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La medida de la longitud se efectu&#243; seg&#250;n la t&#233;cnica habitual en dec&#250;bito supino con un estadi&#243;metro Masia&#174; con rango de lectura de 0 a 70<span class="elsevierStyleHsp" style=""></span>cm y precisi&#243;n de 0&#44;5<span class="elsevierStyleHsp" style=""></span>cm&#46;</p><p id="p0035" class="elsevierStylePara elsevierViewall">La edad gestacional se calcul&#243; utilizando la fecha del &#250;ltimo per&#237;odo menstrual en las mujeres con ciclos regulares y&#47;o mediante examen ecogr&#225;fico realizado antes de la semana 20 del embarazo y que estuviese en concordancia con la fecha de la &#250;ltima regla con variaci&#243;n de &#177; 1 semana&#46; La media y desviaci&#243;n est&#225;ndar &#40;DE&#41; de la edad materna en el momento del parto fue de 28&#44;6 &#177; 5&#44;3 para las gestaciones pret&#233;rmino y de 29&#44;2 &#177; 5&#44;1 a&#241;os para las gestaciones a t&#233;rmino&#46; El 3 &#37; de las madres ten&#237;an una edad comprendida entre los 16 y los 20 a&#241;os&#44; el 43 &#37; entre los 20 y los 30&#44; el 38 &#37; entre los 20 y los 35 y el 16&#37; m&#225;s de 35 a&#241;os&#46; El 43 &#37; de las madres eran prim&#237;paras&#59; el 34 &#37;&#44; secund&#237;paras&#59; el 15 &#37;&#44; terc&#237;paras&#59; el 5 &#37;&#44; cuart&#237;paras&#44; y el 3 &#37;&#44; quint&#237;paras&#46;</p><p id="p0040" class="elsevierStylePara elsevierViewall">En los reci&#233;n nacidos pret&#233;rmino las causas de interrupci&#243;n del embarazo fueron rotura prematura de membranas en el 35 &#37;&#44; coriamnionitis el 29 &#37;&#44; registro card&#237;aco fetal patol&#243;gico en el en el 8&#44;9 &#37;&#44; prolapso del cord&#243;n en el 6&#44;8 &#37;&#44; preeclampsia 10 &#37;&#44; s&#237;ndrome HELLP &#40;hem&#243;lisis&#44; enzimas hep&#225;ticas elevadas y plaquetopenia&#41; en el 5 &#37; y placenta previa en el 5&#44;2 &#37;&#46; En los reci&#233;n nacidos a t&#233;rmino&#44; el parto fue eut&#243;cico por presentaci&#243;n cef&#225;lica en el 61 &#37; de los casos&#44; por presentaci&#243;n de nalgas en el 1 &#37;&#44; con esp&#225;tulas en el 8 &#37; y mediante f&#243;rceps en el 15 &#37;&#46; En el 15 &#37; restante el parto fue mediante ces&#225;rea&#46; No hubo casos de asfixia neonatal y el per&#237;odo neonatal fue normal en todos ellos&#46;</p><p id="p0045" class="elsevierStylePara elsevierViewall">El an&#225;lisis estad&#237;stico se efectu&#243; mediante el paquete estad&#237;stico SAS&#174; versi&#243;n 8&#46;2&#46; Se examinaron las diferencias entre las poblaciones de Barcelona y Zaragoza mediante una regresi&#243;n lineal m&#250;ltiple del logaritmo de la longitud y del peso ajustado por &#8220;grupo de edad&#8220; y por &#8220;centro de procedencia&#8221;&#46; Se utiliz&#243; la t de Student bilateral con grado de significaci&#243;n del 5 &#37; para contrastar las diferencias de peso y talla por sexo entre edades gestacionales&#46; Al no observarse diferencias estad&#237;sticamente significativas ni cl&#237;nicamente relevantes entre los valores correspondientes a cada semana de edad gestacional y sexo entre ambos centros &#40;datos no mostrados&#41;&#44; los datos de &#233;stos se han fusionado y se han valorado como una &#250;nica poblaci&#243;n&#46;</p><p id="p0050" class="elsevierStylePara elsevierViewall">Para la construcci&#243;n de los est&#225;ndares de crecimiento normalizado se estimaron las curvas de referencia de centiles