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Beikost sin intolerancias&#46; Inmunizaci&#243;n correcta &#40;no rotavirus&#41;&#46; Padre con <span class="elsevierStyleItalic">talasemia minor&#46;</span></p><p id="par0020" class="elsevierStylePara elsevierViewall">Exploraci&#243;n al ingreso&#58; peso&#58; 14&#44;3<span class="elsevierStyleHsp" style=""></span>kg&#44; T&#46;&#170;&#58; 36&#44;8<span class="elsevierStyleHsp" style=""></span>&#176;C&#46; Regular estado general&#44; algo deca&#237;da&#46; Nutrici&#243;n e hidrataci&#243;n adecuada&#46; No exantemas ni petequias&#46; Orofaringe normal&#46; Tonos card&#237;acos r&#237;tmicos&#44; sin soplos&#46; Buena ventilaci&#243;n pulmonar con tos escasa&#46; Abdomen blando&#44; no doloroso&#44; sin masas ni megalias&#46; Consciente y orientada&#44; no signos men&#237;ngeos ni focalidad neurol&#243;gica&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Anal&#237;tica al ingreso&#58; hemograma normal y alcalosis mixta con hiponatremia e hipocloremia &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46; 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confirmando la sospecha diagn&#243;stica de GEPP&#44; siendo el &#250;nico agente etiol&#243;gico hallado la infecci&#243;n por <span class="elsevierStyleItalic">Mycoplasma</span>&#44; por lo que se inicia tratamiento con azitromicina&#44; estando pendiente de realizar la endoscopia programada en el 5&#46;&#176; d&#237;a del ingreso&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Al 5&#46;&#176; d&#237;a inicia mejor&#237;a cl&#237;nica evidente con desaparici&#243;n de edemas y presentando balances negativos con aumento paulatino de prote&#237;nas sangu&#237;neas en las anal&#237;ticas seriadas&#44; no realiz&#225;ndose la endoscopia por la mejor&#237;a cl&#237;nica evidente&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">El g&#233;nero <span class="elsevierStyleItalic">Mycoplasma</span> representa los microorganismos autorreplicativos m&#225;s peque&#241;os descritos&#44; responsable de diversas infecciones&#46; El <span class="elsevierStyleItalic">M&#46; pneumoniae</span> es reconocido como causa de neumon&#237;a at&#237;pica afectando ni&#241;os y adultos de forma end&#233;mica&#46; Relacionado con otras enfermedades&#44; como pleuropericarditis&#44; pleuritis&#44; artritis reactivas&#44; vasculitis de predominio cut&#225;neo&#44; urticaria a frigore&#44; meningitis linfocitarias&#44; encefalitis diseminada&#44; s&#237;ndrome de Guillain-Barr&#233;&#44; pupila t&#243;nica de Adie y de forma poco frecuente y en adultos GEPP<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a>&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">El t&#233;rmino GEPP incluye enfermedades poco frecuentes&#44; que tienen en com&#250;n una excesiva p&#233;rdida de prote&#237;nas por el tubo digestivo provocando una hipoproteinemia que puede acompa&#241;arse de edemas&#44; ascitis&#44; derrame pleural y peric&#225;rdico&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Las principales enfermedades que lo producen son parasitosis&#44; amiloidosis&#44; yeyunoile&#237;tis ulcerativa&#44; linfoma intestinal&#44; sobrecrecimiento bacteriano&#44; enfermedad cel&#237;aca&#44; enfermedad de Whipple&#44; linfangiectasia&#44; amiloidosis&#44; enfermedad de Crohn&#44; enfermedad de M&#233;n&#233;trier&#44; gastritis eosin&#243;fila&#44; gastritis erosiva&#44; c&#225;ncer de est&#243;mago&#44; linfoma&#44; colitis ulcerosa&#44; enfermedad de Crohn y c&#225;ncer de colon&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Se caracteriza por hipertrofia de pliegues g&#225;stricos del fundus y cuerpo&#44; hipersecreci&#243;n de la mucosa&#44; p&#233;rdida de prote&#237;nas e hipoclorhidria<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a>&#46; Etiolog&#237;a desconocida plante&#225;ndose hip&#243;tesis infecciosas&#44; autoinmunes&#44; hormonales y gen&#233;ticas&#44; asoci&#225;ndose a mayor riesgo de c&#225;ncer g&#225;strico &#40;10-15&#37;&#41;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;3</span></a>&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">En la infancia es raro&#44; afectando a menores de 6 a&#241;os con evoluci&#243;n benigna&#44; inicio brusco y presencia constante de edema<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a>&#46; En la mayor&#237;a de los casos publicados se considera citomegalovirus &#40;CMV&#41; al agente etiol&#243;gico m&#225;s probable&#44; siendo posible tambi&#233;n <span class="elsevierStyleItalic">Helicobacter pylori&#46;</span> Con menor frecuencia y no descritos el <span class="elsevierStyleItalic">Mycoplasma pneumoniae</span>&#44; la <span class="elsevierStyleItalic">Giardia intestinalis</span> y el herpes simple<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a>&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">La sintomatolog&#237;a inicial es inespec&#237;fica&#44; similar al cuadro viral y apareciendo edema perif&#233;rico cuando hay hipoalbuminemia establecida&#46; Es caracter&#237;stica hipoproteinemia e hipoalbuminemia&#44; siendo la alfa-1-antitripsina fecal un marcador sensible y espec&#237;fico de p&#233;rdida proteica en tubo digestivo<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a>&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">No hay tratamiento espec&#237;fico&#46; La evoluci&#243;n hacia la resoluci&#243;n cl&#237;nica completa&#44; de manera espont&#225;nea&#44; suele ocurrir alrededor de las 5 semanas&#46; El tratamiento conlleva el del agente responsable&#46; Se emplea dieta rica en prote&#237;nas&#44; antisecretores&#44; octre&#243;tido&#44; anticolin&#233;rgicos e incluso anticuerpos monoclonales<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a>&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">El tratamiento quir&#250;rgico cuando hay p&#233;rdida no controlable de prote&#237;nas&#44; sangrado y localizaci&#243;n cerca del cardias o con displasia porque elimina el riesgo de malignizaci&#243;n&#46; Es objeto de debate&#44; siendo lo m&#225;s acertado adaptar la t&#233;cnica a la localizaci&#243;n y grado de displasia<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a>&#46;</p></span>"
