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          "es" => "<p id="spar0130" class="elsevierStyleSimplePara elsevierViewall">Protocolo de actuaci&#243;n en las primeras 6<span class="elsevierStyleHsp" style=""></span>h de vida y &#171;cadena de neuroprotecci&#243;n cerebral&#187;&#46;</p> <p id="spar0135" class="elsevierStyleSimplePara elsevierViewall">aEEG&#58; electroencefalograma integrado por amplitud&#59; BS&#58; patr&#243;n brote supresi&#243;n&#59; CBV&#58; patr&#243;n continuo de bajo voltaje&#59; DB&#58; d&#233;ficit de bases&#59; EG&#58; edad gestacional&#59; EHI&#58; encefalopat&#237;a hip&#243;xico-isqu&#233;mica&#59; FC&#58; frecuencia cardiaca&#59; FiO<span class="elsevierStyleInf">2</span>&#58; fracci&#243;n inspirada de ox&#237;geno&#59; FR&#58; frecuencia respiratoria&#59; g&#58; gramos&#59; hdv&#58; horas de vida&#59; hipoCa<span class="elsevierStyleSup">&#43;&#43;</span>&#58; hipocalcemia&#59; hipoMg<span class="elsevierStyleSup">&#43;&#43;</span>&#58; hipomagnesemia&#59; min&#58; minutos&#59; P&#58; patr&#243;n plano&#59; PaO<span class="elsevierStyleInf">2</span>&#58; presi&#243;n parcial de ox&#237;geno en la sangre arterial&#59; PaCO<span class="elsevierStyleInf">2</span>&#58; presi&#243;n parcial de di&#243;xido de carbono en la sangre arterial&#59; rScO<span class="elsevierStyleInf">2</span>&#58; saturaci&#243;n regional de ox&#237;geno cerebral&#59; REA&#58; reanimaci&#243;n&#59; RN&#58; reci&#233;n nacido&#59; SatO<span class="elsevierStyleInf">2</span>&#58; saturaci&#243;n arterial de ox&#237;geno&#59; T<span class="elsevierStyleSup">a</span>&#58; temperatura&#59; TA&#58; tensi&#243;n arterial&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">Las importantes implicaciones m&#233;dicas&#44; familiares&#44; sociales y legales que asocia la encefalopat&#237;a hip&#243;xico-isqu&#233;mica &#40;EHI&#41; perinatal en el reci&#233;n nacido &#40;RN&#41; a t&#233;rmino o pret&#233;rmino tard&#237;o hacen que constituya un problema sociosanitario relevante<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">1</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">En nuestro pa&#237;s&#44; en el a&#241;o 2011 la Sociedad Espa&#241;ola de Neonatolog&#237;a public&#243; una gu&#237;a de est&#225;ndares para la aplicaci&#243;n cl&#237;nica de la hipotermia terap&#233;utica &#40;HT&#41;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">2</span></a>&#44; y en el a&#241;o 2014&#44; un grupo de expertos elabor&#243; una gu&#237;a de pr&#225;ctica cl&#237;nica basada en la evidencia sobre el manejo integral del neonato con EHI<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">3</span></a>&#46; Cuando se ha analizado la efectividad de la HT en la pr&#225;ctica cl&#237;nica habitual&#44; los resultados parecen ser mejores que los obtenidos en los primeros ensayos cl&#237;nicos<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">4</span></a>&#46; Entre los factores que contribuir&#237;an a esta brecha entre eficacia y efectividad&#44; destacan aquellos que acontecen en las primeras horas de vida&#58; adecuada reanimaci&#243;n en paritorio&#44; comienzo precoz de la HT&#44; y control de factores potencialmente agravantes de la agresi&#243;n hip&#243;xico-isqu&#233;mica&#44; antes y durante la HT&#46; Sin embargo&#44; apenas existen recomendaciones sobre el proceso asistencial desde el nacimiento hasta el inicio de la HT&#44; periodo crucial en el que podemos actuar sobre los factores mencionados y as&#237; mejorar la efectividad neuroprotectora de la hipotermia<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">5&#8211;8</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Los objetivos de este trabajo de &#225;mbito nacional fueron&#58; 1&#41; conocer el manejo del RN con asfixia perinatal durante las primeras 6<span class="elsevierStyleHsp" style=""></span>h de vida en unidades de neonatolog&#237;a de nivel <span class="elsevierStyleSmallCaps">iii</span>&#44; y 2&#41; examinar si existen diferencias entre aquellas unidades que ofrecen HT y aquellas que transfieren los RN asf&#237;cticos a centros de referencia para recibir este tratamiento&#44; as&#237; como entre los diferentes niveles asistenciales tipo <span class="elsevierStyleSmallCaps">iii</span>&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Metodolog&#237;a</span><p id="par0020" class="elsevierStylePara elsevierViewall">Estudio transversal&#44; multic&#233;ntrico dirigido a examinar el proceso asistencial durante las primeras 6<span class="elsevierStyleHsp" style=""></span>h de vida del RN<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>35 semanas de edad gestacional con asfixia perinatal mediante un cuestionario on-line&#46; El estudio fue realizado en 2015 e incluy&#243; todos los hospitales terciarios &#40;p&#250;blicos y privados&#41;&#44; con unidades neonatales de nivel <span class="elsevierStyleSmallCaps">iii</span> de nuestro pa&#237;s<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">9</span></a>&#46; Se solicit&#243; que el responsable de cada centro con mayor experiencia en el manejo de la EHI respondiese al cuestionario&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">En las <a class="elsevierStyleCrossRefs" href="#tbl0005">tablas 1 y 2</a> se recogen las 23 preguntas de la encuesta referentes a la asistencia del RN con criterios de asfixia durante las primeras horas de vida&#46; Esta se defini&#243; por la presencia de al menos uno de los siguientes&#58; 1&#41; pH cord&#243;n o a la hora de vida<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>7 o d&#233;ficit de bases<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>16&#59; 2&#41; Apgar a los 5<span class="elsevierStyleHsp" style=""></span>min<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>5&#59; 3&#41; necesidad de reanimaci&#243;n avanzada &#40;intubaci&#243;n y&#47;o masaje cardiaco y&#47;o administraci&#243;n de f&#225;rmacos&#41;&#46; En la <a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a> se recogen las 8 preguntas referidas a la disponibilidad de profesionales con experiencia en la asistencia del RN con EHI de cada uno de los hospitales que realizaban HT en el momento del cierre de la encuesta &#40;junio 2015&#41;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Para clasificar la calidad de la asistencia ofrecida por cada hospital&#44; se asign&#243; una puntuaci&#243;n a cada pregunta&#58; 4 puntos si la pr&#225;ctica realizada respond&#237;a &#171;casi siempre&#187; al est&#225;ndar asistencial recomendado en las gu&#237;as de pr&#225;ctica cl&#237;nica&#44; 3 puntos si dicha pr&#225;ctica era realizada &#171;con frecuencia&#187; o 1 punto cuando la respuesta fue &#171;raramente o nunca&#187;&#46; Se asign&#243; a cada hospital una categor&#237;a de &#171;asistencia &#243;ptima&#187; si obtuvo 4 puntos en todas las preguntas&#44; &#171;asistencia aceptable&#187; si alguna pregunta obtuvo 3 puntos pero ninguna 1 punto&#44; y &#171;asistencia mejorable&#187; si alguna pregunta obtuvo 1 punto&#46; Se excluyeron de la puntuaci&#243;n las preguntas m&#225;s controvertidas &#40;preguntas 11&#44; 15&#44; 16&#44; 18&#44; 19&#44; 20&#44; 23 y 31&#41;&#46; Las que hac&#237;an referencia al mismo contenido se agruparon&#58; 1-2&#44; 3-4&#44; 24a-24b&#44; 26a-26d&#44; 26b-26c&#46; En las 3 preguntas con respuestas de elecci&#243;n m&#250;ltiple &#40;20&#44; 21 y 22&#41;&#44; se dio 1 punto si se contest&#243; &#171;ninguna&#187; y 4 puntos al resto de las opciones &#40;<a class="elsevierStyleCrossRefs" href="#tbl0005">tablas 1&#8211;3</a>&#41;&#46; El estudio fue aprobado por el comit&#233; de investigaci&#243;n del hospital coordinador&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">An&#225;lisis estad&#237;stico</span><p id="par0040" class="elsevierStylePara elsevierViewall">Los datos descriptivos se expresaron como n&#250;mero y porcentaje&#46; Para examinar diferencias&#44; se utiliz&#243; la prueba de Chi-cuadrado &#40;Fisher&#41; y U de Mann-Whitney&#47;Kruskal-Wallis para variables cualitativas y cuantitativas&#44; respectivamente&#46; Un valor de p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05 se consider&#243; estad&#237;sticamente significativo&#46;</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Resultados</span><p id="par0045" class="elsevierStylePara elsevierViewall">De la totalidad de los 90 servicios de Neonatolog&#237;a nivel <span class="elsevierStyleSmallCaps">iii</span> de nuestro pa&#237;s&#44; 89 aportaron la informaci&#243;n solicitada&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Respecto <span class="elsevierStyleItalic">al manejo al nacimiento</span> &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#44; la mayor&#237;a de los hospitales &#40;98&#37;&#41; indicaron que ante un parto complicado acud&#237;a un neonat&#243;logo junto con una matrona y&#44; en ocasiones&#44; una enfermera neonatal&#46; Adem&#225;s&#44; pr&#225;cticamente todos los hospitales refirieron utilizar protocolos de reanimaci&#243;n&#44; apagar las fuentes ex&#243;genas de calor una vez estabilizado el RN&#44; y rara vez usar calcio o bicarbonato durante la reanimaci&#243;n&#46; Asimismo&#44; era com&#250;n trasladar al RN a la unidad neonatal&#44; incluso aunque se recuperase r&#225;pidamente&#44; si bien en esta circunstancia algunos hospitales &#40;25&#37;&#41; dejaban al RN con su madre&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">En la <a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a> se muestran los resultados referentes a las <span class="elsevierStyleItalic">acciones durante las 6 primeras horas de vida</span>&#46; Mayoritariamente los centros dispon&#237;an de protocolos de actuaci&#243;n espec&#237;fica para este periodo&#44; realizaban controles de glucemia y gasometr&#237;a&#44; monitorizaban la temperatura con el objetivo de mantenerla por debajo de 36<span class="elsevierStyleHsp" style=""></span>&#176;<span class="elsevierStyleSmallCaps">C</span>&#44; y optaban por dejar al RN a dieta con sueroterapia&#46; En cuanto a la valoraci&#243;n de la EHI&#44; la mayor&#237;a &#40;92&#37;&#41; realizaban al menos 2 exploraciones en las primeras 6<span class="elsevierStyleHsp" style=""></span>h de vida&#44; utilizando las escalas de graduaci&#243;n de Garc&#237;a-Alix<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">10</span></a> y Sarnat<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">11</span></a> en el 94&#37; de los casos&#44; siendo el &#237;tem de la capacidad para despertar y mantener la alerta el m&#225;s relevante en el 90&#37; de los hospitales&#46; Respecto al uso del electroencefalograma integrado por amplitud &#40;aEEG&#41; en las primeras 6<span class="elsevierStyleHsp" style=""></span>h de vida&#44; 58 de los 89 hospitales &#40;65&#37;&#41; dispon&#237;an de aEEG&#58; 51 &#40;89&#37;&#41; de las 57 unidades que ofrec&#237;an HT y 7 &#40;22&#37;&#41; de las 32 que no &#40;p&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; Entre los que dispon&#237;an de aEEG&#44; el 90&#37; de los hospitales refirieron utilizarlo siempre o con bastante frecuencia&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Informaci&#243;n sobre la <span class="elsevierStyleItalic">disponibilidad de profesionales con experiencia en el manejo del RN con EHI</span> en los hospitales que realizaban HT fue notificada de 53 de los 57 centros &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>&#41;&#46; La mayor&#237;a de los centros dispon&#237;an siempre de personal con entrenamiento en la exploraci&#243;n neurol&#243;gica &#40;89&#37;&#41;&#44; en la ecograf&#237;a cerebral &#40;87&#37;&#41; e interpretaci&#243;n de la RM &#40;75&#37;&#41;&#44; y en la realizaci&#243;n de ecocardiograf&#237;a &#40;57&#37;&#41;&#46; Sin embargo&#44; en el 25&#37; de los hospitales no hab&#237;a siempre un neonat&#243;logo con experiencia en la realizaci&#243;n de examen neurol&#243;gico o en la interpretaci&#243;n del aEEG&#44; y en el 62&#37; tampoco lo hab&#237;a en la realizaci&#243;n de ecograf&#237;a cerebral&#46; La mayor&#237;a de los hospitales refirieron tener una relaci&#243;n de enfermeras por paciente adecuada&#44; aunque no exist&#237;an protocolos enfermeros espec&#237;ficos en el 28&#37; o experiencia en los cuidados de este grupo de pacientes en el 21&#37;&#46; Finamente&#44; m&#225;s del 50&#37; no dispon&#237;an de apoyo psicol&#243;gico especializado para los padres-familias de estos ni&#241;os&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">En cuanto a la puntuaci&#243;n obtenida en la asistencia en paritorio y en las 6 primeras horas de vida&#44; el 25&#37; de los 89 hospitales obtuvo una calificaci&#243;n de &#171;mejorable&#187;&#44; aunque con puntuaciones elevadas de 54&#44;5 &#40;46&#59;56&#41; puntos de mediana &#40;m&#237;n&#59;m&#225;x&#41; en los hospitales que no ofrec&#237;an HT frente a 56 &#40;49&#59;56&#41; puntos en el resto &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;052&#41;&#40;<a class="elsevierStyleCrossRef" href="#tbl0020">tabla 4</a>&#41;&#46; Los hospitales con HT obtuvieron la calificaci&#243;n de manejo &#171;&#243;ptimo&#187; en m&#225;s casos que los que no dispon&#237;an de HT&#44; especialmente durante la reanimaci&#243;n &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;015&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; Atendiendo al nivel asistencial&#44; la calidad asistencial fue mejor cuanto mayor el nivel asistencial&#44; tanto de forma global&#44; como entre aquellos que realizaban HT &#40;<a class="elsevierStyleCrossRefs" href="#fig0010">figs&#46; 2 y 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Discusi&#243;n</span><p id="par0070" class="elsevierStylePara elsevierViewall">En el RN con asfixia perinatal&#44; la asistencia en la primeras 6<span class="elsevierStyleHsp" style=""></span>h de vida constituye un periodo crucial que incluye diversas etapas asistenciales desde el nacimiento hasta el momento en que se inicia la HT&#58; 1&#41; reanimaci&#243;n y estabilizaci&#243;n del paciente&#44; 2&#41; control de factores com&#243;rbidos&#44; 3&#41; caracterizaci&#243;n precisa de la gravedad de la EHI&#44; y 4&#41; traslado urgente a centros de referencia que ofrecen una asistencia integral a estos RN incluyendo HT<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">2&#44;6&#8211;8&#44;12&#8211;14</span></a>&#46; Los resultados de este trabajo se&#241;alan que la asistencia del RN con asfixia perinatal&#44; analizando cada una de las etapas incluidas en las primeras 6<span class="elsevierStyleHsp" style=""></span>h de vida en los hospitales terciarios de nuestro pa&#237;s&#44; es globalmente satisfactoria aunque con diferencias seg&#250;n el nivel asistencial y si realizan o no HT&#46;</p><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Reanimaci&#243;n y estabilizaci&#243;n en paritorio</span><p id="par0075" class="elsevierStylePara elsevierViewall">En nuestro pa&#237;s todas las unidades de neonatolog&#237;a de centros terciarios aplican protocolos de actuaci&#243;n espec&#237;fica para la reanimaci&#243;n y estabilizaci&#243;n en el paritorio del RN con criterios de asfixia perinatal&#46; Coherentemente con las recomendaciones vigentes&#44; los hospitales disponen de personal entrenado en la reanimaci&#243;n neonatal y evitan la administraci&#243;n de calcio o bicarbonato<a class="elsevierStyleCrossRefs" href="#bib0265"><span class="elsevierStyleSup">15&#44;16</span></a>&#46; Asimismo refieren apagar la cuna de reanimaci&#243;n una vez estabilizado el RN despu&#233;s de la reanimaci&#243;n&#46; A pesar de las recomendaciones actuales que indican evitar la hipertermia e iniciar HT en la EHI moderada-grave&#44; no se hace referencia a qu&#233; medidas iniciar durante la reanimaci&#243;n<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">16&#44;17</span></a>&#46; En cualquier caso&#44; dada la tendencia natural del RN con asfixia a disminuir la temperatura corporal&#44; es mandatorio monitorizar la temperatura central en paritorio m&#225;s a&#250;n si se retiran las fuentes de calor externa<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">18&#44;19</span></a>&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Tras la estabilizaci&#243;n inicial&#44; la monitorizaci&#243;n de diversas funciones fisiol&#243;gicas&#44; incluyendo frecuencia cardiaca&#44; tensi&#243;n arterial&#44; funci&#243;n respiratoria y temperatura&#44; son pr&#225;ctica est&#225;ndar en el cuidado de estos RN&#46; Un punto controvertido es si&#44; en caso de r&#225;pida recuperaci&#243;n del RN en paritorio&#44; este puede quedarse con su madre para favorecer el contacto piel con piel y el inicio de la lactancia materna&#59; o si por el contrario&#44; ser&#237;a conveniente un periodo de monitorizaci&#243;n en la unidad neonatal evitando adem&#225;s el inicio inmediato de la alimentaci&#243;n ante una potencial