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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">El asma y la rinitis son dos enfermedades con elevada prevalencia en la infancia&#44; con tendencia a incrementarse en los &#250;ltimos a&#241;os&#46; En ambas es frecuente el infradiagn&#243;stico&#46;</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Verificar la prevalencia de s&#237;ntomas de asma y rinitis en la poblaci&#243;n infantil&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Hemos realizado&#44; mediante cuestionario escrito&#44; un estudio transversal siguiendo la metodolog&#237;a del International Study of Asthma and Allergies in Childhood &#40;ISAAC&#41;&#44; de prevalencia de sintomatolog&#237;a de asma y rinitis en el &#225;rea de A Coru&#241;a&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Han sido incluidos 3&#46;017 ni&#241;os y ni&#241;as de 6 y 7 a&#241;os &#40;tasa de respuesta del 73&#44;9&#37;&#41;&#44; y 2&#46;981 de 13 y 14 a&#241;os &#40;tasa de respuesta del 93&#44;6&#37;&#41;&#46; Refirieron haber presentado sibilancias alguna vez el 25&#44;3&#37; de los ni&#241;os y ni&#241;as de 13 y 14 a&#241;os y el 37&#44;2&#37; de los de 6 y 7 a&#241;os&#46; Han presentado asma en alguna ocasi&#243;n el 18&#44;5&#37; de los adolescentes y el 13&#44;7 &#37; del grupo de menor edad&#46; La prevalencia de rinitis alguna vez fue del 30&#44;4&#37; a los 6 y 7 a&#241;os y del 47&#44;3&#37; a los 13 y 14 a&#241;os&#46; La mayor prevalencia de rinitis se produjo en el oto&#241;o&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">El asma y la rinitis son especialmente frecuentes en nuestra poblaci&#243;n&#44; superior a la observada en la mayor&#237;a de poblaciones espa&#241;olas estudiadas&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">The prevalence of asthma and rhinitis is high in childhood and has been increasing in the last few years&#46; In both diseases underdiagnosis is frequent&#46;</p> <span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To asses the prevalence of asthma and rhinitis symptoms in childhood&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">We performed a cross-sectional study using a written questionnaire&#44; following the methodology of the International Study of Asthma and Allergies in Childhood &#40;ISAAC&#41;&#44; on the prevalence of symptoms of asthma and rhinitis in La Coru&#241;a&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">A total of 3017 boys and girls aged 6-7 years old &#40;response rate 73&#46;9 &#37;&#41; and 2981 boys and girls aged 13-14 years old &#40;response rate 93&#46;6 &#37;&#41; were included&#46; The prevalence of &#8220;wheezing at some time&#8221; was 25&#46;3&#37; in adolescents aged 13-14 years old and was 37&#46;2 &#37; in children aged 6-7 years&#46; The prevalence of &#8220;asthma at some time&#8221; was 18&#46;5&#37; in adolescents and 13&#46;7&#37; in children&#46; The prevalence of &#8220;rhinitis at some time&#8221; was 30&#46;4&#37; in the group aged 6-7 years and 47&#46;3&#37; in the group of adolescents&#46; The prevalence of rhinitis was highest in autumn&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The prevalence of asthma and rhinitis is high in our population and is higher than that observed in most Spanish populations studied&#46;</p>"
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Originales
Prevalencia de síntomas de asma y rinitis en la población de A Coruña
Prevalence of asthma and rhinitis symptoms in a Coruña (Spain)
A. López-Silvarrey Varelaa,
Autor para correspondencia
angel.lopez-silvarrey.varela@sergas.es

Correspondencia: Dr. A. López-Silvarrey Varela. Polígono de A Grela-Edificio Work Center. Galileo Galilei, 4-A. 15008 A Coruña. España.
