effusion&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">S&#46; aureus</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Skin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Skin exudate&#44; bronchial aspirate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&#47;yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&#47;no&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Convulsive seizures&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">S&#46; pyogenes</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pharynx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pharynx&#44; blood culture&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&#47;no&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&#47;yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Clindamycin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Convulsive seizures&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">S&#46; pyogenes</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Skin &#40;chickenpox&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pharynx&#44; blood culture&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&#47;no&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&#47;no&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Clindamycin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">S&#46; pyogenes</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Skin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pharynx&#44; blood culture&#44; wound exudate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&#47;no&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&#47;no&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IVIG&#47;Clindamycin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pneumonia with pleural effusion<br>Convulsive seizures&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">S&#46; pyogenes</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pharynx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pharynx&#44; blood culture&#44; soft-tissue abscess and osteomyelitis biopsy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&#47;no&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&#47;no&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IVIG&#47;Clindamycin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pyomyositis<br>Osteomyelitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Patient characteristics&#58; age&#44; microbial isolation&#44; need for mechanical ventilation and inotropic treatment&#44; length of stay in PICU&#44; associated kidney failure and need for renal replacement therapy&#44; antitoxin treatment and developed complications&#46;</p>"
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">42&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Posterior desquamation&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">50&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">57&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Gastrointestinal symptoms&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">21&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Thrombocytopenia&#47;coagulopathy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">78&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Liver disease&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">78&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Acute kidney injury&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">71&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Necrotising fasciitis&#47;pyomyositis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">21&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:6 [
            0 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Toxic shock syndrome in Australian children"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "K&#46;Y&#46;H&#46; Chen"
                            1 => "M&#46; Cheung"
                            2 => "D&#46;P&#46; Burgner"
                            3 => "N&#46; Curtis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/archdischild-2015-310121"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dis Child"
                        "fecha" => "2016"
                        "volumen" => "101"
                        "paginaInicial" => "736"
                        "paginaFinal" => "740"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27117838"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
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              ]
            ]
            1 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "S&#237;ndrome de shock t&#243;xico&#58; experiencia en una UCIP"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
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                            0 => "J&#46;A&#46; Costa Orvay"
                            1 => "J&#46; Caritg Bosch"
                            2 => "A&#46; Morillo Palomo"
                            3 => "T&#46; Noguera Juli&#225;n"
                            4 => "E&#46; Esteban Torne"
                            5 => "A&#46; Palomeque Rico"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
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                      "Revista" => array:5 [
                        "tituloSerie" => "An Pediatr &#40;Barc&#41;"
                        "fecha" => "2007"
                        "volumen" => "66"
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                        "paginaFinal" => "572"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:3 [
                  "comentario" => "&#91;Article in Spanish&#93;"
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Streptococcal toxic shock syndrome&#58; an emerging pathology&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46; Dosil Gallardo"
                            1 => "I&#46; Jordan Garcia"
                            2 => "E&#46; Morteruel Arizcuren"
                            3 => "A&#46; Rodr&#237;guez Nu&#241;ez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "An Pediatr &#40;Barc&#41;"
                        "fecha" => "2009"
                        "volumen" => "7"
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                        "paginaFinal" => "311"
                      ]
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                  ]
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            ]
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              "identificador" => "bib0050"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Toxic shock syndrome surveillance in UK children"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
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                            0 => "S&#46; Adalat"
                            1 => "T&#46; Dawson"
                            2 => "S&#46;J&#46; Hackett"
                            3 => "J&#46;E&#46; Clark"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/archdischild-2013-304741"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dis Child"
                        "fecha" => "2014"
                        "volumen" => "99"
                        "paginaInicial" => "1078"
                        "paginaFinal" => "1082"
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24790135"
                            "web" => "Medline"
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                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0055"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical characteristics of children with group A streptococcal toxic shock syndrome admitted to pediatric intensive care units"
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                          "colaboracion" => "ad hoc Streptococcal Toxic Shock Syndrome collaborative group of Spanish Society of Pediatric Intensive Care"
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                          "autores" => array:3 [
                            0 => "A&#46; Rodr&#237;guez-Nu&#241;ez"
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                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00431-010-1337-x"
                      "Revista" => array:6 [
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Journal Information
Vol. 87. Issue 2.
Pages 111-113 (1 August 2017)
Vol. 87. Issue 2.
Pages 111-113 (1 August 2017)
Scientific Letter
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Toxic shock syndrome in a paediatric intensive care unit over the last 15 years
Síndrome de shock tóxico en una unidad de cuidados intensivos pediátricos en los últimos 15 años
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Laura Butragueño Laisecaa,
Corresponding author
laura_bl@hotmail.com

Corresponding author.
, Marina García Morína, Estíbaliz Barredo Valderramaa, Andrés J. Alcaraz Romerob
a Servicio de Pediatría, Hospital General Universitario Gregorio Marañón, Madrid, Spain
b Servicio de Cuidados Intensivos Pediátricos, Hospital General Universitario Gregorio Marañón, Madrid, Spain
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Tables (2)
Table 1. Patient characteristics: age, microbial isolation, need for mechanical ventilation and inotropic treatment, length of stay in PICU, associated kidney failure and need for renal replacement therapy, antitoxin treatment and developed complications.
Table 2. Clinical presentation and associated organ injury.
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Dear Editor:

Toxic shock syndrome (TSS) is an acute and severe disease that is rare in paediatrics (0.5/100,000 inhabitants). It is characterised by fever, exanthema, hypotension and multiple organ failure, and caused by infection by toxin-producing bacteria. Although Staphylococcus aureus is the pathogen most frequently involved in TSS,1,2 erythrogenic toxin-producing streptococci (mainly Streptococcus pyogenes) are currently responsible for a large number of cases. Despite its considerable morbidity and mortality, few studies have analysed the incidence, manifestations, treatment and complications of this disease in the paediatric age group.1

With the purpose of describing the aetiology and clinical and laboratory characteristics of cases of TSS in the PICU of a tertiary-level hospital in recent years, we conducted a retrospective descriptive study between January 2001 and December 2015. We included patients that met the clinical and microbiological criteria established by the Centers for Disease Control and Prevention for the diagnosis of staphylococcal and streptococcal TSS. We collected epidemiological, clinical, microbiological and laboratory data pertaining to PICU admission and outcomes. We present the data as frequencies, percentages, mean (range) and median (interquartile range [IQR]).

There were 14 cases of TSS (Table 1), 50% in male patients, and the median age was 1.9 years (0.9–6.7). Thirteen patients met the diagnostic criteria for streptococcal TSS (11 cases confirmed with isolation of S. pyogenes from normally sterile sites, and 2 probable cases with isolation from non-sterile sites) and TSS was caused by S. aureus in only one patient. The portal of entry was the pharynx in 7 cases, the skin in 6 (3 due to superinfection of lesions caused by varicella) and unknown in 1. All patients developed fever, hypotension and failure of 2 or more organs (Table 2), 8 (57.1%) had decreased level of consciousness or lethargy, and 21.4% had gastrointestinal symptoms. Exanthema developed in 64.3% of the patients (generalised erythematous rash in 6, and macular morbilliform rash in 3), with delayed desquamation in 7 patients.

Table 1.

Patient characteristics: age, microbial isolation, need for mechanical ventilation and inotropic treatment, length of stay in PICU, associated kidney failure and need for renal replacement therapy, antitoxin treatment and developed complications.

Case  Age (years)  Aetiologic agent  Portal of entry  Microbiological specimen collection site  IMV  Inotropic/vasopressor agents  Length of PICU stay in days  Kidney failure/renal replacement therapy  Antitoxin treatment  Complications 
1.08  S. pyogenes  Pharynx  Pharynx, pleura, bronchial aspirate  Yes  Yes/yes  14  Yes/yes  Clindamycin  Pneumonia with pleural effusion 
1.6  S. pyogenes  Skin  Abscess and soft tissue biopsy  Yes  Yes/yes  11  Yes/no  IVIG/clindamycin  Necrotising fasciitis 
2.25  S. pyogenes  Pharynx  Pharynx, blood culture  No  No/no  No/no  –  Convulsive seizures 
19.5  S. pyogenes  Pharynx  Pharynx, blood culture  Yes  Yes/no  15  Yes/no  Clindamycin  Pneumonia with pleural effusion 
6.9  S. pyogenes  Pharynx  Pharynx, pleura  No  No/no  Yes/no  Clindamycin  Pneumonia with pleural effusion 
S. pyogenes  Skin (chickenpox)  Pharynx  No  No/no  No/no  Clindamycin  – 
1.3  S. pyogenes  Skin (chickenpox)  Perianal  Yes  Yes/yes  No/no  Clindamycin  Necrotising fasciitis 
0.75  S. pyogenes  Unknown  Pleura  No  Yes/no  12  Yes/no  Clindamycin  Pneumonia with pleural effusion 
2.3  S. pyogenes  Pharynx  Pharynx, blood culture  Yes  Yes/yes  10  Yes/no  IVIG/Clindamycin  Pneumonia with pleural effusion 
10  0.5  S. aureus  Skin  Skin exudate, bronchial aspirate  Yes  Yes/yes  11  Yes/no  –  Convulsive seizures 
11  6.75  S. pyogenes  Pharynx  Pharynx, blood culture  No  Yes/no  Yes/yes  Clindamycin  Convulsive seizures 
12  1.5  S. pyogenes  Skin (chickenpox)  Pharynx, blood culture  No  Yes/no  Yes/no  Clindamycin  – 
13  0.6  S. pyogenes  Skin  Pharynx, blood culture, wound exudate  Yes  Yes/no  29  No/no  IVIG/Clindamycin  Pneumonia with pleural effusion
Convulsive seizures 
14  S. pyogenes  Pharynx  Pharynx, blood culture, soft-tissue abscess and osteomyelitis biopsy  No  No/no  Yes/no  IVIG/Clindamycin  Pyomyositis
Osteomyelitis 

IMV, invasive mechanical ventilation; IVIG, intravenous immunoglobulin; PICU, paediatric intensive care unit.