situaci&#243;n de hipoperfusi&#243;n intestinal&#46; En nuestro estudio&#44; la gran mayor&#237;a de los centros refirieron ingresar al RN con asfixia aunque el 25&#37; contemplaban la posibilidad de dejar al RN con su madre si la recuperaci&#243;n cl&#237;nica era r&#225;pida y adecuada&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Control de la temperatura</span><p id="par0085" class="elsevierStylePara elsevierViewall">Un aspecto fundamental en el RN con asfixia perinatal es el control de la temperatura desde los minutos siguientes al parto hasta la decisi&#243;n de indicar o no HT&#46; Por cada incremento de 1<span class="elsevierStyleHsp" style=""></span>&#176;C&#44; la odds ratio para muerte o discapacidad neurol&#243;gica moderada-grave se incrementa hasta 4 veces<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">20</span></a>&#46; Coherentemente con este conocimiento&#44; el 98&#37; de los centros refirieron trasladar al RN a la unidad neonatal con la cuna de transporte apagada&#44; y monitorizar durante las primeras horas la temperatura rectal con el objetivo de evitar el sobreenfriamiento y sobre todo&#44; la hipertermia<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">21</span></a>&#46; Adem&#225;s&#44; la mayor&#237;a de los hospitales se&#241;alaron que habitualmente mantienen la temperatura por debajo de 36<span class="elsevierStyleHsp" style=""></span>&#176;C&#46; En el momento actual&#44; no existe evidencia respecto a los efectos beneficiosos o perjudiciales de disminuir la temperatura por debajo de la normotermia e incluso al rango de la HT &#40;33-34<span class="elsevierStyleHsp" style=""></span>&#176;C&#41; a un RN con asfixia perinatal sin esperar a establecer que padece una EHI moderada-grave&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Control de otros factores com&#243;rbidos</span><p id="par0090" class="elsevierStylePara elsevierViewall">Tras una agresi&#243;n hip&#243;xico-isqu&#233;mica&#44; el cerebro es particularmente vulnerable a factores com&#243;rbidos con capacidad potencial para da&#241;ar <span class="elsevierStyleItalic">per se</span> el SNC&#44; acortar la ventana terap&#233;utica y aumentar la gravedad del da&#241;o&#46; Entre estos factores se encuentran la hipoglucemia&#44; la hipocarbia y la hiper-&#47;hipoxia&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">La asfixia perinatal es una causa importante de hipoglucemia debido al metabolismo anaer&#243;bico de la glucosa&#46; Adem&#225;s&#44; la presencia concomitante de hipoxemia e isquemia podr&#237;a aumentar la vulnerabilidad del cerebro neonatal a la hipoglucemia&#46; La hipoglucemia por debajo de 40 o 46&#44;8<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#44; en las primeras horas de vida aumenta el riesgo de desarrollar EHI moderada-grave<a class="elsevierStyleCrossRefs" href="#bib0300"><span class="elsevierStyleSup">22&#8211;25</span></a>&#44; as&#237; como de discapacidad o muerte ulterior<a class="elsevierStyleCrossRefs" href="#bib0310"><span class="elsevierStyleSup">24&#44;25</span></a>&#46; Todos los centros realizaban al menos una medici&#243;n de glucemia e instauraban sueroterapia al ingreso&#46; No hay evidencia cient&#237;fica para establecer la recomendaci&#243;n universal de iniciar glucosa en perfusi&#243;n<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">16</span></a>&#44; frente a la opci&#243;n de monitorizar los valores de glucemia e iniciar la nutrici&#243;n enteral&#46; En este sentido&#44; es recomendable investigar la presencia acidosis o hiperlactatemia que podr&#237;an alertar de una potencial hipoperfusi&#243;n intestinal&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Otra pr&#225;ctica universal en todos los centros fue la realizaci&#243;n de una gasometr&#237;a en las primeras 6<span class="elsevierStyleHsp" style=""></span>h de vida&#46; Esta persigue detectar alteraciones como la hipocarbia grave &#40;pCO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>20<span class="elsevierStyleHsp" style=""></span>mmHg&#41; o la hipocarbia moderada sostenida &#40;pCO<span class="elsevierStyleInf">2</span> 20-25<span class="elsevierStyleHsp" style=""></span>mmHg&#41;&#44; que parecen aumentar el riesgo de muerte o discapacidad neurol&#243;gica moderada-grave en el RN con EHI<a class="elsevierStyleCrossRefs" href="#bib0320"><span class="elsevierStyleSup">26&#8211;28</span></a>&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Identificaci&#243;n del reci&#233;n nacido con encefalopat&#237;a hip&#243;xico-isqu&#233;mica</span><p id="par0105" class="elsevierStylePara elsevierViewall">El aspecto clave&#44; junto con la monitorizaci&#243;n de las constantes vitales y de los factores com&#243;rbidos a trav&#233;s de la anal&#237;tica&#44; es establecer si el RN con asfixia perinatal presenta o no encefalopat&#237;a aguda&#46; Dado que esta tiene un car&#225;cter din&#225;mico&#44; y el diagn&#243;stico y graduaci&#243;n de la gravedad se establece mediante la evaluaci&#243;n cl&#237;nica&#44; es recomendable realizar varias exploraciones neurol&#243;gicas durante las 6 primeras horas de vida<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">2&#44;3&#44;7&#44;13</span></a>&#46; En esta l&#237;nea&#44; los hospitales contestaron que m&#225;s del 90&#37; realizaban habitualmente 2 o m&#225;s exploraciones&#46; De forma pr&#225;ctica&#44; las 3<span class="elsevierStyleHsp" style=""></span>h de vida podr&#237;a ser un momento adecuado para indicar el tratamiento con HT activa en un RN con asfixia al nacimiento y que presenta en ese momento una EHI moderada-grave<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">5</span></a>&#46; Si se tomase la decisi&#243;n de indicar HT inmediatamente al nacimiento en base del mayor beneficio&#44; estar&#237;amos ofreciendo HT a numerosos RN que se recuperar&#237;an en los minutos siguientes con un curso favorable sin el tratamiento&#46; Por el contrario&#44; si se retrasase el inicio de la HT hasta las 6<span class="elsevierStyleHsp" style=""></span>h de vida&#44; se puede perder la m&#225;xima eficacia del tratamiento&#44; que acontece cuanto antes se inicia tras la agresi&#243;n hip&#243;xico-isqu&#233;mica<a class="elsevierStyleCrossRefs" href="#bib0335"><span class="elsevierStyleSup">29&#44;30</span></a>&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Todos los hospitales contestaron que utilizaban escalas para graduar la encefalopat&#237;a&#44; mayoritariamente la escala de Garc&#237;a-Alix<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">10</span></a>&#44; seguida por la escala de Sarnat<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">11</span></a>&#46; Las escalas ofrecen una aproximaci&#243;n estandarizada&#44; sistem&#225;tica y organizada&#44; y homogenizan la caracterizaci&#243;n de la gravedad&#44; por profesionales con diferente grado de entrenamiento neurol&#243;gico y permiten comparar la evoluci&#243;n de los pacientes en grupos homog&#233;neos&#46; Es recomendable que cada centro adquiera confianza y experiencia con la misma escala&#46; Debemos recordar&#44; a la espera de los resultados de un ensayo cl&#237;nico dirigido a aquellos RN con EHI leve&#44; que en el momento actual la indicaci&#243;n de HT es solo para aquellos con EHI moderada-grave&#44; a pesar de que hay series que refieren incluir en el tratamiento con hipotermia al 15-30&#37; de RN con EHI leve<a class="elsevierStyleCrossRefs" href="#bib0345"><span class="elsevierStyleSup">31&#8211;33</span></a>&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">La alteraci&#243;n de la actividad electrocortical mediante el aEEG ha sido utilizada para incluir al RN con asfixia perinatal en HT<a class="elsevierStyleCrossRefs" href="#bib0360"><span class="elsevierStyleSup">34&#44;35</span></a>&#44; y principalmente&#44; para monitorizar la funci&#243;n cerebral durante la fase aguda de la encefalopat&#237;a<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">36</span></a> y detectar convulsiones cl&#237;nicamente silentes&#46; Adem&#225;s&#44; la relativa simplicidad de la interpretaci&#243;n del registro junto con su valor predictivo ha dado lugar a que esta monitorizaci&#243;n sea extremadamente importante en los RN con enfermedad neurol&#243;gica&#44; particularmente en el RN con EHI<a class="elsevierStyleCrossRefs" href="#bib0365"><span class="elsevierStyleSup">35&#44;36</span></a>&#46; Es de destacar que el 35&#37; de los centros no dispon&#237;a de aEEG a pesar de ser unidades terciarias de nivel <span class="elsevierStyleSmallCaps">iii</span>&#44; entre las que se inclu&#237;an varios centros que realizaban HT&#46; Estos datos traducen aspectos de mejora&#44; por cuanto no parece factible ofertar un cuidado &#243;ptimo del RN con HT sin la informaci&#243;n que aporta la monitorizaci&#243;n cerebral&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">A pesar de que los datos de la encuesta muestran un adecuado est&#225;ndar asistencial con puntuaciones similares entre los que realizan HT y los que no&#44; existe margen de mejora ya que solo el 50&#37; de los 89 hospitales terciarios obtuvieron una &#171;asistencia &#243;ptima&#187;&#46; Existen adem&#225;s diferencias atendiendo al nivel asistencial&#44; y a si realizan o no HT&#44; siendo la calidad mejor en las unidades que realizan hipotermia <span class="elsevierStyleSmallCaps">iii</span>c y <span class="elsevierStyleSmallCaps">iii</span>b frente a las <span class="elsevierStyleSmallCaps">iii</span>a en la atenci&#243;n del parto y 6 primeras horas de vida&#44; y en la disponibilidad de profesionales con experiencia en las unidades <span class="elsevierStyleSmallCaps">iii</span>c frente al resto&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Un aspecto clave para mejorar la respuesta en este estrecho marco temporal es la formaci&#243;n adecuada de los pediatras que atienden partos&#44; para as&#237; identificar r&#225;pidamente al RN candidato a HT y activar el &#171;c&#243;digo hipotermia&#187; de manera muy precoz<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">37</span></a>&#46; En nuestro medio&#44; la incidencia de asfixia perinatal est&#225; en torno a 7 por mil RN<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">7</span></a> y si bien la mayor&#237;a de los ni&#241;os no necesitar&#225;n traslado&#44; la activaci&#243;n de este c&#243;digo y la puesta en marcha de una serie de acciones en secuencia que denominamos &#171;cadena de neuroprotecci&#243;n cerebral&#187; permiten poner en alerta al equipo de transporte y al centro de referencia&#44; as&#237; como vigilar de forma estrecha el estado neurol&#243;gico del RN&#44; controlar potenciales factores com&#243;rbidos y determinar la presencia de EHI en el marco de las 6<span class="elsevierStyleHsp" style=""></span>h de oro &#40;<a class="elsevierStyleCrossRef" href="#fig0020">fig&#46; 4</a>&#41;&#46; Nuestro estudio muestra &#225;reas de mejora&#44; como son la dotaci&#243;n tecnol&#243;gica y de personal entrenado&#59; al menos todos los centros que ofrecen HT deber&#237;an tener equipos de aEEG y neonat&#243;logos entrenados en las diferentes herramientas de evaluaci&#243;n neurol&#243;gica junto con experiencia en el manejo de las complicaciones asociadas a la EHI<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">12&#44;38</span></a>&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0130" class="elsevierStylePara elsevierViewall">La fortaleza de este trabajo es que pr&#225;cticamente todos los centros terciarios aportaron informaci&#243;n y gracias a ello disponemos de datos &#250;nicos&#44; no previamente conocidos que ofrecen un panorama global sobre la asistencia que se da al RN con asfixia perinatal y candidato a HT durante las primeras horas de vida en nuestro pa&#237;s&#46; Por otro lado este estudio presenta algunas limitaciones&#46; La metodolog&#237;a de una encuesta puede conllevar sesgos al incorporar al conjunto de datos informaci&#243;n incompleta o err&#243;nea&#46; Como no se dispone de criterios validados para establecer la calidad asistencial en el intervalo temporal de las 6 primeras horas en el contexto de la asfixia perinatal&#44; se sigui&#243; el criterio de puntuar la pr&#225;ctica cl&#237;nica de acuerdo con el est&#225;ndar recomendado en las gu&#237;as de pr&#225;ctica cl&#237;nica <a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">2&#44;3&#44;12&#8211;14</span></a>&#46; Asimismo&#44; se han eliminado las preguntas m&#225;s controvertidas y se ha optado por una escala asim&#233;trica que reforzase una actuaci&#243;n conforme al est&#225;ndar recomendado&#44; frente a una respuesta de &#171;raramente o nunca&#187;&#46; Finalmente&#44; es preciso resaltar que la encuesta eval&#250;a protocolos de actuaci&#243;n generales en cada hospital&#44; pero no es posible a trav&#233;s de ella conocer la calidad real asistencial de los pacientes&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">La informaci&#243;n aportada por este trabajo es relevante especialmente para dimensionar la pr&#225;ctica asistencial en nuestro pa&#237;s durante las horas de oro del RN asf&#237;ctico en riesgo de EHI y mostrar aspectos de posible mejora para poder dirigir adecuadamente los esfuerzos encaminados a ofertar una asistencia adecuada en este marco temporal&#46;</p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Conflicto de intereses</span><p id="par0140" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span></span>"
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              "titulo" => "Control de la temperatura"
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              "titulo" => "Identificaci&#243;n del reci&#233;n nacido con encefalopat&#237;a hip&#243;xico-isqu&#233;mica"
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            1 => "Asfixia"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introducci&#243;n</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El proceso asistencial hasta el inicio de la hipotermia terap&#233;utica &#40;HT&#41; es crucial para mejorar su efectividad y prevenir el agravamiento del da&#241;o hip&#243;xico-isqu&#233;mico&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">M&#233;todo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio transversal nacional realizado en 2015 mediante cuestionario a todas las unidades nivel <span class="elsevierStyleSmallCaps">iii</span> sobre la asistencia al reci&#233;n nacido &#40;RN&#41; con asfixia perinatal en las primeras horas de vida&#46; Se compar&#243; la calidad asistencial entre los hospitales que realizaban o no HT y seg&#250;n el nivel asistencial&#44; de acuerdo a las gu&#237;as de pr&#225;ctica cl&#237;nica&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Participaron 89&#47;90 hospitales&#44; 57&#47;90 realizaban HT&#46; Todos utilizaban protocolos de reanimaci&#243;n y apagaban la cuna tras estabilizaci&#243;n&#46; Fue universal realizar medici&#243;n de glucemia y gasometr&#237;a&#44; monitorizar la temperatura&#44; dejar al RN a dieta y realizar al menos 2 exploraciones para el diagn&#243;stico de encefalopat&#237;a hip&#243;xico-isqu&#233;mica&#46; El 35&#37; no dispon&#237;a de electroencefalograma integrado por amplitud&#59; 6&#47;57 eran hospitales que realizaban HT&#46; La calidad asistencial entre los hospitales con&#47;sin HT fue similar&#44; siendo mejor la del parto en los que hac&#237;an HT&#44; y la de aquellos con mayor nivel asistencial&#46; El 25&#37; de aquellos que realizaban HT no ten&#237;an neonat&#243;logos con experiencia en la exploraci&#243;n neurol&#243;gica o en la interpretaci&#243;n del electroencefalograma integrado por amplitud&#59; ni en la realizaci&#243;n de ecograf&#237;a cerebral en el 62&#37;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Atendiendo a las recomendaciones del RN asf&#237;ctico&#44; existe un adecuado est&#225;ndar asistencial nacional&#44; con diferencias seg&#250;n el nivel asistencial y si realizan o no hipotermia&#46; Son necesarios m&#225;s equipos de electroencefalograma integrado por amplitud y formaci&#243;n de los neonat&#243;logos en las evaluaciones que requerir&#225; el RN con encefalopat&#237;a hip&#243;xico-isqu&#233;mica&#46;</p></span>"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introduction</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The process of care and assistance from birth to the starting of therapeutic hypothermia &#40;TH&#41; is crucial in order to improve its effectiveness and prevent the worsening of hypoxic-ischaemic injury&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A national cross-sectional study carried out in 2015 by use of a questionnaire sent to all level <span class="elsevierStyleSmallCaps">iii</span> units on the care of the newborn<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>35 weeks gestation within the first hours of life after a perinatal asphyxia event&#46; According to clinical practice guidelines&#44; the quality of care was compared between the hospitals that carried out or did not carry out TH&#44; and according to the level of care&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">A total of 89&#47;90 hospitals participated&#44; of which 57&#47;90 performed TH&#46; They all used resuscitation protocols and turned off the radiant warmer after stabilisation&#46; All of them performed glucose and blood gas analysis&#44; monitored the central temperature&#44; put the newborn on a diet&#44; and performed at least two examinations for the diagnosis of hypoxic-ischaemic encephalopathy&#46; Greater than one-third &#40;35&#37;&#41; of hospitals did not have amplitude-integrated electroencephalogram&#44; and 6&#47;57 were TH-hospitals&#46; The quality of care among hospitals with and without TH was similar&#44; childbirth being better in those that performed TH&#44; and those with a higher level of care&#46; Level IIIc hospitals had higher scores than the others&#46; The TH-hospitals mentioned not always having neonatologists with experience in neurological assessment and interpretation of amplitude-integrated electroencephalogram &#40;25&#37;&#41;&#44; or in brain ultrasound &#40;62&#37;&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">In response to the recommendations of the asphyxiated newborn&#44; there is a proper national health care standard with differences according to the level of care and whether TH is offered&#46; More amplitude-integrated electroencephalogram devices are necessary&#44; as well as more neonatologists trained in the evaluations that will be require by the newborn with hypoxic-ischaemic encephalopathy&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0035">Los miembros del Grupo de Trabajo ESP-EHI se presentan en <a class="elsevierStyleCrossRef" href="#sec0055">anexo 1</a>&#46;</p>"
