Semiología inicial del neuroblastoma torácico
Clinical findings in thoracic neuroblastomas
F. Díaz Fernández
, E. Quiroga Cantero
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Unidad de Oncología Pediátrica. Hospital Infantil. Hospital Universitario Virgen del Rocío. Sevilla
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Badia Llach, A. Benavides Ruiz, L. Rajmil Rajmil" "autores" => array:3 [ 0 => array:2 [ "nombre" => "X." "apellidos" => "Badia Llach" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Benavides Ruiz" ] 2 => array:2 [ "nombre" => "L." "apellidos" => "Rajmil Rajmil" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403301775169?idApp=UINPBA00005H" "url" => "/16954033/0000005400000003/v1_201307051543/S1695403301775169/v1_201307051543/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Semiología inicial del neuroblastoma torácico" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "222" "paginaFinal" => "227" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "F. Díaz Fernández, E. Quiroga Cantero" "autores" => array:2 [ 0 => array:4 [ "nombre" => "F." "apellidos" => "Díaz Fernández" "email" => array:1 [ 0 => "649681561@activajoven.tsm.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "E." "apellidos" => "Quiroga Cantero" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Unidad de Oncología Pediátrica. Hospital Infantil. Hospital Universitario Virgen del Rocío. Sevilla" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Geranio, 10, 2.° C. 41008 Sevilla." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Clinical findings in thoracic neuroblastomas" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2000-05-31" "fechaAceptado" => "2000-06-30" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:3 [ "clase" => "keyword" "identificador" => "xpalclavsec186593" "palabras" => array:3 [ 0 => "Neuroblastoma torácico" 1 => "Niños" 2 => "Síntomas" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec186594" "palabras" => array:3 [ 0 => "Thoracic neuroblastoma" 1 => "Children" 2 => "Clinical findings" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Evaluar los síntomas de inicio de un grupo de niños diagnosticados de neuroblastoma torácico, así como otras variables epidemiológicas</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se han revisado 46 casos de neuroblastoma intratorácico diagnosticados y tratados en la unidad de oncología pediátrica desde enero de 1984 a diciembre de 1998. Se excluyeron los neuroblastomas con extensión abdominal</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La edad media de los pacientes fue de 2 años y 5 meses (límites, 0-12 años). El grupo de edad más frecuente fue el de lactantes (85 %). El porcentaje de niños fue superior al de niñas. El 57 % de los casos presentaban algún síntoma inicial, frente al 43 % que se diagnosticaron de forma casual. Los síntomas más frecuentes fueron la tos (18 %) y la presencia de tumor o adenopatía palpable (9 %). El período medio de latencia al diagnóstico en los casos sintomáticos fue de 10 semanas. El método diagnóstico más empleado fue la radiografía de tórax (89 %). El 9% tenían antecedentes personales de otras enfermedades y en el 26 % había antecedentes familiares de enfermedad tumoral. La tasa de supervivencia libre de enfermedad se sitúa en el 90 % a los 5 años.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El neuroblastoma torácico predomina en varones menores de 6 meses. Habitualmente se diagnostica en los primeros 2 meses de iniciados los síntomas en los casos sintomáticos, si bien una gran parte de ellos son asintomáticos por tratarse de hallazgos casuales. El síntoma más frecuente es la tos y la primera prueba diagnóstica es la radiografía torácica en la mayor parte de los casos</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To analyze clinical onset and other epidemiological findings in a group of children diagnosed with thoracic neuroblastoma</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We reviewed 46 non-metastatic thoracic neuroblastomas diagnosed and treated from January 1984 to December 1998 at the Pediatric Oncology Unit. Abdominal neuroblastomas were excluded</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Mean age was 2 years and 5 months (range, 0-12 years). Eighty-five percent of the patients were infants (aged less than 1 year). Neuroblastoma was more frequent in males than in females. Fifty-seven percent of the patients were symptomatic and 43 % were asymptomatic. The most frequent clinical findings were cough (18 %) and palpable tumor or adenopathy (9 %). Mean lag-time to diagnosis was 10 weeks in symptomatic patients. Thoracic x-ray was the most useful diagnostic method (89 %). Previous family history of neoplasias was present in 26 %. Four patients (9%) had personal antecedents of other diseases. At the time of the study the event-free survival for the 46 patients was 90 % at 5 years (1-14 years)</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Thoracic neuroblastoma was more prevalent in male infants aged less than 6 months. Most symptomatic patients were diagnosed in the 2 first months after onset, and asymptomatic cases were common. The most frequent symptom was cough and most of the patients were diagnosed by thoracic x-ray</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:23 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neuroblastoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G.M. Brodeur" 1 => "R.P. Castleberry" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "titulo" => "Pediatric Oncology" "paginaInicial" => "761" "paginaFinal" => "797" "edicion" => "3.