utilizando el m&#233;todo LMS descrito por Cole<a class="elsevierStyleCrossRef" href="#bb0165"><span class="elsevierStyleSup">33</span></a>&#46; El ajuste de este m&#233;todo se realiz&#243; mediante el programa LMSChartmaker Pro&#44; ofrecido por Harlow Printing Limited&#46;</p></span><span id="s0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0025">RESULTADOS</span><p id="p0055" class="elsevierStylePara elsevierViewall">El n&#250;mero de reci&#233;n nacidos evaluado&#44; los valores de la media aritm&#233;tica&#44; de la DE&#44; del &#237;ndice de asimetr&#237;a &#40;Skewness&#41; y los de la distribuci&#243;n percentilada del peso y de la longitud&#44; correspondientes a cada edad gestacional&#44; est&#225;n expresados en las <a class="elsevierStyleCrossRefs" href="#t0005">tablas 1 y 3</a> para los varones y en las <a class="elsevierStyleCrossRefs" href="#t0010">tablas 2 y 4</a> para las ni&#241;as&#46; La representaci&#243;n gr&#225;fica de la distribuci&#243;n percentilada de los valores de peso y longitud para cada edad gestacional y sexo est&#225; recogida en las <a class="elsevierStyleCrossRefs" href="#f0005">figuras 1 y 2</a>&#46;</p><p id="p0060" class="elsevierStylePara elsevierViewall">En ambos sexos existe un incremento progresivo de ambos par&#225;metros antropom&#233;tricos a medida que avanza la duraci&#243;n de la gestaci&#243;n&#46; Hasta la semana 30 de edad gestacional los valores de la media del peso y de la longitud son similares en ni&#241;os y ni&#241;as&#46; A partir de esta semana de edad gestacional&#44; los valores de la media de estos par&#225;metros comienzan a ser progresivamente superiores en los ni&#241;os&#44; sin que existan diferencias estad&#237;sticamente significativas entre ambos sexos hasta la semana 34 de edad gestacional inclusive&#46; Sin embargo&#44; s&#237; se encontraron diferencias estad&#237;sticamente significativas &#40;p &#60; 0&#44;01&#41; para cada uno de estos par&#225;metros&#44; entre ambos sexos&#44; en edades gestacionales posteriores &#40;35&#8211;42 inclusive&#41; &#40;datos no mostrados&#41;&#46; En efecto&#44; y a t&#237;tulo de ejemplo&#44; estas diferencias son de 170<span class="elsevierStyleHsp" style=""></span>g y de 0&#44;8<span class="elsevierStyleHsp" style=""></span>cm en la semana 38 y de 160<span class="elsevierStyleHsp" style=""></span>g y 0&#44;9<span class="elsevierStyleHsp" style=""></span>cm en la semana 42&#44; respectivamente &#40;p &#60; 0&#44;05&#41;&#46;</p><p id="p0065" class="elsevierStylePara elsevierViewall">No se observaron diferencias estad&#237;sticamente significativas en los par&#225;metros antropom&#233;tricos evaluados en funci&#243;n de la edad ni de la paridad materna&#44; as&#237; como entre el tipo de parto eut&#243;cico o dist&#243;cico &#40;datos nos mostrados&#41;&#46;</p></span><span id="s0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0030">DISCUSI&#211;N</span><p id="p0070" class="elsevierStylePara elsevierViewall">La valoraci&#243;n del peso y la longitud al nacer en relaci&#243;n con la edad gestacional son utilizados para la identificaci&#243;n de los reci&#233;n nacidos cuyo crecimiento se aleja de los patrones normales de crecimiento y que pueden estar expuestos a una mayor morbilidad y mortalidad durante el per&#237;odo neonatal y en la edad adulta<a class="elsevierStyleCrossRefs" href="#bb0005"><span class="elsevierStyleSup">1&#8211;9</span></a>&#46; Las tablas de Lubchenco<a class="elsevierStyleCrossRef" href="#bb0045"><span