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            "apendice" => "<p id="par0150" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Grupo de Trabajo ESP-EHI&#46; Unidades de Neonatolog&#237;a&#46; Hospitales terciarios&#44; Espa&#241;a</span></p> <p id="par0155" class="elsevierStylePara elsevierViewall">J&#46; Diez-Delgado &#40;Torrec&#225;rdenas&#44; Almer&#237;a&#41;&#44; <span class="elsevierStyleSmallCaps">I</span>&#46;Benavente &#40;Puerta del Mar&#44; C&#225;diz&#41;&#44; <span class="elsevierStyleSmallCaps">I</span>&#46; Tof&#233; &#40;Reina Sof&#237;a&#44; C&#243;rdoba&#41;&#44; A&#46;E&#46; Jerez &#40;S&#46; Cecilio&#44; Granada&#41;&#44; J&#46;A&#46; Hurtado &#40;Virgen de las Nieves&#44; Granada&#41;&#44; J&#46;M&#46; Ceballos &#40;J&#46;R&#46; Jim&#233;nez&#44; Huelva&#41;&#44; M&#46;L&#46; Mill&#225;n &#40;C&#46; Hospitalario&#44; Ja&#233;n&#41;&#44; M&#46;D&#46; Esquivel &#40;Materno-Infantil&#44; Jerez&#41;&#44; C&#46; Ruiz &#40;Costa del Sol&#44; Marbella&#41;&#44; M&#46; Baca &#40;Quir&#243;n&#44; M&#225;laga&#41;&#44; E&#46; Tapia &#40;G&#46; Universitario&#44; M&#225;laga&#41;&#44; M&#46; Losada &#40;Quir&#243;n S&#46; Coraz&#243;n&#44; Sevilla&#41;&#44; E&#46; Torres &#40;Valme&#44; Sevilla&#41;&#44; A&#46; Pav&#243;n &#40;Virgen del Roc&#237;o&#44; Sevilla&#41;&#44; P&#46;J&#46; Jim&#233;nez &#40;Virgen Macarena&#44; Sevilla&#41;&#44; F&#46; Jim&#233;nez &#40;S&#46; &#193;ngela de la Cruz&#44; Sevilla&#41;&#44; M&#46;P&#46; Ventura &#40;Lozano Blesa&#44; Zaragoza&#41;&#44; S&#46; Rite &#40;Miguel Servet&#44; Zaragoza&#41;&#44; T&#46; Gonz&#225;lez &#40;Cabue&#241;es&#44; Gij&#243;n&#41;&#44; R&#46;P&#46;Arias &#40;Central Asturias&#44; Oviedo&#41;&#44; P&#46;R&#46; Balliu &#40;Son Espases&#44; Mallorca&#41;&#44; J&#46;M&#46;Lloreda-Garc&#237;a &#40;S&#46; Luc&#237;a&#44; Cartagena&#41;&#44; J&#46;L&#46; Alcar&#225;z &#40;Virgen de la Arrixaca&#44; Murcia&#41;&#44; C&#46; Tapia &#40;General&#44; Alicante&#41;&#44; A&#46; de la Morena &#40;S&#46; Juan&#44; Alicante&#41;&#44; <span class="elsevierStyleSmallCaps">I</span>&#46;Centelles &#40;General&#44; 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Madrid&#41;&#44; G&#46; Romera &#40;Montepr&#237;ncipe&#44; Madrid&#41;&#44; A&#46; Cu&#241;arro &#40;Alcorc&#243;n&#41;&#44; C&#46; Mu&#241;&#243;z &#40;Puerta de Hierro&#95;Majadahonda&#44; Madrid&#41;&#44; F&#46; Caba&#241;as &#40;H&#46; U&#46; Quir&#243;n Madrid&#41;&#44; E&#46; Valverde &#40;La Paz&#44; Madrid&#41;&#44; R&#46; Montero &#40;Nisa&#95;Pardo de Aravaca&#44; Madrid&#41;&#44; J&#46;C&#46; Tejedor &#40;General&#44; M&#243;stoles&#41;&#44; C&#46; Santana &#40;Materno Insular&#44; Las Palmas&#41;&#44; B&#46; Reyes &#40;Universitario de Canarias&#44; Tenerife&#41;&#44; S&#46; Romero &#40;N&#46; S&#46; de Candelaria&#44; Tenerife&#41;&#44; A&#46; Orizaola &#40;Marqu&#233;s de Valdecilla&#44; Santander&#41;&#44; M&#46; Baquero &#40;General&#44; Albacete&#41;&#44; D&#46; Hern&#225;ndez &#40;General&#44; Ciudad Real&#41;&#44; A&#46; Pantoja &#40;Virgen de la Salud&#44; Toledo&#41;&#44; C&#46; Vega &#40;HUBU&#44; Burgos&#41;&#44; L&#46; Casta&#241;&#243;n &#40;CAULE&#44; Le&#243;n&#41;&#44; E&#46;P&#46; Guti&#233;rrez &#40;Universitario&#44; Salamanca&#41;&#44; M&#46; Benito &#40;Cl&#237;nico&#44; Valladolid&#41;&#44; S&#46; Caser&#237;o &#40;Rio Hortega&#44; Valladolid&#41;&#44; G&#46; Arca &#40;Cl&#237;nic&#44; Barcelona&#41;&#44; M&#46;J&#46; Garc&#237;a &#40;S&#46; Creu i S&#46; Pau&#44; Barcelona&#41;&#44; M&#46;A&#46; L&#243;pez-V&#237;lchez &#40;H&#46; del Mar&#44; Barcelona&#41;&#44; L&#46; Castells &#40;General de Catalunya&#44; Barcelona&#41;&#44; M&#46; Domingo &#40;Parc Taul&#237;&#44; Sabadell&#41;&#44; W&#46; Coroleu &#40;Germans Trias i Pujol&#44; Badalona&#41;&#44; H&#46; Boix &#40;Vall d¿Hebr&#243;n&#44; Barcelona&#41;&#44; R&#46; Porta &#40;<span class="elsevierStyleSmallCaps">I</span>&#46;Dexeus&#95;Quir&#243;n&#44; Barcelona&#41;&#44; A&#46; Garc&#237;a-Alix &#40;S&#46; Joan de D&#233;u&#44; Barcelona&#41;&#44; S&#46; Mart&#237;nez-Nadal &#40;SCIAS&#44; Barcelona&#41;&#44; E&#46; Jim&#233;nez &#40;Dr&#46; J&#46;Trueta&#44; Girona&#41;&#44; E&#46; Sole &#40;Arnau de Vilanova&#44; Lleida&#41;&#44; M&#46; Alb&#250;jar &#40;Joan <span class="elsevierStyleSmallCaps">XXIII</span>&#44; Tarragona&#41;&#44; E&#46;M&#46; Fern&#225;ndez &#40;Infanta Cristina&#44; Badajoz&#41;&#44; A&#46;R&#46; Barrio &#40;S&#46; Pedro de Alc&#225;ntara&#44; C&#225;ceres&#41;&#44; E&#46; Pi&#241;&#225;n &#40;M&#233;rida&#41;&#44; A&#46; Avila-Alvarez &#40;CHU A Coru&#241;a&#41;&#44; M&#46;E&#46; V&#225;zquez &#40;Lucus Augusti&#44; Lugo&#41;&#44; N&#46; Balado &#40;CHU&#44; Orense&#41;&#44; P&#46;A&#46; Crespo &#40;CHU&#44; Pontevedra&#41;&#44; M&#46;L&#46; Couce &#40;Cl&#237;nico&#44; Santiago de Compostela&#41;&#44; A&#46; Concheiro-Guis&#225;n &#40;Xeral&#44; Vigo&#41;&#44; <span class="elsevierStyleSmallCaps">I</span>&#46; Esteban &#40;S&#46; Pedro&#44; Logro&#241;o&#41;&#44; A&#46; Lavilla &#40;CH&#44; Navarra&#41;&#44; <span class="elsevierStyleSmallCaps">V</span>&#46; Alzina &#40;C&#46; Universidad de Navarra&#41;&#44; A&#46; Aguirre &#40;Basurto&#44; Bilbao&#41;&#44; B&#46; Loureiro &#40;Cruces&#44; Bilbao&#41;&#44; <span class="elsevierStyleSmallCaps">I</span>&#46; Ech&#225;niz &#40;Quir&#243;n&#44; Bilbao&#41;&#44; M&#46;D&#46; Elorza &#40;HU&#46; Donostia&#44; San Sebasti&#225;n&#41;&#44; A&#46; Euba &#40;HUA Txagorritxu&#44; Vitoria&#41;&#46;</p>"
            "etiqueta" => "Anexo 1"
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          "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Calidad de la asistencia de los hospitales que realizan hipotermia terap&#233;utica frente a los que no&#46;</p> <p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">HT&#58; hospital con hipotermia terap&#233;utica&#59; No-HT&#58; hospital sin hipotermia terap&#233;utica&#59; hdv&#58; horas de vida&#46;</p> <p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">&#40;a&#41; Se incluyen las preguntas 5-10&#44; y las agrupadas 1-2 y 3-4&#46;</p> <p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">&#40;b&#41; Se incluyen las preguntas 12-14&#44; 17&#44; 21&#44; 22&#46;</p> <p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">&#40;c&#41; Se incluyen las preguntas 20&#44; 25&#44; 27-30&#44; y las agrupadas 24a-24b&#44; 26a-26d y 26b-26c&#46;</p> <p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Todo<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#40;a&#41;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#40;b&#41;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#40;c&#41;&#46;</p> <p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">&#42; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;015 &#40;test de chi-cuadrado comparando &#8220;clasificaci&#243;n &#243;ptima&#8221; vs&#46; &#8220;clasificaci&#243;n aceptable &#43; mejorable&#8221;&#41;&#46;</p>"
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          "es" => "<p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">Calidad de la asistencia de los hospitales nivel <span class="elsevierStyleSmallCaps">iii</span> que realizan hipotermia terap&#233;utica&#44; seg&#250;n el nivel asistencial&#46;</p> <p id="spar0105" class="elsevierStyleSimplePara elsevierViewall">hdv&#58; horas de vida&#46;</p> <p id="spar0110" class="elsevierStyleSimplePara elsevierViewall">&#40;a&#41; Se incluyen las preguntas 5-10&#44; y las agrupadas 1-2 y 3-4&#46;</p> <p id="spar0115" class="elsevierStyleSimplePara elsevierViewall">&#40;b&#41; Se incluyen las preguntas 12-14&#44; 17&#44; 21&#44; 22&#46;</p> <p id="spar0120" class="elsevierStyleSimplePara elsevierViewall">&#40;c&#41; Se incluyen las preguntas 20&#44; 25&#44; 27-30&#44; y las agrupadas 24a-24b&#44; 26a-26d y 26b-26c&#46;</p> <p id="spar1045" class="elsevierStyleSimplePara elsevierViewall">Todo<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#40;a&#41;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#40;b&#41;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#40;c&#41;&#46;</p> <p id="spar0125" class="elsevierStyleSimplePara elsevierViewall">En las preguntas &#8220;Parto&#46;&#8221; &#8220;6hdv&#8221; y &#8220;Parto-6hdv&#8221; se incluyen las respuestas de los 89 hospitales&#46; En las preguntas &#8220;Profesionales&#8221; y &#8220;Todo&#8221; se incluyen los 53 hospitales con HT que responden a la encuesta &#40;4 IIIA&#44; 34 IIIB y 15 IIIC&#41;&#46;</p>"
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          "es" => "<p id="spar0130" class="elsevierStyleSimplePara elsevierViewall">Protocolo de actuaci&#243;n en las primeras 6<span class="elsevierStyleHsp" style=""></span>h de vida y &#171;cadena de neuroprotecci&#243;n cerebral&#187;&#46;</p> <p id="spar0135" class="elsevierStyleSimplePara elsevierViewall">aEEG&#58; electroencefalograma integrado por amplitud&#59; BS&#58; patr&#243;n brote supresi&#243;n&#59; CBV&#58; patr&#243;n continuo de bajo voltaje&#59; DB&#58; d&#233;ficit de bases&#59; EG&#58; edad gestacional&#59; EHI&#58; encefalopat&#237;a hip&#243;xico-isqu&#233;mica&#59; FC&#58; frecuencia cardiaca&#59; FiO<span class="elsevierStyleInf">2</span>&#58; fracci&#243;n inspirada de ox&#237;geno&#59; FR&#58; frecuencia respiratoria&#59; g&#58; gramos&#59; hdv&#58; horas de vida&#59; hipoCa<span class="elsevierStyleSup">&#43;&#43;</span>&#58; hipocalcemia&#59; hipoMg<span class="elsevierStyleSup">&#43;&#43;</span>&#58; hipomagnesemia&#59; min&#58; minutos&#59; P&#58; patr&#243;n plano&#59; PaO<span class="elsevierStyleInf">2</span>&#58; presi&#243;n parcial de ox&#237;geno en la sangre arterial&#59; PaCO<span class="elsevierStyleInf">2</span>&#58; presi&#243;n parcial de di&#243;xido de carbono en la sangre arterial&#59; rScO<span class="elsevierStyleInf">2</span>&#58; saturaci&#243;n regional de ox&#237;geno cerebral&#59; REA&#58; reanimaci&#243;n&#59; RN&#58; reci&#233;n nacido&#59; SatO<span class="elsevierStyleInf">2</span>&#58; saturaci&#243;n arterial de ox&#237;geno&#59; T<span class="elsevierStyleSup">a</span>&#58; temperatura&#59; TA&#58; tensi&#243;n arterial&#46;</p>"
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                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " colspan="3" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Hospitales que no realizan HT</th><th class="td" title="table-head  " colspan="3" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Hospitales que realizan HT</th></tr><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Casi siempre&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Casi siempre&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Con frecuencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Rara vez o nunca&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " colspan="7" align="left" valign="top"><span class="elsevierStyleBold">En paritorio&#44; en un parto complicado est&#225; presente</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">1&#46; Un pediatra</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">32 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">55 &#40;96&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">2&#46; Un pediatra neonat&#243;logo</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">22 &#40;69&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10 &#40;31&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">43 &#40;75&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12 &#40;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">3&#46; Una enfermera - matrona</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31 &#40;97&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3 &#40;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">4&#46; Una enfermera de la Unidad Neonatal</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8 &#40;25&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9 &#40;28&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15 &#40;47&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">14 &#40;25&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10 &#40;18&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">33 &#40;58&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="7" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="7" align="left" valign="top"><span class="elsevierStyleBold">Si al nacimiento el RN presenta datos de asfixia perinatal</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">5&#46; Tiene un protocolo de actuaci&#243;n espec&#237;fico en paritorio</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30 &#40;94&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">53 &#40;93&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3 &#40;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">6&#46; Aunque el pH sea &#60;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">7&#44;00&#44; evita poner bicarbonato</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26 &#40;81&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">51 &#40;89&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4 &#40;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">7&#46; Evita administrar calcio a&#250;n si precisa reanimaci&#243;n avanzada</span><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26 &#40;81&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">55 &#40;96&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">8&#46; Apaga las fuentes de calor una vez recupere la frecuencia cardiaca</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26 &#40;81&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">55 &#40;96&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">9&#46; Traslada al RN con la cuna de transporte apagada</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29 &#40;91&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">56 &#40;98&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">10&#46; Se ingresa al RN para observaci&#243;n en la Unidad</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31 &#40;97&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">54 &#40;95&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3 &#40;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">11&#46; Si se recupera r&#225;pidamente&#44; se deja al RN con su madre</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7 &#40;22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23 &#40;72&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12 &#40;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">43 &#40;75&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "leyenda" => "<p id="spar0155" class="elsevierStyleSimplePara elsevierViewall">aEEG&#58; electroencefalograma integrado por amplitud&#59; EHI&#58; encefalopat&#237;a hip&#243;xico-isqu&#233;mica&#59; hdv&#58; horas de vida&#59; HT&#58; hipotermia terap&#233;utica&#59; RN&#58; reci&#233;n nacido&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " colspan="3" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Hospitales