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Informaci&#243;n sobre el proyecto a los padres o tutores en la planta de Maternidad&#46;</p><p class="elsevierStylePara elsevierViewall">Explicaci&#243;n verbal y por escrito de los detalles del estudio&#44; seguida de la obtenci&#243;n del consentimiento firmado para su participaci&#243;n&#44; previo al alta del RN&#46; Cuestionario sobre antecedentes de asma&#44; rinitis y dermatitis at&#243;pica en la familia basado en el estudio ISAAC<a class="elsevierStyleCrossRef" href="#bib4"><span class="elsevierStyleSup">4</span></a>&#44; tabaquismo y otras variables sociodemogr&#225;ficas que se detallan en la <a class="elsevierStyleCrossRef" href="#tbl2">tabla 2</a>&#46;</p><elsevierMultimedia ident="tbl2"></elsevierMultimedia></li><li class="elsevierStyleListItem"><span class="elsevierStyleLabel">&#8226;</span><p class="elsevierStylePara elsevierViewall">Etapa 2&#46; An&#225;lisis de los 6 primeros meses de vida&#46;</p><p class="elsevierStylePara elsevierViewall">Revisi&#243;n de las historias cl&#237;nicas informatizadas de atenci&#243;n especializada &#40;Sistema Integrado de Ayuda Asistencial &#91;SIAS&#93;&#41; y primaria &#40;Abucasis&#41; del Departamento 11&#44; con registro de visitas a urgencias hospitalarias y ambulatorias&#44; hospitalizaciones y visitas al pediatra de atenci&#243;n primaria relacionadas con la aparici&#243;n de BS durante los primeros 6 meses de vida&#46; Paralelamente&#44; se env&#237;a por correo un cuestionario modificado del estudio ISAAC&#44; en el que se interroga a los padres sobre la aparici&#243;n de episodios de sibilancias desde el nacimiento del ni&#241;o y sus repercusiones&#44; y otras cuestiones relacionadas con posibles factores de riesgo asociados &#40;<a class="elsevierStyleCrossRef" href="#tbl2">tabla 2</a>&#41;&#46; En caso de no conseguir informaci&#243;n mediante estas fuentes&#44; se recurre a la encuesta telef&#243;nica&#44; dejando transcurrir un m&#225;ximo de 6 meses para obtener respuesta&#46; Se ha considerado como BS todo episodio agudo de sibilancias que un m&#233;dico refleje en la historia cl&#237;nica o que los los padres reflejen en el cuestionario &#40;&#8220;pitos o silbidos en el pecho&#8221;&#41;&#46;</p></li><li class="elsevierStyleListItem"><span class="elsevierStyleLabel">&#8226;</span><p class="elsevierStylePara elsevierViewall">Etapa 3&#46; An&#225;lisis del primer a&#241;o de vida&#46;</p><p class="elsevierStylePara elsevierViewall">Registro de la informaci&#243;n relativa a los 6 meses siguientes hasta llegar al a&#241;o de edad y env&#237;o por correo de un cuestionario similar al de la fase anterior&#44; incluyendo como factor de riesgo en estudio la asistencia a la guarder&#237;a&#46; Junto con el cuestionario&#44; se propone la realizaci&#243;n de un test alergol&#243;gico cualitativo &#40;ImmunoCAP<span class="elsevierStyleSup">&#174;</span> Rapid&#44; Phadia AB&#44; Uppsala&#44; Suecia&#41;&#44; y se adjunta informaci&#243;n al respecto<a class="elsevierStyleCrossRef" href="#bib5"><span class="elsevierStyleSup">5</span></a>&#46; En aquellos casos en los que no se obtiene informaci&#243;n mediante los archivos inform&#225;ticos y el cuestionario&#44; se recurre de nuevo a la encuesta telef&#243;nica&#46; Si se agota esta v&#237;a sin conseguir informaci&#243;n&#44; se considera al paciente p&#233;rdida del estudio&#46;</p></li></ul></p></span><span class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">An&#225;lisis estad&#237;stico</span><p class="elsevierStylePara elsevierViewall">Para el c&#225;lculo del tama&#241;o muestral se ha estimado una incidencia de BS del 30&#37; en los primeros 3 a&#241;os de vida<a class="elsevierStyleCrossRef" href="#bib6"><span class="elsevierStyleSup">6</span></a> y se ha considerado una diferencia absoluta del 15&#37; entre la poblaci&#243;n expuesta y la poblaci&#243;n no expuesta como la m&#237;nima que se debe detectar para considerarla importante desde el punto de vista cl&#237;nico y epidemiol&#243;gico&#46; Utilizando una potencia del 90&#37; y una precisi&#243;n del 5&#37;&#44; el n&#250;mero de sujetos en estudio es de 460&#46; Teniendo en cuenta las p&#233;rdidas potenciales&#44; el n&#250;mero final de sujetos en estudio es de 631&#46;</p><p class="elsevierStylePara elsevierViewall">Los datos descriptivos de las variables &#40;<a class="elsevierStyleCrossRef" href="#tbl2">tabla 2</a>&#41; se expresan como porcentajes o como media con su desviaci&#243;n est&#225;ndar &#40;DE&#41;&#46; Se han calculado la incidencia acumulada&#44; la tasa de incidencia de la variable principal y la incidencia acumulada de otras variables de inter&#233;s&#46; Para la comparaci&#243;n de las variables cualitativas se ha utilizado el test de chi cuadrado o el test de Fisher&#46; La comparaci&#243;n de las variables cuantitativas se ha realizado mediante el test t de Student&#46; Se ha llevado a cabo un an&#225;lisis bivariante y posteriormente multivariante mediante regresi&#243;n de Cox para el an&#225;lisis de los factores de riesgo de sibilancias&#46; Las variables cuantitativas se han categorizado s&#243;lo en caso de mejorar la precisi&#243;n del modelo en el que intervienen&#46;</p><p class="elsevierStylePara elsevierViewall">En todos los casos se consider&#243; estad&#237;sticamente significativo un valor de p &#60;0&#44;05&#46; El an&#225;lisis se ha realizado con el paquete estad&#237;stico SPSS&#44; versi&#243;n 15&#46;0 para Windows&#46;</p></span></span><span class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Resultados</span><span class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Descriptivos</span><p class="elsevierStylePara elsevierViewall">La muestra inicial est&#225; compuesta por 636 ni&#241;os &#40;<a class="elsevierStyleCrossRef" href="#fig1">fig&#46; 1</a>&#41;&#46; En el momento del an&#225;lisis se hab&#237;an producido 16 p&#233;rdidas de seguimiento &#40;2&#44;5&#37;&#41;&#46; En el 47&#37; de los casos se respondi&#243; el cuestionario remitido a los 6 meses&#46; La informaci&#243;n sobre las variables pudo completarse en su totalidad en el 94&#37; de los pacientes&#46; Los datos descriptivos seg&#250;n la existencia o no de sibilancias quedan reflejados en la <a class="elsevierStyleCrossRef" href="#tbl3">tabla 3</a>&#46; El promedio de edad de las madres fue de 29&#44;5 a&#241;os &#40;DE&#58; 5&#44;5&#41;&#44; y las de origen inmigrante fueron significativamente m&#225;s j&#243;venes &#40;promedio de 26&#44;6 versus 30&#44;6 a&#241;os&#59; p&#60;0&#44;001&#41;&#46; No hubo diferencias significativas entre ambos grupos en lo que respecta al peso y la edad gestacional&#46; Los hijos de madres inmigrantes suponen un 25&#37; del total de la muestra&#46; En la mayor parte de los casos proceden de pa&#237;ses de Europa del Este &#40;52&#37;&#41;&#44; seguido por Latinoam&#233;rica y pa&#237;ses del Magreb en igual proporci&#243;n &#40;21&#37;&#41; y a m&#225;s distancia por otros pa&#237;ses de Asia y &#193;frica&#46; El 65&#37; de los ni&#241;os recib&#237;a lactancia materna en el momento del alta de la maternidad&#46; Este porcentaje fue significativamente mayor en los hijos de madres inmigrantes &#40;el 85 versus el 54&#37;&#59; p&#60;0&#44;001&#41;&#46; A los 3 meses&#44; s&#243;lo el 47&#37; de los ni&#241;os recib&#237;a lactancia materna&#44; y se manten&#237;a el predominio en los hijos de inmigrantes &#40;el 65 versus el 41&#37;&#59; p&#60;0&#44;001&#41;&#46;</p><elsevierMultimedia ident="fig1"></elsevierMultimedia><elsevierMultimedia ident="tbl3"></elsevierMultimedia></span><span class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Incidencia de bronquitis sibilantes y otros episodios de inter&#233;s</span><p class="elsevierStylePara elsevierViewall">La incidencia acumulada de BS &#40;al menos un episodio en los primeros 6 meses&#41; fue del 25&#44;2&#37;&#44; lo que equivale a una tasa de incidencia absoluta de 7&#44;8 episodios por mes y a una tasa de incidencia relativa de 14 episodios por 100 pacientes&#47;mes&#46; El promedio de edad del primer episodio fue de 3&#44;7 meses &#40;DE&#58; 1&#44;5&#41;&#46; La incidencia de BS recurrentes &#40;asma&#41; fue del 5&#44;6&#37;&#46; El 11&#44;6&#37; de los pacientes precis&#243; &#8212;al menos en una ocasi&#243;n&#8212; acudir a urgencias&#59; el 6&#44;6&#37; recibi&#243; tratamiento corticoideo oral&#44; el 4&#37; requiri&#243; ingreso hospitalario y el 0&#44;6&#37; requiri&#243; traslado a la UCI pedi&#225;trica &#40;<a class="elsevierStyleCrossRef" href="#fig2">fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig2"></elsevierMultimedia></span><span class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">An&#225;lisis bivariante</span><p class="elsevierStylePara elsevierViewall">Los resultados quedan resumidos en la <a class="elsevierStyleCrossRef" href="#tbl4">tabla 4</a>&#44; y expresan el riesgo relativo &#40;RR&#41; de cada factor de riesgo sobre la categor&#237;a de referencia con su intervalo de confianza &#40;IC&#41; del 95&#37;&#46; Seg&#250;n este an&#225;lisis&#44; se comportan como factores de riesgo de BS el sexo masculino&#44; la menor edad gestacional&#44; el nacimiento en el tercer y cuarto trimestre del a&#241;o&#44; el menor nivel de estudios de los padres&#44; la existencia de hermanos mayores&#44; el antecedente de asma en &#233;stos y de atopia en la madre y la exposici&#243;n al tabaco&#59; se comporta como factor protector la lactancia materna durante un per&#237;odo igual o superior a 3 meses&#46;</p><elsevierMultimedia ident="tbl4"></elsevierMultimedia></span><span class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">An&#225;lisis multivariante</span><p class="elsevierStylePara elsevierViewall">En la <a class="elsevierStyleCrossRef" href="#tbl5">tabla 5</a> se exponen las variables incluidas en el modelo final&#46; Algunos factores&#44; como la edad materna&#44; el peso al nacimiento y el tabaquismo durante el embarazo se han tenido en cuenta en el an&#225;lisis multivariante por cuestiones te&#243;ricas&#44; aunque resultaran ser no significativos en el an&#225;lisis bivariante&#46;</p><elsevierMultimedia ident="tbl5"></elsevierMultimedia><p class="elsevierStylePara elsevierViewall">Dada la colinealidad entre los factores &#8220;existencia de hermanos mayores&#8221; y &#8220;asma en los hermanos&#8221;&#44; se analizaron junto con el resto de los factores en modelos separados&#46; El modelo con mayor capacidad predictiva es el que incluye el factor &#8220;existencia de hermanos mayores&#8221; y&#44; por tanto&#44; ha sido el seleccionado&#46;</p><p class="elsevierStylePara elsevierViewall">Seg&#250;n este an&#225;lisis&#44; y teniendo en cuenta los distintos factores de confusi&#243;n&#44; se comportan como factores de riesgo de BS el sexo masculino&#44; la menor edad gestacional&#44; el nacimiento en el tercer y cuarto trimestre del a&#241;o&#44; la menor edad materna&#44; la existencia de hermanos mayores&#44; la exposici&#243;n al tabaco y el antecedente de asma en la madre&#59; se comportan como factores protectores la lactancia materna durante un per&#237;odo igual o superior a 3 meses y el origen inmigrante de los padres&#46;</p></span></span><span class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discusi&#243;n</span><p class="elsevierStylePara elsevierViewall">La incidencia acumulada de BS en los primeros 6 meses de vida en nuestra poblaci&#243;n es algo superior a la reflejada en otros estudios prospectivos&#46; El estudio ALSPAC &#40;Avon Longitudinal Study of Parents and Children&#41;&#44; llevado a cabo en Bristol &#40;Reino Unido&#41;&#44; estableci&#243; una incidencia a los 6 meses de vida del 21&#44;5&#37;<a class="elsevierStyleCrossRef" href="#bib7"><span class="elsevierStyleSup">7</span></a>&#46; Martindale et al siguieron a una cohorte de RN en Aberdeen &#40;Escocia&#41;&#44; y en este caso la incidencia fue del 19&#44;1&#37;<a class="elsevierStyleCrossRef" href="#bib8"><span class="elsevierStyleSup">8</span></a>&#46; En el estudio de Verhulst et al&#44; realizado en Wilrijk &#40;B&#233;lgica&#41;&#44; el 18&#44;4&#37; de los ni&#241;os present&#243; al menos un episodio de BS en los primeros 6 meses de vida<a class="elsevierStyleCrossRef" href="#bib9"><span class="elsevierStyleSup">9</span></a>&#46; Los valores m&#225;s bajos a esta edad son los publicados por Henderson et al&#44; procedentes de un estudio realizado en 2 poblaciones de la Rep&#250;blica Checa&#44; en el que la incidencia fue del 10&#44;3&#37;<a class="elsevierStyleCrossRef" href="#bib10"><span class="elsevierStyleSup">10</span></a>&#46;</p><p class="elsevierStylePara elsevierViewall">Nuestras cifras superan incluso a las observadas en algunos trabajos en los que el punto de corte se estableci&#243; en el primer a&#241;o de vida&#46; En la cohorte sueca estudiada por Alm et al&#44; el 20&#44;2&#37; de los lactantes hab&#237;a presentado al menos un episodio de BS en los primeros 12 meses&#44; mientras que el 5&#44;3&#37; hab&#237;a presentado 3 o m&#225;s episodios<a class="elsevierStyleCrossRef" href="#bib11"><span class="elsevierStyleSup">11</span></a>&#44; cifra que se asemeja bastante a la observada en nuestra poblaci&#243;n a los 6 meses&#46; La incidencia de bronquiolitis en el primer a&#241;o de vida en la cohorte de Tucson fue del 19&#44;6&#37;<a class="elsevierStyleCrossRef" href="#bib12"><span class="elsevierStyleSup">12</span></a>&#44; mientras que en el estudio de Verhulst et al el 23&#44;5&#37; de los ni&#241;os hab&#237;a presentado alg&#250;n episodio de sibilancias en el mismo per&#237;odo<a class="elsevierStyleCrossRef" href="#bib9"><span class="elsevierStyleSup">9</span></a>&#46; En nuestro medio disponemos de los datos del estudio AMICS &#40;Asthma Multicenter International Cohort Study&#41;<a class="elsevierStyleCrossRef" href="#bib13"><span class="elsevierStyleSup">13</span></a>&#44; en el que la incidencia acumulada de BS en el primer a&#241;o de vida fue del 28&#37; en Barcelona y del 24&#37; en Menorca&#46; Por otro lado&#44; la prevalencia de episodios de sibilancias en el lactante seg&#250;n los primeros datos del Estudio Internacional de las Sibilancias en el Lactante oscila entre el 28&#44;7&#37; en Valencia y el 39&#44;1&#37; en Cartagena&#46; Si se trata de sibilancias recurrentes &#40;3 o m&#225;s episodios&#41;&#44; las cifras m&#225;s bajas vuelven a registrarse en Valencia &#40;12&#44;1&#37;&#41; y las m&#225;s altas en Bilbao &#40;18&#44;6&#37;&#41;&#46; En lo que respecta a visitas a urgencias e ingresos hospitalarios&#44; Valencia alcanza las cifras m&#225;s altas&#44; con una prevalencia del 21&#44;4 y el 5&#44;4&#37; respectivamente<a class="elsevierStyleCrossRef" href="#bib14"><span class="elsevierStyleSup">14</span></a>&#46;</p><p class="elsevierStylePara elsevierViewall">Diversos autores han se&#241;alado