Glucocorticoides inhalados y sibilancias posbronquiolitis
Inhaled corticosteroids and wheezing post-bronchiolitis
M. Callén Blecua*, P. Aizpurua Galdeano, I. Ozcoidi Erro, L. Mancisidor Aguinagalde, C. Guedea Adiego, E. Busselo Ortega, I. Ibarrondo Uriarte
CAP de Amara Centro, Beraun, Andoain e Irún. Servicio Vasco de Salud-Osakidetza. Gipuzkoa
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"apellidos" => "Aizpurua Galdeano" ] 2 => array:2 [ "nombre" => "I." "apellidos" => "Ozcoidi Erro" ] 3 => array:2 [ "nombre" => "L." "apellidos" => "Mancisidor Aguinagalde" ] 4 => array:2 [ "nombre" => "C." "apellidos" => "Guedea Adiego" ] 5 => array:2 [ "nombre" => "E." "apellidos" => "Busselo Ortega" ] 6 => array:2 [ "nombre" => "I." "apellidos" => "Ibarrondo Uriarte" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "CAP de Amara Centro, Beraun, Andoain e Irún. Servicio Vasco de Salud-Osakidetza. Gipuzkoa" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: CAP de Amara-Centro. Prim, 61. 20009 San Sebastián. Trabajo de investigación financiado con una beca FIS 96/1350" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Inhaled corticosteroids and wheezing post-bronchiolitis" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1999-08-31" "fechaAceptado" => "2000-01-31" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec186268" "palabras" => array:4 [ 0 => "Niños" 1 => "Bronquiolitis" 2 => "Sibilancias" 3 => "Glucocorticoides inhalados" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec186267" "palabras" => array:4 [ 0 => "Infants" 1 => "Bronchiolitis" 2 => "Wheezing" 3 => "Inhaled corticosteroids" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Determinar si el tratamiento con glucocorticoides inhalados durante 3 meses, después de una bronquiolitis leve, disminuye la incidencia y/o la gravedad de los episodios de sibilancias durante los siguientes 12 meses.</p> <span class="elsevierStyleSectionTitle">Diseño</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio de intervención, multicéntrico, controlado, en grupos paralelos, con asignación aleatoria por bloques.</p> <span class="elsevierStyleSectionTitle">Ámbito de estudio</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Centros de atención primaria de Lezo, Beraun, Andoain e Irún (Gipuzkoa).</p> <span class="elsevierStyleSectionTitle">Sujetos del estudio</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Niños menores de 12 meses (n = 94) diagnosticados de bronquiolitis leve.</p> <span class="elsevierStyleSectionTitle">Instrumentalización</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Se establecieron dos grupos de sujetos: grupo 1 (n = 47), tratados con beclometasona inhalada (250 mg/12 h) con cámara espaciadora Babyhaler®, 8 días después del diagnóstico de bronquiolitis durante 3 meses; grupo 2 (n = 47), sin tratamiento. Se han comparado el número y gravedad de los episodios de sibilancias durante el período de intervención (3 meses) y durante el período de seguimiento (12 meses), mediante las pruebas de la t de Student y la χ2.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se han estudiado 89 niños (grupo 1, n = 42; grupo 2, n = 47). El 67% presentaron episodios de sibilancias durante el período del estudio (15 meses). No hubo diferencias significativas entre ambos grupos en los dos períodos estudiados.