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                  \t\t\t\t">459&#46;000<span class="elsevierStyleHsp" style=""></span>mg&#47;l&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">44&#44;1<span class="elsevierStyleHsp" style=""></span>mmHg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">O<span class="elsevierStyleInf">2</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">58<span class="elsevierStyleHsp" style=""></span>mmHg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">40&#44;8<span class="elsevierStyleHsp" style=""></span>mmHg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8212;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">120<span class="elsevierStyleHsp" style=""></span>mEq&#47;l&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">131<span class="elsevierStyleHsp" style=""></span>mEq&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">137<span class="elsevierStyleHsp" style=""></span>mEq&#47;l&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">6<span class="elsevierStyleHsp" style=""></span>mEq&#47;l&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3&#44;13<span class="elsevierStyleHsp" style=""></span>mEq&#47;l&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">4&#44;44<span class="elsevierStyleHsp" style=""></span>mEq&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">83<span class="elsevierStyleHsp" style=""></span>mEq&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">95<span class="elsevierStyleHsp" style=""></span>mEq&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">102<span class="elsevierStyleHsp" style=""></span>mEq&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">EB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8722;4<span class="elsevierStyleHsp" style=""></span>mmol&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8722;2<span class="elsevierStyleHsp" style=""></span>mmol&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8212;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">7&#44;1<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#44;3<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Prote&#237;nas totales&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8212;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3<span class="elsevierStyleHsp" style=""></span>g&#47;dl&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">5<span class="elsevierStyleHsp" style=""></span>g&#47;dl&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Albumina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&#8212;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#44;68<span class="elsevierStyleHsp" style=""></span>g&#47;dl&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2&#44;71<span class="elsevierStyleHsp" style=""></span>g&#47;dl&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Alfa-1-antitripsina en heces&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8212;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;27<span class="elsevierStyleHsp" style=""></span>mg&#47;g heces&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;18<span class="elsevierStyleHsp" style=""></span>mg&#47;g heces&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Al 4&#46;&#176; d&#237;a del ingreso&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Negativa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Mycoplasma pneumoniae</span> &#40;IgM&#47;IgG&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">IgM 10<span class="elsevierStyleHsp" style=""></span>U&#47;ml &#40;0-14&#41;IgG negativo &#40;0-25&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">IgM 23<span class="elsevierStyleHsp" style=""></span>U&#47;ml &#40;0-14&#41;IgG negativo &#40;0-25&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">Toxoplasma &#40;IgM&#47;IgG&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Mycoplasma tuberculosis &#40;</span>IgM&#47;IgG&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">No solicitado&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Epstein-Barr &#40;IgM&#47;IgG&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Negativo&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">No solicitado&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Falta muestra&nbsp;\t\t\t\t\t\t\n
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                        "tituloSerie" => "J Port Gastrenterol"
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                            2 => "E&#46; Mart&#237;nez-Ojinaga Nodal"
                            3 => "M&#46; Molina Arias"
                            4 => "J&#46; Sarr&#237;a Os&#233;s"
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                        "tituloSerie" => "An Pediatr &#40;Barc&#41;"
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                            3 => "Rodr&#237;guez Agudo J&#46;L&#46;"
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Una complicación digestiva de la infección por Mycoplasma a tener en cuenta
A gastrointestinal complication of Mycoplasma infection to take into account
Eva Carvajal Rocaa,b, Rosa Fornes Vivasa,b,
Autor para correspondencia
rfornes@comv.es

Autor para correspondencia.