que no realizan HT</th><th class="td" title="table-head  " colspan="3" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Hospitales que realizan HT</th></tr><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Casi siempre&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Con frecuencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Rara vez o nunca&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Casi siempre&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Con frecuencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Rara vez o nunca&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " colspan="7" align="left" valign="top"><span class="elsevierStyleBold">Durante las primeras 6 hdv en el RN con asfixia perinatal</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">12&#46; Aplica un protocolo de actuaci&#243;n espec&#237;fico</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26 &#40;81&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5 &#40;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">52 &#40;91&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5 &#40;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">13&#46; Realiza gasometr&#237;a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">32 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">57 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">14&#46; Realiza glucemia</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">32 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">57 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">15&#46; Le deja a dieta absoluta</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">32 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">56 &#40;98&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">16&#46; Le deja a dieta absoluta con sueroterapia</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">32 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">48 &#40;84&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8 &#40;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">17&#46; Monitoriza la temperatura central continua o intermitente&#47;30</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">min</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">22 &#40;69&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10 &#40;31&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">42 &#40;74&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12 &#40;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3 &#40;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">18&#46; Mantiene la temperatura central por debajo de 36</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#176;C</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27 &#40;84&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3 &#40;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">40 &#40;70&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12 &#40;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5 &#40;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">19&#46; Si dispone de aEEG&#44; monitoriza la funci&#243;n cerebral</span><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5 &#40;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">38 &#40;67&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8 &#40;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5 &#40;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="7" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">20&#46; N&#46;</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">o</span></span><span class="elsevierStyleItalic">de aparatos de aEEG</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12 &#40;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Uno&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7 &#40;22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">39 &#40;68&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Ninguno&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">25 &#40;78&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6 &#40;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="7" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">21&#46; &#191;Cu&#225;ntas exploraciones realiza para graduar la EHI&#63;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29 &#40;91&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">53 &#40;93&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Una&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3 &#40;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4 &#40;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Ninguna&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="7" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">22&#46; &#191;Qu&#233; escala utiliza para graduar la EHI&#63;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Garc&#237;a-Alix&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">20 &#40;63&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">39 &#40;68&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Sarnat&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12 &#40;38&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13 &#40;23&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Otra&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5 &#40;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Ninguna&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="7" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">23&#46; En la escala que utiliza&#44; da prioridad al &#237;tem</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Despertar y mantener la alerta&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30 &#40;94&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">50 &#40;88&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Tono muscular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6 &#40;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Movimientos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Otros&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "es" => "<p id="spar0150" class="elsevierStyleSimplePara elsevierViewall">Preguntas formuladas respecto a la asistencia del reci&#233;n nacido con asfixia perinatal durante las 6 primeras horas de vida</p>"
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          "leyenda" => "<p id="spar0165" class="elsevierStyleSimplePara elsevierViewall">Cincuenta y tres del total de 57 hospitales que realizaban hipotermia contestaron a las preguntas&#46;</p><p id="spar0170" class="elsevierStyleSimplePara elsevierViewall">aEEG&#58; electroencefalograma integrado por amplitud&#59; EHI&#58; encefalopat&#237;a hip&#243;xico-isqu&#233;mica&#59; RM&#58; resonancia magn&#233;tica cerebral&#46;</p>"
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Casi siempre&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Con frecuencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Rara vez o nunca&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">24&#46; Profesionales entrenados en la exploraci&#243;n neurol&#243;gica neonatal</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>a&#46; Neonat&#243;logo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">40 &#40;75&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12 &#40;23&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>b&#46; Neur&#243;logo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">28 &#40;53&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">14 &#40;26&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11 &#40;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">25&#46; Neonat&#243;logos entrenados en la interpretaci&#243;n del aEEG</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">40 &#40;75&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8 &#40;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5 &#40;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">26&#46; Profesionales entrenados en la neuroimagen cerebral</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>a&#46; Neonat&#243;logo entrenado en la interpretaci&#243;n de la RM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">20 &#40;38&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26 &#40;49&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>b&#46; Neonat&#243;logo entrenado en ecograf&#237;a y doppler&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">20 &#40;38&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15 &#40;28&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18 &#40;34&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>c&#46; Radi&#243;logo entrenado en ecograf&#237;a y doppler&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">34 &#40;64&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11 &#40;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8 &#40;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>d&#46; Radi&#243;logo entrenado en la interpretaci&#243;n de la RM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">39 &#40;74&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12 &#40;23&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">27&#46; Neonat&#243;logo entrenado en ecocardio&#47;cardi&#243;logo infantil</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30 &#40;57&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">16 &#40;30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">28&#46; Equipo de enfermer&#237;a con formaci&#243;n espec&#237;fica en EHI</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">42 &#40;79&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8 &#40;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">29&#46; Plan de cuidados espec&#237;fico dise&#241;ado por enfermer&#237;a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">38 &#40;72&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6 &#40;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9 &#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">30&#46; Ratio de enfermeras igual al de otro paciente grave</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">43 &#40;81&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9 &#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">31&#46; Psic&#243;logo de apoyo a los padres en este tipo de situaci&#243;n</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15 &#40;28&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11 &#40;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27 &#40;51&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1862590.png"
              ]
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          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0160" class="elsevierStyleSimplePara elsevierViewall">Preguntas dirigidas a los hospitales que realizaban hipotermia sobre la disponibilidad de profesionales con experiencia en el manejo del reci&#233;n nacido con encefalopat&#237;a hip&#243;xico-isqu&#233;mica</p>"
        ]
      ]
      7 => array:8 [
        "identificador" => "tbl0020"
        "etiqueta" => "Tabla 4"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at4"
            "detalle" => "Tabla "
            "rol" => "short"
          ]
        ]
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0180" class="elsevierStyleSimplePara elsevierViewall">HT&#58; hipotermia terap&#233;utica&#46;</p><p id="spar0185" class="elsevierStyleSimplePara elsevierViewall">Datos en mediana &#40;m&#237;n&#59;m&#225;x&#41;&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " colspan="3" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Realizaci&#243;n si&#47;no HT</th><th class="td" title="table-head  " colspan="4" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Seg&#250;n el nivel asistencial</th></tr><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Preguntas referidas a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">No-HT &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>32&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">S&#237;-HT &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>57&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Valor de p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">IIIA &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>25&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">IIIB &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>47&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">IIIC &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Valor de p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">La asistencia durante el parto<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31&#44;5 &#40;25&#59;32&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">32 &#40;26&#59;32&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31 &#40;25&#59;32&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">32 &#40;25&#59;32&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">32 &#40;26&#59;32&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;034&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">La asistencia durante las 6 primeras horas<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24 &#40;20&#59;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24 &#40;20&#59;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;426&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24 &#40;21&#59;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24 &#40;20&#59;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24 &#40;20&#59;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;827&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">La asistencia durante el parto y las 6 primeras horas de vida<a class="elsevierStyleCrossRefs" href="#tblfn0015"><span class="elsevierStyleSup">a&#44;b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">54&#44;5 &#40;46&#59;56&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">56 &#40;49&#59;56&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;052&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">55 &#40;48&#59;56&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">56 &#40;47&#59;56&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">56 &#40;46&#59;56&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;105&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">La disponibilidad de profesionales con experiencia<a class="elsevierStyleCrossRefs" href="#tblfn0025"><span class="elsevierStyleSup">c&#44;d</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">34 &#40;21&#59;36&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31&#44;5 &#40;27&#59;36&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">33 &#40;24&#59;36&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">35 &#40;21&#59;36&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;129&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Todas<a class="elsevierStyleCrossRefs" href="#tblfn0015"><span class="elsevierStyleSup">a&#44;b&#44;c&#44;d</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">89 &#40;72&#59;92&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">84 &#40;81&#59;90&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">88&#44;5 &#40;77&#59;92&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">91 &#40;72&#59;92&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;027&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1862589.png"
              ]
            ]
          ]
          "notaPie" => array:4 [
            0 => array:3 [
              "identificador" => "tblfn0015"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Se incluyen las preguntas 5-10&#44; y las agrupadas 1-2 y 3-4&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0020"
              "etiqueta" => "b"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Se incluyen las preguntas 12-14&#44; 17&#44; 21&#44; 22&#46;</p>"
            ]
            2 => array:3 [
              "identificador" => "tblfn0025"
              "etiqueta" => "c"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0025">Se incluyen las preguntas 20&#44; 25&#44; 27-30&#44; y las agrupadas 24a-24b&#44; 26a-26d y 26b-26c&#46;</p>"
            ]
            3 => array:3 [
              "identificador" => "tblfn0030"
              "etiqueta" => "d"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0030">Solo se incluyen 53 de los 57 hospitales con hipotermia que contestaron a la encuesta &#40;4 IIIA&#44; 34 IIIB y 15 IIIC&#41;&#46;</p>"
            ]
          ]
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Asistencia en España del recién nacido con asfixia perinatal candidato a hipotermia terapéutica durante las primeras seis horas de vida
Care of the newborn with perinatal asphyxia candidate for therapeutic hypothermia during the first six hours of life in Spain
Juan Arnaeza,b,
Autor para correspondencia
juan.arnaez@neurologianeonatal.com

Autor para correspondencia.
