Hemorragia intraventricular neonatal por déficit de factor V

Cancho Candela, R.; Andrés de Llano, J.M.; Sánchez Marcos, M.J.; Urueña Leal, C.

doi:10.1016/S1695-4033(00)77505-9

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Anales de Pediatría

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El déficit congénito de factor V es una rara coagulopatía autosómica recesiva cuya sintomatología suele aparecer tras el período neonatal. Se describe el caso de un neonate sin antecedentes patológicos obstétricos que presentó hemorragia intraventricular espontánea. El estudio de coagulación se encontraba alterado, encontrándose déficit grave de factor V. El estado de heterozigosis en padres se demostró al hallar concentraciones medias de factor V en ambos

Palabras clave:

Déficit de factor V

Hemorragia intraventricular

Re-cién nacido

Congenital factor V deficiency is an unusual recessive autosomal coagulopathy. Symptoms usually appear after the neonatal period. We report the case of a newborn infant with no obstetric antecedents who presented spontaneous intraventricular hemorrhage. Coagulation studies showed alterations, and we found severe factor V deficiency. Heterozygosity of the parents was revealed by reduced factor V levels in both

Keywords:

Factor V deficiency

Intraventricular hemorrhage

New-born

El Texto completo está disponible en PDF

Bibliografía

[1.]

Owren PA. Parahemophilia: haemorrhage diathesis due to absence of a previously unknown clotting factor. Lancet 1947; 446-448.

[2.]

P.B. Tracy, A.R. Giles, K.G. Mann, L.L. Eide, H. Hoogendoorn, G.E. Rivard.

Factor V (Quebec): a bleeding diathesis associated with a qualitative platelet Factor V deficiency.

J Clin Invest, 74 (1984), pp. 1221-1228