class="elsevierStyleSup">9</span></a>&#44; elaboradas en Denver &#40;EE&#46;UU&#46;&#41;&#44; fueron pioneras y su uso se generaliz&#243;&#46; Sin embargo&#44; estudios posteriores evaluando otras poblaciones en Estados Unidos&#44; Canad&#225;&#44; Europa y Espa&#241;a mostraron que sus datos no eran extrapolables a otras poblaciones y enfatizaron la necesidad de que cada comunidad dispusiese de sus propios patrones de referencia y de que &#233;stos sean actualizados peri&#243;dicamente<a class="elsevierStyleCrossRefs" href="#bb0045"><span class="elsevierStyleSup">9&#8211;32</span></a>&#46;</p><p id="p0075" class="elsevierStylePara elsevierViewall">Adem&#225;s&#44; la heterogeneidad de las poblaciones obst&#233;tricas con relaci&#243;n a la raza&#44; edad materna&#44; paridad&#44; caracter&#237;sticas antropom&#233;tricas maternas&#44; el estado nutricional y la condici&#243;n socioecon&#243;mica materna&#44; entre otras&#44; pone de relieve las dificultades inherentes que tiene la elaboraci&#243;n de los patrones de crecimiento intrauterino normal&#44; particularmente para los reci&#233;n nacidos pret&#233;rmino&#44; en quienes el embarazo no puede considerarse estrictamente normal al haberse interrumpido de forma prematura&#46;</p><p id="p0080" class="elsevierStylePara elsevierViewall">En este sentido&#44; y sin que exista un amplio consenso con relaci&#243;n a la selecci&#243;n de los reci&#233;n nacidos que se han de incluir en la elaboraci&#243;n de estos est&#225;ndares antropom&#233;tricos neonatales&#44; parece adecuado incluir solamente los reci&#233;n nacidos de una misma raza sin malformaciones cong&#233;nitas mayores o cromosomopat&#237;as que sean producto de gestaciones &#250;nicas no complicadas de madres sin enfermedades cr&#243;nicas y no expuestas a t&#243;xicos en el transcurso del embarazo y en las que se haya podido establecer con total exactitud la edad gestacional<a class="elsevierStyleCrossRefs" href="#bb0105"><span class="elsevierStyleSup">21&#8211;23</span></a>&#44; as&#237; como expresar los resultados de forma independiente para cada sexo<a class="elsevierStyleCrossRefs" href="#bb0115"><span class="elsevierStyleSup">23&#8211;29</span></a> y para cada etnia<a class="elsevierStyleCrossRef" href="#bb0145"><span class="elsevierStyleSup">29&#44;</span></a><a class="elsevierStyleCrossRef" href="#bb0155"><span class="elsevierStyleSup">31</span></a>&#46; Adem&#225;s&#44; debe tenerse en cuenta que la participaci&#243;n de m&#250;ltiples investigadores e instituciones y el empleo de diferentes dispositivos de medida puede conllevar errores que contribuyen a la dispersi&#243;n de los valores publicados&#46;</p><p id="p0085" class="elsevierStylePara elsevierViewall">En estudios previos y de forma separada publicamos parte de los datos incluidos en este estudio correspondientes a las poblaciones de Barcelona<a class="elsevierStyleCrossRef" href="#bb0140"><span class="elsevierStyleSup">28</span></a> y de Zaragoza<a class="elsevierStyleCrossRef" href="#bb0150"><span class="elsevierStyleSup">30</span></a> y ahora&#44; tras comprobar que no existen diferencias estad&#237;sticamente significativas ni cl&#237;nicamente relevantes entre los datos antropom&#233;tricos de peso y longitud de ambos estudios &#40;datos no mostrados&#41;&#44; hemos fusionado ambas poblaciones con objeto de obtener un mayor n&#250;mero de casos que permitan dar m&#225;s fiabilidad a los datos obtenidos e incrementar el n&#250;mero de reci&#233;n