, F.J. González Barcalab, J.J. Paz Esquetec, T.R. Pérez Castroa, L. Valdés Cuadradob, A. Castro Iglesiasd
a Fundación María José Jove
b Servicio de Neumología-Complejo Hospitalario de Santiago de Compostela, España
c Servicio de Medicina Preventiva-Complejo Hospitalario de Pontevedra, España
d Departamento de Medicina-Universidad de A Coruña. España
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">El asma y la rinitis son dos enfermedades con elevada prevalencia en la infancia&#44; con tendencia a incrementarse en los &#250;ltimos a&#241;os&#46; En ambas es frecuente el infradiagn&#243;stico&#46;</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Verificar la prevalencia de s&#237;ntomas de asma y rinitis en la poblaci&#243;n infantil&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Hemos realizado&#44; mediante cuestionario escrito&#44; un estudio transversal siguiendo la metodolog&#237;a del International Study of Asthma and Allergies in Childhood &#40;ISAAC&#41;&#44; de prevalencia de sintomatolog&#237;a de asma y rinitis en el &#225;rea de A Coru&#241;a&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Han sido incluidos 3&#46;017 ni&#241;os y ni&#241;as de 6 y 7 a&#241;os &#40;tasa de respuesta del 73&#44;9&#37;&#41;&#44; y 2&#46;981 de 13 y 14 a&#241;os &#40;tasa de respuesta del 93&#44;6&#37;&#41;&#46; Refirieron haber presentado sibilancias alguna vez el 25&#44;3&#37; de los ni&#241;os y ni&#241;as de 13 y 14 a&#241;os y el 37&#44;2&#37; de los de 6 y 7 a&#241;os&#46; Han presentado asma en alguna ocasi&#243;n el 18&#44;5&#37; de los adolescentes y el 13&#44;7 &#37; del grupo de menor edad&#46; La prevalencia de rinitis alguna vez fue del 30&#44;4&#37; a los 6 y 7 a&#241;os y del 47&#44;3&#37; a los 13 y 14 a&#241;os&#46; La mayor prevalencia de rinitis se produjo en el oto&#241;o&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">El asma y la rinitis son especialmente frecuentes en nuestra poblaci&#243;n&#44; superior a la observada en la mayor&#237;a de poblaciones espa&#241;olas estudiadas&#46;</p>"
      ]
      "en" => array:1 [
        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">The prevalence of asthma and rhinitis is high in childhood and has been increasing in the last few years&#46; In both diseases underdiagnosis is frequent&#46;</p> <span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To asses the prevalence of asthma and rhinitis symptoms in childhood&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">We performed a cross-sectional study using a written questionnaire&#44; following the methodology of the International Study of Asthma and Allergies in Childhood &#40;ISAAC&#41;&#44; on the prevalence of symptoms of asthma and rhinitis in La Coru&#241;a&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">A total of 3017 boys and girls aged 6-7 years old &#40;response rate 73&#46;9 &#37;&#41; and 2981 boys and girls aged 13-14 years old &#40;response rate 93&#46;6 &#37;&#41; were included&#46; The prevalence of &#8220;wheezing at some time&#8221; was 25&#46;3&#37; in adolescents aged 13-14 years old and was 37&#46;2 &#37; in children aged 6-7 years&#46; The prevalence of &#8220;asthma at some time&#8221; was 18&#46;5&#37; in adolescents and 13&#46;7&#37; in children&#46; The prevalence of &#8220;rhinitis at some time&#8221; was 30&#46;4&#37; in the group aged 6-7 years and 47&#46;3&#37; in the group of adolescents&#46; The prevalence of rhinitis was highest in autumn&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The prevalence of asthma and rhinitis is high in our population and is higher than that observed in most Spanish populations studied&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara">Financiaci&#243;n y promoci&#243;n&#58; Fundaci&#243;n &#8220;Mar&#237;a Jos&#233; Jove&#8221;&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
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        0 => array:1 [
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              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
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                    0 => array:2 [
                      "titulo" => "Population disparities in asthma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;R&#46; Gold"
                            1 => "R&#46; Wright"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1146/annurev.publhealth.26.021304.144528"
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                        "tituloSerie" => "Annu Rev Public Health"
                        "fecha" => "2005"
                        "volumen" => "26"
                        "paginaInicial" => "89"
                        "paginaFinal" => "113"
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15760282"
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                          ]
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              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The burden of asthma in children&#58; A European perspective"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "F&#46;H&#46; Sennhauser"
                            1 => "C&#46; Braun-Fahrlander"
                            2 => "J&#46;H&#46; Wildhaber"
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                  ]
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                    0 => array:2 [
                      "doi" => "10.1016/j.prrv.2004.11.001"
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                        "tituloSerie" => "Paediatr Respir Rev&#46;"
                        "fecha" => "2005"
                        "volumen" => "6"
                        "paginaInicial" => "2"
                        "paginaFinal" => "7"
                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15698807"
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                  ]
                ]
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              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Trends in childhood asthma&#58; Prevalence&#44; health care utilization&#44; and mortality"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "L&#46;J&#46; Akinbami"
                            1 => "K&#46;C&#46; Schoendorf"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatrics"
                        "fecha" => "2002"
                        "volumen" => "110"
                        "paginaInicial" => "315"
                        "paginaFinal" => "322"
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12165584"
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                  ]
                ]
              ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Trends in asthma&#44; allergic rhinitis and eczema among Swedish conscripts from farming and non-farming environments&#46; A nationwide study over three decades"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "L&#46; Braback"
                            1 => "A&#46; Hjern"
                            2 => "F&#46; Rasmussen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Allergy"
                        "fecha" => "2004"
                        "volumen" => "34"
                        "paginaInicial" => "38"
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14720260"
                            "web" => "Medline"
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                ]
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Stabilization of asthma prevalence among adolescents and increase among schoolchildren &#40;ISAAC phases I and III&#41; in Spain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Garc&#237;a-Marcos"
                            1 => "A&#46;B&#46; Quir&#243;s"
                            2 => "G&#46;G&#46; Hern&#225;ndez"
                            3 => "F&#46; Guill&#233;n-Grima"
                            4 => "C&#46;G&#46; D&#237;az"
                            5 => "I&#46;C&#46; Urena"
                          ]
                        ]
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                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1111/j.1398-9995.2004.00562.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Allergy"
                        "fecha" => "2004"
