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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Evaluar los s&#237;ntomas de inicio de un grupo de ni&#241;os diagnosticados de neuroblastoma tor&#225;cico&#44; as&#237; como otras variables epidemiol&#243;gicas</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se han revisado 46 casos de neuroblastoma intrator&#225;cico diagnosticados y tratados en la unidad de oncolog&#237;a pedi&#225;trica desde enero de 1984 a diciembre de 1998&#46; Se excluyeron los neuroblastomas con extensi&#243;n abdominal</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La edad media de los pacientes fue de 2 a&#241;os y 5 meses &#40;l&#237;mites&#44; 0-12 a&#241;os&#41;&#46; El grupo de edad m&#225;s frecuente fue el de lactantes &#40;85 &#37;&#41;&#46; El porcentaje de ni&#241;os fue superior al de ni&#241;as&#46; El 57 &#37; de los casos presentaban alg&#250;n s&#237;ntoma inicial&#44; frente al 43 &#37; que se diagnosticaron de forma casual&#46; Los s&#237;ntomas m&#225;s frecuentes fueron la tos &#40;18 &#37;&#41; y la presencia de tumor o adenopat&#237;a palpable &#40;9 &#37;&#41;&#46; El per&#237;odo medio de latencia al diagn&#243;stico en los casos sintom&#225;ticos fue de 10 semanas&#46; El m&#233;todo diagn&#243;stico m&#225;s empleado fue la radiograf&#237;a de t&#243;rax &#40;89 &#37;&#41;&#46; El 9&#37; ten&#237;an antecedentes personales de otras enfermedades y en el 26 &#37; hab&#237;a antecedentes familiares de enfermedad tumoral&#46; La tasa de supervivencia libre de enfermedad se sit&#250;a en el 90 &#37; a los 5 a&#241;os&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El neuroblastoma tor&#225;cico predomina en varones menores de 6 meses&#46; Habitualmente se diagnostica en los primeros 2 meses de iniciados los s&#237;ntomas en los casos sintom&#225;ticos&#44; si bien una gran parte de ellos son asintom&#225;ticos por tratarse de hallazgos casuales&#46; El s&#237;ntoma m&#225;s frecuente es la tos y la primera prueba diagn&#243;stica es la radiograf&#237;a tor&#225;cica en la mayor parte de los casos</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To analyze clinical onset and other epidemiological findings in a group of children diagnosed with thoracic neuroblastoma</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We reviewed 46 non-metastatic thoracic neuroblastomas diagnosed and treated from January 1984 to December 1998 at the Pediatric Oncology Unit&#46; Abdominal neuroblastomas were excluded</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Mean age was 2 years and 5 months &#40;range&#44; 0-12 years&#41;&#46; Eighty-five percent of the patients were infants &#40;aged less than 1 year&#41;&#46; Neuroblastoma was more frequent in males than in females&#46; Fifty-seven percent of the patients were symptomatic and 43 &#37; were asymptomatic&#46; The most frequent clinical findings were cough &#40;18 &#37;&#41; and palpable tumor or adenopathy &#40;9 &#37;&#41;&#46; Mean lag-time to diagnosis was 10 weeks in symptomatic patients&#46; Thoracic x-ray was the most useful diagnostic method &#40;89 &#37;&#41;&#46; Previous family history of neoplasias was present in 26 &#37;&#46; Four patients &#40;9&#37;&#41; had personal antecedents of other diseases&#46; At the time of the study the event-free survival for the 46 patients was 90 &#37; at 5 years &#40;1-14 years&#41;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Thoracic neuroblastoma was more prevalent in male infants aged less than 6 months&#46; Most symptomatic patients were diagnosed in the 2 first months after onset&#44; and asymptomatic cases were common&#46; The most frequent symptom was cough and most of the patients were diagnosed by thoracic x-ray</p>"
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Semiología inicial del neuroblastoma torácico
Clinical findings in thoracic neuroblastomas
F. Díaz Fernández
Autor para correspondencia
649681561@activajoven.tsm.es

Correspondencia: Geranio, 10, 2.° C. 41008 Sevilla.
