Índice de Fisher como indicador de gravedad y su evolución en el postoperatorio inmediato del trasplante hepático en niños
Fisher’s index as an indicator of severity and its evolution in the postoperative period following liver transplantation in children
M.A. Delgado Domínguez*, F. Ruza Tarrío, V. González Ojeda, P. Dorao Martínez-Romillo, P. de la Oliva Senovilla, F. Goded Rambaud, F. Alvarado Ortega
Servicio de Cuidados Intensivos Pediátricos. Hospital Infantil La Paz. Madrid.
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Alvarado Ortega" "autores" => array:7 [ 0 => array:3 [ "nombre" => "M.A." "apellidos" => "Delgado Domínguez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "F." "apellidos" => "Ruza Tarrío" ] 2 => array:2 [ "nombre" => "V." "apellidos" => "González Ojeda" ] 3 => array:2 [ "nombre" => "P." "apellidos" => "Dorao Martínez-Romillo" ] 4 => array:2 [ "nombre" => "P." "apellidos" => "de la Oliva Senovilla" ] 5 => array:2 [ "nombre" => "F." "apellidos" => "Goded Rambaud" ] 6 => array:2 [ "nombre" => "F." "apellidos" => "Alvarado Ortega" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Cuidados Intensivos Pediátricos. Hospital Infantil La Paz. Madrid." ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: C/ Joaquín Lorenzo, 64-A. 28035 Madrid." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Fisher’s index as an indicator of severity and its evolution in the postoperative period following liver transplantation in children" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1999-07-31" "fechaAceptado" => "1999-12-31" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec186263" "palabras" => array:4 [ 0 => "Aminoácidos" 1 => "Índice de Fisher" 2 => "Trasplante hepático" 3 => "Niños" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec186264" "palabras" => array:4 [ 0 => "Amino acid" 1 => "Fisher index" 2 => "Liver transplant" 3 => "Children" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Estudiar la evolución del índice de Fisher y su utilidad como indicador de gravedad, durante el postoperatorio inmediato de pacientes pediátricos sometidos a un trasplante de hígado.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El estudio comprende 32 trasplantes de hígado realizados en 26 niños. En todos los casos el índice BCAA/AAA fue determinado antes del trasplante, al ingreso postrasplante y los días 1, 2, 3, 4, 5, 6 y 7 después del trasplante.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Comparado con el grupo control, el índice de Fisher de los pacientes fue significativamente más bajo en el pretrasplante (p < 0,0001), al ingreso (p < 0,001) y los días 1 (p < 0,0001), 2 (p < 0,0001) y 3 (p < 0,0001). Al comparer el grupo de pacientes vivos con el grupo de pacientes fallecidos, se evidencia una disminución significativa en el grupo de pacientes fallecidos los días 1 (p < 0,02), 3 (p < 0,02), 4 (p < 0,005), 5 (p < 0,002), 6 (p < 0,03) y 7 (p < 0,01).