el tabaquismo materno durante el embarazo como factor de riesgo de BS en los primeros a&#241;os de vida<a class="elsevierStyleCrossRefs" href="#bib15"><span class="elsevierStyleSup">15&#8211;19</span></a>&#44; aunque en este estudio no se ha observado esa asociaci&#243;n&#46; Dado que la informaci&#243;n sobre el tabaquismo procede exclusivamente de la encuesta verbal realizada poco despu&#233;s del parto&#44; podr&#237;a pensarse en la existencia de un sesgo debido a un menor reconocimiento del h&#225;bito tab&#225;quico por parte de la madre&#46; Aun asumiendo que los cuestionarios sobre tabaquismo se ajustan bastante a la realidad<a class="elsevierStyleCrossRef" href="#bib20"><span class="elsevierStyleSup">20</span></a>&#44; reconocemos como limitaci&#243;n de nuestro estudio el hecho de no haber empleado medidas objetivas&#44; como los niveles de cotinina en orina o en plasma en la madre o el ni&#241;o&#46; En cualquier caso&#44; la variable &#8220;exposici&#243;n al tabaco&#8221;&#44; que tiene en cuenta tanto el tabaquismo prenatal como el posnatal en la madre o el padre&#44; aument&#243; de forma significativa el riesgo de BS en comparaci&#243;n con la nula exposici&#243;n&#46;</p><p class="elsevierStylePara elsevierViewall">La falta de asociaci&#243;n entre el peso al nacimiento y los episodios de sibilancias en los primeros 6 meses de vida se ha descrito en otros estudios&#44; aunque para el caso de las sibilancias de inicio tard&#237;o &#40;pasados los 6 meses&#41; el riesgo es mayor en los ni&#241;os con menor peso al nacer<a class="elsevierStyleCrossRef" href="#bib8"><span class="elsevierStyleSup">8</span></a>&#46; Linnenberg et al hallaron una mayor incidencia de BS en ni&#241;os de bajo peso durante los primeros 18 meses de vida&#44; independientemente de la edad de inicio<a class="elsevierStyleCrossRef" href="#bib21"><span class="elsevierStyleSup">21</span></a>&#46; En cambio&#44; Taveras et al no apreciaron ninguna relaci&#243;n entre este antecedente y la aparici&#243;n de BS durante los 2 primeros a&#241;os de vida<a class="elsevierStyleCrossRef" href="#bib22"><span class="elsevierStyleSup">22</span></a>&#46; Al margen de estas discrepancias&#44; hay que se&#241;alar que s&#243;lo el 7&#37; de los ni&#241;os de nuestra muestra tuvo un peso al nacimiento menor de 2&#46;500<span class="elsevierStyleHsp" style=""></span>g&#46; Por eso es probable que peque&#241;as diferencias con el resto de los ni&#241;os no alcancen significaci&#243;n estad&#237;stica&#46; Adem&#225;s&#44; la mayor&#237;a de los trabajos que encuentran una asociaci&#243;n entre el peso al nacimiento y la aparici&#243;n de sibilancias se basan en poblaciones de edad gestacional y peso muy inferiores a los de nuestro estudio<a class="elsevierStyleCrossRefs" href="#bib23"><span class="elsevierStyleSup">23&#8211;27</span></a>&#46;</p><p class="elsevierStylePara elsevierViewall">Algunos factores de riesgo&#44; como la edad materna&#44; el antecedente de asma materno y el origen inmigrante&#44; no asociados a la aparici&#243;n de BS en el an&#225;lisis bivariante&#44; pasan a formar parte del modelo multivariante&#46; En el caso de la edad de la madre&#44; se comportaron como factores de confusi&#243;n la existencia de hermanos mayores y el origen inmigrante&#46; Efectivamente&#44; las madres mult&#237;paras suelen ser m&#225;s a&#241;osas que las prim&#237;paras&#44; con lo que el posible factor protector de la edad queda contrarrestado por el riesgo que supone tener hermanos mayores&#46; Adem&#225;s&#44; el promedio de edad de las madres inmigrantes fue significativamente menor que el resto&#46; Dado que el riesgo de BS fue inferior en los ni&#241;os de origen inmigrante&#44; el posible efecto negativo de la juventud materna queda de esta manera compensado&#46; Al ajustar el modelo incluyendo estas variables&#44; la edad materna se comporta como un factor protector independiente sobre la aparici&#243;n de BS&#44; como han se&#241;alado otros autores<a class="elsevierStyleCrossRef" href="#bib28"><span class="elsevierStyleSup">28</span></a>&#46; En cuanto al antecedente de asma en la madre&#44; la existencia de hermanos mayores vuelve a actuar como principal factor de confusi&#243;n&#46; Se ha dado la circunstancia de que las madres con antecedentes de asma presentan un &#250;nico hijo en una proporci&#243;n significativamente mayor que el resto de las madres&#46; De esta manera&#44; el efecto negativo del antecedente materno de asma queda enmascarado en el an&#225;lisis bivariante por el efecto protector derivado de la ausencia de hermanos mayores&#46;</p><p class="elsevierStylePara elsevierViewall">Hay que destacar el efecto protector que supone ser hijo de inmigrante sobre la aparici&#243;n de BS&#44; despu&#233;s de ajustar seg&#250;n distintos factores como la lactancia materna&#44; la existencia de hermanos mayores&#44; la edad de la madre y el nivel educacional&#46; Migliore et al tambi&#233;n observaron una menor incidencia de bronquitis en los 2 primeros a&#241;os de vida en los ni&#241;os italianos hijos de padres inmigrantes&#44; sin una explicaci&#243;n clara que justificara este hallazgo<a class="elsevierStyleCrossRef" href="#bib29"><span class="elsevierStyleSup">29</span></a>&#46; Cabr&#237;a pensar en la posible influencia de determinados factores relacionados con el estilo de vida o factores gen&#233;ticos que actuar&#237;an como protectores frente a las sibilancias&#46; En este sentido&#44; debemos se&#241;alar que la mayor parte de los inmigrantes de nuestro estudio proceden de Europa del Este&#44; cuyos pa&#237;ses presentan una menor prevalencia de asma<a class="elsevierStyleCrossRef" href="#bib4"><span class="elsevierStyleSup">4</span></a>&#46; En cualquier caso&#44; hubiera sido interesante disponer de estudios de funci&#243;n pulmonar al nacimiento&#44; con el fin de detectar posibles diferencias entre ni&#241;os de una u otra procedencia&#46;</p><p class="elsevierStylePara elsevierViewall">El nivel educacional ha quedado descartado del modelo final&#46; En este caso&#44; los principales factores de confusi&#243;n han sido la exposici&#243;n al tabaco&#44; la menor edad gestacional y la existencia de hermanos mayores&#46; Todos ellos son factores de riesgo independientes de BS y su participaci&#243;n es mayor conforme disminuye el nivel educacional&#46; Tras ajustar por estas variables&#44; el efecto del nivel educacional sobre la aparici&#243;n de BS desaparece y su inclusi&#243;n en el modelo final no aumenta la capacidad predictiva de &#233;ste&#46;</p><p class="elsevierStylePara elsevierViewall">El antecedente de atopia en la madre queda excluido debido al efecto de confusi&#243;n generado por el trimestre de nacimiento&#46; Casualmente&#44; la proporci&#243;n de ni&#241;os nacidos en el trimestre de mayor riesgo &#8212;el tercero&#8212;&#44; fue mucho mayor en los hijos de madres con antecedentes de atopia&#44; lo que hace que exista una asociaci&#243;n espuria entre este antecedente y la aparici&#243;n de BS&#46;</p><p class="elsevierStylePara elsevierViewall">Tambi&#233;n quedan descartados el antecedente de asma y atopia en el padre&#44; la atopia en los hermanos y la existencia de dermatitis at&#243;pica en el ni&#241;o&#44; lo que estar&#237;a en concordancia con lo que han observado autores como Linnenberg et al<a class="elsevierStyleCrossRef" href="#bib21"><span class="elsevierStyleSup">21</span></a>&#46;</p><p class="elsevierStylePara elsevierViewall">El resto de los factores que forman parte del modelo final &#8212;sexo masculino&#44; tiempo de lactancia materna&#44; existencia de hermanos mayores&#44; trimestre de nacimiento y edad gestacional&#8212; coinciden con los ya se&#241;alados en anteriores publicaciones<a class="elsevierStyleCrossRefs" href="#bib6"><span class="elsevierStyleSup">6&#8211;12</span></a>&#46;</p><p class="elsevierStylePara elsevierViewall">En conclusi&#243;n&#44; hemos detectado una alta incidencia de BS en los primeros 6 meses de vida&#44; que supera la de otras poblaciones europeas&#46; Los factores de riesgo independientes para la aparici&#243;n de BS son el sexo masculino&#44; la menor edad gestacional&#44; el nacimiento en el tercer y cuarto trimestre del a&#241;o&#44; la menor edad materna&#44; la existencia de hermanos mayores&#44; la exposici&#243;n al tabaco y el antecedente de asma en la madre&#46; Los factores protectores son la lactancia materna durante un per&#237;odo igual o superior a 3 meses y el origen inmigrante de los padres&#46; El riesgo m&#225;s alto corresponde a la existencia de hermanos mayores y al nacimiento en el tercer trimestre del a&#241;o&#44; lo que refleja el importante papel de las infecciones v&#237;ricas como desencadenante de las BS a estas edades&#46; Es objeto de futuros an&#225;lisis averiguar la influencia de &#233;stos y otros factores sobre el riesgo de BS en edades posteriores&#46;</p><span class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicto de intereses</span><p class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span><span class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Financiaci&#243;n</span><p class="elsevierStylePara elsevierViewall">Proyecto financiado por el Departamento de Salud de Alzira &#40;Becas 2007&#41; y por la Sociedad Espa&#241;ola de Neumolog&#237;a Pedi&#225;trica &#40;Premios GSK&#44; 2007&#41;&#46;</p></span></span></span>"
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            2 => "M&#233;todos"
            3 => "Resultados"
            4 => "Conclusiones"
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec92652"
          "titulo" => "Palabras clave"
        ]
        2 => array:2 [
          "identificador" => "xres105264"
          "titulo" => array:5 [
            0 => "Abstract"
            1 => "Objectives"
            2 => "Methods"
            3 => "Results"
            4 => "Conclusion"
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec92651"
          "titulo" => "Keywords"
        ]
        4 => array:1 [
          "titulo" => "Introducci&#243;n"
        ]
        5 => array:1 [
          "titulo" => "Dise&#241;o"
        ]
        6 => array:1 [
          "titulo" => "Pacientes"
        ]
        7 => array:2 [
          "titulo" => "M&#233;todos"
          "secciones" => array:2 [
            0 => array:1 [
              "titulo" => "Etapas de la fase i del proyecto RESPIR"
            ]
            1 => array:1 [
              "titulo" => "An&#225;lisis estad&#237;stico"
            ]
          ]
        ]
        8 => array:2 [
          "titulo" => "Resultados"
          "secciones" => array:4 [
            0 => array:1 [
              "titulo" => "Descriptivos"
            ]
            1 => array:1 [
              "titulo" => "Incidencia de bronquitis sibilantes y otros episodios de inter&#233;s"
            ]
            2 => array:1 [
              "titulo" => "An&#225;lisis bivariante"
            ]
            3 => array:1 [
              "titulo" => "An&#225;lisis multivariante"
            ]
          ]
        ]
        9 => array:2 [
          "titulo" => "Discusi&#243;n"
          "secciones" => array:2 [
            0 => array:1 [
              "titulo" => "Conflicto de intereses"
            ]
            1 => array:1 [
              "titulo" => "Financiaci&#243;n"
            ]
          ]
        ]
        10 => array:1 [
          "titulo" => "Bibliograf&#237;a"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2009-08-05"
    "fechaAceptado" => "2009-09-09"
    "PalabrasClave" => array:2 [
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec92652"
          "palabras" => array:5 [
            0 => "Lactante"
            1 => "Bronquitis"
            2 => "Sibilantes recurrentes"
            3 => "Asma"
            4 => "Factores de riesgo"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec92651"
          "palabras" => array:5 [
            0 => "Infant"
            1 => "Bronchitis"
            2 => "Recurrent wheezing"
            3 => "Asthma"
            4 => "Risk factors"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p class="elsevierStyleSimplePara elsevierViewall">Determinar la incidencia de bronquitis sibilantes &#40;BS&#41; en los primeros 6 meses de vida en la poblaci&#243;n de Alzira &#40;Valencia&#41; y analizar los factores de riesgo asociados&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Estudio longitudinal prospectivo basado en una cohorte de 636 ni&#241;os&#44; incluidos consecutivamente entre marzo de 2007 y noviembre de 2008 tras el nacimiento&#46; Revisi&#243;n de historias cl&#237;nicas hospitalarias y ambulatorias a los 6 meses de vida y env&#237;o de cuestionarios por correo&#46; An&#225;lisis bivariante y multivariante de los distintos factores de riesgo registrados mediante regresi&#243;n de Cox&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">A los 6 meses&#44; el 25&#44;2&#37; de los ni&#241;os hab&#237;a presentado al menos un episodio de BS&#44; y el 5&#44;6&#37; hab&#237;a presentado 3 o m&#225;s episodios&#46; El 11&#44;6&#37; de los ni&#241;os recibi&#243; atenci&#243;n en urgencias en alguna ocasi&#243;n&#44; el 6&#44;6&#37; recibi&#243; corticoides orales y el 4&#37; precis&#243; ingreso hospitalario&#46; Se comportaron como factores de riesgo independientes de BS el sexo masculino &#40;riesgo relativo &#91;RR&#93;&#58; 2&#44;1&#59; intervalo de confianza &#91;IC&#93; del 95&#37;&#58; 1&#44;5-2&#44;9&#41;&#44; la menor edad gestacional &#40;RR&#58; 1&#44;1&#59; IC del 95&#37;&#58; 1&#44;0-1&#44;2&#41;&#44; el nacimiento en el tercer trimestre &#40;RR&#58; 3&#44;5&#59; IC del 95&#37;&#58; 2&#44;0-5&#44;9&#41;&#44; el cuarto trimestre &#40;RR&#58; 2&#44;0&#59; IC del 95&#37;&#58; 1&#44;1-3&#44;6&#41; del a&#241;o&#44; la menor edad materna &#40;RR&#58; 0&#44;9&#59; IC del 95&#37;&#58; 1&#44;0-1&#44;1&#41;&#44; la existencia de hermanos mayores &#40;RR&#58; 3&#44;1&#59; IC del 95&#37;&#58; 2&#44;2-4&#44;5&#41;&#44; la exposici&#243;n al tabaco &#40;RR&#58; 1&#44;4&#59; IC del 95&#37;&#58; 1&#44;0-2&#44;0&#41; y el antecedente de asma en la madre &#40;RR&#58; 1&#44;7&#59; IC del 95&#37;&#58; 1&#44;0-3&#44;0&#41;&#59; lo hicieron como factores protectores la lactancia materna durante un per&#237;odo igual o superior a 3 meses &#40;RR&#58; 0&#44;6&#59; IC del 95&#37;&#58; 0&#44;4-0&#44;8&#41; y el origen inmigrante de los padres &#40;RR&#58; 0&#44;6&#44; IC del 95&#37;&#58; 0&#44;4- 0&#44;9&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">La incidencia acumulada de BS en los primeros 6 meses de vida en nuestra poblaci&#243;n es elevada&#44; y supera la descrita en otros estudios&#46; La mayor parte de los factores de riesgo coinciden con los que se&#241;alan otros autores&#46; Destacan como m&#225;s importantes la existencia de hermanos mayores y el nacimiento en el tercer trimestre del a&#241;o&#44; lo que refleja el importante papel de las infecciones v&#237;ricas en la patogenia de las BS a estas edades&#46;</p>"