nacidos prematuros&#46; El tama&#241;o de la muestra de 9&#46;362 reci&#233;n nacidos &#40;4&#46;884 varones y 4&#46;478 ni&#241;as&#41; nos ha permitido obtener un n&#250;mero considerable de sujetos &#40;n &#61; 100&#8211;1&#46;062&#41; para cada sexo y edad gestacional&#44; exceptuando el grupo de edades extremas&#58; grandes prematuros 26&#8211;32 semanas y la semana 42 para los reci&#233;n nacidos a t&#233;rmino&#44; en las que el n&#250;mero de sujetos incluidos var&#237;a entre 20 y 89&#46; Sin embargo&#44; la metodolog&#237;a LMS utilizada otorga tambi&#233;n un alto &#237;ndice de fiabilidad a los datos correspondientes a estas edades gestacionales<a class="elsevierStyleCrossRefs" href="#bb0160"><span class="elsevierStyleSup">32&#44;33</span></a>&#46; Adem&#225;s la escasa dispersi&#243;n del &#237;ndice de Skewness indica una distribuci&#243;n similar del n&#250;mero de valores situados por encima y por debajo de los correspondientes a la media&#46;</p><p id="p0090" class="elsevierStylePara elsevierViewall">En el grupo de reci&#233;n nacidos a t&#233;rmino se procedi&#243; a una rigurosa selecci&#243;n para que se cumpliesen todos los criterios de inclusi&#243;n y exclusi&#243;n&#44; tras una exhaustiva anamnesis materna y an&#225;lisis de su historia obst&#233;trica&#44; con objeto de obtener una muestra en la que se incluyesen embarazos de evoluci&#243;n estrictamente normal en gestantes normales&#46; Adem&#225;s&#44; las mediciones antropom&#233;tricas fueron efectuadas por un &#250;nico investigador en cada hospital y con los mismos instrumentos de medida&#44; lo que otorga sin lugar a dudas una gran homogeneidad a los resultados obtenidos&#46; En consecuencia&#44; nuestros datos ser&#237;an representativos del crecimiento normal de nuestras poblaciones&#46;</p><p id="p0095" class="elsevierStylePara elsevierViewall">Una cuesti&#243;n muy debatida es hasta qu&#233; punto los datos obtenidos en una poblaci&#243;n de reci&#233;n nacidos prematuros pueden ser representativos del crecimiento fetal normal&#44; es decir&#44; del de aquellos fetos que permanecen en &#250;tero y llegan a t&#233;rmino&#44; particularmente en situaciones cl&#237;nicas en las que una patolog&#237;a materna cr&#243;nica durante el embarazo pueda ser la causa de su interrupci&#243;n prematura&#46; Sin embargo&#44; esta situaci&#243;n no podr&#237;a ser aplicable a aquellas gestaciones en las que la interrupci&#243;n del embarazo sea debida a una causa aguda&#46; En nuestra serie&#44; el 85 &#37; de los embarazos fueron interrumpidos por causas agudas y presumiblemente habr&#225;n tenido poca repercusi&#243;n sobre el crecimiento fetal&#46; Sin embargo&#44; este hecho no puede ser totalmente excluido&#46;</p><p id="p0100" class="elsevierStylePara elsevierViewall">Nuestros datos muestran claramente un dimorfismo sexual en el crecimiento fetal y concuerdan con los previamente publicados<a class="elsevierStyleCrossRefs" href="#bb0115"><span class="elsevierStyleSup">23&#8211;32</span></a>&#46; Por tanto&#44; este dimorfismo sexual debe tenerse en cuenta y&#44; en consecuencia&#44; expresar de forma independiente los valores para cada sexo&#46;</p><p id="p0105" class="elsevierStylePara elsevierViewall">Siguiendo las recomendaciones de Styne<a class="elsevierStyleCrossRef" href="#bb0005"><span class="elsevierStyleSup">1</span></a>&#44; se tiende a clasificar a los reci&#233;n nacidos como grandes para su edad gestacional cuando presentan un peso superior al percentil 