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La evolución del índice de Fisher puede servir como parámetro indicador de gravedad en pacientes pediátricos sometidos a un trasplante de hígado, lo que permitiría establecer un tratamiento más intensivo que pudiera mejorar el pronóstico de estos enfermos.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To study the evolution of Fisher index during the early postoperative period after liver transplantation in children.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We have studied 32 liver transplants performed on 26 pediatric patients, during the first week of the post-operative period. In all cases the BCAA/AAA quotient was determined before transplant, at the time of PICU admission, and on days 1, 2, 3, 4, 5, 6 and 7 after transplant.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Compared to control group values, the Fisher index for these patients is significantly lower at pre-transplant (p < 0,0001), upon admission (p < 0,001), and days 1 (p < 0,0001), 2 (p < 0,0001) and 3 (p < 0,0001). Comparison between non-survivors and survivors shows a significant reduction in the first group on the index in days 1 (p < 0,02), 3 (p < 0,02), 4 (p < 0,005), 5 (p < 0,002), 6 (p < 0,03) and 7 (p < 0,01) of post-transplant.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The evolution of the Fisher index can be useful as an indication of the severity of the condition of these kinds of patients, which would help to establish more aggressive treatment to improve prognosis.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:28 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 5 | 10 | 15 |
| 2024 Octubre | 70 | 55 | 125 |
| 2024 Septiembre | 55 | 44 | 99 |
| 2024 Agosto | 67 | 71 | 138 |
| 2024 Julio | 54 | 45 | 99 |
| 2024 Junio | 66 | 44 | 110 |
| 2024 Mayo | 67 | 43 | 110 |
| 2024 Abril | 62 | 39 | 101 |
| 2024 Marzo | 49 | 42 | 91 |
| 2024 Febrero | 40 | 41 | 81 |
| 2024 Enero | 41 | 30 | 71 |
| 2023 Diciembre | 50 | 20 | 70 |
| 2023 Noviembre | 33 | 30 | 63 |
| 2023 Octubre | 28 | 24 | 52 |
| 2023 Septiembre | 41 | 26 | 67 |
| 2023 Agosto | 39 | 29 | 68 |
| 2023 Julio | 34 | 46 | 80 |
| 2023 Junio | 47 | 32 | 79 |
| 2023 Mayo | 59 | 38 | 97 |
| 2023 Abril | 39 | 39 | 78 |
| 2023 Marzo | 47 | 43 | 90 |
| 2023 Febrero | 31 | 30 | 61 |
| 2023 Enero | 32 | 44 | 76 |
| 2022 Diciembre | 43 | 36 | 79 |
| 2022 Noviembre | 80 | 49 | 129 |
| 2022 Octubre | 87 | 42 | 129 |
| 2022 Septiembre | 49 | 29 | 78 |
| 2022 Agosto | 62 | 59 | 121 |
| 2022 Julio | 48 | 45 | 93 |
| 2022 Junio | 44 | 48 | 92 |
| 2022 Mayo | 47 | 59 | 106 |
| 2022 Abril | 56 | 51 | 107 |
| 2022 Marzo | 40 | 83 | 123 |
| 2022 Febrero | 40 | 46 | 86 |
| 2022 Enero | 34 | 74 | 108 |
| 2021 Diciembre | 33 | 72 | 105 |
| 2021 Noviembre | 51 | 66 | 117 |
| 2021 Octubre | 49 | 78 | 127 |
| 2021 Septiembre | 33 | 67 | 100 |
| 2021 Agosto | 42 | 43 | 85 |
| 2021 Julio | 43 | 51 | 94 |
| 2021 Junio | 74 | 74 | 148 |