      ]
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p class="elsevierStyleSimplePara elsevierViewall">To determine the incidence of wheezing at 6 months of life in the town of Alzira &#40;Valencia&#44; Spain&#41;&#44; and to analyse associated risk factors&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p class="elsevierStyleSimplePara elsevierViewall">We included 636 newborns in a longitudinal birth cohort study between March 2007 and November 2008&#46; Data were collected from hospital and primary care medical records and from questionnaires sent at 6 months post-natal&#46; Bivariate and multivariate Cox regression analysis were performed to examine the risk factors associated with wheezing&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">At 6 months&#44; 25&#46;2&#37; of infants had had 1 or more episodes of wheezing&#44; whereas 5&#46;6&#37; had had 3 or more episodes&#46; Emergency visits were reported in 11&#46;6&#37; of the infants&#44; treatment with oral corticosteroids in 6&#46;6&#37; and admission to hospital in 4&#37;&#46; Independent risk factors for wheezing were male sex &#40;relative risk &#91;RR&#93;&#58; 2&#46;1&#44; 95&#37; confidence interval &#91;95&#37; CI&#93;&#58; 1&#46;5 to 2&#46;9&#41;&#44; younger gestational age &#40;RR&#58; 1&#46;1&#44; 95&#37; CI&#58; 1&#46;0 to 1&#46;2&#41;&#44; season of birth between July and September &#40;RR&#58; 3&#46;5&#44; 95&#37; CI&#58; 2&#46;0 to 5&#46;9&#41; and between October and December &#40;RR&#58; 2&#46;0&#44; 95&#37; CI&#58; 1&#46;1 to 3&#46;6&#41;&#44; younger maternal age &#40;RR&#58; 1&#46;0&#44; 95&#37; CI&#58; 1&#46;0 to 1&#46;1&#41;&#44; having siblings &#40;RR&#58; 3&#46;1&#44; 95&#37; CI&#58; 2&#46;2 to 4&#46;5&#41;&#44; exposure to smoke &#40;RR&#58; 1&#46;4&#44; 95&#37; CI&#58; 12&#46;0 to 2&#46;0&#41; and history of maternal asthma &#40;RR&#58; 1&#46;7&#44; 95&#37; CI&#58; 1&#46;0 to 3&#46;0&#41;&#46; Breast feeding for at least 3 months &#40;RR&#58; 0&#46;6&#44; 95&#37; CI&#58; 0&#46;4 to 0&#46;8&#41; and having immigrant parents &#40;RR&#58; 0&#46;6&#44; 95&#37; CI&#58; 0&#46;4 to 0&#46;9&#41; were protective against wheezing&#46;</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p class="elsevierStyleSimplePara elsevierViewall">A high cumulative incidence of wheezing in the first 6 months of life was found in our population&#44; in comparison with data reported in other cohort studies&#46; Estimated risk factors were generally in accordance with those described by other authors&#46; Having siblings and season of birth between July and September were the most important risk factors&#44; reflecting the role of viral infections in the pathogenesis of wheezing in early childhood&#46;</p>"
      ]
    ]
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      0 => array:7 [
        "identificador" => "fig1"
        "etiqueta" => "Figura 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1262
            "Ancho" => 1628
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        ]
        "descripcion" => array:1 [
          "es" => "<p class="elsevierStyleSimplePara elsevierViewall">Proceso de inclusi&#243;n de pacientes&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig2"
        "etiqueta" => "Figura 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
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          "es" => "<p class="elsevierStyleSimplePara elsevierViewall">Incidencia acumulada de bronquitis sibilantes y de la necesidad de asistencia sanitaria &#40;visitas a urgencias&#44; tratamiento con corticoides orales&#44; hospitalizaci&#243;n e ingresos en UCIP&#41;&#44; en relaci&#243;n con &#233;stas&#44; en los primeros 6 meses de vida&#46;</p>"
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Criterios de exclusi&#243;n</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><ul class="elsevierStyleList"><li class="elsevierStyleListItem"><span class="elsevierStyleLabel">&#8226;</span><p class="elsevierStylePara elsevierViewall">Prematuridad inferior a 34 semanas o peso al nacimiento menor de 1&#46;500<span class="elsevierStyleHsp" style=""></span>g</p></li><li class="elsevierStyleListItem"><span class="elsevierStyleLabel">&#8226;</span><p class="elsevierStylePara elsevierViewall">Enfermedad respiratoria perinatal que precise ventilaci&#243;n mec&#225;nica m&#225;s de 2 d&#237;as</p></li><li class="elsevierStyleListItem"><span class="elsevierStyleLabel">&#8226;</span><p class="elsevierStylePara elsevierViewall">Enfermedad neurol&#243;gica grave secundaria a asfixia perinatal u otras causas</p></li><li class="elsevierStyleListItem"><span class="elsevierStyleLabel">&#8226;</span><p class="elsevierStylePara elsevierViewall">Malformaciones mayores o cromosomopat&#237;as</p></li><li class="elsevierStyleListItem"><span class="elsevierStyleLabel">&#8226;</span><p class="elsevierStylePara elsevierViewall">Problema social grave</p></li><li class="elsevierStyleListItem"><span class="elsevierStyleLabel">&#8226;</span><p class="elsevierStylePara elsevierViewall">Cambio de poblaci&#243;n</p></li></ul>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:.5px"></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Grupos de pacientes</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><ul class="elsevierStyleList"><li class="elsevierStyleListItem"><span class="elsevierStyleLabel">&#8226;</span><p class="elsevierStylePara elsevierViewall">Sin episodios de bronquitis sibilantes&#58; pacientes que no han presentado episodios de bronquitis sibilantes desde el nacimiento hasta el momento del an&#225;lisis&#46;</p></li><li class="elsevierStyleListItem"><span class="elsevierStyleLabel">&#8226;</span><p class="elsevierStylePara elsevierViewall">Con episodios de bronquitis sibilantes&#58; pacientes que han presentado al menos un episodio de bronquitis sibilante durante ese per&#237;odo&#46;</p></li><li class="elsevierStyleListItem"><span class="elsevierStyleLabel">&#8226;</span><p class="elsevierStylePara elsevierViewall">Bronquitis sibilantes recurrentes o asma&#58; pacientes que han presentado 3 o m&#225;s episodios o que no est&#225;n libres de sibilancias durante per&#237;odos superiores a 2 meses&#46;</p></li></ul>&nbsp;\t\t\t\t\t\t\n
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        "tabla" => array:2 [
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Cuestionario basal</span></td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Factores perinatales</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Factores sociales</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Factores medioambientales</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Antecedentes familiares</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">Sexo&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">Tabaquismo materno en el embarazo&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Asma o atopia &#40;rinitis al&#233;rgica o dermatitis at&#243;pica&#41; en los padres y en los hermanos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">Tipo de lactancia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">Nivel de estudios<a class="elsevierStyleCrossRef" href="#tblfn2ast"><span class="elsevierStyleSup">¿</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">Tabaquismo paterno&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">Edad gestacional&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">Origen inmigrante&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Peso al nacimiento&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hermanos mayores&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Trimestre de nacimiento&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">Las mismas variables que a los 6 meses&#44; a las que se a&#241;ade el test alergol&#243;gico cualitativo y la asistencia a guarder&#237;a</td></tr></tbody></table>
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">25 &#40;4&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Julio-septiembre&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Octubre-diciembre&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">39 &#40;6&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Lactancia materna</span> &#8805;<span class="elsevierStyleBold">3 meses</span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">99 &#40;15&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">290 &#40;46&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">231 &#40;37&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">59 &#40;9&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Factores sociales</span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " colspan="4" align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">Edad de la madre &#40;a&#241;os&#41;</span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#60;20&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">27 &#40;4&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">18 &#40;2&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">9 &#40;1&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>20&#8211;24&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">84 &#40;13&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">66 &#40;10&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">18 &#40;2&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#62;24&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">379 &#40;61&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">130 &#40;21&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Nivel de estudios padres</span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Universitarios&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">166 &#40;26&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">135 &#40;21&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">31 &#40;5&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Secundarios&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">173 &#40;27&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Primarios&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">196 &#40;31&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">140 &#40;22&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">56 &#40;9&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sin estudios&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">27 &#40;4&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 &#40;2&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 &#40;1&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Hijo de inmigrantes</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">464 &#40;74&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">342 &#40;55&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">122 &#40;19&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">156 &#40;25&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">121 &#40;19&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35 &#40;5&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Hermanos mayores</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">341 &#40;55&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">285 &#40;46&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">56 &#40;9&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">279 &#40;45&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">178 &#40;28&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">101 &#40;16&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Factores medioambientales</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Tabaquismo durante el embarazo</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">476 &#40;76&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">358 &#40;57&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">118 &#40;19&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">144 &#40;23&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">105 &#40;16&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">39 &#40;6&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Exposici&#243;n a tabaco</span><a class="elsevierStyleCrossRef" href="#tblfn3ast"><span class="elsevierStyleSup">¿</span></a></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">255 &#40;43&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">203 &#40;34&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">52 &#40;8&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">334 &#40;56&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">238 &#40;40&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">96 &#40;16&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Mascotas en domicilio</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">425 &#40;73&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">321 &#40;55&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">104 &#40;18&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">151 &#40;26&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">113 &#40;19&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38 &#40;6&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Antecedentes familiares</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Asma en la madre</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">571 &#40;92&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">430 &#40;69&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">141 &#40;22&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49 &#40;7&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33 &#40;5&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16 &#40;2&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Asma en el padre</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">588 &#40;94&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">438 &#40;70&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">150 &#40;24&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32 &#40;5&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25 &#40;4&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;1&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Asma en hermanos</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">541 &#40;87&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">420 &#40;67&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">121 &#40;19&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">79 &#40;12&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">43 &#40;6&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36 &#40;6&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Atopia en la madre</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">557 &#40;89&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">423 &#40;68&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">134 &#40;21&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">63 &#40;10&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40 &#40;6&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23 &#40;3&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Atopia en el padre</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">538 &#40;86&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">396 &#40;63&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">142 &#40;22&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Primarios&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">1&#44;8&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">1&#44;1&#8211;2&#44;8&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sin estudios&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">2&#44;9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">1&#44;5&#8211;5&#46;9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&#60;0&#44;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Hijo de inmigrantes</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">620&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Referencia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">0&#44;8&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">0&#44;5&#8211;1&#44;2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">0&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Hermanos mayores</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">620&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Referencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">2&#44;4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">1&#44;7&#8211;3&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&#60;0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Factores medioambientales</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Tabaquismo durante el embarazo</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">620&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Referencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">1&#44;1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">0&#44;7&#8211;1&#44;6&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">0&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Exposici&#243;n a tabaco</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">589&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Referencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;1&#8211;2&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#44;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Mascotas en domicilio</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">587&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Referencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#44;7&#8211;1&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Antecedentes familiares</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Asma en la madre</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">620&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Referencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;8&#8211;2&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Asma en el padre</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">620&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Referencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;4&#8211;1&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Asma en hermanos</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">620&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Referencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;1&#8211;2&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#44;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Atopia en la madre</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">620&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Referencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;1&#8211;2&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#44;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;0&#8211;1&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#44;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Trimestre de nacimiento</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Enero-marzo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Referencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Abril-junio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;5&#8211;1&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Julio-septiembre&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;0&#8211;5&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Octubre-diciembre&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">1&#44;1&#8211;3&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Lactancia materna &#8805;3 meses</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Referencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;4&#8211;0&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#44;005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Factores sociales</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Edad de la madre</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;0&#8211;1&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#44;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Hijo de inmigrantes</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Referencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;4&#8211;0&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#44;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Hermanos mayores</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">3&#44;1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
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          "es" => "<p class="elsevierStyleSimplePara elsevierViewall">Factores de riesgo de bronquitis sibilantes &#40;al menos un episodio&#41; en los primeros 6 meses de vida&#46; An&#225;lisis multivariante</p>"
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                    0 => array:2 [
                      "titulo" => "Stabilization of asthma prevalence among adolescents and increase among schoolchildren &#40;ISAAC phases I and III&#41; in Spain"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Garc&#237;a-Marcos"
                            1 => "A&#46; Blanco"
                            2 => "G&#46; Garc&#237;a"
                            3 => "F&#46; Guill&#233;n-Grima"
                            4 => "C&#46; Gonz&#225;lez"
                            5 => "I&#46; Carvajal"
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15507099"
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                    0 => array:2 [
                      "titulo" => "Definition&#44; assessment and treatment of wheezing disorders in preschool children&#58; An evidence-based approach"
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                            0 => "P&#46;L&#46;P&#46; Brand"
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                            2 => "H&#46; Bisgaard"
                            3 => "A&#46;L&#46; Boner"
                            4 => "J&#46;A&#46; Castro-Rodriguez"
                            5 => "A&#46; Custovic"
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                    0 => array:2 [
                      "doi" => "10.1183/09031936.00002108"
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                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2008"
                        "volumen" => "32"
                        "paginaInicial" => "1096"
                        "paginaFinal" => "1110"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18827155"
                            "web" => "Medline"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "The International Study of Wheezing in Infants&#58; Questionnaire validation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Mallol"
                            1 => "L&#46; Garc&#237;a-Marcos"
                            2 => "V&#46; Aguirre"
                            3 => "A&#46; Mart&#237;nez-Torres"
                            4 => "V&#46; P&#233;rez-Fern&#225;ndez"
                            5 => "A&#46; Gallardo"
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                    0 => array:2 [
                      "doi" => "10.1159/000102613"
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                        "tituloSerie" => "Int Arch Allergy Immunol"
                        "fecha" => "2007"
                        "volumen" => "144"
                        "paginaInicial" => "44"
                        "paginaFinal" => "50"
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17505136"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Worldwide variations in the prevalence of asthma symptoms&#46; The International Study of Asthma and Allergies in Childhood &#40;ISAAC&#41;"
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                        0 => array:2 [
                          "colaboracion" => "Anonymous"
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                        "tituloSerie" => "Eur Respir J"
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                        "paginaFinal" => "335"
                        "link" => array:1 [
                          0 => array:2 [
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Accuracy of ImmunoCAP&#40;R&#41; Rapid in the diagnosis of allergic sensitization in children between 1 and 14 years with recurrent wheezing&#58; The IReNE study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; D&#237;az"
                            1 => "M&#46;J&#46; Torregrosa"
                            2 => "I&#46; Carvajal"
                            3 => "A&#46; Cano"
                            4 => "E&#46; Fos"
                            5 => "A&#46; Garc&#237;a"
                          ]
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                  ]
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                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "Pediatr Allergy Immunol"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Asthma and wheezing in the first six years of life"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "F&#46;D&#46; Mart&#237;nez"
                            1 => "A&#46;L&#46; Wright"
                            2 => "L&#46;M&#46; Taussig"
                            3 => "CJ&#46; Holberg"
                            4 => "M&#46; Halonen"
                            5 => "WJ&#46; Morgan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199501193320301"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1995"
                        "volumen" => "332"
                        "paginaInicial" => "133"
                        "paginaFinal" => "138"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7800004"
                            "web" => "Medline"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Avon Longitudinal Study of Parents and Children&#46; Risk factor associations with wheezing patterns in children followed longitudinally from birth to 3&#40;1&#47;2&#41; years"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "ALSPAC Study Team"
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Sherriff"
                            1 => "T&#46;J&#46; Peters"
                            2 => "J&#46; Henderson"
                            3 => "D&#46; Strachan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Epidemiol"
                        "fecha" => "2001"
                        "volumen" => "30"
                        "paginaInicial" => "1473"
                        "paginaFinal" => "1484"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11821366"
                            "web" => "Medline"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Antioxidant intake in pregnancy in relation to wheeze and eczema in the first two years of life"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46; Martindale"
                            1 => "G&#46; McNeill"
                            2 => "G&#46; Devereux"
                            3 => "D&#46; Campbell"
                            4 => "G&#46; Russell"
                            5 => "A&#46; Seaton"
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                    0 => array:2 [
                      "doi" => "10.1164/rccm.200402-220OC"
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                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2005"
                        "volumen" => "171"
                        "paginaInicial" => "121"
                        "paginaFinal" => "128"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15531754"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "A longitudinal analysis on the association between antibiotic use&#44; intestinal microflora&#44; and wheezing during the first year of life"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46;L&#46; Verhulst"
                            1 => "C&#46; Vael"
                            2 => "C&#46; Beunckens"
                            3 => "V&#46; Nelen"
                            4 => "H&#46; Goossens"
                            5 => "K&#46; Desager"
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                        ]
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                    0 => array:2 [
                      "doi" => "10.1080/02770900802339734"
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                        "tituloSerie" => "J Asthma"
                        "fecha" => "2008"
                        "volumen" => "45"
                        "paginaInicial" => "828"
                        "paginaFinal" => "832"
                        "link" => array:1 [
                          0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Pre- and postnatal parental smoking and wheeze in infancy&#58; cross cultural differences&#46; Avon Study of Parents and Children &#40;ALSPAC&#41; Study Team&#44; European Longitudinal Study of Pregnancy and Childhood &#40;ELSPAC&#41; Co-ordinating Centre"
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                          "etal" => false
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                            1 => "A&#46; Sherriff"
                            2 => "K&#46; Northstone"
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Incidencia y factores de riesgo de bronquitis sibilantes en los primeros 6 meses de vida en una cohorte de Alzira (Valencia)
Incidence of wheezing and associated risk factors in the first 6 months of life of a cohort in Valencia (Spain)
S. Pérez Tarazonaa,
Autor para correspondencia
saperez@ono.com

Autor para correspondencia.