, Alfredo Garcia-Alixb,c,d,e, Sara Calvof, Simón Lubián-Lópezb,g, Grupo de Trabajo ESP-EHI
a Unidad de Neonatología, Hospital Universitario de Burgos, Burgos, España
b Fundación NeNe, España
c Institut de Recerca Pediatrica Sant Joan de Déu, Hospital Sant Joan de Dèu, Barcelona, España
d Universitat de Barcelona, Barcelona, España
e CIBER de Enfermedades Raras (CIBERER), U724, Madrid, España
f Unidad de Investigación, Departamento de Estadística, Hospital Universitario de Burgos, Burgos, España
g Unidad de Neonatología, Hospital Universitario Puerta del Mar, Cádiz, España
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          "es" => "<p id="spar0130" class="elsevierStyleSimplePara elsevierViewall">Protocolo de actuaci&#243;n en las primeras 6<span class="elsevierStyleHsp" style=""></span>h de vida y &#171;cadena de neuroprotecci&#243;n cerebral&#187;&#46;</p> <p id="spar0135" class="elsevierStyleSimplePara elsevierViewall">aEEG&#58; electroencefalograma integrado por amplitud&#59; BS&#58; patr&#243;n brote supresi&#243;n&#59; CBV&#58; patr&#243;n continuo de bajo voltaje&#59; DB&#58; d&#233;ficit de bases&#59; EG&#58; edad gestacional&#59; EHI&#58; encefalopat&#237;a hip&#243;xico-isqu&#233;mica&#59; FC&#58; frecuencia cardiaca&#59; FiO<span class="elsevierStyleInf">2</span>&#58; fracci&#243;n inspirada de ox&#237;geno&#59; FR&#58; frecuencia respiratoria&#59; g&#58; gramos&#59; hdv&#58; horas de vida&#59; hipoCa<span class="elsevierStyleSup">&#43;&#43;</span>&#58; hipocalcemia&#59; hipoMg<span class="elsevierStyleSup">&#43;&#43;</span>&#58; hipomagnesemia&#59; min&#58; minutos&#59; P&#58; patr&#243;n plano&#59; PaO<span class="elsevierStyleInf">2</span>&#58; presi&#243;n parcial de ox&#237;geno en la sangre arterial&#59; PaCO<span class="elsevierStyleInf">2</span>&#58; presi&#243;n parcial de di&#243;xido de carbono en la sangre arterial&#59; rScO<span class="elsevierStyleInf">2</span>&#58; saturaci&#243;n regional de ox&#237;geno cerebral&#59; REA&#58; reanimaci&#243;n&#59; RN&#58; reci&#233;n nacido&#59; SatO<span class="elsevierStyleInf">2</span>&#58; saturaci&#243;n arterial de ox&#237;geno&#59; T<span class="elsevierStyleSup">a</span>&#58; temperatura&#59; TA&#58; tensi&#243;n arterial&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">Las importantes implicaciones m&#233;dicas&#44; familiares&#44; sociales y legales que asocia la encefalopat&#237;a hip&#243;xico-isqu&#233;mica &#40;EHI&#41; perinatal en el reci&#233;n nacido &#40;RN&#41; a t&#233;rmino o pret&#233;rmino tard&#237;o hacen que constituya un problema sociosanitario relevante<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">1</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">En nuestro pa&#237;s&#44; en el a&#241;o 2011 la Sociedad Espa&#241;ola de Neonatolog&#237;a public&#243; una gu&#237;a de est&#225;ndares para la aplicaci&#243;n cl&#237;nica de la hipotermia terap&#233;utica &#40;HT&#41;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">2</span></a>&#44; y en el a&#241;o 2014&#44; un grupo de expertos elabor&#243; una gu&#237;a de pr&#225;ctica cl&#237;nica basada en la evidencia sobre el manejo integral del neonato con EHI<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">3</span></a>&#46; Cuando se ha analizado la efectividad de la HT en la pr&#225;ctica cl&#237;nica habitual&#44; los resultados parecen ser mejores que los obtenidos en los primeros ensayos cl&#237;nicos<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">4</span></a>&#46; Entre los factores que contribuir&#237;an a esta brecha entre eficacia y efectividad&#44; destacan aquellos que acontecen en las primeras horas de vida&#58; adecuada reanimaci&#243;n en paritorio&#44; comienzo precoz de la HT&#44; y control de factores potencialmente agravantes de la agresi&#243;n hip&#243;xico-isqu&#233;mica&#44; antes y durante la HT&#46; Sin embargo&#44; apenas existen recomendaciones sobre el proceso asistencial desde el nacimiento hasta el inicio de la HT&#44; periodo crucial en el que podemos actuar sobre los factores mencionados y as&#237; mejorar la efectividad neuroprotectora de la hipotermia<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">5&#8211;8</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Los objetivos de este trabajo de &#225;mbito nacional fueron&#58; 1&#41; conocer el manejo del RN con asfixia perinatal durante las primeras 6<span class="elsevierStyleHsp" style=""></span>h de vida en unidades de neonatolog&#237;a de nivel <span class="elsevierStyleSmallCaps">iii</span>&#44; y 2&#41; examinar si existen diferencias entre aquellas unidades que ofrecen HT y aquellas que transfieren los RN asf&#237;cticos a centros de referencia para recibir este tratamiento&#44; as&#237; como entre los diferentes niveles asistenciales tipo <span class="elsevierStyleSmallCaps">iii</span>&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Metodolog&#237;a</span><p id="par0020" class="elsevierStylePara elsevierViewall">Estudio transversal&#44; multic&#233;ntrico dirigido a examinar el proceso asistencial durante las primeras 6<span class="elsevierStyleHsp" style=""></span>h de vida del RN<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>35 semanas de edad gestacional con asfixia perinatal mediante un cuestionario on-line&#46; El estudio fue realizado en 2015 e incluy&#243; todos los hospitales terciarios &#40;p&#250;blicos y privados&#41;&#44; con unidades neonatales de nivel <span class="elsevierStyleSmallCaps">iii</span> de nuestro pa&#237;s<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">9</span></a>&#46; Se solicit&#243; que el responsable de cada centro con mayor experiencia en el manejo de la EHI respondiese al cuestionario&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">En las <a class="elsevierStyleCrossRefs" href="#tbl0005">tablas 1 y 2</a> se recogen las 23 preguntas de la encuesta referentes a la asistencia del RN con criterios de asfixia durante las primeras horas de vida&#46; Esta se defini&#243; por la presencia de al menos uno de los siguientes&#58; 1&#41; pH cord&#243;n o a la hora de vida<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>7 o d&#233;ficit de bases<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>16&#59; 2&#41; Apgar a los 5<span class="elsevierStyleHsp" style=""></span>min<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>5&#59; 3&#41; necesidad de reanimaci&#243;n avanzada &#40;intubaci&#243;n y&#47;o masaje cardiaco y&#47;o administraci&#243;n de f&#225;rmacos&#41;&#46; En la <a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a> se recogen las 8 preguntas referidas a la disponibilidad de profesionales con experiencia en la asistencia del RN con EHI de cada uno de los hospitales que realizaban HT en el momento del cierre de la encuesta &#40;junio 2015&#41;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Para clasificar la calidad de la asistencia ofrecida por cada hospital&#44; se asign&#243; una puntuaci&#243;n a cada pregunta&#58; 4 puntos si la pr&#225;ctica realizada respond&#237;a &#171;casi siempre&#187; al est&#225;ndar asistencial recomendado en las gu&#237;as de pr&#225;ctica cl&#237;nica&#44; 3 puntos si dicha pr&#225;ctica era realizada &#171;con frecuencia&#187; o 1 punto cuando la respuesta fue &#171;raramente o nunca&#187;&#46; Se asign&#243; a cada hospital una categor&#237;a de &#171;asistencia &#243;ptima&#187; si obtuvo 4 puntos en todas las preguntas&#44; &#171;asistencia aceptable&#187; si alguna pregunta obtuvo 3 puntos pero ninguna 1 punto&#44; y &#171;asistencia mejorable&#187; si alguna pregunta obtuvo 1 punto&#46; Se excluyeron de la puntuaci&#243;n las preguntas m&#225;s controvertidas &#40;preguntas 11&#44; 15&#44; 16&#44; 18&#44; 19&#44; 20&#44; 23 y 31&#41;&#46; Las que hac&#237;an referencia al mismo contenido se agruparon&#58; 1-2&#44; 3-4&#44; 24a-24b&#44; 26a-26d&#44; 26b-26c&#46; En las 3 preguntas con respuestas de elecci&#243;n m&#250;ltiple &#40;20&#44; 21 y 22&#41;&#44; se dio 1 punto si se contest&#243; &#171;ninguna&#187; y 4 puntos al resto de las opciones &#40;<a class="elsevierStyleCrossRefs" href="#tbl0005">tablas 1&#8211;3</a>&#41;&#46; El estudio fue aprobado por el comit&#233; de investigaci&#243;n del hospital coordinador&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">An&#225;lisis estad&#237;stico</span><p id="par0040" class="elsevierStylePara elsevierViewall">Los datos descriptivos se expresaron como n&#250;mero y porcentaje&#46; Para examinar diferencias&#44; se utiliz&#243; la prueba de Chi-cuadrado &#40;Fisher&#41; y U de Mann-Whitney&#47;Kruskal-Wallis para variables cualitativas y cuantitativas&#44; respectivamente&#46; Un valor de p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05 se consider&#243; estad&#237;sticamente significativo&#46;</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Resultados</span><p id="par0045" class="elsevierStylePara elsevierViewall">De la totalidad de los 90 servicios de Neonatolog&#237;a nivel <span class="elsevierStyleSmallCaps">iii</span> de nuestro pa&#237;s&#44; 89 aportaron la informaci&#243;n solicitada&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Respecto <span class="elsevierStyleItalic">al manejo al nacimiento</span> &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#44; la mayor&#237;a de los hospitales &#40;98&#37;&#41; indicaron que ante un parto complicado acud&#237;a un neonat&#243;logo junto con una matrona y&#44; en ocasiones&#44; una enfermera neonatal&#46; Adem&#225;s&#44; pr&#225;cticamente todos los hospitales refirieron utilizar protocolos de reanimaci&#243;n&#44; apagar las fuentes ex&#243;genas de calor una vez estabilizado el RN&#44; y rara vez usar calcio o bicarbonato durante la reanimaci&#243;n&#46; Asimismo&#44; era com&#250;n trasladar al RN a la unidad neonatal&#44; incluso aunque se recuperase r&#225;pidamente&#44; si bien en esta circunstancia algunos hospitales &#40;25&#37;&#41; dejaban al RN con su madre&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">En la <a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a> se muestran los resultados referentes a las <span class="elsevierStyleItalic">acciones durante las 6 primeras horas de vida</span>&#46; Mayoritariamente los centros dispon&#237;an de protocolos de actuaci&#243;n espec&#237;fica para este periodo&#44; realizaban controles de glucemia y gasometr&#237;a&#44; monitorizaban la temperatura con el objetivo de mantenerla por debajo de 36<span class="elsevierStyleHsp" style=""></span>&#176;<span class="elsevierStyleSmallCaps">C</span>&#44; y optaban por dejar al RN a dieta con sueroterapia&#46; En cuanto a la valoraci&#243;n de la EHI&#44; la mayor&#237;a &#40;92&#37;&#41; realizaban al menos 2 exploraciones en las primeras 6<span class="elsevierStyleHsp" style=""></span>h de vida&#44; utilizando las escalas de graduaci&#243;n de Garc&#237;a-Alix<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">10</span></a> y Sarnat<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">11</span></a> en el 94&#37; de los casos&#44; siendo el &#237;tem de la capacidad para despertar y mantener la alerta el m&#225;s relevante en el 90&#37; de los hospitales&#46; Respecto al uso del electroencefalograma integrado por amplitud &#40;aEEG&#41; en las primeras 6<span class="elsevierStyleHsp" style=""></span>h de vida&#44; 58 de los 89 hospitales &#40;65&#37;&#41; dispon&#237;an de aEEG&#58; 51 &#40;89&#37;&#41; de las 57 unidades que ofrec&#237;an HT y 7 &#40;22&#37;&#41; de las 32 que no &#40;p&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; Entre los que dispon&#237;an de aEEG&#44; el 90&#37; de los hospitales refirieron utilizarlo siempre o con bastante frecuencia&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Informaci&#243;n sobre la <span class="elsevierStyleItalic">disponibilidad de profesionales con experiencia en el manejo del RN con EHI</span> en los hospitales que realizaban HT fue notificada de 53 de los 57 centros &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>&#41;&#46; La mayor&#237;a de los centros dispon&#237;an siempre de personal con entrenamiento en la exploraci&#243;n neurol&#243;gica &#40;89&#37;&#41;&#44; en la ecograf&#237;a cerebral &#40;87&#37;&#41; e interpretaci&#243;n de la RM &#40;75&#37;&#41;&#44; y en la realizaci&#243;n de ecocardiograf&#237;a &#40;57&#37;&#41;&#46; Sin embargo&#44; en el 25&#37; de los hospitales no hab&#237;a siempre un neonat&#243;logo con experiencia en la realizaci&#243;n de examen neurol&#243;gico o en la interpretaci&#243;n del aEEG&#44; y en el 62&#37; tampoco lo hab&#237;a en la realizaci&#243;n de ecograf&#237;a cerebral&#46; La mayor&#237;a de los hospitales refirieron tener una relaci&#243;n de enfermeras por paciente adecuada&#44; aunque no exist&#237;an protocolos enfermeros espec&#237;ficos en el 28&#37; o experiencia en los cuidados de este grupo de pacientes en el 21&#37;&#46; Finamente&#44; m&#225;s del 50&#37; no dispon&#237;an de apoyo psicol&#243;gico especializado para los padres-familias de estos ni&#241;os&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">En cuanto a la puntuaci&#243;n obtenida en la asistencia en paritorio y en las 6 primeras horas de vida&#44; el 25&#37; de los 89 hospitales obtuvo una calificaci&#243;n de &#171;mejorable&#187;&#44; aunque con puntuaciones elevadas de 54&#44;5 &#40;46&#59;56&#41; puntos de mediana &#40;m&#237;n&#59;m&#225;x&#41; en los hospitales que no ofrec&#237;an HT frente a 56 &#40;49&#59;56&#41; puntos en el resto &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;052&#41;&#40;<a class="elsevierStyleCrossRef" href="#tbl0020">tabla 4</a>&#41;&#46; Los hospitales con HT obtuvieron la calificaci&#243;n de manejo &#171;&#243;ptimo&#187; en m&#225;s casos que los que no dispon&#237;an de HT&#44; especialmente durante la reanimaci&#243;n &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;015&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; Atendiendo al nivel asistencial&#44; la calidad asistencial fue mejor cuanto mayor el nivel asistencial&#44; tanto de forma global&#44; como entre aquellos que realizaban HT &#40;<a class="elsevierStyleCrossRefs" href="#fig0010">figs&#46; 2 y 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Discusi&#243;n</span><p id="par0070" class="elsevierStylePara elsevierViewall">En el RN con asfixia perinatal&#44; la asistencia en la primeras 6<span class="elsevierStyleHsp" style=""></span>h de vida constituye un periodo crucial que incluye diversas etapas asistenciales desde el nacimiento hasta el momento en que se inicia la HT&#58; 1&#41; reanimaci&#243;n y estabilizaci&#243;n del paciente&#44; 2&#41; control de factores com&#243;rbidos&#44; 3&#41; caracterizaci&#243;n precisa de la gravedad de la EHI&#44; y 4&#41; traslado urgente a centros de referencia que ofrecen una asistencia integral a estos RN incluyendo HT<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">2&#44;6&#8211;8&#44;12&#8211;14</span></a>&#46; Los resultados de este trabajo se&#241;alan que la asistencia del RN con asfixia perinatal&#44; analizando cada una de las etapas incluidas en las primeras 6<span class="elsevierStyleHsp" style=""></span>h de vida en los hospitales terciarios de nuestro pa&#237;s&#44; es globalmente satisfactoria aunque con diferencias seg&#250;n el nivel asistencial y si realizan o no HT&#46;</p><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Reanimaci&#243;n y estabilizaci&#243;n en paritorio</span><p id="par0075" class="elsevierStylePara elsevierViewall">En nuestro pa&#237;s todas las unidades de neonatolog&#237;a de centros terciarios aplican protocolos de actuaci&#243;n espec&#237;fica para la reanimaci&#243;n y estabilizaci&#243;n en el paritorio del RN con criterios de asfixia perinatal&#46; Coherentemente con las recomendaciones vigentes&#44; los hospitales disponen de personal entrenado en la reanimaci&#243;n neonatal y evitan la administraci&#243;n de calcio o bicarbonato<a class="elsevierStyleCrossRefs" href="#bib0265"><span class="elsevierStyleSup">15&#44;16</span></a>&#46; Asimismo refieren apagar la cuna de reanimaci&#243;n una vez estabilizado el RN despu&#233;s de la reanimaci&#243;n&#46; A pesar de las recomendaciones actuales que indican evitar la hipertermia e iniciar HT en la EHI moderada-grave&#44; no se hace referencia a qu&#233; medidas iniciar durante la reanimaci&#243;n<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">16&#44;17</span></a>&#46; En cualquier caso&#44; dada la tendencia natural del RN con asfixia a disminuir la temperatura corporal&#44; es mandatorio monitorizar la temperatura central en paritorio m&#225;s a&#250;n si se retiran las fuentes de calor externa<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">18&#44;19</span></a>&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Tras la estabilizaci&#243;n inicial&#44; la monitorizaci&#243;n de diversas funciones fisiol&#243;gicas&#44; incluyendo frecuencia cardiaca&#44; tensi&#243;n arterial&#44; funci&#243;n respiratoria y temperatura&#44; son pr&#225;ctica est&#225;ndar en el cuidado de estos RN&#46; Un punto controvertido es si&#44; en caso de r&#225;pida recuperaci&#243;n del RN en paritorio&#44; este puede quedarse con su madre para favorecer el contacto piel con piel y el inicio de la lactancia materna&#59; o si por el contrario&#44; ser&#237;a conveniente un periodo de monitorizaci&#243;n en la unidad neonatal evitando adem&#225;s el inicio inmediato de la alimentaci&#243;n ante una potencial situaci&#243;n de hipoperfusi&#243;n intestinal&#46; En