| 2021 Mayo | 44 | 80 | 124 |
| 2021 Abril | 128 | 134 | 262 |
| 2021 Marzo | 61 | 71 | 132 |
| 2021 Febrero | 56 | 45 | 101 |
| 2021 Enero | 60 | 67 | 127 |
| 2020 Diciembre | 35 | 59 | 94 |
| 2020 Noviembre | 25 | 51 | 76 |
| 2020 Octubre | 32 | 36 | 68 |
| 2020 Septiembre | 24 | 30 | 54 |
| 2020 Agosto | 27 | 45 | 72 |
| 2020 Julio | 35 | 41 | 76 |
| 2020 Junio | 13 | 33 | 46 |
| 2020 Mayo | 39 | 53 | 92 |
| 2020 Abril | 35 | 41 | 76 |
| 2020 Marzo | 19 | 39 | 58 |
| 2020 Febrero | 31 | 31 | 62 |
| 2020 Enero | 35 | 39 | 74 |
| 2019 Diciembre | 42 | 30 | 72 |
| 2019 Noviembre | 34 | 33 | 67 |
| 2019 Octubre | 25 | 13 | 38 |
| 2019 Septiembre | 24 | 28 | 52 |
| 2019 Agosto | 22 | 21 | 43 |
| 2019 Julio | 27 | 19 | 46 |
| 2019 Junio | 42 | 36 | 78 |
| 2019 Mayo | 43 | 46 | 89 |
| 2019 Abril | 24 | 66 | 90 |
| 2019 Marzo | 23 | 18 | 41 |
| 2019 Febrero | 28 | 15 | 43 |
| 2019 Enero | 16 | 11 | 27 |
| 2018 Diciembre | 19 | 22 | 41 |
| 2018 Noviembre | 28 | 14 | 42 |
| 2018 Octubre | 46 | 27 | 73 |
| 2018 Septiembre | 17 | 7 | 24 |
| 2018 Mayo | 5 | 0 | 5 |
| 2018 Abril | 11 | 0 | 11 |
| 2018 Marzo | 9 | 0 | 9 |
| 2018 Febrero | 7 | 0 | 7 |
| 2018 Enero | 6 | 0 | 6 |
| 2017 Diciembre | 8 | 0 | 8 |
| 2017 Noviembre | 10 | 0 | 10 |
| 2017 Octubre | 13 | 0 | 13 |
| 2017 Septiembre | 10 | 0 | 10 |
| 2017 Agosto | 11 | 0 | 11 |
| 2017 Julio | 11 | 0 | 11 |
| 2017 Junio | 16 | 21 | 37 |
| 2017 Mayo | 24 | 8 | 32 |
| 2017 Abril | 16 | 14 | 30 |
| 2017 Marzo | 15 | 26 | 41 |
| 2017 Febrero | 7 | 6 | 13 |
| 2017 Enero | 6 | 5 | 11 |
| 2016 Diciembre | 13 | 7 | 20 |
| 2016 Noviembre | 28 | 7 | 35 |
| 2016 Octubre | 28 | 13 | 41 |
| 2016 Septiembre | 22 | 11 | 33 |
| 2016 Agosto | 18 | 3 | 21 |
| 2016 Julio | 13 | 10 | 23 |
| 2016 Mayo | 1 | 0 | 1 |
| 2016 Abril | 1 | 0 | 1 |
| 2015 Diciembre | 2 | 0 | 2 |
| 2015 Julio | 8 | 0 | 8 |
| 2015 Junio | 8 | 0 | 8 |
| 2015 Mayo | 13 | 0 | 13 |
| 2015 Abril | 14 | 0 | 14 |
| 2015 Marzo | 10 | 0 | 10 |
| 2015 Febrero | 5 | 0 | 5 |
| 2015 Enero | 3 | 0 | 3 |
| 2014 Diciembre | 18 | 1 | 19 |
| 2014 Noviembre | 14 | 0 | 14 |
| 2014 Octubre | 7 | 0 | 7 |
| 2014 Septiembre | 6 | 0 | 6 |
| 2014 Agosto | 16 | 0 | 16 |
| 2014 Julio | 11 | 1 | 12 |
| 2014 Junio | 26 | 0 | 26 |
| 2014 Mayo | 24 | 3 | 27 |
| 2014 Abril | 19 | 1 | 20 |
| 2014 Marzo | 24 | 11 | 35 |
| 2014 Febrero | 5 | 8 | 13 |
| 2014 Enero | 15 | 6 | 21 |
| 2013 Diciembre | 19 | 8 | 27 |
| 2013 Noviembre | 12 | 5 | 17 |
| 2013 Octubre | 26 | 6 | 32 |
| 2013 Septiembre | 13 | 6 | 19 |
| 2013 Agosto | 14 | 4 | 18 |
| 2013 Julio | 3 | 3 | 6 |
| 2013 Junio | 2 | 0 | 2 |
| 2013 Mayo | 3 | 5 | 8 |
| 2013 Abril | 2 | 2 | 4 |
| 2013 Marzo | 5 | 5 | 10 |
| 2013 Febrero | 21 | 3 | 24 |
| 2013 Enero | 12 | 3 | 15 |
| 2012 Diciembre | 11 | 1 | 12 |
| 2012 Noviembre | 8 | 2 | 10 |
| 2012 Octubre | 4 | 1 | 5 |
| 2012 Septiembre | 0 | 1 | 1 |
| 2000 Marzo | 623 | 0 | 623 |
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