, J. Alfonso Diegoa, A. Amat Madramanyb, L. Chofre Escrihuelab, E. Lucas Sáezc, R. Bou Monterded
a Unidad de Neumología Pediátrica, Hospital Universitario de La Ribera, Alzira, Valencia, España
b Servicio de Pediatría, Hospital Universitario de La Ribera, Alzira, Valencia, España
c Centro de Salud de Alzira, Valencia, España
d Servicio de Medicina Preventiva, Hospital Universitario de La Ribera, Alzira, Valencia, España
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debido en parte a la falta de un criterio un&#225;nime para definir el asma en las etapas precoces de la vida&#46; Por este motivo&#44; la informaci&#243;n procedente de la mayor parte de los estudios a estas edades suele expresarse en t&#233;rminos de bronquitis sibilantes &#40;BS&#41;&#44; sibilancias recurrentes o enfermedades que cursan con sibilancias<a class="elsevierStyleCrossRef" href="#bib2"><span class="elsevierStyleSup">2</span></a>&#46;</p><p class="elsevierStylePara elsevierViewall">Entre los pediatras existe un inter&#233;s creciente por el conocimiento de la epidemiolog&#237;a e historia natural de las BS del lactante y el preescolar&#44; debido principalmente a&#58; <ul class="elsevierStyleList"><li class="elsevierStyleListItem"><span class="elsevierStyleLabel">&#8226;</span><p class="elsevierStylePara elsevierViewall">Su elevada prevalencia&#58; es uno de los principales motivos de consulta tanto en el &#225;mbito ambulatorio como en el hospitalario&#46;</p></li><li class="elsevierStyleListItem"><span class="elsevierStyleLabel">&#8226;</span><p class="elsevierStylePara elsevierViewall">La existencia de diversos fenotipos de BS&#44; cada uno con sus propios factores de riesgo y su curso evolutivo&#44; dif&#237;ciles de diferenciar en la pr&#225;ctica cl&#237;nica&#46;</p></li><li class="elsevierStyleListItem"><span class="elsevierStyleLabel">&#8226;</span><p class="elsevierStylePara elsevierViewall">La influencia de la intervenci&#243;n precoz de algunos factores&#44; como las infecciones virales&#44; la alimentaci&#243;n y la exposici&#243;n a al&#233;rgenos ambientales en el desarrollo posterior de asma&#46;</p></li></ul></p><p class="elsevierStylePara elsevierViewall">Pocos estudios epidemiol&#243;gicos han analizado en nuestro medio la prevalencia de las BS en estas edades&#44; as&#237; como los posibles factores de riesgo asociados&#46; En la actualidad se est&#225; desarrollando el Estudio Internacional de las Sibilancias en el Lactante en el que participan Espa&#241;a&#44; Portugal y varios pa&#237;ses de Latinoam&#233;rica<a class="elsevierStyleCrossRef" href="#bib3"><span class="elsevierStyleSup">3</span></a>&#46; Es el primer estudio multic&#233;ntrico internacional a estas edades y est&#225; basado en la metodolog&#237;a del estudio ISAAC<a class="elsevierStyleCrossRef" href="#bib4"><span class="elsevierStyleSup">4</span></a>&#46;</p><p class="elsevierStylePara elsevierViewall">El presente trabajo forma parte del proyecto de investigaci&#243;n RESPIR &#40;Registro y An&#225;lisis Epidemiol&#243;gico de las Sibilancias y el Asma en una Poblaci&#243;n Infantil de La Ribera&#41;&#44; cuyo principal objetivo es determinar la incidencia de las BS en el lactante &#40;fase <span class="elsevierStyleSmallCaps">i</span>&#41; y preescolar &#40;fase <span class="elsevierStyleSmallCaps">ii</span>&#41; en la poblaci&#243;n de Alzira &#40;Valencia&#41; y sus repercusiones &#40;visitas a urgencias&#44; hospitalizaciones y consumo de corticoides orales&#41;&#46; Otros objetivos son analizar los posibles factores de riesgo asociados y describir su historia natural en nuestra poblaci&#243;n&#46; En este art&#237;culo se presentan los resultados del an&#225;lisis efectuado a los 6 meses de edad&#44; aunque a continuaci&#243;n se expone la metodolog&#237;a de la fase <span class="elsevierStyleSmallCaps">i</span> del proyecto RESPIR en su conjunto&#46;</p></span><span class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Dise&#241;o</span><p class="elsevierStylePara elsevierViewall">Estudio longitudinal prospectivo de cohortes&#44; basado en una cohorte de nacimiento&#46; Realizado en el Servicio de Pediatr&#237;a del Hospital Universitario de La Ribera &#40;Alzira&#41;&#44; perteneciente al Departamento de Salud 11 de la Comunidad Valenciana&#46; Revisado y aprobado por la Comisi&#243;n de Investigaci&#243;n del Hospital&#46;</p></span><span class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Pacientes</span><p class="elsevierStylePara elsevierViewall">Reci&#233;n nacidos &#40;RN&#41; procedentes de la poblaci&#243;n de Alzira&#44; con fecha de nacimiento entre marzo de 2007 y noviembre de 2008&#46; En la <a class="elsevierStyleCrossRef" href="#tbl1">tabla 1</a> se especifican los criterios de exclusi&#243;n y la definici&#243;n de los distintos grupos de pacientes&#46;</p><elsevierMultimedia ident="tbl1"></elsevierMultimedia></span><span class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">M&#233;todos</span><span class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Etapas de la fase <span class="elsevierStyleSmallCaps">i</span> del proyecto RESPIR</span><p class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList"><li class="elsevierStyleListItem"><span class="elsevierStyleLabel">&#8226;</span><p class="elsevierStylePara elsevierViewall">Etapa 1&#46; Informaci&#243;n sobre el proyecto a los padres o tutores en la planta de Maternidad&#46;</p><p class="elsevierStylePara elsevierViewall">Explicaci&#243;n verbal y por escrito de los detalles del estudio&#44; seguida de la obtenci&#243;n del consentimiento firmado para su participaci&#243;n&#44; previo al alta del RN&#46; Cuestionario sobre antecedentes de asma&#44; rinitis y dermatitis at&#243;pica en la familia basado en el estudio ISAAC<a class="elsevierStyleCrossRef" href="#bib4"><span class="elsevierStyleSup">4</span></a>&#44; tabaquismo y otras variables sociodemogr&#225;ficas que se detallan en la <a class="elsevierStyleCrossRef" href="#tbl2">tabla 2</a>&#46;</p><elsevierMultimedia ident="tbl2"></elsevierMultimedia></li><li class="elsevierStyleListItem"><span class="elsevierStyleLabel">&#8226;</span><p class="elsevierStylePara elsevierViewall">Etapa 2&#46; An&#225;lisis de los 6 primeros meses de vida&#46;</p><p class="elsevierStylePara elsevierViewall">Revisi&#243;n de las historias cl&#237;nicas informatizadas de atenci&#243;n especializada &#40;Sistema Integrado de Ayuda Asistencial &#91;SIAS&#93;&#41; y primaria &#40;Abucasis&#41; del Departamento 11&#44; con registro de visitas a urgencias hospitalarias y ambulatorias&#44; hospitalizaciones y visitas al pediatra de atenci&#243;n primaria relacionadas con la aparici&#243;n de BS durante los primeros 6 meses de vida&#46; Paralelamente&#44; se env&#237;a por correo un cuestionario modificado del estudio ISAAC&#44; en el que se interroga a los padres sobre la aparici&#243;n de episodios de sibilancias desde el nacimiento del ni&#241;o y sus repercusiones&#44; y otras cuestiones relacionadas con posibles factores de riesgo asociados &#40;<a class="elsevierStyleCrossRef" href="#tbl2">tabla 2</a>&#41;&#46; En caso de no conseguir informaci&#243;n mediante estas fuentes&#44; se recurre a la encuesta telef&#243;nica&#44; dejando transcurrir un m&#225;ximo de 6 meses para obtener respuesta&#46; Se ha considerado como BS todo episodio agudo de sibilancias que un m&#233;dico refleje en la historia cl&#237;nica o que los los padres reflejen en el cuestionario &#40;&#8220;pitos o silbidos en el pecho&#8221;&#41;&#46;</p></li><li class="elsevierStyleListItem"><span class="elsevierStyleLabel">&#8226;</span><p class="elsevierStylePara elsevierViewall">Etapa 3&#46; An&#225;lisis del primer a&#241;o de vida&#46;</p><p class="elsevierStylePara elsevierViewall">Registro de la informaci&#243;n relativa a los 6 meses siguientes hasta llegar al a&#241;o de edad y env&#237;o por correo de un cuestionario similar al de la fase anterior&#44; incluyendo como factor de riesgo en estudio la asistencia a la guarder&#237;a&#46; Junto con el cuestionario&#44; se propone la realizaci&#243;n de un test alergol&#243;gico cualitativo &#40;ImmunoCAP<span class="elsevierStyleSup">&#174;</span> Rapid&#44; Phadia AB&#44; Uppsala&#44; Suecia&#41;&#44; y se adjunta informaci&#243;n al respecto<a class="elsevierStyleCrossRef" href="#bib5"><span class="elsevierStyleSup">5</span></a>&#46; En aquellos casos en los que no se obtiene informaci&#243;n mediante los archivos inform&#225;ticos y el cuestionario&#44; se recurre de nuevo a la encuesta telef&#243;nica&#46; Si se agota esta v&#237;a sin conseguir informaci&#243;n&#44; se considera al paciente p&#233;rdida del estudio&#46;</p></li></ul></p></span><span class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">An&#225;lisis estad&#237;stico</span><p class="elsevierStylePara elsevierViewall">Para el c&#225;lculo del tama&#241;o muestral se ha estimado una incidencia de BS del 30&#37; en los primeros 3 a&#241;os de vida<a class="elsevierStyleCrossRef" href="#bib6"><span class="elsevierStyleSup">6</span></a> y se ha considerado una diferencia absoluta del 15&#37; entre la poblaci&#243;n expuesta y la poblaci&#243;n no expuesta como la m&#237;nima que se debe detectar para considerarla importante desde el punto de vista cl&#237;nico y epidemiol&#243;gico&#46; Utilizando una potencia del 90&#37; y una precisi&#243;n del 5&#37;&#44; el n&#250;mero de sujetos en estudio es de 460&#46; Teniendo en cuenta las p&#233;rdidas potenciales&#44; el n&#250;mero final de sujetos en estudio es de 631&#46;</p><p class="elsevierStylePara elsevierViewall">Los datos descriptivos de las variables &#40;<a class="elsevierStyleCrossRef" href="#tbl2">tabla 2</a>&#41; se expresan como porcentajes o como media con su desviaci&#243;n est&#225;ndar &#40;DE&#41;&#46; Se han calculado la incidencia acumulada&#44; la tasa de incidencia de la variable principal y la incidencia acumulada de otras variables de inter&#233;s&#46; Para la comparaci&#243;n de las variables cualitativas se ha utilizado el test de chi cuadrado o el test de Fisher&#46; La comparaci&#243;n de las variables cuantitativas se ha realizado mediante el test t de Student&#46; Se ha llevado a cabo un an&#225;lisis bivariante y posteriormente multivariante mediante regresi&#243;n de Cox para el an&#225;lisis de los factores de riesgo de sibilancias&#46; Las variables cuantitativas se han categorizado s&#243;lo en caso de mejorar la precisi&#243;n del modelo en el que intervienen&#46;</p><p class="elsevierStylePara elsevierViewall">En todos los casos se consider&#243; estad&#237;sticamente significativo un valor de p &#60;0&#44;05&#46; El an&#225;lisis se ha realizado con el paquete estad&#237;stico SPSS&#44; versi&#243;n 15&#46;0 para Windows&#46;</p></span></span><span class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Resultados</span><span class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Descriptivos</span><p class="elsevierStylePara elsevierViewall">La muestra inicial est&#225; compuesta por 636 ni&#241;os &#40;<a class="elsevierStyleCrossRef" href="#fig1">fig&#46; 1</a>&#41;&#46; En el momento del an&#225;lisis se hab&#237;an producido 16 p&#233;rdidas de seguimiento &#40;2&#44;5&#37;&#41;&#46; En el 47&#37; de los casos se respondi&#243; el cuestionario remitido a los 6 meses&#46; La informaci&#243;n sobre las variables pudo completarse en su totalidad en el 94&#37; de los pacientes&#46; Los datos descriptivos seg&#250;n la existencia o no de sibilancias quedan reflejados en la <a class="elsevierStyleCrossRef" href="#tbl3">tabla 3</a>&#46; El promedio de edad de las madres fue de 29&#44;5 a&#241;os &#40;DE&#58; 5&#44;5&#41;&#44; y las de origen inmigrante fueron significativamente m&#225;s j&#243;venes &#40;promedio de 26&#44;6 versus 30&#44;6 a&#241;os&#59; p&#60;0&#44;001&#41;&#46; No hubo diferencias significativas entre ambos grupos en lo que respecta al peso y la edad gestacional&#46; Los hijos de madres inmigrantes suponen un 25&#37; del total de la muestra&#46; En la mayor parte de los casos proceden de pa&#237;ses de Europa del Este &#40;52&#37;&#41;&#44; seguido por Latinoam&#233;rica y pa&#237;ses del Magreb en igual proporci&#243;n &#40;21&#37;&#41; y a m&#225;s distancia por otros pa&#237;ses de Asia y &#193;frica&#46; El 65&#37; de los ni&#241;os recib&#237;a lactancia materna en el momento del alta de la maternidad&#46; Este porcentaje fue significativamente mayor en los hijos de madres inmigrantes &#40;el 85 versus el 54&#37;&#59; p&#60;0&#44;001&#41;&#46; A los 3 meses&#44; s&#243;lo el 47&#37; de los ni&#241;os recib&#237;a lactancia materna&#44; y se manten&#237;a el predominio en los hijos de inmigrantes &#40;el 65 versus el 41&#37;&#59; p&#60;0&#44;001&#41;&#46;</p><elsevierMultimedia ident="fig1"></elsevierMultimedia><elsevierMultimedia ident="tbl3"></elsevierMultimedia></span><span class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Incidencia de bronquitis sibilantes y otros episodios de inter&#233;s</span><p class="elsevierStylePara elsevierViewall">La incidencia acumulada de BS &#40;al menos un episodio en los primeros 6 meses&#41; fue del 25&#44;2&#37;&#44; lo que equivale a una tasa de incidencia absoluta de 7&#44;8 episodios por mes y a una tasa de incidencia relativa de 14 episodios por 100 pacientes&#47;mes&#46; El promedio de edad del primer episodio fue de 3&#44;7 meses &#40;DE&#58; 1&#44;5&#41;&#46; La incidencia de BS recurrentes &#40;asma&#41; fue del 5&#44;6&#37;&#46; El 11&#44;6&#37; de los pacientes precis&#243; &#8212;al menos en una ocasi&#243;n&#8212; acudir a urgencias&#59; el 6&#44;6&#37; recibi&#243; tratamiento corticoideo oral&#44; el 4&#37; requiri&#243; ingreso hospitalario y el 0&#44;6&#37; requiri&#243; traslado a la UCI pedi&#225;trica &#40;<a class="elsevierStyleCrossRef" href="#fig2">fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig2"></elsevierMultimedia></span><span class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">An&#225;lisis bivariante</span><p class="elsevierStylePara elsevierViewall">Los resultados quedan resumidos en la <a class="elsevierStyleCrossRef" href="#tbl4">tabla 4</a>&#44; y expresan el riesgo relativo &#40;RR&#41; de cada factor de riesgo sobre la categor&#237;a de referencia con su intervalo de confianza &#40;IC&#41; del 95&#37;&#46; Seg&#250;n este an&#225;lisis&#44; se comportan como factores de riesgo de BS el sexo masculino&#44; la menor edad gestacional&#44; el nacimiento en el tercer y cuarto trimestre del a&#241;o&#44; el menor nivel de estudios de los padres&#44; la existencia de hermanos mayores&#44; el antecedente de asma en &#233;stos y de atopia en la madre y la exposici&#243;n al tabaco&#59; se comporta como factor protector la lactancia