nuestro estudio&#44; la gran mayor&#237;a de los centros refirieron ingresar al RN con asfixia aunque el 25&#37; contemplaban la posibilidad de dejar al RN con su madre si la recuperaci&#243;n cl&#237;nica era r&#225;pida y adecuada&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Control de la temperatura</span><p id="par0085" class="elsevierStylePara elsevierViewall">Un aspecto fundamental en el RN con asfixia perinatal es el control de la temperatura desde los minutos siguientes al parto hasta la decisi&#243;n de indicar o no HT&#46; Por cada incremento de 1<span class="elsevierStyleHsp" style=""></span>&#176;C&#44; la odds ratio para muerte o discapacidad neurol&#243;gica moderada-grave se incrementa hasta 4 veces<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">20</span></a>&#46; Coherentemente con este conocimiento&#44; el 98&#37; de los centros refirieron trasladar al RN a la unidad neonatal con la cuna de transporte apagada&#44; y monitorizar durante las primeras horas la temperatura rectal con el objetivo de evitar el sobreenfriamiento y sobre todo&#44; la hipertermia<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">21</span></a>&#46; Adem&#225;s&#44; la mayor&#237;a de los hospitales se&#241;alaron que habitualmente mantienen la temperatura por debajo de 36<span class="elsevierStyleHsp" style=""></span>&#176;C&#46; En el momento actual&#44; no existe evidencia respecto a los efectos beneficiosos o perjudiciales de disminuir la temperatura por debajo de la normotermia e incluso al rango de la HT &#40;33-34<span class="elsevierStyleHsp" style=""></span>&#176;C&#41; a un RN con asfixia perinatal sin esperar a establecer que padece una EHI moderada-grave&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Control de otros factores com&#243;rbidos</span><p id="par0090" class="elsevierStylePara elsevierViewall">Tras una agresi&#243;n hip&#243;xico-isqu&#233;mica&#44; el cerebro es particularmente vulnerable a factores com&#243;rbidos con capacidad potencial para da&#241;ar <span class="elsevierStyleItalic">per se</span> el SNC&#44; acortar la ventana terap&#233;utica y aumentar la gravedad del da&#241;o&#46; Entre estos factores se encuentran la hipoglucemia&#44; la hipocarbia y la hiper-&#47;hipoxia&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">La asfixia perinatal es una causa importante de hipoglucemia debido al metabolismo anaer&#243;bico de la glucosa&#46; Adem&#225;s&#44; la presencia concomitante de hipoxemia e isquemia podr&#237;a aumentar la vulnerabilidad del cerebro neonatal a la hipoglucemia&#46; La hipoglucemia por debajo de 40 o 46&#44;8<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#44; en las primeras horas de vida aumenta el riesgo de desarrollar EHI moderada-grave<a class="elsevierStyleCrossRefs" href="#bib0300"><span class="elsevierStyleSup">22&#8211;25</span></a>&#44; as&#237; como de discapacidad o muerte ulterior<a class="elsevierStyleCrossRefs" href="#bib0310"><span class="elsevierStyleSup">24&#44;25</span></a>&#46; Todos los centros realizaban al menos una medici&#243;n de glucemia e instauraban sueroterapia al ingreso&#46; No hay evidencia cient&#237;fica para establecer la recomendaci&#243;n universal de iniciar glucosa en perfusi&#243;n<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">16</span></a>&#44; frente a la opci&#243;n de monitorizar los valores de glucemia e iniciar la nutrici&#243;n enteral&#46; En este sentido&#44; es recomendable investigar la presencia acidosis o hiperlactatemia que podr&#237;an alertar de una potencial hipoperfusi&#243;n intestinal&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Otra pr&#225;ctica universal en todos los centros fue la realizaci&#243;n de una gasometr&#237;a en las primeras 6<span class="elsevierStyleHsp" style=""></span>h de vida&#46; Esta persigue detectar alteraciones como la hipocarbia grave &#40;pCO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>20<span class="elsevierStyleHsp" style=""></span>mmHg&#41; o la hipocarbia moderada sostenida &#40;pCO<span class="elsevierStyleInf">2</span> 20-25<span class="elsevierStyleHsp" style=""></span>mmHg&#41;&#44; que parecen aumentar el riesgo de muerte o discapacidad neurol&#243;gica moderada-grave en el RN con EHI<a class="elsevierStyleCrossRefs" href="#bib0320"><span class="elsevierStyleSup">26&#8211;28</span></a>&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Identificaci&#243;n del reci&#233;n nacido con encefalopat&#237;a hip&#243;xico-isqu&#233;mica</span><p id="par0105" class="elsevierStylePara elsevierViewall">El aspecto clave&#44; junto con la monitorizaci&#243;n de las constantes vitales y de los factores com&#243;rbidos a trav&#233;s de la anal&#237;tica&#44; es establecer si el RN con asfixia perinatal presenta o no encefalopat&#237;a aguda&#46; Dado que esta tiene un car&#225;cter din&#225;mico&#44; y el diagn&#243;stico y graduaci&#243;n de la gravedad se establece mediante la evaluaci&#243;n cl&#237;nica&#44; es recomendable realizar varias exploraciones neurol&#243;gicas durante las 6 primeras horas de vida<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">2&#44;3&#44;7&#44;13</span></a>&#46; En esta l&#237;nea&#44; los hospitales contestaron que m&#225;s del 90&#37; realizaban habitualmente 2 o m&#225;s exploraciones&#46; De forma pr&#225;ctica&#44; las 3<span class="elsevierStyleHsp" style=""></span>h de vida podr&#237;a ser un momento adecuado para indicar el tratamiento con HT activa en un RN con asfixia al nacimiento y que presenta en ese momento una EHI moderada-grave<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">5</span></a>&#46; Si se tomase la decisi&#243;n de indicar HT inmediatamente al nacimiento en base del mayor beneficio&#44; estar&#237;amos ofreciendo HT a numerosos RN que se recuperar&#237;an en los minutos siguientes con un curso favorable sin el tratamiento&#46; Por el contrario&#44; si se retrasase el inicio de la HT hasta las 6<span class="elsevierStyleHsp" style=""></span>h de vida&#44; se puede perder la m&#225;xima eficacia del tratamiento&#44; que acontece cuanto antes se inicia tras la agresi&#243;n hip&#243;xico-isqu&#233;mica<a class="elsevierStyleCrossRefs" href="#bib0335"><span class="elsevierStyleSup">29&#44;30</span></a>&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Todos los hospitales contestaron que utilizaban escalas para graduar la encefalopat&#237;a&#44; mayoritariamente la escala de Garc&#237;a-Alix<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">10</span></a>&#44; seguida por la escala de Sarnat<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">11</span></a>&#46; Las escalas ofrecen una aproximaci&#243;n estandarizada&#44; sistem&#225;tica y organizada&#44; y homogenizan la caracterizaci&#243;n de la gravedad&#44; por profesionales con diferente grado de entrenamiento neurol&#243;gico y permiten comparar la evoluci&#243;n de los pacientes en grupos homog&#233;neos&#46; Es recomendable que cada centro adquiera confianza y experiencia con la misma escala&#46; Debemos recordar&#44; a la espera de los resultados de un ensayo cl&#237;nico dirigido a aquellos RN con EHI leve&#44; que en el momento actual la indicaci&#243;n de HT es solo para aquellos con EHI moderada-grave&#44; a pesar de que hay series que refieren incluir en el tratamiento con hipotermia al 15-30&#37; de RN con EHI leve<a class="elsevierStyleCrossRefs" href="#bib0345"><span class="elsevierStyleSup">31&#8211;33</span></a>&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">La alteraci&#243;n de la actividad electrocortical mediante el aEEG ha sido utilizada para incluir al RN con asfixia perinatal en HT<a class="elsevierStyleCrossRefs" href="#bib0360"><span class="elsevierStyleSup">34&#44;35</span></a>&#44; y principalmente&#44; para monitorizar la funci&#243;n cerebral durante la fase aguda de la encefalopat&#237;a<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">36</span></a> y detectar convulsiones cl&#237;nicamente silentes&#46; Adem&#225;s&#44; la relativa simplicidad de la interpretaci&#243;n del registro junto con su valor predictivo ha dado lugar a que esta monitorizaci&#243;n sea extremadamente importante en los RN con enfermedad neurol&#243;gica&#44; particularmente en el RN con EHI<a class="elsevierStyleCrossRefs" href="#bib0365"><span class="elsevierStyleSup">35&#44;36</span></a>&#46; Es de destacar que el 35&#37; de los centros no dispon&#237;a de aEEG a pesar de ser unidades terciarias de nivel <span class="elsevierStyleSmallCaps">iii</span>&#44; entre las que se inclu&#237;an varios centros que realizaban HT&#46; Estos datos traducen aspectos de mejora&#44; por cuanto no parece factible ofertar un cuidado &#243;ptimo del RN con HT sin la informaci&#243;n que aporta la monitorizaci&#243;n cerebral&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">A pesar de que los datos de la encuesta muestran un adecuado est&#225;ndar asistencial con puntuaciones similares entre los que realizan HT y los que no&#44; existe margen de mejora ya que solo el 50&#37; de los 89 hospitales terciarios obtuvieron una &#171;asistencia &#243;ptima&#187;&#46; Existen adem&#225;s diferencias atendiendo al nivel asistencial&#44; y a si realizan o no HT&#44; siendo la calidad mejor en las unidades que realizan hipotermia <span class="elsevierStyleSmallCaps">iii</span>c y <span class="elsevierStyleSmallCaps">iii</span>b frente a las <span class="elsevierStyleSmallCaps">iii</span>a en la atenci&#243;n del parto y 6 primeras horas de vida&#44; y en la disponibilidad de profesionales con experiencia en las unidades <span class="elsevierStyleSmallCaps">iii</span>c frente al resto&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Un aspecto clave para mejorar la respuesta en este estrecho marco temporal es la formaci&#243;n adecuada de los pediatras que atienden partos&#44; para as&#237; identificar r&#225;pidamente al RN candidato a HT y activar el &#171;c&#243;digo hipotermia&#187; de manera muy precoz<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">37</span></a>&#46; En nuestro medio&#44; la incidencia de asfixia perinatal est&#225; en torno a 7 por mil RN<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">7</span></a> y si bien la mayor&#237;a de los ni&#241;os no necesitar&#225;n traslado&#44; la activaci&#243;n de este c&#243;digo y la puesta en marcha de una serie de acciones en secuencia que denominamos &#171;cadena de neuroprotecci&#243;n cerebral&#187; permiten poner en alerta al equipo de transporte y al centro de referencia&#44; as&#237; como vigilar de forma estrecha el estado neurol&#243;gico del RN&#44; controlar potenciales factores com&#243;rbidos y determinar la presencia de EHI en el marco de las 6<span class="elsevierStyleHsp" style=""></span>h de oro &#40;<a class="elsevierStyleCrossRef" href="#fig0020">fig&#46; 4</a>&#41;&#46; Nuestro estudio muestra &#225;reas de mejora&#44; como son la dotaci&#243;n tecnol&#243;gica y de personal entrenado&#59; al menos todos los centros que ofrecen HT deber&#237;an tener equipos de aEEG y neonat&#243;logos entrenados en las diferentes herramientas de evaluaci&#243;n neurol&#243;gica junto con experiencia en el manejo de las complicaciones asociadas a la EHI<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">12&#44;38</span></a>&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0130" class="elsevierStylePara elsevierViewall">La fortaleza de este trabajo es que pr&#225;cticamente todos los centros terciarios aportaron informaci&#243;n y gracias a ello disponemos de datos &#250;nicos&#44; no previamente conocidos que ofrecen un panorama global sobre la asistencia que se da al RN con asfixia perinatal y candidato a HT durante las primeras horas de vida en nuestro pa&#237;s&#46; Por otro lado este estudio presenta algunas limitaciones&#46; La metodolog&#237;a de una encuesta puede conllevar sesgos al incorporar al conjunto de datos informaci&#243;n incompleta o err&#243;nea&#46; Como no se dispone de criterios validados para establecer la calidad asistencial en el intervalo temporal de las 6 primeras horas en el contexto de la asfixia perinatal&#44; se sigui&#243; el criterio de puntuar la pr&#225;ctica cl&#237;nica de acuerdo con el est&#225;ndar recomendado en las gu&#237;as de pr&#225;ctica cl&#237;nica <a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">2&#44;3&#44;12&#8211;14</span></a>&#46; Asimismo&#44; se han eliminado las preguntas m&#225;s controvertidas y se ha optado por una escala asim&#233;trica que reforzase una actuaci&#243;n conforme al est&#225;ndar recomendado&#44; frente a una respuesta de &#171;raramente o nunca&#187;&#46; Finalmente&#44; es preciso resaltar que la encuesta eval&#250;a protocolos de actuaci&#243;n generales en cada hospital&#44; pero no es posible a trav&#233;s de ella conocer la calidad real asistencial de los pacientes&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">La informaci&#243;n aportada por este trabajo es relevante especialmente para dimensionar la pr&#225;ctica asistencial en nuestro pa&#237;s durante las horas de oro del RN asf&#237;ctico en riesgo de EHI y mostrar aspectos de posible mejora para poder dirigir adecuadamente los esfuerzos encaminados a ofertar una asistencia adecuada en este marco temporal&#46;</p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Conflicto de intereses</span><p id="par0140" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introducci&#243;n</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El proceso asistencial hasta el inicio de la hipotermia terap&#233;utica &#40;HT&#41; es crucial para mejorar su efectividad y prevenir el agravamiento del da&#241;o hip&#243;xico-isqu&#233;mico&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">M&#233;todo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio transversal nacional realizado en 2015 mediante cuestionario a todas las unidades nivel <span class="elsevierStyleSmallCaps">iii</span> sobre la asistencia al reci&#233;n nacido &#40;RN&#41; con asfixia perinatal en las primeras horas de vida&#46; Se compar&#243; la calidad asistencial entre los hospitales que realizaban o no HT y seg&#250;n el nivel asistencial&#44; de acuerdo a las gu&#237;as de pr&#225;ctica cl&#237;nica&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Participaron 89&#47;90 hospitales&#44; 57&#47;90 realizaban HT&#46; Todos utilizaban protocolos de reanimaci&#243;n y apagaban la cuna tras estabilizaci&#243;n&#46; Fue universal realizar medici&#243;n de glucemia y gasometr&#237;a&#44; monitorizar la temperatura&#44; dejar al RN a dieta y realizar al menos 2 exploraciones para el diagn&#243;stico de encefalopat&#237;a hip&#243;xico-isqu&#233;mica&#46; El 35&#37; no dispon&#237;a de electroencefalograma integrado por amplitud&#59; 6&#47;57 eran hospitales que realizaban HT&#46; La calidad asistencial entre los hospitales con&#47;sin HT fue similar&#44; siendo mejor la del parto en los que hac&#237;an HT&#44; y la de aquellos con mayor nivel asistencial&#46; El 25&#37; de aquellos que realizaban HT no ten&#237;an neonat&#243;logos con experiencia en la exploraci&#243;n neurol&#243;gica o en la interpretaci&#243;n del electroencefalograma integrado por amplitud&#59; ni en la realizaci&#243;n de ecograf&#237;a cerebral en el 62&#37;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Atendiendo a las recomendaciones del RN asf&#237;ctico&#44; existe un adecuado est&#225;ndar asistencial nacional&#44; con diferencias seg&#250;n el nivel asistencial y si realizan o no hipotermia&#46; Son necesarios m&#225;s equipos de electroencefalograma integrado por amplitud y formaci&#243;n de los neonat&#243;logos en las evaluaciones que requerir&#225; el RN con encefalopat&#237;a hip&#243;xico-isqu&#233;mica&#46;</p></span>"
        "secciones" => array:4 [
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            "identificador" => "abst0010"
            "titulo" => "M&#233;todo"
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          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Resultados"
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            "identificador" => "abst0020"
            "titulo" => "Conclusiones"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introduction</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The process of care and assistance from birth to the starting of therapeutic hypothermia &#40;TH&#41; is crucial in order to improve its effectiveness and prevent the worsening of hypoxic-ischaemic injury&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A national cross-sectional study carried out in 2015 by use of a questionnaire sent to all level <span class="elsevierStyleSmallCaps">iii</span> units on the care of the newborn<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>35 weeks gestation within the first hours of life after a perinatal asphyxia event&#46; According to clinical practice guidelines&#44; the quality of care was compared between the hospitals that carried out or did not carry out TH&#44; and according to the level of care&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">A total of 89&#47;90 hospitals participated&#44; of which 57&#47;90 performed TH&#46; They all used resuscitation protocols and turned off the radiant warmer after stabilisation&#46; All of them performed glucose and blood gas analysis&#44; monitored the central temperature&#44; put the newborn on a diet&#44; and performed at least two examinations for the diagnosis of hypoxic-ischaemic encephalopathy&#46; Greater than one-third &#40;35&#37;&#41; of hospitals did not have amplitude-integrated electroencephalogram&#44; and 6&#47;57 were TH-hospitals&#46; The quality of care among hospitals with and without TH was similar&#44; childbirth being better in those that performed TH&#44; and those with a higher level of care&#46; Level IIIc hospitals had higher scores than the others&#46; The TH-hospitals mentioned not always having neonatologists with experience in neurological assessment and interpretation of amplitude-integrated electroencephalogram &#40;25&#37;&#41;&#44; or in brain ultrasound &#40;62&#37;&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">In response to the recommendations of the asphyxiated newborn&#44; there is a proper national health care standard with differences according to the level of care and whether TH is offered&#46; More amplitude-integrated electroencephalogram devices are necessary&#44; as well as more neonatologists trained in the evaluations that will be require by the newborn with hypoxic-ischaemic encephalopathy&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0035">Los miembros del Grupo de Trabajo ESP-EHI se presentan en <a class="elsevierStyleCrossRef" href="#sec0055">anexo 1</a>&#46;</p>"
