Títulos de anti-HBs tras un programa de vacunación en niños y adolescentes: ¿revacunar?
Anti-hepatitis b Virus Surface Antigen Titers After a Vaccination Program In Children And Adolescents. Should a Booster Dose Be Given?
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"tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "32" "paginaFinal" => "37" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "L.A. García Llop, A. Asensi Alcoverro, P. Coll Más, M.<span class="elsevierStyleSup">a</span>A. Ramada Benedito, C. Grafiá Juan" "autores" => array:5 [ 0 => array:4 [ "nombre" => "L.A." "apellidos" => "García Llop" "email" => array:1 [ 0 => "lugallo@retemail.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "A." "apellidos" => "Asensi Alcoverro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "P." "apellidos" => "Coll Más" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "M.<span class="elsevierStyleSup">a</span>A." "apellidos" => "Ramada Benedito" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "C." "apellidos" => "Grafiá Juan" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Centro de Salud de Manises. Valencia" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Centro de Salud Ingeniero Joaquín Benlloch. Valencia" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: San Jacinto, 27-28. 46008 Valencia" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Anti-hepatitis b Virus Surface Antigen Titers After a Vaccination Program In Children And Adolescents. Should a Booster Dose Be Given?" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2000-01-31" "fechaAceptado" => "2000-10-31" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec186540" "palabras" => array:8 [ 0 => "acuna de la hepatitis B" 1 => "Antígeno" 2 => "Dosis" 3 => "Calendario" 4 => "Inmunización" 5 => "Recién nacido" 6 => "Adolescente" 7 => "Memoria in-munológica" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec186541" "palabras" => array:7 [ 0 => "epatitis B vaccine" 1 => "Antigen" 2 => "Dose" 3 => "Schedule" 4 => "Immunization" 5 => "Adolescent" 6 => "Immunologic memory" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Tras haber pasado 6 años desde el inicio de la campaña de vacunación masiva de la hepatitis B en recién nacidos y adolescentes (12 años), se pretende conocer la eficacia e inmunogenicidad de la misma, la persistencia de los valores de anti-HBs y la necesidad de realizar dosis de recuerdo.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se utilizó la vacuna Engerix<span class="elsevierStyleSup">®</span> desde 1993 hasta 1987 (10 μg) y desde entonces la vacuna Recombivax<span class="elsevierStyleSup">®</span> (5 μg). El calendario vacunal fue el estándar de 3 dosis (0, 1 y 6 años). Para realizar el estudio se aprovechó cualquier análisis de sangre para cuantificar el título de anti-HBs, entre octubre de 1998 y mayo de 2000.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se obtuvieron 382 casos. A los 5 años de la primera dosis, el 96,1% (73/76) tenían anti-HBs y el 75% (57/76) por encima de 10 U/l. A los 6–7 años de la vacunación, en el 94,1% (32/34) de los niños se detectaba anti-HBs y en el 70,6% (24/34) de éstos por encima de 10 U/l. Sólo en 5 niños fue negativo el anticuerpo.