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            2 => "Trasplante hep&#225;tico"
            3 => "Ni&#241;os"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Estudiar la evoluci&#243;n del &#237;ndice de Fisher y su utilidad como indicador de gravedad&#44; durante el postoperatorio inmediato de pacientes pedi&#225;tricos sometidos a un trasplante de h&#237;gado&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El estudio comprende 32 trasplantes de h&#237;gado realizados en 26 ni&#241;os&#46; En todos los casos el &#237;ndice BCAA&#47;AAA fue determinado antes del trasplante&#44; al ingreso postrasplante y los d&#237;as 1&#44; 2&#44; 3&#44; 4&#44; 5&#44; 6 y 7 despu&#233;s del trasplante&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Comparado con el grupo control&#44; el &#237;ndice de Fisher de los pacientes fue significativamente m&#225;s bajo en el pretrasplante &#40;p &#60; 0&#44;0001&#41;&#44; al ingreso &#40;p &#60; 0&#44;001&#41; y los d&#237;as 1 &#40;p &#60; 0&#44;0001&#41;&#44; 2 &#40;p &#60; 0&#44;0001&#41; y 3 &#40;p &#60; 0&#44;0001&#41;&#46; Al comparer el grupo de pacientes vivos con el grupo de pacientes fallecidos&#44; se evidencia una disminuci&#243;n significativa en el grupo de pacientes fallecidos los d&#237;as 1 &#40;p &#60; 0&#44;02&#41;&#44; 3 &#40;p &#60; 0&#44;02&#41;&#44; 4 &#40;p &#60; 0&#44;005&#41;&#44; 5 &#40;p &#60; 0&#44;002&#41;&#44; 6 &#40;p &#60; 0&#44;03&#41; y 7 &#40;p &#60; 0&#44;01&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La evoluci&#243;n del &#237;ndice de Fisher puede servir como par&#225;metro indicador de gravedad en pacientes pedi&#225;tricos sometidos a un trasplante de h&#237;gado&#44; lo que permitir&#237;a establecer un tratamiento m&#225;s intensivo que pudiera mejorar el pron&#243;stico de estos enfermos&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To study the evolution of Fisher index during the early postoperative period after liver transplantation in children&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We have studied 32 liver transplants performed on 26 pediatric patients&#44; during the first week of the post-operative period&#46; In all cases the BCAA&#47;AAA quotient was determined before transplant&#44; at the time of PICU admission&#44; and on days 1&#44; 2&#44; 3&#44; 4&#44; 5&#44; 6 and 7 after transplant&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Compared to control group values&#44; the Fisher index for these patients is significantly lower at pre-transplant &#40;p &#60; 0&#44;0001&#41;&#44; upon admission &#40;p &#60; 0&#44;001&#41;&#44; and days 1 &#40;p &#60; 0&#44;0001&#41;&#44; 2 &#40;p &#60; 0&#44;0001&#41; and 3 &#40;p &#60; 0&#44;0001&#41;&#46; Comparison between non-survivors and survivors shows a significant reduction in the first group on the index in days 1 &#40;p &#60; 0&#44;02&#41;&#44; 3 &#40;p &#60; 0&#44;02&#41;&#44; 4 &#40;p &#60; 0&#44;005&#41;&#44; 5 &#40;p &#60; 0&#44;002&#41;&#44; 6 &#40;p &#60; 0&#44;03&#41; and 7 &#40;p &#60; 0&#44;01&#41; of post-transplant&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The evolution of the Fisher index can be useful as an indication of the severity of the condition of these kinds of patients&#44; which would help to establish more aggressive treatment to improve prognosis&#46;</p>"
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Vol. 52. Núm. 4.
Páginas 314-318 (abril 2000)
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Vol. 52. Núm. 4.
Páginas 314-318 (abril 2000)
Acceso a texto completo
Índice de Fisher como indicador de gravedad y su evolución en el postoperatorio inmediato del trasplante hepático en niños
Fisher’s index as an indicator of severity and its evolution in the postoperative period following liver transplantation in children
Visitas
7960
M.A. Delgado Domínguez*, F. Ruza Tarrío, V. González Ojeda, P. Dorao Martínez-Romillo, P. de la Oliva Senovilla, F. Goded Rambaud, F. Alvarado Ortega
Servicio de Cuidados Intensivos Pediátricos. Hospital Infantil La Paz. Madrid.
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Información del artículo
Objetivos

Estudiar la evolución del índice de Fisher y su utilidad como indicador de gravedad, durante el postoperatorio inmediato de pacientes pediátricos sometidos a un trasplante de hígado.

Pacientes y métodos

El estudio comprende 32 trasplantes de hígado realizados en 26 niños. En todos los casos el índice BCAA/AAA fue determinado antes del trasplante, al ingreso postrasplante y los días 1, 2, 3, 4, 5, 6 y 7 después del trasplante.

Resultados

Comparado con el grupo control, el índice de Fisher de los pacientes fue significativamente más bajo en el pretrasplante (p < 0,0001), al ingreso (p < 0,001) y los días 1 (p < 0,0001), 2 (p < 0,0001) y 3 (p < 0,0001). Al comparer el grupo de pacientes vivos con el grupo de pacientes fallecidos, se evidencia una disminución significativa en el grupo de pacientes fallecidos los días 1 (p < 0,02), 3 (p < 0,02), 4 (p < 0,005), 5 (p < 0,002), 6 (p < 0,03) y 7 (p < 0,01).

Conclusiones

La evolución del índice de Fisher puede servir como parámetro indicador de gravedad en pacientes pediátricos sometidos a un trasplante de hígado, lo que permitiría establecer un tratamiento más intensivo que pudiera mejorar el pronóstico de estos enfermos.

Palabras clave:
Aminoácidos
Índice de Fisher
Trasplante hepático
Niños
Objectives

To study the evolution of Fisher index during the early postoperative period after liver transplantation in children.

Patients and methods

We have studied 32 liver transplants performed on 26 pediatric patients, during the first week of the post-operative period. In all cases the BCAA/AAA quotient was determined before transplant, at the time of PICU admission, and on days 1, 2, 3, 4, 5, 6 and 7 after transplant.

Results

Compared to control group values, the Fisher index for these patients is significantly lower at pre-transplant (p < 0,0001), upon admission (p < 0,001), and days 1 (p < 0,0001), 2 (p < 0,0001) and 3 (p < 0,0001). Comparison between non-survivors and survivors shows a significant reduction in the first group on the index in days 1 (p < 0,02), 3 (p < 0,02), 4 (p < 0,005), 5 (p < 0,002), 6 (p < 0,03) and 7 (p < 0,01) of post-transplant.

Conclusions

The evolution of the Fisher index can be useful as an indication of the severity of the condition of these kinds of patients, which would help to establish more aggressive treatment to improve prognosis.

Key words:
Amino acid
Fisher index
Liver transplant
Children
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