, Marisa Tronchoni Beldaa
a Departamento de Pediatría, Hospital Casa de Salud, Valencia, España
b Universidad Católica de Valencia San Vicente Mártir, Valencia, España
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Beikost sin intolerancias&#46; Inmunizaci&#243;n correcta &#40;no rotavirus&#41;&#46; Padre con <span class="elsevierStyleItalic">talasemia minor&#46;</span></p><p id="par0020" class="elsevierStylePara elsevierViewall">Exploraci&#243;n al ingreso&#58; peso&#58; 14&#44;3<span class="elsevierStyleHsp" style=""></span>kg&#44; T&#46;&#170;&#58; 36&#44;8<span class="elsevierStyleHsp" style=""></span>&#176;C&#46; Regular estado general&#44; algo deca&#237;da&#46; Nutrici&#243;n e hidrataci&#243;n adecuada&#46; No exantemas ni petequias&#46; Orofaringe normal&#46; Tonos card&#237;acos r&#237;tmicos&#44; sin soplos&#46; Buena ventilaci&#243;n pulmonar con tos escasa&#46; Abdomen blando&#44; no doloroso&#44; sin masas ni megalias&#46; Consciente y orientada&#44; no signos men&#237;ngeos ni focalidad neurol&#243;gica&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Anal&#237;tica al ingreso&#58; hemograma normal y alcalosis mixta con hiponatremia e hipocloremia &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46; Se decide ingreso para rehidrataci&#243;n intravenosa &#40;iv&#41; con diagn&#243;stico de gastroenteritis&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Se ingresa con fluidoterapia est&#225;ndar&#46; Ante la leve mejor&#237;a de la hiponatremia con oliguria&#44; rechazo de ingesta y decaimiento&#44; se revalora deshidrataci&#243;n aportando d&#233;ficit y solicitando gasometr&#237;as seriadas&#46; Persiste hiponatremia&#44; a pesar de ceder v&#243;mitos y administrar aportes adecuados de sodio iv&#46; Al segundo d&#237;a manifiesta catarro y distensi&#243;n abdominal y al tercer d&#237;a aparecen edemas perif&#233;ricos sobre todo palpebrales con tos continua&#44; disfon&#237;a y mayor distensi&#243;n abdominal&#46; Se ampl&#237;a estudio anal&#237;tico objetivando hipoproteinemia con hipoalbuminemia&#44; hiponatremia&#44; hipourinemia con creatinemia y cloremia normales &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46; Labstix negativo&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Ecograf&#237;a abdominal detecta solo l&#237;quido libre en pelvis&#46; Ante la sospecha de GEPP se procede a control estricto del balance de l&#237;quidos&#44; cuantificaci&#243;n de alfa-1-antitripsina en heces 3 d&#237;as consecutivos&#44; y se solicita endoscopia digestiva alta&#46; Se instaura dieta hiperproteica seca&#44; aportes h&#237;dricos seg&#250;n balance e inhibidor de la bomba protones iv&#46; Se completa estudio con serolog&#237;a evidenciando positividad a <span class="elsevierStyleItalic">Mycoplasma</span> con aumento de t&#237;tulos de IGM realizado 24<span class="elsevierStyleHsp" style=""></span>h antes del ingreso con respecto al control realizado al 4&#46;&#176; d&#237;a del ingreso&#44; no pudi&#233;ndose realizar la PCR espec&#237;fica por falta de muestra &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">La cuantificaci&#243;n de alfa-1-antitripsina aparece elevada &#40;2&#44;27<span class="elsevierStyleHsp" style=""></span>mg&#47;g&#41; confirmando la sospecha diagn&#243;stica de GEPP&#44; siendo el &#250;nico agente etiol&#243;gico hallado la infecci&#243;n por <span class="elsevierStyleItalic">Mycoplasma</span>&#44; por lo que se inicia tratamiento con azitromicina&#44; estando pendiente de realizar la endoscopia programada en el 5&#46;&#176; d&#237;a del ingreso&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Al 5&#46;&#176; d&#237;a inicia mejor&#237;a cl&#237;nica evidente con desaparici&#243;n de edemas y presentando balances negativos con aumento paulatino de prote&#237;nas sangu&#237;neas en las anal&#237;ticas seriadas&#44; no realiz&#225;ndose la endoscopia por la mejor&#237;a cl&#237;nica evidente&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">El g&#233;nero <span class="elsevierStyleItalic">Mycoplasma</span> representa los microorganismos autorreplicativos m&#225;s peque&#241;os descritos&#44; responsable de diversas infecciones&#46; El <span class="elsevierStyleItalic">M&#46; pneumoniae</span> es reconocido como causa de neumon&#237;a at&#237;pica afectando ni&#241;os y adultos de