Table 2.

Clinical presentation and associated organ injury.

  N  Percentage 
Shock  14  100 
Fever  14  100 
Exanthema  64.3 
Erythroderma  42.8 
Posterior desquamation  50 
Neurologic dysfunction  57.1 
Gastrointestinal symptoms  21.4 
Thrombocytopenia/coagulopathy  11  78.6 
Liver disease  11  78.6 
Acute kidney injury  10  71.4 
Necrotising fasciitis/pyomyositis  21.4 

Ten patients (71.4%) required vasoactive support, including administration of vasopressors in 5 patients for a mean of 6.2 days (2–12), and with a mean vasoactive-inotropic score of 42. Nine out of the 14 patients required ventilatory support, 7 with intubation (mean duration, 10 days; range, 6–25) and 2 with noninvasive mechanical ventilation (mean duration, 2.5 days). Some of the findings compatible with multiple organ failure were: thrombocytopenia and/or coagulopathy as well as abnormal liver function test results in 11 patients (78.6%); hypocalcaemia in 5 (35.7%); acute kidney injury in 10 (71.4%), 2 of whom required renal replacement therapy for a mean of 4 days. Three patients developed soft-tissue necrosis in the form of necrotising fasciitis or pyomyositis that required surgical debridement.

In 12 out of the 13 cases of streptococcal TSS, clindamycin was added to the initial treatment with cefotaxime. Four patients received immunoglobulin therapy (3 with necrotising fasciitis or pyomyositis) and 2 received steroid therapy. The patient with staphylococcal infection initially received cefotaxime, followed by cloxacillin. All patients had favourable outcomes, and none died. Close contacts and household members did not receive prophylactic antibiotherapy in any case, and there was no documentation of any associated events.

Our study reflects the severity of the illness developed by these patients, with a large proportion requiring advanced haemodynamic and respiratory support.1 Most patients were less than 2 years of age, which was consistent with other series.3 The most frequent portals of entry were the pharynx and the skin, and varicella infection was a significant risk factor, consistent with the literature.1 Ninety-three percent of cases were caused by S. pyogenes, which diverges from previous studies conducted in Spain and recent international publications, in which S. aureus continues to be the most prevalent causative agent.1,2

Although streptococcal TSS is associated with a high mortality of up to 30–60% compared to 5% in staphylococcal TSS,1,3–5 there were no deaths in our case series, probably due to the early initiation of treatment. The administration of prophylactic antibiotics to close contacts remains controversial, and is recommended in a few countries, such as Canada.6

It is crucial that this condition is detected early and the patient referred to a facility with intensive care services.1,5 When TSS is suspected, the patient should be placed on life support, as would be done in cases of septic shock, with the addition of antitoxin treatment (antimicrobials such as clindamycin), surgical debridement, and administration of immunoglobulin to enhance plasma neutralising activity against toxins.6

References
[1]
K.Y.H. Chen, M. Cheung, D.P. Burgner, N. Curtis.
Toxic shock syndrome in Australian children.
Arch Dis Child, 101 (2016), pp. 736-740
[2]
J.A. Costa Orvay, J. Caritg Bosch, A. Morillo Palomo, T. Noguera Julián, E. Esteban Torne, A. Palomeque Rico.
Síndrome de shock tóxico: experiencia en una UCIP.
An Pediatr (Barc), 66 (2007), pp. 566-572
[3]
S. Dosil Gallardo, I. Jordan Garcia, E. Morteruel Arizcuren, A. Rodríguez Nuñez.
Streptococcal toxic shock syndrome: an emerging pathology?.
An Pediatr (Barc), 7 (2009), pp. 310-311
[Article in Spanish]
[4]
S. Adalat, T. Dawson, S.J. Hackett, J.E. Clark.
Toxic shock syndrome surveillance in UK children.
Arch Dis Child, 99 (2014), pp. 1078-1082
[5]
A. Rodríguez-Nuñez, S. Dosil-Gallardo, I. Jordan, ad hoc Streptococcal Toxic Shock Syndrome collaborative group of Spanish Society of Pediatric Intensive Care.
Clinical characteristics of children with group A streptococcal toxic shock syndrome admitted to pediatric intensive care units.
Eur J Pediatr, 170 (2011), pp. 639-644
[6]
J.R. Carapetis, P. Jacoby, K. Carville, S.J. Ang, N. Curtis, R. Andrews.
Effectiveness of clindamycin and intravenous immunoglobulin, and risk of disease in contacts, in invasive group A streptococcal infections.
Clin Infect Dis, 59 (2014), pp. 358-365

Please cite this article as: Butragueño Laiseca L, García Morín M, Barredo Valderrama E, Alcaraz Romero AJ. Síndrome de shock tóxico en una unidad de cuidados intensivos pediátricos en los últimos 15 años. An Pediatr (Barc). 2017;87:111–113.

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