90 y como peque&#241;os para la edad gestacional cuando su peso es inferior al percentil 10&#59; estos criterios guardan relaci&#243;n con la prevalencia de la patolog&#237;a neonatal&#46; En nuestros datos&#44; adem&#225;s de la distribuci&#243;n percentilada&#44; hemos incluido la media y DE&#44; ya que el retraso de crecimiento intrauterino se define como aquella situaci&#243;n en la que el peso y&#47;o la longitud al nacer son inferiores a &#8722;<span class="elsevierStyleHsp" style=""></span>2 DE de los valores de la media<a class="elsevierStyleCrossRefs" href="#bb0015"><span class="elsevierStyleSup">3&#8211;5</span></a>&#44; y al ser estos reci&#233;n nacidos quienes pueden desarrollar s&#237;ndrome metab&#243;lico durante la infancia y edad adulta<a class="elsevierStyleCrossRefs" href="#bb0030"><span class="elsevierStyleSup">6&#8211;8&#44;</span></a><a class="elsevierStyleCrossRefs" href="#bb0170"><span class="elsevierStyleSup">34&#44;35</span></a>&#44; es deseable identificarlos correctamente ya en el per&#237;odo neonatal&#46;</p><p id="p0110" class="elsevierStylePara elsevierViewall">En nuestro pa&#237;s diversos estudios han mostrado incrementos progresivos en los valores de peso y longitud de los reci&#233;n nacidos pret&#233;rmino y a t&#233;rmino evaluados en los per&#237;odos de 1970&#8211;1984 y 1987-1992<a class="elsevierStyleCrossRefs" href="#bb0075"><span class="elsevierStyleSup">15&#8211;20&#44;</span></a><a class="elsevierStyleCrossRef" href="#bb0135"><span class="elsevierStyleSup">27</span></a>&#46; M&#225;s recientemente&#44; nosotros tambi&#233;n se&#241;al&#225;bamos estos incrementos en nuestra poblaci&#243;n de Barcelona evaluada entre 1997 y 2002 respecto a datos previos de nuestro hospital evaluados en 1984-1986<a class="elsevierStyleCrossRef" href="#bb0085"><span class="elsevierStyleSup">17</span></a> y a los de otros hospitales espa&#241;oles evaluados entre 1987 y 1992<a class="elsevierStyleCrossRefs" href="#bb0095"><span class="elsevierStyleSup">19&#44;20</span></a>&#44; aunque se&#241;al&#225;bamos la dificultad para hacer comparaciones fiables&#44; pues en estos estudios<a class="elsevierStyleCrossRef" href="#bb0085"><span class="elsevierStyleSup">17&#44;</span></a><a class="elsevierStyleCrossRefs" href="#bb0095"><span class="elsevierStyleSup">19&#44;20</span></a> los datos no se daban separados para cada sexo&#44; sino agrupados en una &#250;nica poblaci&#243;n<a class="elsevierStyleCrossRef" href="#bb0140"><span class="elsevierStyleSup">28</span></a>&#46; M&#225;s recientemente&#44; Alonso<a class="elsevierStyleCrossRef" href="#bb0135"><span class="elsevierStyleSup">27</span></a> ha publicado datos diferenciados para cada sexo recogidos entre 1987 y 2001 en el Hospital San Carlos de Madrid&#46; La comparaci&#243;n de los datos del presente estudio con los de Alonso confirma la aceleraci&#243;n secular de peso y longitud observada previamente&#46; En efecto&#44; y a t&#237;tulo de ejemplo&#44; a las semanas 30&#44; 34&#44; y 40 de edad gestacional los valores de la media correspondiente a los varones de nuestro estudio son&#44; respectivamente&#44; 244&#44; 166 y 123<span class="elsevierStyleHsp" style=""></span>g&#44; y 1&#44;48&#44; 1&#44;03 y 0&#44;70<span class="elsevierStyleHsp" style=""></span>cm superiores a los del estudio de Alonso&#46; Estas mismas diferencias son para las ni&#241;as 211&#44; 241 y 134<span class="elsevierStyleHsp" style=""></span>g y 1&#44;9&#44; 0&#44;8 y 1&#44;1<span