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">El tratamiento con beclometasona durante 3 meses no modifica los episodios de sibilancias durante el tratamiento ni en los 12 meses siguientes.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">To determine whether inhaled corticosteroid therapy given for 3 months after mild bronchiolitis decreases the incidence and/or severity of wheezing in the following 12 months.</p> <span class="elsevierStyleSectionTitle">Design</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Multicentric, single-blind, controlled, randomised intervention study.</p> <span class="elsevierStyleSectionTitle">Setting</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Primary Health Care Centers in Lezo, Beraun, Andoain and Irún (Gipuzkoa, Spain).</p> <span class="elsevierStyleSectionTitle">Patients</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Infants less than 12 months old (n = 94) diagnosed with mild bronchiolitis.</p> <span class="elsevierStyleSectionTitle">Intervention</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">We established two groups of patients: group 1 (n = 47) was treated with inhaled beclomethasone (250 µg/12 hours) using a valved holding chamber (Babyhaler®); the treatment started eight days after diagnosis of bronchiolitis and lasted 3 months. Group 2 (n = 47) received no treatment. We compared the number of wheezing episodes and their severity during the intervention period (3 months) and the follow-up period (12 months) with the Student's t-test and the Chi-squared test.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">We studied 89 infants (group 1, n = 42; group 2, n = 47), 67% of whom wheezed during the study period (15 months). There were no significant differences between the treatment and the control group in the study periods.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Inhaled beclomethasone given for 3 months does not significantly modify the occurrence of wheezing episodes during the treatment period or during the following 12 months.</p>" ] ] "NotaPie" => array:1 [ 0 => array:1 [ "nota" => "<p class="elsevierStyleNotepara">Trabajo de investigación financiado con una beca FIS 96/1350.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:25 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 4 | 11 | 15 |
| 2024 Octubre | 34 | 57 | 91 |
| 2024 Septiembre | 35 | 32 | 67 |
| 2024 Agosto | 40 | 75 | 115 |
| 2024 Julio | 26 | 45 | 71 |
| 2024 Junio | 43 | 40 | 83 |
| 2024 Mayo | 35 | 45 | 80 |
| 2024 Abril | 24 | 31 | 55 |
| 2024 Marzo | 30 | 45 | 75 |
| 2024 Febrero | 38 | 39 | 77 |
| 2024 Enero | 33 | 32 | 65 |
| 2023 Diciembre | 27 | 29 | 56 |
| 2023 Noviembre | 37 | 24 | 61 |
| 2023 Octubre | 41 | 31 | 72 |
| 2023 Septiembre | 19 | 24 | 43 |
| 2023 Agosto | 25 | 23 | 48 |
| 2023 Julio | 27 | 31 | 58 |
| 2023 Junio | 29 | 27 | 56 |
| 2023 Mayo | 33 | 37 | 70 |
| 2023 Abril | 25 | 28 | 53 |
| 2023 Marzo | 14 | 28 | 42 |
| 2023 Febrero | 18 | 24 | 42 |
| 2023 Enero | 14 | 20 | 34 |
| 2022 Diciembre | 24 | 14 | 38 |
| 2022 Noviembre | 28 | 56 | 84 |
| 2022 Octubre | 27 | 42 | 69 |
| 2022 Septiembre | 48 | 29 | 77 |
| 2022 Agosto | 61 | 58 | 119 |
| 2022 Julio | 30 | 42 | 72 |
| 2022 Junio | 21 | 42 | 63 |
| 2022 Mayo | 21 | 36 | 57 |