                        "volumen" => "59"
                        "paginaInicial" => "1301"
                        "paginaFinal" => "1307"
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15507099"
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                ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hospitalizations for childhood asthma in Athens&#44; Greece&#44; from 1978 to 2000"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "K&#46; Priftis"
                            1 => "P&#46; Panagiotopoulou-Gartagani"
                            2 => "P&#46; Tapratzi-Potamianou"
                            3 => "A&#46; Zachariadi-Xypolita"
                            4 => "A&#46; Sagriotis"
                            5 => "P&#46; Saxoni-Papageorgiou"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1399-3038.2005.00196.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Allergy Immunol&#46;"
                        "fecha" => "2005"
                        "volumen" => "16"
                        "paginaInicial" => "82"
                        "paginaFinal" => "85"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15693917"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increasing prevalence of allergic rhinitis but not asthma among children in Hong Kong from 1995 to 2001 &#40;Phase 3 International Study of Asthma and Allergies in Childhood&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46;L&#46; Lee"
                            1 => "W&#46; Wong"
                            2 => "Y&#46;L&#46; Lau"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Allergy Immunol&#46;"
                        "fecha" => "2004"
                        "volumen" => "15"
                        "paginaInicial" => "72"
                        "paginaFinal" => "78"
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14998385"
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                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tendencia temporal y variaciones geogr&#225;ficas de la prevalencia de s&#237;ntomas de rinitis al&#233;rgica en escolares de 6-7 a&#241;os de ocho &#225;reas espa&#241;olas&#44; seg&#250;n el ISAAC"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Arnedo-Pena"
                            1 => "L&#46; Garc&#237;a-Marcos"
                            2 => "G&#46; Garc&#237;a Hern&#225;ndez"
                            3 => "I&#46; Aguinaga Ontoso"
                            4 => "C&#46; Gonz&#225;lez D&#237;az"
                            5 => "M&#46; Morales Su&#225;rez-Varela"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "An Pediatr &#40;Barc&#41;"
                        "fecha" => "2005"
                        "volumen" => "62"
                        "paginaInicial" => "229"
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                      ]
                    ]
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                ]
              ]
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              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Unawareness and undertreatment of asthma and allergic rhinitis in a general population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46; Nolte"
                            1 => "S&#46; Nepper-Christensen"
                            2 => "V&#46; Backer"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1016/j.rmed.2005.05.012"
                      "Revista" => array:6 [
                        "tituloSerie" => "Respir Med&#46;"
                        "fecha" => "2006"
                        "volumen" => "100"
                        "paginaInicial" => "354"
                        "paginaFinal" => "362"
                        "link" => array:1 [
                          0 => array:2 [
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                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of asthma and asthma-like symptoms in inner-city schoolchildren"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Mvula"
                            1 => "M&#46; Larzelere"
                            2 => "M&#46; Kraus"
                            3 => "K&#46; Moisiewicz"
                            4 => "C&#46; Morgan"
                            5 => "S&#46; Pierce"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Asthma"
                        "fecha" => "2005"
                        "volumen" => "42"
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                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
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                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Mart&#237;nez-Moratalla"
                            1 => "E&#46; Almar"
                            2 => "J&#46; Sunyer"
                            3 => "J&#46; Ramos"
                            4 => "A&#46; Pereira"
                            5 => "F&#46; Payo"
                          ]
                        ]
                      ]
                    ]
                  ]
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                        "volumen" => "35"
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                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
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                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "I&#46; Aguinaga Ontoso"
                            1 => "A&#46; Arnedo Pena"
                            2 => "J&#46; Bellido"
                            3 => "F&#46; Guill&#233;n Grima"
                            4 => "M&#46;M&#46; Su&#225;rez Varela"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
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                      "Revista" => array:5 [
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                        "fecha" => "1999"
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            12 => array:3 [
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                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "The International Study of Asthma&#44; Allergies in Childhood &#40;ISAAC&#41; Steering Committee"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
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                        "fecha" => "1998"
                        "volumen" => "12"
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                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Changes in prevalence of asthma and allergies among children and adolescents in Italy&#58; 1994-2002"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Galassi"
                            1 => "M&#46; De Sario"
                            2 => "A&#46; Biggeri"
                            3 => "L&#46; Bisanti"
                            4 => "E&#46; Chellini"
                            5 => "G&#46; Ciccone"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1542/peds.2004-2709"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatrics"
                        "fecha" => "2006"
                        "volumen" => "117"
                        "paginaInicial" => "34"
                        "paginaFinal" => "42"
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                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Trends in prevalence of asthma&#44; allergic rhinitis and atopic dermatitis in 5-7-year old Swiss children from 1992 to 2001"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Grize"
                            1 => "M&#46; Gassner"
                            2 => "B&#46; Wuthrich"
                            3 => "B&#46; Bringolf-Isler"
                            4 => "K&#46; Takken-Sahli"
                            5 => "F&#46;H&#46; Sennhauser"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1398-9995.2006.01030.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Allergy"
                        "fecha" => "2006"
                        "volumen" => "61"
                        "paginaInicial" => "556"
                        "paginaFinal" => "562"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16629784"
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ISSN: 16954033
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