forma end&#233;mica&#46; Relacionado con otras enfermedades&#44; como pleuropericarditis&#44; pleuritis&#44; artritis reactivas&#44; vasculitis de predominio cut&#225;neo&#44; urticaria a frigore&#44; meningitis linfocitarias&#44; encefalitis diseminada&#44; s&#237;ndrome de Guillain-Barr&#233;&#44; pupila t&#243;nica de Adie y de forma poco frecuente y en adultos GEPP<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a>&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">El t&#233;rmino GEPP incluye enfermedades poco frecuentes&#44; que tienen en com&#250;n una excesiva p&#233;rdida de prote&#237;nas por el tubo digestivo provocando una hipoproteinemia que puede acompa&#241;arse de edemas&#44; ascitis&#44; derrame pleural y peric&#225;rdico&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Las principales enfermedades que lo producen son parasitosis&#44; amiloidosis&#44; yeyunoile&#237;tis ulcerativa&#44; linfoma intestinal&#44; sobrecrecimiento bacteriano&#44; enfermedad cel&#237;aca&#44; enfermedad de Whipple&#44; linfangiectasia&#44; amiloidosis&#44; enfermedad de Crohn&#44; enfermedad de M&#233;n&#233;trier&#44; gastritis eosin&#243;fila&#44; gastritis erosiva&#44; c&#225;ncer de est&#243;mago&#44; linfoma&#44; colitis ulcerosa&#44; enfermedad de Crohn y c&#225;ncer de colon&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Se caracteriza por hipertrofia de pliegues g&#225;stricos del fundus y cuerpo&#44; hipersecreci&#243;n de la mucosa&#44; p&#233;rdida de prote&#237;nas e hipoclorhidria<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a>&#46; Etiolog&#237;a desconocida plante&#225;ndose hip&#243;tesis infecciosas&#44; autoinmunes&#44; hormonales y gen&#233;ticas&#44; asoci&#225;ndose a mayor riesgo de c&#225;ncer g&#225;strico &#40;10-15&#37;&#41;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;3</span></a>&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">En la infancia es raro&#44; afectando a menores de 6 a&#241;os con evoluci&#243;n benigna&#44; inicio brusco y presencia constante de edema<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a>&#46; En la mayor&#237;a de los casos publicados se considera citomegalovirus &#40;CMV&#41; al agente etiol&#243;gico m&#225;s probable&#44; siendo posible tambi&#233;n <span class="elsevierStyleItalic">Helicobacter pylori&#46;</span> Con menor frecuencia y no descritos el <span class="elsevierStyleItalic">Mycoplasma pneumoniae</span>&#44; la <span class="elsevierStyleItalic">Giardia intestinalis</span> y el herpes simple<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a>&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">La sintomatolog&#237;a inicial es inespec&#237;fica&#44; similar al cuadro viral y apareciendo edema perif&#233;rico cuando hay hipoalbuminemia establecida&#46; Es caracter&#237;stica hipoproteinemia e hipoalbuminemia&#44; siendo la alfa-1-antitripsina fecal un marcador sensible y espec&#237;fico de p&#233;rdida proteica en tubo digestivo<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a>&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">No hay tratamiento espec&#237;fico&#46; La evoluci&#243;n hacia la resoluci&#243;n cl&#237;nica completa&#44; de manera espont&#225;nea&#44; suele ocurrir alrededor de las 5 semanas&#46; El tratamiento conlleva el del agente responsable&#46; Se emplea dieta rica en prote&#237;nas&#44; antisecretores&#44; octre&#243;tido&#44; anticolin&#233;rgicos e incluso anticuerpos monoclonales<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a>&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">El tratamiento quir&#250;rgico cuando hay p&#233;rdida no controlable de prote&#237;nas&#44; sangrado y localizaci&#243;n cerca del cardias o con displasia porque elimina el riesgo de malignizaci&#243;n&#46; Es objeto de debate&#44; siendo lo m&#225;s acertado adaptar la t&#233;cnica a la localizaci&#243;n y grado de displasia<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a>&#46;</p></span>"