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">En este estudio se ha encontrado un alto porcentaje de niños con buenos valores de anti-HBs, tras 6–7 años de la vacunación. La bibliografía reciente demuestra que, dada la memoria inmunológica que produce la vacuna, no es necesaria la revacunación. También debe olvidarse el denominado nivel protectivo de anti-HBs (> 10 U/l), sólo válido cuando se aplica inmunidad pasiva con inmunoglobu-linas.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To determine the efficacy and immunogenicity achieved 6 years after the start of a massive vaccination campaign against hepatitis B in newborn infants and adolescents (12 years). The persistence of anti-hepatitis B virus surface antigen (HBs) levels and the need for a booster dose were also assessed.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">From 1993 to 1997 the Engerix<span class="elsevierStyleSup">®</span> vaccine (10 μg) was used and since then the Recombivax<span class="elsevierStyleSup">®</span> vaccine (5 ^.g). The vaccination schedule was the standard of three doses (0, 1, 6). Blood analyses were used for determination of anti-HBs between October of 1998 and May of 2000.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">We studied 382 cases. Five years after the first dose, 96.1% (73/76) had anti-HBs and in 75% (57/76) levels were above 10 Ul/l. Six to seven years after vaccination anti-HBs were detected in 94.1 % (32/34) of the children and in 70.6% (24/34) of these, levels were above 10 Ul/l.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">A high percentage of children were found to have good levels of anti-HBs 6–7 years after vaccination. Recent studies show that booster doses are not required because of the immunologic memory that produces the vaccine. The anti-HB protective level (> 10 Ul/l) should not be taken into consideration because this level is only valid when passive immunity with immunoglobulins is applied.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliogrífia" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:41 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 8 | 12 | 20 |
| 2024 Octubre | 56 | 45 | 101 |
| 2024 Septiembre | 64 | 69 | 133 |
| 2024 Agosto | 78 | 109 | 187 |
| 2024 Julio | 40 | 42 | 82 |
| 2024 Junio | 56 | 32 | 88 |
| 2024 Mayo | 45 | 38 | 83 |
| 2024 Abril | 48 | 36 | 84 |
| 2024 Marzo | 46 | 28 | 74 |
| 2024 Febrero | 44 | 41 | 85 |
| 2024 Enero | 26 | 33 | 59 |
| 2023 Diciembre | 22 | 20 | 42 |
| 2023 Noviembre | 34 | 50 | 84 |
| 2023 Octubre | 36 | 34 | 70 |
| 2023 Septiembre | 25 | 28 | 53 |
| 2023 Agosto | 28 | 21 | 49 |
| 2023 Julio | 44 | 29 | 73 |
| 2023 Junio | 36 | 21 | 57 |
| 2023 Mayo | 37 | 29 | 66 |
| 2023 Abril | 29 | 20 | 49 |
| 2023 Marzo | 24 | 24 | 48 |
| 2023 Febrero | 24 | 14 | 38 |
| 2023 Enero | 26 | 39 | 65 |
| 2022 Diciembre | 39 | 21 | 60 |
| 2022 Noviembre | 44 | 38 | 82 |
| 2022 Octubre | 30 | 37 | 67 |
| 2022 Septiembre | 33 | 18 | 51 |
| 2022 Agosto | 28 | 45 | 73 |
| 2022 Julio | 19 | 35 | 54 |
| 2022 Junio | 28 | 40 | 68 |
| 2022 Mayo | 29 | 40 | 69 |
| 2022 Abril | 29 | 47 | 76 |
| 2022 Marzo | 36 | 38 | 74 |
| 2022 Febrero | 26 | 40 | 66 |
| 2022 Enero | 29 | 43 | 72 |