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            "apendice" => "<p id="par0150" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Grupo de Trabajo ESP-EHI&#46; Unidades de Neonatolog&#237;a&#46; Hospitales terciarios&#44; Espa&#241;a</span></p> <p id="par0155" class="elsevierStylePara elsevierViewall">J&#46; Diez-Delgado &#40;Torrec&#225;rdenas&#44; Almer&#237;a&#41;&#44; <span class="elsevierStyleSmallCaps">I</span>&#46;Benavente &#40;Puerta del Mar&#44; C&#225;diz&#41;&#44; <span class="elsevierStyleSmallCaps">I</span>&#46; Tof&#233; &#40;Reina Sof&#237;a&#44; C&#243;rdoba&#41;&#44; A&#46;E&#46; Jerez &#40;S&#46; Cecilio&#44; Granada&#41;&#44; J&#46;A&#46; Hurtado &#40;Virgen de las Nieves&#44; Granada&#41;&#44; J&#46;M&#46; Ceballos &#40;J&#46;R&#46; Jim&#233;nez&#44; Huelva&#41;&#44; M&#46;L&#46; Mill&#225;n &#40;C&#46; Hospitalario&#44; Ja&#233;n&#41;&#44; M&#46;D&#46; Esquivel &#40;Materno-Infantil&#44; Jerez&#41;&#44; C&#46; Ruiz &#40;Costa del Sol&#44; Marbella&#41;&#44; M&#46; Baca &#40;Quir&#243;n&#44; M&#225;laga&#41;&#44; E&#46; Tapia &#40;G&#46; Universitario&#44; M&#225;laga&#41;&#44; M&#46; Losada &#40;Quir&#243;n S&#46; Coraz&#243;n&#44; Sevilla&#41;&#44; E&#46; Torres &#40;Valme&#44; Sevilla&#41;&#44; A&#46; Pav&#243;n &#40;Virgen del Roc&#237;o&#44; Sevilla&#41;&#44; P&#46;J&#46; Jim&#233;nez &#40;Virgen Macarena&#44; Sevilla&#41;&#44; F&#46; Jim&#233;nez &#40;S&#46; &#193;ngela de la Cruz&#44; Sevilla&#41;&#44; M&#46;P&#46; Ventura &#40;Lozano Blesa&#44; Zaragoza&#41;&#44; S&#46; Rite &#40;Miguel Servet&#44; Zaragoza&#41;&#44; T&#46; Gonz&#225;lez &#40;Cabue&#241;es&#44; Gij&#243;n&#41;&#44; R&#46;P&#46;Arias &#40;Central Asturias&#44; Oviedo&#41;&#44; P&#46;R&#46; Balliu &#40;Son Espases&#44; Mallorca&#41;&#44; J&#46;M&#46;Lloreda-Garc&#237;a &#40;S&#46; Luc&#237;a&#44; Cartagena&#41;&#44; J&#46;L&#46; Alcar&#225;z &#40;Virgen de la Arrixaca&#44; Murcia&#41;&#44; C&#46; Tapia &#40;General&#44; Alicante&#41;&#44; A&#46; de la Morena &#40;S&#46; Juan&#44; Alicante&#41;&#44; <span class="elsevierStyleSmallCaps">I</span>&#46;Centelles &#40;General&#44; Castell&#243;n&#41;&#44; <span class="elsevierStyleSmallCaps">I</span>&#46;G&#252;emes &#40;Casa de Salud&#44; Valencia&#41;&#44; J&#46; Esta&#241; &#40;Clinico&#44; Valencia&#41;&#44; A&#46; Alberola &#40;La F&#233;&#44; Valencia&#41;&#44; S&#46; Aparici &#40;Quir&#243;n&#44; Valencia&#41;&#44; R&#46; L&#243;pez &#40;Nisa&#95;9 de Octubre&#44; Valencia&#41;&#44; J&#46; Beceiro &#40;Pr&#237;ncipe de Asturias&#44; Alcal&#225; de Henares&#41;&#44; B&#46; Garc&#237;a &#40;General&#44; Fuenlabrada&#41;&#44; L&#46; Mart&#237;nez &#40;General&#44; Getafe&#41;&#44; E&#46; Gonz&#225;lez &#40;Severo Ochoa&#44; Legan&#233;s&#41;&#44; L&#46; Arruza &#40;Cl&#237;nico S&#46; Carlos&#44; Madrid&#41;&#44; M&#46;D&#46; Blanco &#40;Gregorio Mara&#241;&#243;n&#44; Madrid&#41;&#44; M&#46;T&#46; Moral &#40;12 de Octubre&#44; Madrid&#41;&#44; B&#46; Arias &#40;La Zarzuela&#44; Madrid&#41;&#44; F&#46; Mar &#40;Ruber <span class="elsevierStyleSmallCaps">I</span>&#46;&#44; Madrid&#41;&#44; J&#46; Jim&#233;nez &#40;Sanitas&#95;La Moraleja&#44; Madrid&#41;&#44; G&#46; Romera &#40;Montepr&#237;ncipe&#44; Madrid&#41;&#44; A&#46; Cu&#241;arro &#40;Alcorc&#243;n&#41;&#44; C&#46; Mu&#241;&#243;z &#40;Puerta de Hierro&#95;Majadahonda&#44; Madrid&#41;&#44; F&#46; Caba&#241;as &#40;H&#46; U&#46; Quir&#243;n Madrid&#41;&#44; E&#46; Valverde &#40;La Paz&#44; Madrid&#41;&#44; R&#46; Montero &#40;Nisa&#95;Pardo de Aravaca&#44; Madrid&#41;&#44; J&#46;C&#46; Tejedor &#40;General&#44; M&#243;stoles&#41;&#44; C&#46; Santana &#40;Materno Insular&#44; Las Palmas&#41;&#44; B&#46; Reyes &#40;Universitario de Canarias&#44; Tenerife&#41;&#44; S&#46; Romero &#40;N&#46; S&#46; de Candelaria&#44; Tenerife&#41;&#44; A&#46; Orizaola &#40;Marqu&#233;s de Valdecilla&#44; Santander&#41;&#44; M&#46; Baquero &#40;General&#44; Albacete&#41;&#44; D&#46; Hern&#225;ndez &#40;General&#44; Ciudad Real&#41;&#44; A&#46; Pantoja &#40;Virgen de la Salud&#44; Toledo&#41;&#44; C&#46; Vega &#40;HUBU&#44; Burgos&#41;&#44; L&#46; Casta&#241;&#243;n &#40;CAULE&#44; Le&#243;n&#41;&#44; E&#46;P&#46; Guti&#233;rrez &#40;Universitario&#44; Salamanca&#41;&#44; M&#46; Benito &#40;Cl&#237;nico&#44; Valladolid&#41;&#44; S&#46; Caser&#237;o &#40;Rio Hortega&#44; Valladolid&#41;&#44; G&#46; Arca &#40;Cl&#237;nic&#44; Barcelona&#41;&#44; M&#46;J&#46; Garc&#237;a &#40;S&#46; Creu i S&#46; Pau&#44; Barcelona&#41;&#44; M&#46;A&#46; L&#243;pez-V&#237;lchez &#40;H&#46; del Mar&#44; Barcelona&#41;&#44; L&#46; Castells &#40;General de Catalunya&#44; Barcelona&#41;&#44; M&#46; Domingo &#40;Parc Taul&#237;&#44; Sabadell&#41;&#44; W&#46; Coroleu &#40;Germans Trias i Pujol&#44; Badalona&#41;&#44; H&#46; Boix &#40;Vall d¿Hebr&#243;n&#44; Barcelona&#41;&#44; R&#46; Porta &#40;<span class="elsevierStyleSmallCaps">I</span>&#46;Dexeus&#95;Quir&#243;n&#44; Barcelona&#41;&#44; A&#46; Garc&#237;a-Alix &#40;S&#46; Joan de D&#233;u&#44; Barcelona&#41;&#44; S&#46; Mart&#237;nez-Nadal &#40;SCIAS&#44; Barcelona&#41;&#44; E&#46; Jim&#233;nez &#40;Dr&#46; J&#46;Trueta&#44; Girona&#41;&#44; E&#46; Sole &#40;Arnau de Vilanova&#44; Lleida&#41;&#44; M&#46; Alb&#250;jar &#40;Joan <span class="elsevierStyleSmallCaps">XXIII</span>&#44; Tarragona&#41;&#44; E&#46;M&#46; Fern&#225;ndez &#40;Infanta Cristina&#44; Badajoz&#41;&#44; A&#46;R&#46; Barrio &#40;S&#46; Pedro de Alc&#225;ntara&#44; C&#225;ceres&#41;&#44; E&#46; Pi&#241;&#225;n &#40;M&#233;rida&#41;&#44; A&#46; Avila-Alvarez &#40;CHU A Coru&#241;a&#41;&#44; M&#46;E&#46; V&#225;zquez &#40;Lucus Augusti&#44; Lugo&#41;&#44; N&#46; Balado &#40;CHU&#44; Orense&#41;&#44; P&#46;A&#46; Crespo &#40;CHU&#44; Pontevedra&#41;&#44; M&#46;L&#46; Couce &#40;Cl&#237;nico&#44; Santiago de Compostela&#41;&#44; A&#46; Concheiro-Guis&#225;n &#40;Xeral&#44; Vigo&#41;&#44; <span class="elsevierStyleSmallCaps">I</span>&#46; Esteban &#40;S&#46; Pedro&#44; Logro&#241;o&#41;&#44; A&#46; Lavilla &#40;CH&#44; Navarra&#41;&#44; <span class="elsevierStyleSmallCaps">V</span>&#46; Alzina &#40;C&#46; Universidad de Navarra&#41;&#44; A&#46; Aguirre &#40;Basurto&#44; Bilbao&#41;&#44; B&#46; Loureiro &#40;Cruces&#44; Bilbao&#41;&#44; <span class="elsevierStyleSmallCaps">I</span>&#46; Ech&#225;niz &#40;Quir&#243;n&#44; Bilbao&#41;&#44; M&#46;D&#46; Elorza &#40;HU&#46; Donostia&#44; San Sebasti&#225;n&#41;&#44; A&#46; Euba &#40;HUA Txagorritxu&#44; Vitoria&#41;&#46;</p>"
            "etiqueta" => "Anexo 1"
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          "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Calidad de la asistencia de los hospitales que realizan hipotermia terap&#233;utica frente a los que no&#46;</p> <p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">HT&#58; hospital con hipotermia terap&#233;utica&#59; No-HT&#58; hospital sin hipotermia terap&#233;utica&#59; hdv&#58; horas de vida&#46;</p> <p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">&#40;a&#41; Se incluyen las preguntas 5-10&#44; y las agrupadas 1-2 y 3-4&#46;</p> <p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">&#40;b&#41; Se incluyen las preguntas 12-14&#44; 17&#44; 21&#44; 22&#46;</p> <p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">&#40;c&#41; Se incluyen las preguntas 20&#44; 25&#44; 27-30&#44; y las agrupadas 24a-24b&#44; 26a-26d y 26b-26c&#46;</p> <p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Todo<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#40;a&#41;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#40;b&#41;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#40;c&#41;&#46;</p> <p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">&#42; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;015 &#40;test de chi-cuadrado comparando &#8220;clasificaci&#243;n &#243;ptima&#8221; vs&#46; &#8220;clasificaci&#243;n aceptable &#43; mejorable&#8221;&#41;&#46;</p>"
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          "es" => "<p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">Calidad de la asistencia de los hospitales nivel <span class="elsevierStyleSmallCaps">iii</span> que realizan hipotermia terap&#233;utica&#44; seg&#250;n el nivel asistencial&#46;</p> <p id="spar0105" class="elsevierStyleSimplePara elsevierViewall">hdv&#58; horas de vida&#46;</p> <p id="spar0110" class="elsevierStyleSimplePara elsevierViewall">&#40;a&#41; Se incluyen las preguntas 5-10&#44; y las agrupadas 1-2 y 3-4&#46;</p> <p id="spar0115" class="elsevierStyleSimplePara elsevierViewall">&#40;b&#41; Se incluyen las preguntas 12-14&#44; 17&#44; 21&#44; 22&#46;</p> <p id="spar0120" class="elsevierStyleSimplePara elsevierViewall">&#40;c&#41; Se incluyen las preguntas 20&#44; 25&#44; 27-30&#44; y las agrupadas 24a-24b&#44; 26a-26d y 26b-26c&#46;</p> <p id="spar1045" class="elsevierStyleSimplePara elsevierViewall">Todo<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#40;a&#41;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#40;b&#41;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#40;c&#41;&#46;</p> <p id="spar0125" class="elsevierStyleSimplePara elsevierViewall">En las preguntas &#8220;Parto&#46;&#8221; &#8220;6hdv&#8221; y &#8220;Parto-6hdv&#8221; se incluyen las respuestas de los 89 hospitales&#46; En las preguntas &#8220;Profesionales&#8221; y &#8220;Todo&#8221; se incluyen los 53 hospitales con HT que responden a la encuesta &#40;4 IIIA&#44; 34 IIIB y 15 IIIC&#41;&#46;</p>"
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          "leyenda" => "<p id="spar0145" class="elsevierStyleSimplePara elsevierViewall">HT&#58; hipotermia terap&#233;utica&#59; RN&#58; reci&#233;n nacido&#46;</p>"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " colspan="3" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Hospitales que no realizan HT</th><th class="td" title="table-head  " colspan="3" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Hospitales que realizan HT</th></tr><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Casi siempre&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Con frecuencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Rara vez o nunca&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Casi siempre&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Con frecuencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Rara vez o nunca&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " colspan="7" align="left" valign="top"><span class="elsevierStyleBold">En paritorio&#44; en un parto complicado est&#225; presente</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">1&#46; Un pediatra</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">32 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">55 &#40;96&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">2&#46; Un pediatra neonat&#243;logo</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">22 &#40;69&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10 &#40;31&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">43 &#40;75&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12 &#40;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">3&#46; Una enfermera - matrona</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31 &#40;97&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">52 &#40;91&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3 &#40;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">4&#46; Una enfermera de la Unidad Neonatal</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8 &#40;25&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9 &#40;28&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15 &#40;47&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">14 &#40;25&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10 &#40;18&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">33 &#40;58&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="7" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="7" align="left" valign="top"><span class="elsevierStyleBold">Si al nacimiento el RN presenta datos de asfixia perinatal</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">5&#46; Tiene un protocolo de actuaci&#243;n espec&#237;fico en paritorio</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30 &#40;94&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">53 &#40;93&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3 &#40;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">6&#46; Aunque el pH sea &#60;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">7&#44;00&#44; evita poner bicarbonato</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26 &#40;81&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">51 &#40;89&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4 &#40;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">7&#46; Evita administrar calcio a&#250;n si precisa reanimaci&#243;n avanzada</span><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26 &#40;81&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">55 &#40;96&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">8&#46; Apaga las fuentes de calor una vez recupere la frecuencia cardiaca</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26 &#40;81&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">55 &#40;96&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">9&#46; Traslada al RN con la cuna de transporte apagada</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29 &#40;91&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">56 &#40;98&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">10&#46; Se ingresa al RN para observaci&#243;n en la Unidad</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31 &#40;97&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">54 &#40;95&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3 &#40;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">11&#46; Si se recupera r&#225;pidamente&#44; se deja al RN con su madre</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7 &#40;22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23 &#40;72&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12 &#40;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">43 &#40;75&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">incluye intubaci&#243;n y&#47;o masaje cardiaco y&#47;o administraci&#243;n de f&#225;rmacos&#46;</p>"
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          "es" => "<p id="spar0140" class="elsevierStyleSimplePara elsevierViewall">Preguntas formuladas respecto a la asistencia del reci&#233;n nacido con asfixia perinatal en paritorio</p>"
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          "leyenda" => "<p id="spar0155" class="elsevierStyleSimplePara elsevierViewall">aEEG&#58; electroencefalograma integrado por amplitud&#59; EHI&#58; encefalopat&#237;a hip&#243;xico-isqu&#233;mica&#59; hdv&#58; horas de vida&#59; HT&#58; hipotermia terap&#233;utica&#59; RN&#58; reci&#233;n nacido&#46;</p>"
