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        "resumen" => "<span class="elsevierStyleSectionTitle">Antecedentes</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El s&#237;ndrome X fr&#225;gil &#40;SXF&#41; es la causa hereditaria m&#225;s frecuente de retraso mental&#46; Puede diagnosticarse con t&#233;cnicas de gen&#233;tica molecular&#44; pero su variada expresi&#243;n dificulta la sospecha cl&#237;nica</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se valora la utilidad de un test de seis criterios cl&#237;nicos como m&#233;todo de preselecci&#243;n a los ni&#241;os candidatos para estudio gen&#233;tico del s&#237;ndrome</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se estudiaron 70 pacientes varones entre 2 y 10 a&#241;os&#44; con retraso mental de causa desconocida&#44; aplic&#225;ndoseles un test con seis criterios cl&#237;nicos &#40;retraso mental&#44; historia familiar de retraso mental&#44; facies alargada&#44; orejas grandes&#44; conducta aut&#237;stica y d&#233;ficit de atenci&#243;n&#41; que se valoraron de 0 a 2 puntos&#46; En todos se realiz&#243; estudio molecular del gen SXF usando reacci&#243;n en cadena de la polimerasa y Southern-blot</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El estudio molecular confirm&#243; la mutaci&#243;n complete &#40;&#62; 200 repeticiones CGG&#41; en 14&#47;70 &#40;20 &#37;&#41; ni&#241;os&#46; La suma de 6 puntos en el test fue el l&#237;mite m&#225;s discriminativo y fue alcanzado por los 14 enfermos con mutaci&#243;n &#40;100 &#37;&#41;&#44; pero s&#243;lo por 2 de 56 casos &#40;3&#44;5 &#37;&#41; sin mutaci&#243;n&#46; El mejor modelo diagn&#243;stico fue la asociaci&#243;n del retraso mental&#44; deficiencia de atenci&#243;n e hiperactividad&#44; historia familiar de retraso mental y orejas grandes seguido de la facies alargada y la conducta autista</p> <span class="elsevierStyleSectionTitle">Conclusi&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Un test cl&#237;nico de 6 par&#225;metros facilita la preselecci&#243;n de ni&#241;os con sospecha de SXF para ser confirmados luego con t&#233;cnicas de gen&#233;tica molecular</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Fragile X syndrome &#40;FXS&#41; is the most frequent hereditary cause of mental retardation&#46; It can be diagnosed by molecular genetic techniques&#44; but clinical suspicion is made less likely by it variable expression</p> <span class="elsevierStyleSectionTitle">Objective</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">To assess the effectiveness of a six-item checklist in the preselection of children who are candidates for FXS genetic study</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">W e studied 70 male patients aged between 2 and 10 years with mental retardation of unknown cause&#46; In all patients a checklist with six clinical criteria &#40;mental retardation&#44; history of familial mental retardation&#44; long face&#44; large ears&#44; autistic-like behaviour&#44; and attention deficit disorder with hyperactivity&#41; measured from 0-2 points was applied and molecular genetic studies using polymerase chain reaction and Southern-blot were performed</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">In 14 of the 70 children &#40;20 &#37;&#41; molecular study confirmed full mutation &#40;&#62; 200 CGG repeats&#41;&#46; A score of six points in the test had the greatest discriminatory power and was reached by 14 patients &#40;100 &#37;&#41; with mutation&#44; but only by 2 of 56 patients &#40;3&#46;5 &#37;&#41; without mutation&#46; The most accurate diagnostic model was the association of mental retardation&#44; attention deficit disorder with hyperactivity&#44; large ears and a history of familial mental retardation followed by long face and autistic-like behaviour</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">The six-item checklist improved the preselection of children with suspicion of FXS&#44; which was later confirmed by molecular genetic techniques</p>"
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Eficacia de un test clínico como preselección de niños con sospecha de síndrome X frágil
Effectiveness of a clinical checklist in the preselection of children with suspicion of fragile X syndrome
I. Fernández Carvajala, A. Blanco Quirósa,
Autor para correspondencia
ablanco@ped.uva.es

Correspondencia: Área de Pediatría. Facultad de Medicina. Ramón y Cajal, 5. 47005 Valladolid
, J. Fernández Toralb, J.J. Tellería Orriolsa, M.J. Alonso Ramosa, A. Sanz Cantalapiedraa, J.F. Martín Rodríguezc, R. Palencia Luancesd