| 2021 Diciembre | 29 | 41 | 70 |
| 2021 Noviembre | 24 | 47 | 71 |
| 2021 Octubre | 70 | 40 | 110 |
| 2021 Septiembre | 35 | 41 | 76 |
| 2021 Agosto | 24 | 32 | 56 |
| 2021 Julio | 27 | 33 | 60 |
| 2021 Junio | 38 | 33 | 71 |
| 2021 Mayo | 38 | 24 | 62 |
| 2021 Abril | 89 | 52 | 141 |
| 2021 Marzo | 101 | 20 | 121 |
| 2021 Febrero | 87 | 14 | 101 |
| 2021 Enero | 57 | 14 | 71 |
| 2020 Diciembre | 59 | 6 | 65 |
| 2020 Noviembre | 43 | 14 | 57 |
| 2020 Octubre | 22 | 11 | 33 |
| 2020 Septiembre | 18 | 5 | 23 |
| 2020 Agosto | 42 | 10 | 52 |
| 2020 Julio | 66 | 16 | 82 |
| 2020 Junio | 40 | 18 | 58 |
| 2020 Mayo | 53 | 15 | 68 |
| 2020 Abril | 28 | 10 | 38 |
| 2020 Marzo | 37 | 8 | 45 |
| 2020 Febrero | 36 | 13 | 49 |
| 2020 Enero | 27 | 11 | 38 |
| 2019 Diciembre | 44 | 21 | 65 |
| 2019 Noviembre | 29 | 16 | 45 |
| 2019 Octubre | 33 | 10 | 43 |
| 2019 Septiembre | 25 | 18 | 43 |
| 2019 Agosto | 34 | 21 | 55 |
| 2019 Julio | 29 | 36 | 65 |
| 2019 Junio | 36 | 36 | 72 |
| 2019 Mayo | 96 | 46 | 142 |
| 2019 Abril | 105 | 21 | 126 |
| 2019 Marzo | 35 | 14 | 49 |
| 2019 Febrero | 23 | 9 | 32 |
| 2019 Enero | 25 | 21 | 46 |
| 2018 Diciembre | 21 | 32 | 53 |
| 2018 Noviembre | 51 | 26 | 77 |
| 2018 Octubre | 53 | 19 | 72 |
| 2018 Septiembre | 16 | 6 | 22 |
| 2018 Agosto | 2 | 0 | 2 |
| 2018 Junio | 1 | 0 | 1 |
| 2018 Mayo | 4 | 0 | 4 |
| 2018 Abril | 12 | 0 | 12 |
| 2018 Marzo | 13 | 0 | 13 |
| 2018 Febrero | 11 | 0 | 11 |
| 2018 Enero | 9 | 0 | 9 |
| 2017 Diciembre | 7 | 0 | 7 |
| 2017 Noviembre | 20 | 0 | 20 |
| 2017 Octubre | 19 | 0 | 19 |
| 2017 Septiembre | 10 | 0 | 10 |
| 2017 Agosto | 14 | 0 | 14 |
| 2017 Julio | 13 | 0 | 13 |
| 2017 Junio | 21 | 20 | 41 |
| 2017 Mayo | 24 | 28 | 52 |
| 2017 Abril | 28 | 19 | 47 |
| 2017 Marzo | 11 | 18 | 29 |
| 2017 Febrero | 15 | 10 | 25 |
| 2017 Enero | 10 | 4 | 14 |
| 2016 Diciembre | 21 | 11 | 32 |
| 2016 Noviembre | 46 | 13 | 59 |
| 2016 Octubre | 44 | 14 | 58 |
| 2016 Septiembre | 48 | 22 | 70 |
| 2016 Agosto | 15 | 3 | 18 |
| 2016 Julio | 18 | 8 | 26 |
| 2016 Abril | 3 | 0 | 3 |
| 2016 Marzo | 6 | 15 | 21 |
| 2015 Diciembre | 1 | 0 | 1 |
| 2015 Agosto | 3 | 0 | 3 |
| 2015 Julio | 11 | 0 | 11 |
| 2015 Junio | 13 | 0 | 13 |
| 2015 Mayo | 14 | 0 | 14 |
| 2015 Abril | 15 | 0 | 15 |
| 2015 Marzo | 14 | 0 | 14 |
| 2015 Febrero | 15 | 0 | 15 |
| 2015 Enero | 13 | 0 | 13 |
| 2014 Diciembre | 17 | 1 | 18 |
| 2014 Noviembre | 9 | 0 | 9 |
| 2014 Octubre | 10 | 1 | 11 |
| 2014 Septiembre | 12 | 5 | 17 |
| 2014 Agosto | 9 | 1 | 10 |
| 2014 Julio | 8 | 1 | 9 |
| 2014 Junio | 13 | 3 | 16 |
| 2014 Mayo | 12 | 4 | 16 |
| 2014 Abril | 15 | 3 | 18 |
| 2014 Marzo | 19 | 7 | 26 |
| 2014 Febrero | 9 | 9 | 18 |
| 2014 Enero | 6 | 5 | 11 |
| 2013 Diciembre | 16 | 14 | 30 |
| 2013 Noviembre | 9 | 9 | 18 |
| 2013 Octubre | 18 | 7 | 25 |
| 2013 Septiembre | 22 | 9 | 31 |
| 2013 Agosto | 10 | 7 | 17 |
| 2013 Julio | 3 | 3 | 6 |
| 2013 Junio | 2 | 2 | 4 |
| 2013 Mayo | 3 | 2 | 5 |
| 2013 Abril | 1 | 3 | 4 |
| 2013 Marzo | 5 | 2 | 7 |
| 2013 Febrero | 20 | 1 | 21 |
| 2013 Enero | 17 | 1 | 18 |
| 2012 Diciembre | 7 | 1 | 8 |
| 2012 Noviembre | 6 | 1 | 7 |
| 2012 Septiembre | 0 | 1 | 1 |
| 2012 Agosto | 2 | 0 | 2 |
| 2001 Enero | 1076 | 0 | 1076 |
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