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            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " colspan="3" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Hospitales que no realizan HT</th><th class="td" title="table-head  " colspan="3" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Hospitales que realizan HT</th></tr><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Casi siempre&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Con frecuencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Rara vez o nunca&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Casi siempre&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Con frecuencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Rara vez o nunca&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " colspan="7" align="left" valign="top"><span class="elsevierStyleBold">Durante las primeras 6 hdv en el RN con asfixia perinatal</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">12&#46; Aplica un protocolo de actuaci&#243;n espec&#237;fico</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26 &#40;81&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5 &#40;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">52 &#40;91&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5 &#40;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">13&#46; Realiza gasometr&#237;a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">32 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">57 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">14&#46; Realiza glucemia</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">32 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">57 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">15&#46; Le deja a dieta absoluta</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">32 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">56 &#40;98&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">16&#46; Le deja a dieta absoluta con sueroterapia</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">32 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">48 &#40;84&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8 &#40;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">17&#46; Monitoriza la temperatura central continua o intermitente&#47;30</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">min</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">22 &#40;69&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10 &#40;31&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">42 &#40;74&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12 &#40;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3 &#40;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">18&#46; Mantiene la temperatura central por debajo de 36</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#176;C</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27 &#40;84&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3 &#40;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">40 &#40;70&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12 &#40;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5 &#40;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">19&#46; Si dispone de aEEG&#44; monitoriza la funci&#243;n cerebral</span><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5 &#40;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">38 &#40;67&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8 &#40;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5 &#40;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="7" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">20&#46; N&#46;</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">o</span></span><span class="elsevierStyleItalic">de aparatos de aEEG</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12 &#40;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Uno&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7 &#40;22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">39 &#40;68&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Ninguno&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">25 &#40;78&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6 &#40;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="7" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">21&#46; &#191;Cu&#225;ntas exploraciones realiza para graduar la EHI&#63;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29 &#40;91&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">53 &#40;93&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Una&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3 &#40;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4 &#40;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Ninguna&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="7" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">22&#46; &#191;Qu&#233; escala utiliza para graduar la EHI&#63;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Garc&#237;a-Alix&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">20 &#40;63&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">39 &#40;68&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Sarnat&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12 &#40;38&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13 &#40;23&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Otra&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5 &#40;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Ninguna&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="7" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">23&#46; En la escala que utiliza&#44; da prioridad al &#237;tem</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Despertar y mantener la alerta&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30 &#40;94&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">50 &#40;88&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Tono muscular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6 &#40;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Movimientos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Otros&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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                0 => "xTab1862588.png"
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            0 => array:3 [
              "identificador" => "tblfn0010"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Respuestas de 7 hospitales que no realizan HT y 51 que s&#237; lo hacen&#44; y que disponen de aEEG&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0150" class="elsevierStyleSimplePara elsevierViewall">Preguntas formuladas respecto a la asistencia del reci&#233;n nacido con asfixia perinatal durante las 6 primeras horas de vida</p>"
        ]
      ]
      6 => array:8 [
        "identificador" => "tbl0015"
        "etiqueta" => "Tabla 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
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          0 => array:3 [
            "identificador" => "at3"
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        "tabla" => array:2 [
          "leyenda" => "<p id="spar0165" class="elsevierStyleSimplePara elsevierViewall">Cincuenta y tres del total de 57 hospitales que realizaban hipotermia contestaron a las preguntas&#46;</p><p id="spar0170" class="elsevierStyleSimplePara elsevierViewall">aEEG&#58; electroencefalograma integrado por amplitud&#59; EHI&#58; encefalopat&#237;a hip&#243;xico-isqu&#233;mica&#59; RM&#58; resonancia magn&#233;tica cerebral&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Casi siempre&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Con frecuencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Rara vez o nunca&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">24&#46; Profesionales entrenados en la exploraci&#243;n neurol&#243;gica neonatal</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>a&#46; Neonat&#243;logo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">40 &#40;75&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12 &#40;23&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>b&#46; Neur&#243;logo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">28 &#40;53&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">14 &#40;26&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11 &#40;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">25&#46; Neonat&#243;logos entrenados en la interpretaci&#243;n del aEEG</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">40 &#40;75&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8 &#40;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5 &#40;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">26&#46; Profesionales entrenados en la neuroimagen cerebral</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>a&#46; Neonat&#243;logo entrenado en la interpretaci&#243;n de la RM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">20 &#40;38&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26 &#40;49&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>b&#46; Neonat&#243;logo entrenado en ecograf&#237;a y doppler&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">20 &#40;38&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15 &#40;28&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18 &#40;34&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>c&#46; Radi&#243;logo entrenado en ecograf&#237;a y doppler&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">34 &#40;64&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11 &#40;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8 &#40;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>d&#46; Radi&#243;logo entrenado en la interpretaci&#243;n de la RM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">39 &#40;74&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12 &#40;23&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">27&#46; Neonat&#243;logo entrenado en ecocardio&#47;cardi&#243;logo infantil</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30 &#40;57&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">16 &#40;30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">28&#46; Equipo de enfermer&#237;a con formaci&#243;n espec&#237;fica en EHI</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">42 &#40;79&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8 &#40;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">29&#46; Plan de cuidados espec&#237;fico dise&#241;ado por enfermer&#237;a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">38 &#40;72&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6 &#40;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9 &#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">30&#46; Ratio de enfermeras igual al de otro paciente grave</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">43 &#40;81&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9 &#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">31&#46; Psic&#243;logo de apoyo a los padres en este tipo de situaci&#243;n</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15 &#40;28&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11 &#40;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27 &#40;51&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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          "es" => "<p id="spar0160" class="elsevierStyleSimplePara elsevierViewall">Preguntas dirigidas a los hospitales que realizaban hipotermia sobre la disponibilidad de profesionales con experiencia en el manejo del reci&#233;n nacido con encefalopat&#237;a hip&#243;xico-isqu&#233;mica</p>"
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        "etiqueta" => "Tabla 4"
        "tipo" => "MULTIMEDIATABLA"
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          "leyenda" => "<p id="spar0180" class="elsevierStyleSimplePara elsevierViewall">HT&#58; hipotermia terap&#233;utica&#46;</p><p id="spar0185" class="elsevierStyleSimplePara elsevierViewall">Datos en mediana &#40;m&#237;n&#59;m&#225;x&#41;&#46;</p>"
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            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " colspan="3" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Realizaci&#243;n si&#47;no HT</th><th class="td" title="table-head  " colspan="4" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Seg&#250;n el nivel asistencial</th></tr><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Preguntas referidas a&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Valor de p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">IIIA &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>25&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">IIIB &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>47&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">IIIC &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Valor de p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">La asistencia durante el parto<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31&#44;5 &#40;25&#59;32&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">32 &#40;26&#59;32&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31 &#40;25&#59;32&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">32 &#40;25&#59;32&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">32 &#40;26&#59;32&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;034&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">La asistencia durante las 6 primeras horas<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24 &#40;20&#59;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24 &#40;20&#59;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;426&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24 &#40;21&#59;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24 &#40;20&#59;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24 &#40;20&#59;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;827&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">La asistencia durante el parto y las 6 primeras horas de vida<a class="elsevierStyleCrossRefs" href="#tblfn0015"><span class="elsevierStyleSup">a&#44;b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">54&#44;5 &#40;46&#59;56&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">56 &#40;49&#59;56&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;052&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">55 &#40;48&#59;56&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">56 &#40;47&#59;56&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">56 &#40;46&#59;56&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;105&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">La disponibilidad de profesionales con experiencia<a class="elsevierStyleCrossRefs" href="#tblfn0025"><span class="elsevierStyleSup">c&#44;d</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">34 &#40;21&#59;36&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31&#44;5 &#40;27&#59;36&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">33 &#40;24&#59;36&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">35 &#40;21&#59;36&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;129&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Todas<a class="elsevierStyleCrossRefs" href="#tblfn0015"><span class="elsevierStyleSup">a&#44;b&#44;c&#44;d</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">89 &#40;72&#59;92&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">84 &#40;81&#59;90&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">88&#44;5 &#40;77&#59;92&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">91 &#40;72&#59;92&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;027&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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                0 => "xTab1862589.png"
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            0 => array:3 [
              "identificador" => "tblfn0015"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Se incluyen las preguntas 5-10&#44; y las agrupadas 1-2 y 3-4&#46;</p>"
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            1 => array:3 [
              "identificador" => "tblfn0020"
              "etiqueta" => "b"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Se incluyen las preguntas 12-14&#44; 17&#44; 21&#44; 22&#46;</p>"
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            2 => array:3 [
              "identificador" => "tblfn0025"
              "etiqueta" => "c"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0025">Se incluyen las preguntas 20&#44; 25&#44; 27-30&#44; y las agrupadas 24a-24b&#44; 26a-26d y 26b-26c&#46;</p>"
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            3 => array:3 [
              "identificador" => "tblfn0030"
              "etiqueta" => "d"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0030">Solo se incluyen 53 de los 57 hospitales con hipotermia que contestaron a la encuesta &#40;4 IIIA&#44; 34 IIIB y 15 IIIC&#41;&#46;</p>"
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          "es" => "<p id="spar0175" class="elsevierStyleSimplePara elsevierViewall">Puntuaciones obtenidas por los 89 hospitales que realizaban HT frente a los que no y seg&#250;n el nivel asistencial</p>"
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                      ]
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                      ]
                    ]
                  ]
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                      ]
                    ]
                  ]
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
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                            2 => "S&#46;G&#46; Golombek"
                            3 => "H&#46; Baquero"
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                      "Revista" => array:5 [
                        "tituloSerie" => "NeoReviews&#46;"
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                        "paginaInicial" => "554"
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              "referencia" => array:1 [
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hypothermia for newborns with hypoxic ischemic encephalopathy"
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                        0 => array:3 [
                          "colaboracion" => "Canadian Paediatric Society&#44; Fetus and Newborn Committee"
                          "etal" => false
                          "autores" => array:1 [
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ISSN: 16954033
Idioma original: Español
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