materna durante un per&#237;odo igual o superior a 3 meses&#46;</p><elsevierMultimedia ident="tbl4"></elsevierMultimedia></span><span class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">An&#225;lisis multivariante</span><p class="elsevierStylePara elsevierViewall">En la <a class="elsevierStyleCrossRef" href="#tbl5">tabla 5</a> se exponen las variables incluidas en el modelo final&#46; Algunos factores&#44; como la edad materna&#44; el peso al nacimiento y el tabaquismo durante el embarazo se han tenido en cuenta en el an&#225;lisis multivariante por cuestiones te&#243;ricas&#44; aunque resultaran ser no significativos en el an&#225;lisis bivariante&#46;</p><elsevierMultimedia ident="tbl5"></elsevierMultimedia><p class="elsevierStylePara elsevierViewall">Dada la colinealidad entre los factores &#8220;existencia de hermanos mayores&#8221; y &#8220;asma en los hermanos&#8221;&#44; se analizaron junto con el resto de los factores en modelos separados&#46; El modelo con mayor capacidad predictiva es el que incluye el factor &#8220;existencia de hermanos mayores&#8221; y&#44; por tanto&#44; ha sido el seleccionado&#46;</p><p class="elsevierStylePara elsevierViewall">Seg&#250;n este an&#225;lisis&#44; y teniendo en cuenta los distintos factores de confusi&#243;n&#44; se comportan como factores de riesgo de BS el sexo masculino&#44; la menor edad gestacional&#44; el nacimiento en el tercer y cuarto trimestre del a&#241;o&#44; la menor edad materna&#44; la existencia de hermanos mayores&#44; la exposici&#243;n al tabaco y el antecedente de asma en la madre&#59; se comportan como factores protectores la lactancia materna durante un per&#237;odo igual o superior a 3 meses y el origen inmigrante de los padres&#46;</p></span></span><span class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discusi&#243;n</span><p class="elsevierStylePara elsevierViewall">La incidencia acumulada de BS en los primeros 6 meses de vida en nuestra poblaci&#243;n es algo superior a la reflejada en otros estudios prospectivos&#46; El estudio ALSPAC &#40;Avon Longitudinal Study of Parents and Children&#41;&#44; llevado a cabo en Bristol &#40;Reino Unido&#41;&#44; estableci&#243; una incidencia a los 6 meses de vida del 21&#44;5&#37;<a class="elsevierStyleCrossRef" href="#bib7"><span class="elsevierStyleSup">7</span></a>&#46; Martindale et al siguieron a una cohorte de RN en Aberdeen &#40;Escocia&#41;&#44; y en este caso la incidencia fue del 19&#44;1&#37;<a class="elsevierStyleCrossRef" href="#bib8"><span class="elsevierStyleSup">8</span></a>&#46; En el estudio de Verhulst et al&#44; realizado en Wilrijk &#40;B&#233;lgica&#41;&#44; el 18&#44;4&#37; de los ni&#241;os present&#243; al menos un episodio de BS en los primeros 6 meses de vida<a class="elsevierStyleCrossRef" href="#bib9"><span class="elsevierStyleSup">9</span></a>&#46; Los valores m&#225;s bajos a esta edad son los publicados por Henderson et al&#44; procedentes de un estudio realizado en 2 poblaciones de la Rep&#250;blica Checa&#44; en el que la incidencia fue del 10&#44;3&#37;<a class="elsevierStyleCrossRef" href="#bib10"><span class="elsevierStyleSup">10</span></a>&#46;</p><p class="elsevierStylePara elsevierViewall">Nuestras cifras superan incluso a las observadas en algunos trabajos en los que el punto de corte se estableci&#243; en el primer a&#241;o de vida&#46; En la cohorte sueca estudiada por Alm et al&#44; el 20&#44;2&#37; de los lactantes hab&#237;a presentado al menos un episodio de BS en los primeros 12 meses&#44; mientras que el 5&#44;3&#37; hab&#237;a presentado 3 o m&#225;s episodios<a class="elsevierStyleCrossRef" href="#bib11"><span class="elsevierStyleSup">11</span></a>&#44; cifra que se asemeja bastante a la observada en nuestra poblaci&#243;n a los 6 meses&#46; La incidencia de bronquiolitis en el primer a&#241;o de vida en la cohorte de Tucson fue del 19&#44;6&#37;<a class="elsevierStyleCrossRef" href="#bib12"><span class="elsevierStyleSup">12</span></a>&#44; mientras que en el estudio de Verhulst et al el 23&#44;5&#37; de los ni&#241;os hab&#237;a presentado alg&#250;n episodio de sibilancias en el mismo per&#237;odo<a class="elsevierStyleCrossRef" href="#bib9"><span class="elsevierStyleSup">9</span></a>&#46; En nuestro medio disponemos de los datos del estudio AMICS &#40;Asthma Multicenter International Cohort Study&#41;<a class="elsevierStyleCrossRef" href="#bib13"><span class="elsevierStyleSup">13</span></a>&#44; en el que la incidencia acumulada de BS en el primer a&#241;o de vida fue del 28&#37; en Barcelona y del 24&#37; en Menorca&#46; Por otro lado&#44; la prevalencia de episodios de sibilancias en el lactante seg&#250;n los primeros datos del Estudio Internacional de las Sibilancias en el Lactante oscila entre el 28&#44;7&#37; en Valencia y el 39&#44;1&#37; en Cartagena&#46; Si se trata de sibilancias recurrentes &#40;3 o m&#225;s episodios&#41;&#44; las cifras m&#225;s bajas vuelven a registrarse en Valencia &#40;12&#44;1&#37;&#41; y las m&#225;s altas en Bilbao &#40;18&#44;6&#37;&#41;&#46; En lo que respecta a visitas a urgencias e ingresos hospitalarios&#44; Valencia alcanza las cifras m&#225;s altas&#44; con una prevalencia del 21&#44;4 y el 5&#44;4&#37; respectivamente<a class="elsevierStyleCrossRef" href="#bib14"><span class="elsevierStyleSup">14</span></a>&#46;</p><p class="elsevierStylePara elsevierViewall">Diversos autores han se&#241;alado el tabaquismo materno durante el embarazo como factor de riesgo de BS en los primeros a&#241;os de vida<a class="elsevierStyleCrossRefs" href="#bib15"><span class="elsevierStyleSup">15&#8211;19</span></a>&#44; aunque en este estudio no se ha observado esa asociaci&#243;n&#46; Dado que la informaci&#243;n sobre el tabaquismo procede exclusivamente de la encuesta verbal realizada poco despu&#233;s del parto&#44; podr&#237;a pensarse en la existencia de un sesgo debido a un menor reconocimiento del h&#225;bito tab&#225;quico por parte de la madre&#46; Aun asumiendo que los cuestionarios sobre tabaquismo se ajustan bastante a la realidad<a class="elsevierStyleCrossRef" href="#bib20"><span class="elsevierStyleSup">20</span></a>&#44; reconocemos como limitaci&#243;n de nuestro estudio el hecho de no haber empleado medidas objetivas&#44; como los niveles de cotinina en orina o en plasma en la madre o el ni&#241;o&#46; En cualquier caso&#44; la variable &#8220;exposici&#243;n al tabaco&#8221;&#44; que tiene en cuenta tanto el tabaquismo prenatal como el posnatal en la madre o el padre&#44; aument&#243; de forma significativa el riesgo de BS en comparaci&#243;n con la nula exposici&#243;n&#46;</p><p class="elsevierStylePara elsevierViewall">La falta de asociaci&#243;n entre el peso al nacimiento y los episodios de sibilancias en los primeros 6 meses de vida se ha descrito en otros estudios&#44; aunque para el caso de las sibilancias de inicio tard&#237;o &#40;pasados los 6 meses&#41; el riesgo es mayor en los ni&#241;os con menor peso al nacer<a class="elsevierStyleCrossRef" href="#bib8"><span class="elsevierStyleSup">8</span></a>&#46; Linnenberg et al hallaron una mayor incidencia de BS en ni&#241;os de bajo peso durante los primeros 18 meses de vida&#44; independientemente de la edad de inicio<a class="elsevierStyleCrossRef" href="#bib21"><span class="elsevierStyleSup">21</span></a>&#46; En cambio&#44; Taveras et al no apreciaron ninguna relaci&#243;n entre este antecedente y la aparici&#243;n de BS durante los 2 primeros a&#241;os de vida<a class="elsevierStyleCrossRef" href="#bib22"><span class="elsevierStyleSup">22</span></a>&#46; Al margen de estas discrepancias&#44; hay que se&#241;alar que s&#243;lo el 7&#37; de los ni&#241;os de nuestra muestra tuvo un peso al nacimiento menor de 2&#46;500<span class="elsevierStyleHsp" style=""></span>g&#46; Por eso es probable que peque&#241;as diferencias con el resto de los ni&#241;os no alcancen significaci&#243;n estad&#237;stica&#46; Adem&#225;s&#44; la mayor&#237;a de los trabajos que encuentran una asociaci&#243;n entre el peso al nacimiento y la aparici&#243;n de sibilancias se basan en poblaciones de edad gestacional y peso muy inferiores a los de nuestro estudio<a class="elsevierStyleCrossRefs" href="#bib23"><span class="elsevierStyleSup">23&#8211;27</span></a>&#46;</p><p class="elsevierStylePara elsevierViewall">Algunos factores de riesgo&#44; como la edad materna&#44; el antecedente de asma materno y el origen inmigrante&#44; no asociados a la aparici&#243;n de BS en el an&#225;lisis bivariante&#44; pasan a formar parte del modelo multivariante&#46; En el caso de la edad de la madre&#44; se comportaron como factores de confusi&#243;n la existencia de hermanos mayores y el origen inmigrante&#46; Efectivamente&#44; las madres mult&#237;paras suelen ser m&#225;s a&#241;osas que las prim&#237;paras&#44; con lo que el posible factor protector de la edad queda contrarrestado por el riesgo que supone tener hermanos mayores&#46; Adem&#225;s&#44; el promedio de edad de las madres inmigrantes fue significativamente menor que el resto&#46; Dado que el riesgo de BS fue inferior en los ni&#241;os de origen inmigrante&#44; el posible efecto negativo de la juventud materna queda de esta manera compensado&#46; Al ajustar el modelo incluyendo estas variables&#44; la edad materna se comporta como un factor protector independiente sobre la aparici&#243;n de BS&#44; como han se&#241;alado otros autores<a class="elsevierStyleCrossRef" href="#bib28"><span class="elsevierStyleSup">28</span></a>&#46; En cuanto al antecedente de asma en la madre&#44; la existencia de hermanos mayores vuelve a actuar como principal factor de confusi&#243;n&#46; Se ha dado la circunstancia de que las madres con antecedentes de asma presentan un &#250;nico hijo en una proporci&#243;n significativamente mayor que el resto de las madres&#46; De esta manera&#44; el efecto negativo del antecedente materno de asma queda enmascarado en el an&#225;lisis bivariante por el efecto protector derivado de la ausencia de hermanos mayores&#46;</p><p class="elsevierStylePara elsevierViewall">Hay que destacar el efecto protector que supone ser hijo de inmigrante sobre la aparici&#243;n de BS&#44; despu&#233;s de ajustar seg&#250;n distintos factores como la lactancia materna&#44; la existencia de hermanos mayores&#44; la edad de la madre y el nivel educacional&#46; Migliore et al tambi&#233;n observaron una menor incidencia de bronquitis en los 2 primeros a&#241;os de vida en los ni&#241;os italianos hijos de padres inmigrantes&#44; sin una explicaci&#243;n clara que justificara este hallazgo<a class="elsevierStyleCrossRef" href="#bib29"><span class="elsevierStyleSup">29</span></a>&#46; Cabr&#237;a pensar en la posible influencia de determinados factores relacionados con el estilo de vida o factores gen&#233;ticos que actuar&#237;an como protectores frente a las sibilancias&#46; En este sentido&#44; debemos se&#241;alar que la mayor parte de los inmigrantes de nuestro estudio proceden de Europa del Este&#44; cuyos pa&#237;ses presentan una menor prevalencia de asma<a class="elsevierStyleCrossRef" href="#bib4"><span class="elsevierStyleSup">4</span></a>&#46; En cualquier caso&#44; hubiera sido interesante disponer de estudios de funci&#243;n pulmonar al nacimiento&#44; con el fin de detectar posibles diferencias entre ni&#241;os de una u otra procedencia&#46;</p><p class="elsevierStylePara elsevierViewall">El nivel educacional ha quedado descartado del modelo final&#46; En este caso&#44; los principales factores de confusi&#243;n han sido la exposici&#243;n al tabaco&#44; la menor edad gestacional y la existencia de hermanos mayores&#46; Todos ellos son factores de riesgo independientes de BS y su participaci&#243;n es mayor conforme disminuye el nivel educacional&#46; Tras ajustar por estas variables&#44; el efecto del nivel educacional sobre la aparici&#243;n de BS desaparece y su inclusi&#243;n en el modelo final no aumenta la capacidad predictiva de &#233;ste&#46;</p><p class="elsevierStylePara elsevierViewall">El antecedente de atopia en la madre queda excluido debido al efecto de confusi&#243;n generado por el trimestre de nacimiento&#46; Casualmente&#44; la proporci&#243;n de ni&#241;os nacidos en el trimestre de mayor riesgo &#8212;el tercero&#8212;&#44; fue mucho mayor en los hijos de madres con antecedentes de atopia&#44; lo que hace que exista una asociaci&#243;n espuria entre este antecedente y la aparici&#243;n de BS&#46;</p><p class="elsevierStylePara elsevierViewall">Tambi&#233;n quedan descartados el antecedente de asma y atopia en el padre&#44; la atopia en los hermanos y la existencia de dermatitis at&#243;pica en el ni&#241;o&#44; lo que estar&#237;a en concordancia con lo que han observado autores como Linnenberg et al<a class="elsevierStyleCrossRef" href="#bib21"><span class="elsevierStyleSup">21</span></a>&#46;</p><p class="elsevierStylePara elsevierViewall">El resto de los factores que forman parte del modelo final &#8212;sexo masculino&#44; tiempo de lactancia materna&#44; existencia de hermanos mayores&#44; trimestre de nacimiento y edad gestacional&#8212; coinciden con los ya se&#241;alados en anteriores publicaciones<a class="elsevierStyleCrossRefs" href="#bib6"><span class="elsevierStyleSup">6&#8211;12</span></a>&#46;</p><p class="elsevierStylePara elsevierViewall">En conclusi&#243;n&#44; hemos detectado una alta incidencia de BS en los primeros 6 meses de vida&#44; que supera la de otras poblaciones europeas&#46; Los factores de riesgo independientes para la aparici&#243;n de BS son el sexo masculino&#44; la menor edad gestacional&#44; el nacimiento en el tercer y cuarto trimestre del a&#241;o&#44; la menor edad materna&#44; la existencia de hermanos mayores&#44; la exposici&#243;n al tabaco y el antecedente de asma en la madre&#46; Los factores protectores son la lactancia materna durante un per&#237;odo igual o superior a 3 meses y el origen inmigrante de los padres&#46; El riesgo m&#225;s alto corresponde a la existencia de hermanos mayores y al nacimiento en el tercer trimestre del a&#241;o&#44; lo que refleja el importante papel de las infecciones v&#237;ricas como desencadenante de las BS a estas edades&#46; Es objeto de futuros an&#225;lisis averiguar la influencia de &#233;stos y otros factores sobre el riesgo de BS en edades posteriores&#46;</p><span class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicto de intereses</span><p class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span><span class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Financiaci&#243;n</span><p class="elsevierStylePara elsevierViewall">Proyecto financiado por el Departamento de Salud de Alzira &#40;Becas 2007&#41; y por la Sociedad Espa&#241;ola de Neumolog&#237;a Pedi&#225;trica &#40;Premios GSK&#44; 2007&#41;&#46;</p></span></span></span>"