<span class="elsevierStyleSup">a</span>" "serieFecha" => "1997" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neuroblastoma quístico fetal: a propósito de 2 casos" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. Ferrer" 1 => "J. Ortega" 2 => "M. riondo" 3 => "J. Moreno" 4 => "O. Cruz" 5 => "R. Manzanares" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "An Esp Pediatr" "fecha" => "1998" "volumen" => "49" "paginaInicial" => "299" "paginaFinal" => "301" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9803557" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neuroblastoma diagnosed antenatally: a treatment dilemma with implications for screening" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. Huddart" 1 => "J. Mann" 2 => "M.C.G. Stevens" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Ped Oncol" "fecha" => "1992" "volumen" => "20" "paginaInicial" => "156" "paginaFinal" => "161" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prenatally diagnosed Neuroblastoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. Acharya" 1 => "S. Jayabose" 2 => "S.J. Kogan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1997" "volumen" => "80" "paginaInicial" => "304" "paginaFinal" => "310" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9217044" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fetal neuroblastoma: prenatal diagnosis and natural history" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R.W. Jennings" 1 => "M.P. LaQuaglia" 2 => "K. Leong" 3 => "W.H. Hendren" 4 => "N.S. Adzick" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Pediatr Surg" "fecha" => "1993" "volumen" => "28" "paginaInicial" => "1168" "paginaFinal" => "1174" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8308685" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prenatal detection of neuroblastoma: a ten year experience from the Dana-Farber Cáncer Institute and Children's Hospital" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "T.C. Peter" 1 => "J.A. Estroff" 2 => "H. Kozakewich" 3 => "R.C. Shamberger" 4 => "C.W. Lillehei" 5 => "H.E. Grier" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatrics" "fecha" => "1993" "volumen" => "92" "paginaInicial" => "358" "paginaFinal" => "364" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8361790" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neuroblastoma quístico. Estudio de bcl-2" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.E. Cerrato" 1 => "M.F. Fresno" 2 => "A. Ramos" 3 => "C. Moro" 4 => "P.M. Santos" 5 => "A. Herrero" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "An Esp Pediatr" "fecha" => "1997" "volumen" => "47" "paginaInicial" => "424" "paginaFinal" => "426" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9499315" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Is Neuroblastoma screening evaluation needed and feasible?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. Esteve" 1 => "L. Parker" 2 => "F. Herrman" 3 => "S. Duffy" 4 => "D. Frappaz" 5 => "C. Lasser" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Br J Cancer" "fecha" => "1995" "volumen" => "71" "paginaInicial" => "1129" "paginaFinal" => "1131" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Screening for neuroblastoma in North America. Preliminary results of a pathology review from the Quebec Project" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "L.A. Takeuchi" 1 => "Y. Hachitanda" 2 => "W.G. Woods" 3 => "M. Tuchman" 4 => "B. Lemieux" 5 => "L. Brisson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cáncer" "fecha" => "1995" "volumen" => "76" "paginaInicial" => "2363" "paginaFinal" => "2371" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8635044" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mass screening of neuroblastoma in Sapporo City, Japan" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Nishi" 1 => "H. Miyake" 2 => "T. Takeda" 3 => "Y. Kikuchi" 4 => "J. Hanai" 5 => "H. Yonemori" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Pediatr Hematol Oncol" "fecha" => "1992" "volumen" => "14" "paginaInicial" => "327" "paginaFinal" => "331" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1456398" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "International neuroblastoma system stage 1. Neuroblastoma: a prospective study and literature review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "B.H. Kushner" 