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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Determinar si el tratamiento con glucocorticoides inhalados durante 3 meses&#44; despu&#233;s de una bronquiolitis leve&#44; disminuye la incidencia y&#47;o la gravedad de los episodios de sibilancias durante los siguientes 12 meses&#46;</p> <span class="elsevierStyleSectionTitle">Dise&#241;o</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio de intervenci&#243;n&#44; multic&#233;ntrico&#44; controlado&#44; en grupos paralelos&#44; con asignaci&#243;n aleatoria por bloques&#46;</p> <span class="elsevierStyleSectionTitle">&#193;mbito de estudio</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Centros de atenci&#243;n primaria de Lezo&#44; Beraun&#44; Andoain e Ir&#250;n &#40;Gipuzkoa&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Sujetos del estudio</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Ni&#241;os menores de 12 meses &#40;n &#61; 94&#41; diagnosticados de bronquiolitis leve&#46;</p> <span class="elsevierStyleSectionTitle">Instrumentalizaci&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Se establecieron dos grupos de sujetos&#58; grupo 1 &#40;n &#61; 47&#41;&#44; tratados con beclometasona inhalada &#40;250 mg&#47;12 h&#41; con c&#225;mara espaciadora Babyhaler&#174;&#44; 8 d&#237;as despu&#233;s del diagn&#243;stico de bronquiolitis durante 3 meses&#59; grupo 2 &#40;n &#61; 47&#41;&#44; sin tratamiento&#46; Se han comparado el n&#250;mero y gravedad de los episodios de sibilancias durante el per&#237;odo de intervenci&#243;n &#40;3 meses&#41; y durante el per&#237;odo de seguimiento &#40;12 meses&#41;&#44; mediante las pruebas de la t de Student y la &#967;2&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se han estudiado 89 ni&#241;os &#40;grupo 1&#44; n &#61; 42&#59; grupo 2&#44; n &#61; 47&#41;&#46; El 67&#37; presentaron episodios de sibilancias durante el per&#237;odo del estudio &#40;15 meses&#41;&#46; No hubo diferencias significativas entre ambos grupos en los dos per&#237;odos estudiados&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">El tratamiento con beclometasona durante 3 meses no modifica los episodios de sibilancias durante el tratamiento ni en los 12 meses siguientes&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">To determine whether inhaled corticosteroid therapy given for 3 months after mild bronchiolitis decreases the incidence and&#47;or severity of wheezing in the following 12 months&#46;</p> <span class="elsevierStyleSectionTitle">Design</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Multicentric&#44; single-blind&#44; controlled&#44; randomised intervention study&#46;</p> <span class="elsevierStyleSectionTitle">Setting</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Primary Health Care Centers in Lezo&#44; Beraun&#44; Andoain and Ir&#250;n &#40;Gipuzkoa&#44; Spain&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Patients</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Infants less than 12 months old &#40;n &#61; 94&#41; diagnosed with mild bronchiolitis&#46;</p> <span class="elsevierStyleSectionTitle">Intervention</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">We established two groups of patients&#58; group 1 &#40;n &#61; 47&#41; was treated with inhaled beclomethasone &#40;250 &#181;g&#47;12 hours&#41; using a valved holding chamber &#40;Babyhaler&#174;&#41;&#59; the treatment started eight days after diagnosis of bronchiolitis and lasted 3 months&#46; Group 2 &#40;n &#61; 47&#41; received no treatment&#46; We compared the number of wheezing episodes and their severity during the intervention period &#40;3 months&#41; and the follow-up period &#40;12 months&#41; with the Student&#39;s t-test and the Chi-squared test&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">We studied 89 infants &#40;group 1&#44; n &#61; 42&#59; group 2&#44; n &#61; 47&#41;&#44; 67&#37; of whom wheezed during the study period &#40;15 months&#41;&#46; There were no significant differences between the treatment and the control group in the study periods&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Inhaled beclomethasone given for 3 months does not significantly modify the occurrence of wheezing episodes during the treatment period or during the following 12 months&#46;</p>"
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Vol. 52. Núm. 4.
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Vol. 52. Núm. 4.
Páginas 351-355 (abril 2000)
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Glucocorticoides inhalados y sibilancias posbronquiolitis
Inhaled corticosteroids and wheezing post-bronchiolitis
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M. Callén Blecua*, P. Aizpurua Galdeano, I. Ozcoidi Erro, L. Mancisidor Aguinagalde, C. Guedea Adiego, E. Busselo Ortega, I. Ibarrondo Uriarte
CAP de Amara Centro, Beraun, Andoain e Irún. Servicio Vasco de Salud-Osakidetza. Gipuzkoa
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Información del artículo
Objetivo

Determinar si el tratamiento con glucocorticoides inhalados durante 3 meses, después de una bronquiolitis leve, disminuye la incidencia y/o la gravedad de los episodios de sibilancias durante los siguientes 12 meses.

Diseño

Estudio de intervención, multicéntrico, controlado, en grupos paralelos, con asignación aleatoria por bloques.

Ámbito de estudio

Centros de atención primaria de Lezo, Beraun, Andoain e Irún (Gipuzkoa).

Sujetos del estudio

Niños menores de 12 meses (n = 94) diagnosticados de bronquiolitis leve.

Instrumentalización

Se establecieron dos grupos de sujetos: grupo 1 (n = 47), tratados con beclometasona inhalada (250 mg/12 h) con cámara espaciadora Babyhaler®, 8 días después del diagnóstico de bronquiolitis durante 3 meses; grupo 2 (n = 47), sin tratamiento. Se han comparado el número y gravedad de los episodios de sibilancias durante el período de intervención (3 meses) y durante el período de seguimiento (12 meses), mediante las pruebas de la t de Student y la χ2.

Resultados

Se han estudiado 89 niños (grupo 1, n = 42; grupo 2, n = 47). El 67% presentaron episodios de sibilancias durante el período del estudio (15 meses). No hubo diferencias significativas entre ambos grupos en los dos períodos estudiados.

Conclusiones

El tratamiento con beclometasona durante 3 meses no modifica los episodios de sibilancias durante el tratamiento ni en los 12 meses siguientes.

Palabras clave:
Niños
Bronquiolitis
Sibilancias
Glucocorticoides inhalados
Objective

To determine whether inhaled corticosteroid therapy given for 3 months after mild bronchiolitis decreases the incidence and/or severity of wheezing in the following 12 months.

Design

Multicentric, single-blind, controlled, randomised intervention study.

Setting

Primary Health Care Centers in Lezo, Beraun, Andoain and Irún (Gipuzkoa, Spain).

Patients

Infants less than 12 months old (n = 94) diagnosed with mild bronchiolitis.

Intervention

We established two groups of patients: group 1 (n = 47) was treated with inhaled beclomethasone (250 µg/12 hours) using a valved holding chamber (Babyhaler®); the treatment started eight days after diagnosis of bronchiolitis and lasted 3 months. Group 2 (n = 47) received no treatment. We compared the number of wheezing episodes and their severity during the intervention period (3 months) and the follow-up period (12 months) with the Student's t-test and the Chi-squared test.

Results

We studied 89 infants (group 1, n = 42; group 2, n = 47), 67% of whom wheezed during the study period (15 months). There were no significant differences between the treatment and the control group in the study periods.

Conclusions

Inhaled beclomethasone given for 3 months does not significantly modify the occurrence of wheezing episodes during the treatment period or during the following 12 months.

Key words:
Infants
Bronchiolitis
Wheezing
Inhaled corticosteroids
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Trabajo de investigación financiado con una beca FIS 96/1350.

Copyright © 2000. Asociación Española de Pediatría
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