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          "titulo" => array:5 [
            0 => "Resumen"
            1 => "Objetivos"
            2 => "M&#233;todos"
            3 => "Resultados"
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          "titulo" => array:5 [
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        3 => array:2 [
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        4 => array:1 [
          "titulo" => "Introducci&#243;n"
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        5 => array:1 [
          "titulo" => "Dise&#241;o"
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        6 => array:1 [
          "titulo" => "Pacientes"
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        7 => array:2 [
          "titulo" => "M&#233;todos"
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            0 => array:1 [
              "titulo" => "Etapas de la fase i del proyecto RESPIR"
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            1 => array:1 [
              "titulo" => "An&#225;lisis estad&#237;stico"
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          "titulo" => "Resultados"
          "secciones" => array:4 [
            0 => array:1 [
              "titulo" => "Descriptivos"
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            1 => array:1 [
              "titulo" => "Incidencia de bronquitis sibilantes y otros episodios de inter&#233;s"
            ]
            2 => array:1 [
              "titulo" => "An&#225;lisis bivariante"
            ]
            3 => array:1 [
              "titulo" => "An&#225;lisis multivariante"
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        9 => array:2 [
          "titulo" => "Discusi&#243;n"
          "secciones" => array:2 [
            0 => array:1 [
              "titulo" => "Conflicto de intereses"
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            1 => array:1 [
              "titulo" => "Financiaci&#243;n"
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          ]
        ]
        10 => array:1 [
          "titulo" => "Bibliograf&#237;a"
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    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2009-08-05"
    "fechaAceptado" => "2009-09-09"
    "PalabrasClave" => array:2 [
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        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec92652"
          "palabras" => array:5 [
            0 => "Lactante"
            1 => "Bronquitis"
            2 => "Sibilantes recurrentes"
            3 => "Asma"
            4 => "Factores de riesgo"
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        0 => array:4 [
          "clase" => "keyword"
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          "palabras" => array:5 [
            0 => "Infant"
            1 => "Bronchitis"
            2 => "Recurrent wheezing"
            3 => "Asthma"
            4 => "Risk factors"
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        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p class="elsevierStyleSimplePara elsevierViewall">Determinar la incidencia de bronquitis sibilantes &#40;BS&#41; en los primeros 6 meses de vida en la poblaci&#243;n de Alzira &#40;Valencia&#41; y analizar los factores de riesgo asociados&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Estudio longitudinal prospectivo basado en una cohorte de 636 ni&#241;os&#44; incluidos consecutivamente entre marzo de 2007 y noviembre de 2008 tras el nacimiento&#46; Revisi&#243;n de historias cl&#237;nicas hospitalarias y ambulatorias a los 6 meses de vida y env&#237;o de cuestionarios por correo&#46; An&#225;lisis bivariante y multivariante de los distintos factores de riesgo registrados mediante regresi&#243;n de Cox&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">A los 6 meses&#44; el 25&#44;2&#37; de los ni&#241;os hab&#237;a presentado al menos un episodio de BS&#44; y el 5&#44;6&#37; hab&#237;a presentado 3 o m&#225;s episodios&#46; El 11&#44;6&#37; de los ni&#241;os recibi&#243; atenci&#243;n en urgencias en alguna ocasi&#243;n&#44; el 6&#44;6&#37; recibi&#243; corticoides orales y el 4&#37; precis&#243; ingreso hospitalario&#46; Se comportaron como factores de riesgo independientes de BS el sexo masculino &#40;riesgo relativo &#91;RR&#93;&#58; 2&#44;1&#59; intervalo de confianza &#91;IC&#93; del 95&#37;&#58; 1&#44;5-2&#44;9&#41;&#44; la menor edad gestacional &#40;RR&#58; 1&#44;1&#59; IC del 95&#37;&#58; 1&#44;0-1&#44;2&#41;&#44; el nacimiento en el tercer trimestre &#40;RR&#58; 3&#44;5&#59; IC del 95&#37;&#58; 2&#44;0-5&#44;9&#41;&#44; el cuarto trimestre &#40;RR&#58; 2&#44;0&#59; IC del 95&#37;&#58; 1&#44;1-3&#44;6&#41; del a&#241;o&#44; la menor edad materna &#40;RR&#58; 0&#44;9&#59; IC del 95&#37;&#58; 1&#44;0-1&#44;1&#41;&#44; la existencia de hermanos mayores &#40;RR&#58; 3&#44;1&#59; IC del 95&#37;&#58; 2&#44;2-4&#44;5&#41;&#44; la exposici&#243;n al tabaco &#40;RR&#58; 1&#44;4&#59; IC del 95&#37;&#58; 1&#44;0-2&#44;0&#41; y el antecedente de asma en la madre &#40;RR&#58; 1&#44;7&#59; IC del 95&#37;&#58; 1&#44;0-3&#44;0&#41;&#59; lo hicieron como factores protectores la lactancia materna durante un per&#237;odo igual o superior a 3 meses &#40;RR&#58; 0&#44;6&#59; IC del 95&#37;&#58; 0&#44;4-0&#44;8&#41; y el origen inmigrante de los padres &#40;RR&#58; 0&#44;6&#44; IC del 95&#37;&#58; 0&#44;4- 0&#44;9&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">La incidencia acumulada de BS en los primeros 6 meses de vida en nuestra poblaci&#243;n es elevada&#44; y supera la descrita en otros estudios&#46; La mayor parte de los factores de riesgo coinciden con los que se&#241;alan otros autores&#46; Destacan como m&#225;s importantes la existencia de hermanos mayores y el nacimiento en el tercer trimestre del a&#241;o&#44; lo que refleja el importante papel de las infecciones v&#237;ricas en la patogenia de las BS a estas edades&#46;</p>"
      ]
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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p class="elsevierStyleSimplePara elsevierViewall">To determine the incidence of wheezing at 6 months of life in the town of Alzira &#40;Valencia&#44; Spain&#41;&#44; and to analyse associated risk factors&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p class="elsevierStyleSimplePara elsevierViewall">We included 636 newborns in a longitudinal birth cohort study between March 2007 and November 2008&#46; Data were collected from hospital and primary care medical records and from questionnaires sent at 6 months post-natal&#46; Bivariate and multivariate Cox regression analysis were performed to examine the risk factors associated with wheezing&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">At 6 months&#44; 25&#46;2&#37; of infants had had 1 or more episodes of wheezing&#44; whereas 5&#46;6&#37; had had 3 or more episodes&#46; Emergency visits were reported in 11&#46;6&#37; of the infants&#44; treatment with oral corticosteroids in 6&#46;6&#37; and admission to hospital in 4&#37;&#46; Independent risk factors for wheezing were male sex &#40;relative risk &#91;RR&#93;&#58; 2&#46;1&#44; 95&#37; confidence interval &#91;95&#37; CI&#93;&#58; 1&#46;5 to 2&#46;9&#41;&#44; younger gestational age &#40;RR&#58; 1&#46;1&#44; 95&#37; CI&#58; 1&#46;0 to 1&#46;2&#41;&#44; season of birth between July and September &#40;RR&#58; 3&#46;5&#44; 95&#37; CI&#58; 2&#46;0 to 5&#46;9&#41; and between October and December &#40;RR&#58; 2&#46;0&#44; 95&#37; CI&#58; 1&#46;1 to 3&#46;6&#41;&#44; younger maternal age &#40;RR&#58; 1&#46;0&#44; 95&#37; CI&#58; 1&#46;0 to 1&#46;1&#41;&#44; having siblings &#40;RR&#58; 3&#46;1&#44; 95&#37; CI&#58; 2&#46;2 to 4&#46;5&#41;&#44; exposure to smoke &#40;RR&#58; 1&#46;4&#44; 95&#37; CI&#58; 12&#46;0 to 2&#46;0&#41; and history of maternal asthma &#40;RR&#58; 1&#46;7&#44; 95&#37; CI&#58; 1&#46;0 to 3&#46;0&#41;&#46; Breast feeding for at least 3 months &#40;RR&#58; 0&#46;6&#44; 95&#37; CI&#58; 0&#46;4 to 0&#46;8&#41; and having immigrant parents &#40;RR&#58; 0&#46;6&#44; 95&#37; CI&#58; 0&#46;4 to 0&#46;9&#41; were protective against wheezing&#46;</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p class="elsevierStyleSimplePara elsevierViewall">A high cumulative incidence of wheezing in the first 6 months of life was found in our population&#44; in comparison with data reported in other cohort studies&#46; Estimated risk factors were generally in accordance with those described by other authors&#46; Having siblings and season of birth between July and September were the most important risk factors&#44; reflecting the role of viral infections in the pathogenesis of wheezing in early childhood&#46;</p>"
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                  \t\t\t\t">Sexo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Edad de la madre&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tabaquismo materno en el embarazo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Asma o atopia &#40;rinitis al&#233;rgica o dermatitis at&#243;pica&#41; en los padres y en los hermanos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">Tipo de lactancia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tabaquismo paterno&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
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                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Cuestionario un a&#241;o</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Las mismas variables que a los 6 meses&#44; a las que se a&#241;ade el test alergol&#243;gico cualitativo y la asistencia a guarder&#237;a</td></tr></tbody></table>
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                  \t\t\t\t" style="border-bottom: 2px solid black">n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Femenino&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">299 &#40;46&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">244 &#40;39&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">55 &#40;8&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Masculino&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">321 &#40;51&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">219 &#40;35&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">54 &#40;8&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">39 &#40;6&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>37&#8211;40&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">136 &#40;21&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">33 &#40;5&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">10 &#40;1&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">174 &#40;28&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">128 &#40;20&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleBold">Trimestre de nacimiento</span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Enero-marzo&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Abril-junio&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Julio-septiembre&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">77 &#40;12&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Octubre-diciembre&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">153 &#40;24&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">114 &#40;18&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">39 &#40;6&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " colspan="4" align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">Lactancia materna</span> &#8805;<span class="elsevierStyleBold">3 meses</span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">330 &#40;53&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">231 &#40;37&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">99 &#40;15&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">290 &#40;46&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">231 &#40;37&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">59 &#40;9&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Factores sociales</span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " colspan="4" align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">Edad de la madre &#40;a&#241;os&#41;</span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#60;20&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">27 &#40;4&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">9 &#40;1&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>20&#8211;24&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">84 &#40;13&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">66 &#40;10&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">18 &#40;2&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#62;24&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">509 &#40;82&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">379 &#40;61&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">130 &#40;21&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Nivel de estudios padres</span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Universitarios&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">166 &#40;26&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">135 &#40;21&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">31 &#40;5&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Secundarios&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">231 &#40;37&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">173 &#40;27&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">58 &#40;9&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Primarios&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">196 &#40;31&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">140 &#40;22&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">56 &#40;9&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sin estudios&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27 &#40;4&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 &#40;2&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 &#40;1&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Hijo de inmigrantes</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">464 &#40;74&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">342 &#40;55&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">122 &#40;19&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">156 &#40;25&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">121 &#40;19&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35 &#40;5&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Hermanos