| 2022 Abril | 26 | 48 | 74 |
| 2022 Marzo | 26 | 55 | 81 |
| 2022 Febrero | 21 | 39 | 60 |
| 2022 Enero | 23 | 42 | 65 |
| 2021 Diciembre | 22 | 62 | 84 |
| 2021 Noviembre | 19 | 42 | 61 |
| 2021 Octubre | 27 | 42 | 69 |
| 2021 Septiembre | 22 | 52 | 74 |
| 2021 Agosto | 29 | 31 | 60 |
| 2021 Julio | 30 | 44 | 74 |
| 2021 Junio | 23 | 48 | 71 |
| 2021 Mayo | 26 | 32 | 58 |
| 2021 Abril | 74 | 59 | 133 |
| 2021 Marzo | 70 | 24 | 94 |
| 2021 Febrero | 68 | 24 | 92 |
| 2021 Enero | 29 | 25 | 54 |
| 2020 Diciembre | 32 | 23 | 55 |
| 2020 Noviembre | 14 | 9 | 23 |
| 2020 Octubre | 22 | 17 | 39 |
| 2020 Septiembre | 58 | 3 | 61 |
| 2020 Agosto | 62 | 7 | 69 |
| 2020 Julio | 56 | 16 | 72 |
| 2020 Junio | 28 | 9 | 37 |
| 2020 Mayo | 30 | 21 | 51 |
| 2020 Abril | 34 | 15 | 49 |
| 2020 Marzo | 19 | 9 | 28 |
| 2020 Febrero | 17 | 9 | 26 |
| 2020 Enero | 31 | 23 | 54 |
| 2019 Diciembre | 46 | 15 | 61 |
| 2019 Noviembre | 16 | 9 | 25 |
| 2019 Octubre | 23 | 12 | 35 |
| 2019 Septiembre | 17 | 18 | 35 |
| 2019 Agosto | 31 | 15 | 46 |
| 2019 Julio | 24 | 12 | 36 |
| 2019 Junio | 26 | 29 | 55 |
| 2019 Mayo | 36 | 45 | 81 |
| 2019 Abril | 33 | 32 | 65 |
| 2019 Marzo | 14 | 15 | 29 |
| 2019 Febrero | 22 | 3 | 25 |
| 2019 Enero | 17 | 14 | 31 |
| 2018 Diciembre | 21 | 20 | 41 |
| 2018 Noviembre | 21 | 13 | 34 |
| 2018 Octubre | 29 | 20 | 49 |
| 2018 Septiembre | 19 | 7 | 26 |
| 2018 Julio | 1 | 0 | 1 |
| 2018 Mayo | 9 | 0 | 9 |
| 2018 Abril | 11 | 0 | 11 |
| 2018 Marzo | 16 | 0 | 16 |
| 2018 Febrero | 12 | 0 | 12 |
| 2018 Enero | 4 | 0 | 4 |
| 2017 Diciembre | 11 | 0 | 11 |
| 2017 Noviembre | 10 | 0 | 10 |
| 2017 Octubre | 9 | 0 | 9 |
| 2017 Septiembre | 16 | 0 | 16 |
| 2017 Agosto | 3 | 0 | 3 |
| 2017 Julio | 9 | 0 | 9 |
| 2017 Junio | 29 | 6 | 35 |
| 2017 Mayo | 23 | 3 | 26 |
| 2017 Abril | 17 | 11 | 28 |
| 2017 Marzo | 18 | 9 | 27 |
| 2017 Febrero | 83 | 2 | 85 |
| 2017 Enero | 10 | 1 | 11 |
| 2016 Diciembre | 47 | 5 | 52 |
| 2016 Noviembre | 83 | 6 | 89 |
| 2016 Octubre | 52 | 5 | 57 |
| 2016 Septiembre | 59 | 6 | 65 |
| 2016 Agosto | 38 | 5 | 43 |
| 2016 Julio | 15 | 3 | 18 |
| 2016 Junio | 1 | 0 | 1 |
| 2016 Abril | 3 | 0 | 3 |
| 2016 Febrero | 1 | 0 | 1 |
| 2015 Diciembre | 2 | 0 | 2 |
| 2015 Julio | 6 | 0 | 6 |
| 2015 Junio | 10 | 0 | 10 |
| 2015 Mayo | 23 | 0 | 23 |
| 2015 Abril | 14 | 0 | 14 |
| 2015 Marzo | 10 | 0 | 10 |
| 2015 Febrero | 9 | 0 | 9 |
| 2015 Enero | 11 | 0 | 11 |
| 2014 Diciembre | 7 | 2 | 9 |
| 2014 Noviembre | 9 | 0 | 9 |
| 2014 Octubre | 3 | 0 | 3 |
| 2014 Septiembre | 5 | 0 | 5 |
| 2014 Agosto | 10 | 0 | 10 |
| 2014 Julio | 5 | 0 | 5 |
| 2014 Junio | 6 | 0 | 6 |
| 2014 Mayo | 21 | 1 | 22 |
| 2014 Abril | 16 | 1 | 17 |
| 2014 Marzo | 10 | 6 | 16 |
| 2014 Febrero | 10 | 4 | 14 |
| 2014 Enero | 8 | 4 | 12 |
| 2013 Diciembre | 11 | 7 | 18 |
| 2013 Noviembre | 9 | 6 | 15 |
| 2013 Octubre | 19 | 3 | 22 |
| 2013 Septiembre | 10 | 7 | 17 |
| 2013 Agosto | 7 | 4 | 11 |
| 2013 Julio | 5 | 2 | 7 |
| 2013 Junio | 2 | 1 | 3 |
| 2013 Mayo | 3 | 2 | 5 |
| 2013 Abril | 2 | 1 | 3 |
| 2013 Marzo | 8 | 4 | 12 |
| 2013 Febrero | 12 | 3 | 15 |
| 2013 Enero | 6 | 1 | 7 |
| 2012 Diciembre | 5 | 2 | 7 |
| 2012 Noviembre | 6 | 3 | 9 |
| 2012 Octubre | 4 | 4 | 8 |
| 2012 Septiembre | 2 | 1 | 3 |
| 2000 Marzo | 408 | 0 | 408 |
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