a Instituto de Biología Molecular y Genética (IBGM)
b Unidad de Genética. Hospital Central de Oviedo
c Área de Estadística. Universidad de Valladolid
d Servicio de Pediatría. Hospital Clínico de Valladolid
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        "titulo" => "Effectiveness of a clinical checklist in the preselection of children with suspicion of fragile X syndrome"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Antecedentes</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El s&#237;ndrome X fr&#225;gil &#40;SXF&#41; es la causa hereditaria m&#225;s frecuente de retraso mental&#46; Puede diagnosticarse con t&#233;cnicas de gen&#233;tica molecular&#44; pero su variada expresi&#243;n dificulta la sospecha cl&#237;nica</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se valora la utilidad de un test de seis criterios cl&#237;nicos como m&#233;todo de preselecci&#243;n a los ni&#241;os candidatos para estudio gen&#233;tico del s&#237;ndrome</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se estudiaron 70 pacientes varones entre 2 y 10 a&#241;os&#44; con retraso mental de causa desconocida&#44; aplic&#225;ndoseles un test con seis criterios cl&#237;nicos &#40;retraso mental&#44; historia familiar de retraso mental&#44; facies alargada&#44; orejas grandes&#44; conducta aut&#237;stica y d&#233;ficit de atenci&#243;n&#41; que se valoraron de 0 a 2 puntos&#46; En todos se realiz&#243; estudio molecular del gen SXF usando reacci&#243;n en cadena de la polimerasa y Southern-blot</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El estudio molecular confirm&#243; la mutaci&#243;n complete &#40;&#62; 200 repeticiones CGG&#41; en 14&#47;70 &#40;20 &#37;&#41; ni&#241;os&#46; La suma de 6 puntos en el test fue el l&#237;mite m&#225;s discriminativo y fue alcanzado por los 14 enfermos con mutaci&#243;n &#40;100 &#37;&#41;&#44; pero s&#243;lo por 2 de 56 casos &#40;3&#44;5 &#37;&#41; sin mutaci&#243;n&#46; El mejor modelo diagn&#243;stico fue la asociaci&#243;n del retraso mental&#44; deficiencia de atenci&#243;n e hiperactividad&#44; historia familiar de retraso mental y orejas grandes seguido de la facies alargada y la conducta autista</p> <span class="elsevierStyleSectionTitle">Conclusi&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Un test cl&#237;nico de 6 par&#225;metros facilita la preselecci&#243;n de ni&#241;os con sospecha de SXF para ser confirmados luego con t&#233;cnicas de gen&#233;tica molecular</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Fragile X syndrome &#40;FXS&#41; is the most frequent hereditary cause of mental retardation&#46; It can be diagnosed by molecular genetic techniques&#44; but clinical suspicion is made less likely by it variable expression</p> <span class="elsevierStyleSectionTitle">Objective</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">To assess the effectiveness of a six-item checklist in the preselection of children who are candidates for FXS genetic study</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">W e studied 70 male patients aged between 2 and 10 years with mental retardation of unknown cause&#46; In all patients a checklist with six clinical criteria &#40;mental retardation&#44; history of familial mental retardation&#44; long face&#44; large ears&#44; autistic-like behaviour&#44; and attention deficit disorder with hyperactivity&#41; measured from 0-2 points was applied and molecular genetic studies using polymerase chain reaction and Southern-blot were performed</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">In 14 of the 70 children &#40;20 &#37;&#41; molecular study confirmed full mutation &#40;&#62; 200 CGG repeats&#41;&#46; A score of six points in the test had the greatest discriminatory power and was reached by 14 patients &#40;100 &#37;&#41; with mutation&#44; but only by 2 of 56 patients &#40;3&#46;5 &#37;&#41; without mutation&#46; The most accurate diagnostic model was the association of mental retardation&#44; attention deficit disorder with hyperactivity&#44; large ears and a history of familial mental retardation followed by long face and autistic-like behaviour</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">The six-item checklist improved the preselection of children with suspicion of FXS&#44; which was later confirmed by molecular genetic techniques</p>"
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ISSN: 16954033
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