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">D&#237;a 1&#46;&#176; del ingreso&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">8&#46;000<span class="elsevierStyleHsp" style=""></span>mg&#47;l&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">10<span class="elsevierStyleHsp" style=""></span>g&#47;dl&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">389&#46;000<span class="elsevierStyleHsp" style=""></span>mg&#47;l&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">271&#46;000<span class="elsevierStyleHsp" style=""></span>mg&#47;l&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">459&#46;000<span class="elsevierStyleHsp" style=""></span>mg&#47;l&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">pH&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">7&#44;4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">44&#44;1<span class="elsevierStyleHsp" style=""></span>mmHg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">O<span class="elsevierStyleInf">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">58<span class="elsevierStyleHsp" style=""></span>mmHg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">40&#44;8<span class="elsevierStyleHsp" style=""></span>mmHg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8212;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Na&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">120<span class="elsevierStyleHsp" style=""></span>mEq&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">131<span class="elsevierStyleHsp" style=""></span>mEq&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">137<span class="elsevierStyleHsp" style=""></span>mEq&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">6<span class="elsevierStyleHsp" style=""></span>mEq&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;13<span class="elsevierStyleHsp" style=""></span>mEq&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;44<span class="elsevierStyleHsp" style=""></span>mEq&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">83<span class="elsevierStyleHsp" style=""></span>mEq&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">95<span class="elsevierStyleHsp" style=""></span>mEq&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">102<span class="elsevierStyleHsp" style=""></span>mEq&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;4<span class="elsevierStyleHsp" style=""></span>mmol&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;2<span class="elsevierStyleHsp" style=""></span>mmol&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8212;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Calcio&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#8212;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">9&#44;3<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Prote&#237;nas totales&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3<span class="elsevierStyleHsp" style=""></span>g&#47;dl&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">5<span class="elsevierStyleHsp" style=""></span>g&#47;dl&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Albumina&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#8212;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2&#44;27<span class="elsevierStyleHsp" style=""></span>mg&#47;g heces&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;18<span class="elsevierStyleHsp" style=""></span>mg&#47;g heces&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Mycoplasma tuberculosis &#40;</span>IgM&#47;IgG&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                      "titulo" => "Beyond gastritis and before cancer&#58; The strange case of M&#233;n&#233;trier&#39;s disease"
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                      "titulo" => "Doen&#231;a de M&#233;n&#233;trier&#58; Regress&#227;o Completa ap&#243;s Erradica&#231;&#227;o do Helicobacter Pylori"
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                            3 => "M&#46; Molina Arias"
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                            3 => "Rodr&#237;guez Agudo J&#46;L&#46;"
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                            5 => "E&#46; Olmo Brieba"
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                            2 => "M&#46; Figueiredo"
                            3 => "L&#46; Morais"
                            4 => "H&#46; Ferreira"
                            5 => "L&#46; Marques"
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Información del artículo
ISSN: 16954033
Idioma original: Español
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