mayores</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">341 &#40;55&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">285 &#40;46&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">56 &#40;9&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">279 &#40;45&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">178 &#40;28&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">101 &#40;16&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Factores medioambientales</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Tabaquismo durante el embarazo</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">476 &#40;76&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">358 &#40;57&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">118 &#40;19&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">144 &#40;23&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">105 &#40;16&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">39 &#40;6&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Exposici&#243;n a tabaco</span><a class="elsevierStyleCrossRef" href="#tblfn3ast"><span class="elsevierStyleSup">¿</span></a></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">255 &#40;43&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">203 &#40;34&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">52 &#40;8&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">334 &#40;56&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">238 &#40;40&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">96 &#40;16&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Mascotas en domicilio</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">425 &#40;73&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">321 &#40;55&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">104 &#40;18&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">151 &#40;26&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">113 &#40;19&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38 &#40;6&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Antecedentes familiares</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Asma en la madre</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">571 &#40;92&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">430 &#40;69&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">141 &#40;22&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49 &#40;7&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33 &#40;5&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16 &#40;2&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Asma en el padre</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">588 &#40;94&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">438 &#40;70&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">150 &#40;24&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32 &#40;5&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25 &#40;4&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;1&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Asma en hermanos</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">541 &#40;87&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">420 &#40;67&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">121 &#40;19&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">43 &#40;6&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Atopia en la madre</span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">557 &#40;89&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">423 &#40;68&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Atopia en el padre</span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">538 &#40;86&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">396 &#40;63&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Datos de atopia en el ni&#241;o</span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " colspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">536 &#40;91&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">405 &#40;69&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">131 &#40;22&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">16 &#40;2&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Masculino&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#60;0&#44;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleBold">Nivel de estudios padres</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Universitarios&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Referencia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Secundarios&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Primarios&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sin estudios&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleBold">Hijo de inmigrantes</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleBold">Hermanos mayores</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " colspan="5" align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">Factores medioambientales</span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">Tabaquismo durante el embarazo</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">620&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Referencia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;7&#8211;1&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">0&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Exposici&#243;n a tabaco</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">589&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Referencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">1&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">1&#44;1&#8211;2&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#44;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Mascotas en domicilio</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">587&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Referencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#44;7&#8211;1&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Antecedentes familiares</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Asma en la madre</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">620&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Referencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">1&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">0&#44;8&#8211;2&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">0&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Asma en el padre</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">620&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Referencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;4&#8211;1&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Asma en hermanos</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">620&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Referencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">0&#44;2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">Factores perinatales</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " colspan="5" align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">Sexo</span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Femenino&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Referencia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Masculino&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleBold">Edad gestacional</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " colspan="5" align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">Trimestre de nacimiento</span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Enero-marzo&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Referencia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Abril-junio&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Julio-septiembre&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Octubre-diciembre&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleBold">Lactancia materna &#8805;3 meses</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Referencia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#60;0&#44;005&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " colspan="5" align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">Factores sociales</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">Edad de la madre</span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">Hijo de inmigrantes</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Referencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;4&#8211;0&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#44;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Hermanos mayores</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Referencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;2&#8211;4&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Factores medioambientales</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Exposici&#243;n a tabaco</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Referencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;0&#8211;2&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#44;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Antecedentes familiares</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Asma en la madre</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Referencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;0&#8211;3&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#44;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "es" => "<p class="elsevierStyleSimplePara elsevierViewall">Factores de riesgo de bronquitis sibilantes &#40;al menos un episodio&#41; en los primeros 6 meses de vida&#46; An&#225;lisis multivariante</p>"
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    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
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        0 => array:1 [
          "bibliografiaReferencia" => array:29 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Stabilization of asthma prevalence among adolescents and increase among schoolchildren &#40;ISAAC phases I and III&#41; in Spain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Garc&#237;a-Marcos"
                            1 => "A&#46; Blanco"
                            2 => "G&#46; Garc&#237;a"
                            3 => "F&#46; Guill&#233;n-Grima"
                            4 => "C&#46; Gonz&#225;lez"
                            5 => "I&#46; Carvajal"
                          ]
                        ]
                      ]
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                    0 => array:2 [
                      "doi" => "10.1111/j.1398-9995.2004.00562.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Allergy"
                        "fecha" => "2004"
                        "volumen" => "59"
                        "paginaInicial" => "1301"
                        "paginaFinal" => "1307"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15507099"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
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            1 => array:3 [
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Definition&#44; assessment and treatment of wheezing disorders in preschool children&#58; An evidence-based approach"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46;L&#46;P&#46; Brand"
                            1 => "E&#46; Baraldi"
                            2 => "H&#46; Bisgaard"
                            3 => "A&#46;L&#46; Boner"
                            4 => "J&#46;A&#46; Castro-Rodriguez"
                            5 => "A&#46; Custovic"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/09031936.00002108"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2008"
                        "volumen" => "32"
                        "paginaInicial" => "1096"
                        "paginaFinal" => "1110"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18827155"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
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                ]
              ]
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            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The International Study of Wheezing in Infants&#58; Questionnaire validation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Mallol"
                            1 => "L&#46; Garc&#237;a-Marcos"
                            2 => "V&#46; Aguirre"
                            3 => "A&#46; Mart&#237;nez-Torres"
                            4 => "V&#46; P&#233;rez-Fern&#225;ndez"
                            5 => "A&#46; Gallardo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000102613"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int Arch Allergy Immunol"
                        "fecha" => "2007"
                        "volumen" => "144"
                        "paginaInicial" => "44"
                        "paginaFinal" => "50"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17505136"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Worldwide variations in the prevalence of asthma symptoms&#46; The International Study of Asthma and Allergies in Childhood &#40;ISAAC&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "Anonymous"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "1998"
                        "volumen" => "12"
                        "paginaInicial" => "315"
                        "paginaFinal" => "335"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9727780"
                            "web" => "Medline"
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            ]
            4 => array:3 [
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              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Accuracy of ImmunoCAP&#40;R&#41; Rapid in the diagnosis of allergic sensitization in children between 1 and 14 years with recurrent wheezing&#58; The IReNE study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; D&#237;az"
                            1 => "M&#46;J&#46; Torregrosa"
                            2 => "I&#46; Carvajal"
                            3 => "A&#46; Cano"
                            4 => "E&#46; Fos"
                            5 => "A&#46; Garc&#237;a"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "Pediatr Allergy Immunol"
                        "fecha" => "2009"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
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                0 => array:2 [
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Información del artículo
ISSN: 16954033
Idioma original: Español
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