class="elsevierStyleHsp" style=""></span>cm&#44; respectivamente&#46; Datos similares tambi&#233;n han sido recientemente comunicados en estudios realizados en Canad&#225; y en Estados Unidos<a class="elsevierStyleCrossRefs" href="#bb0120"><span class="elsevierStyleSup">24&#44;25&#44;</span></a><a class="elsevierStyleCrossRef" href="#bb0155"><span class="elsevierStyleSup">31</span></a>&#46;</p><p id="p0115" class="elsevierStylePara elsevierViewall">Recientemente&#44; nosotros hemos publicado datos de peso y longitud para el grupo de los reci&#233;n nacidos a t&#233;rmino en nuestro pa&#237;s&#44; pero cuyos progenitores eran originarios del &#193;frica subsahariana&#44; de Marruecos y de Sudam&#233;rica y hemos mostrado que respecto a la poblaci&#243;n aut&#243;ctona cauc&#225;sica&#44; los reci&#233;n nacidos de ambos sexos hijos de padres originarios de Marruecos y Sudam&#233;rica muestran valores superiores de peso y longitud&#44; sin que estas diferencias est&#233;n presentes en aqu&#233;llos cuyos padres eran originarios del &#193;frica subsaharina<a class="elsevierStyleCrossRef" href="#bb0145"><span class="elsevierStyleSup">29</span></a>&#46; Estos datos preliminares necesitan confirmarse con la evaluaci&#243;n de un n&#250;mero mayor de reci&#233;n nacidos&#44; pero sugieren que cada etnia puede tener su propio patr&#243;n de crecimiento y deben ser tenidos en cuenta en la valoraci&#243;n de su crecimiento fetal&#46;</p><p id="p0120" class="elsevierStylePara elsevierViewall">En resumen&#44; presentamos los patrones de crecimiento intrauterino de los reci&#233;n nacidos hijos de padres cauc&#225;sicos espa&#241;oles de 26 a 42 semanas de gestaci&#243;n procedentes de dos hospitales espa&#241;oles&#46; Nuestros datos muestran un dimorfismo sexual y una aceleraci&#243;n secular respecto a estudios espa&#241;oles anteriores&#44; confirmando la necesidad de disponer de medidas antropom&#233;tricas actualizadas para poder identificar aquellos que debido a su bajo peso y&#47;o retraso de crecimiento intrauterino pueden ser m&#225;s susceptibles para desarrollar morbilidad ya en el per&#237;odo neonatal inmediato o durante la infancia&#44; adolescencia y vida adulta&#46;</p></span></span>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p id="sp0055" class="elsevierStyleSimplePara elsevierViewall">La edad gestacional&#44; el peso y la longitud al nacer son factores relacionados con la morbilidad y mortalidad en el per&#237;odo neonatal y en la vida adulta&#46;</p> <span class="elsevierStyleSectionTitle">Sujetos y m&#233;todos</span><p id="sp0060" class="elsevierStyleSimplePara elsevierViewall">Valoraci&#243;n del peso y la longitud v&#233;rtice-tal&#243;n al nacer&#44; en 9&#46;362 reci&#233;n nacidos vivos de raza cauc&#225;sica &#40;4&#46;884 varones y 4&#46;478 ni&#241;as&#41; y de gestaciones &#250;nicas &#40;26-42 semanas de edad gestacional&#41;&#44; nacidos entre 1999 y 2002 en el Hospital Materno-Infantil Vall d&#8217;Hebron de Barcelona y en el Hospital Materno-Infantil Miguel Servet de Zaragoza&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="sp0065" class="elsevierStyleSimplePara elsevierViewall">Valores de la media y desviaci&#243;n est&#225;ndar&#44; y distribuci&#243;n percentilada del peso y de la longitud en los reci&#233;n nacidos de ambos sexos seg&#250;n su edad gestacional&#46; Existe un incremento progresivo con la edad gestacional y un dimorfismo sexual a partir de la semana 30 de gestaci&#243;n con diferencias