, E. Quiroga Cantero
Unidad de Oncología Pediátrica. Hospital Infantil. Hospital Universitario Virgen del Rocío. Sevilla
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Evaluar los s&#237;ntomas de inicio de un grupo de ni&#241;os diagnosticados de neuroblastoma tor&#225;cico&#44; as&#237; como otras variables epidemiol&#243;gicas</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se han revisado 46 casos de neuroblastoma intrator&#225;cico diagnosticados y tratados en la unidad de oncolog&#237;a pedi&#225;trica desde enero de 1984 a diciembre de 1998&#46; Se excluyeron los neuroblastomas con extensi&#243;n abdominal</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La edad media de los pacientes fue de 2 a&#241;os y 5 meses &#40;l&#237;mites&#44; 0-12 a&#241;os&#41;&#46; El grupo de edad m&#225;s frecuente fue el de lactantes &#40;85 &#37;&#41;&#46; El porcentaje de ni&#241;os fue superior al de ni&#241;as&#46; El 57 &#37; de los casos presentaban alg&#250;n s&#237;ntoma inicial&#44; frente al 43 &#37; que se diagnosticaron de forma casual&#46; Los s&#237;ntomas m&#225;s frecuentes fueron la tos &#40;18 &#37;&#41; y la presencia de tumor o adenopat&#237;a palpable &#40;9 &#37;&#41;&#46; El per&#237;odo medio de latencia al diagn&#243;stico en los casos sintom&#225;ticos fue de 10 semanas&#46; El m&#233;todo diagn&#243;stico m&#225;s empleado fue la radiograf&#237;a de t&#243;rax &#40;89 &#37;&#41;&#46; El 9&#37; ten&#237;an antecedentes personales de otras enfermedades y en el 26 &#37; hab&#237;a antecedentes familiares de enfermedad tumoral&#46; La tasa de supervivencia libre de enfermedad se sit&#250;a en el 90 &#37; a los 5 a&#241;os&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El neuroblastoma tor&#225;cico predomina en varones menores de 6 meses&#46; Habitualmente se diagnostica en los primeros 2 meses de iniciados los s&#237;ntomas en los casos sintom&#225;ticos&#44; si bien una gran parte de ellos son asintom&#225;ticos por tratarse de hallazgos casuales&#46; El s&#237;ntoma m&#225;s frecuente es la tos y la primera prueba diagn&#243;stica es la radiograf&#237;a tor&#225;cica en la mayor parte de los casos</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To analyze clinical onset and other epidemiological findings in a group of children diagnosed with thoracic neuroblastoma</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We reviewed 46 non-metastatic thoracic neuroblastomas diagnosed and treated from January 1984 to December 1998 at the Pediatric Oncology Unit&#46; Abdominal neuroblastomas were excluded</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Mean age was 2 years and 5 months &#40;range&#44; 0-12 years&#41;&#46; Eighty-five percent of the patients were infants &#40;aged less than 1 year&#41;&#46; Neuroblastoma was more frequent in males than in females&#46; Fifty-seven percent of the patients were symptomatic and 43 &#37; were asymptomatic&#46; The most frequent clinical findings were cough &#40;18 &#37;&#41; and palpable tumor or adenopathy &#40;9 &#37;&#41;&#46; Mean lag-time to diagnosis was 10 weeks in symptomatic patients&#46; Thoracic x-ray was the most useful diagnostic method &#40;89 &#37;&#41;&#46; Previous family history of neoplasias was present in 26 &#37;&#46; Four patients &#40;9&#37;&#41; had personal antecedents of other diseases&#46; At the time of the study the event-free survival for the 46 patients was 90 &#37; at 5 years &#40;1-14 years&#41;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Thoracic neuroblastoma was more prevalent in male infants aged less than 6 months&#46; Most symptomatic patients were diagnosed in the 2 first months after onset&#44; and asymptomatic cases were common&#46; The most frequent symptom was cough and most of the patients were diagnosed by thoracic x-ray</p>"
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ISSN: 16954033
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