estad&#237;sticamente significativas entre ambos sexos para ambos par&#225;metros &#40;p &#60; 0&#44;01&#41; a partir de la semana 35 de edad gestacional&#46; A las 38 y 42 semanas de edad gestacional los valores de la media para el peso y para la longitud son&#44; respectivamente&#44; 170 y 160 g&#44; y 0&#44;8 y 0&#44;9 cm superiores en los varones que en las ni&#241;as&#46; Tambi&#233;n se observ&#243; un incremento en los valores de la media de peso y longitud respecto a estudios previos &#40;1987-1992&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="sp0070" class="elsevierStyleSimplePara elsevierViewall">Existe un dimorfismo sexual en el peso y la longitud de los reci&#233;n nacidos pret&#233;rmino y a t&#233;rmino&#46; Estos par&#225;metros cambian con el tiempo y deben ser revisados peri&#243;dicamente&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="sp0075" class="elsevierStyleSimplePara elsevierViewall">Gestational age and neonatal anthropometric parameters are related to neonatal and postnatal morbidity and mortality&#46;</p> <span class="elsevierStyleSectionTitle">Subjects and methods</span><p id="sp0080" class="elsevierStyleSimplePara elsevierViewall">Weight and vertex-heel length were evaluated in 9&#46;362 caucasian newborns &#40;4&#46;884 males and 4&#46;478 females&#41; products of single pregnancies&#44; 26-42 weeks of gestational age&#44; born between 1999 and 2002 in Vall d&#8217;Hebron &#40;Barcelona&#44; Spain&#41; and Miguel Servet &#40;Zaragoza&#44; Spain&#41; Children&#8217;s Hospitals&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="sp0085" class="elsevierStyleSimplePara elsevierViewall">Mean and standard deviation and percentile distribution values of weight&#44; and length according to sex and gestational age are presented&#46; A progressive increase in these parameters with gestational age and a sexual dimorphism was observed from the 30 week of gestational age onwards&#44; with statistically-significant differences &#40;p &#60; 0&#46;01&#41; from 35 weeks of gestational age&#46; At 38 and 42 weeks of gestational ages these differences were 170 g&#44; 160 g&#44; 0&#44;8 cm and 0&#44;9 cm respectively&#46; An increase in weight and length values in relation to previous Spanish studies &#40;1987-1992&#41; was also documented&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="sp0090" class="elsevierStyleSimplePara elsevierViewall">A sexual dimorphism in intrauterine anthropometric growth parameters was observed&#46; These parameters change with time and may be updated&#46;</p>"
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                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab192859.png"
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        ]
        "descripcion" => array:1 [
          "es" => "<p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">Media&#44; desviaci&#243;n est&#225;ndar&#44; &#237;ndice de Skewness y distribuci&#243;n percentilada de los valores del peso &#40;g&#41; al nacimiento seg&#250;n la edad gestacional en reci&#233;n nacidos varones</p>"
        ]
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        "mostrarFloat" => true
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                  """
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                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab192858.png"
              ]
            ]
          ]
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