1 => "N.V. Cheung" 2 => "M.P. LaQuaglia" 3 => "P.F. Ambros" 4 => "I.M. Ambros" 5 => "M.A. Bonilla" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/jco.1996.14.7.2174" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "1996" "volumen" => "14" "paginaInicial" => "2174" "paginaFinal" => "2180" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8683252" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tumores de la cresta neural" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "B. López Ibor" 1 => "L. Moreno" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Hematología y oncología pediátricas" "paginaInicial" => "501" "paginaFinal" => "520" "serieFecha" => "1997" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neurogenic tumors of the thorax" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.E. Ribet" 1 => "G.R. Cardot" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Thorac Surg" "fecha" => "1994" "volumen" => "58" "paginaInicial" => "1091" "paginaFinal" => "1095" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7944757" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neuroblastoma. Resultados del protocolo N-I-87" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "V. Castel" 1 => "M.D. Badal" 2 => "J.L. Bezanilla" 3 => "A. Herrero" 4 => "A. Llombart" 5 => "J.I. Ruiz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "An Esp Pediatr" "fecha" => "1993" "volumen" => "38" "paginaInicial" => "471" "paginaFinal" => "476" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8503598" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neuroblastoma en niños menores de 1 año" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "V. Castel" 1 => "C. Melero" 2 => "P. García-Miguel" 3 => "A. Navajas" 4 => "J.I. Ruiz" 5 => "S. Navarro" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "An Esp Pediatr" "fecha" => "1997" "volumen" => "47" "paginaInicial" => "584" "paginaFinal" => "590" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9575117" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neuroblastoma in the first year of life: clinical and biologic factors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.L. Grosfeld" 1 => "F.J. Rescolda" 2 => "K.W. West" 3 => "J. Goldman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Semin Pediatr Surg" "fecha" => "1993" "volumen" => "2" "paginaInicial" => "37" "paginaFinal" => "46" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8062021" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk factors in neuroblastoma of infants" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "F. Berthold" 1 => "D. Harms" 2 => "F. Lampert" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Contrib Oncol" "fecha" => "1990" "volumen" => "41" "paginaInicial" => "101" "paginaFinal" => "117" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Factores pronóstico del neuroblastoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.A. López" 1 => "J. Ferrís" 2 => "A. Verdeguer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "An Esp Pediatr" "fecha" => "1994" "volumen" => "41" "paginaInicial" => "309" "paginaFinal" => "314" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Revision in the international criteria for neuroblastomadiagnosis, staging and response to treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "G.M. Brodeur" 1 => "J. Pritchard" 2 => "F. Berthold" 3 => "N.L.T. Carlsen" 4 => "V. Castel" 5 => "R. Castleberry" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/jco.1993.11.8.1466" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "1993" "volumen" => "11" "paginaInicial" => "1466" "paginaFinal" => "1477" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8336186" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Age-linked prognostic categorization based on a new histologic grading system of neuroblastoma: a clinicopathologic study of 211 cases from the Pediatric Oncology Group" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "V.V. Joshi" 1 => "A.B. Cantor" 2 => "G. Altshuler" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Cáncer" "fecha" => "1992" "volumen" => "8" "paginaInicial" => "2197" "paginaFinal" => "2211" ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thoracic neuroblastoma: a Pediatric Oncology Group study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "G.A. Adams" 1 => "S.J. Shochat" 2 => "E.I. Smit" 3 => "J.J. Shuster" 4 => "V.V. Joshi" 5 => "G. Altshuler" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Pediatr Surg" "fecha" => "1993" "volumen" => "28" "paginaInicial" => "372" "paginaFinal" => "378" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8468649" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nonmetastatic thoracic neuroblastomas: a review of 40 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "H. Rubie" 1 => "O. Hartmann" 2 => "A. Giron" 3 => "G. Lemoine" 4 => "M. Gruner" 5 => "L. Brugieres" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Ped Oncol" "fecha" => "1991" "volumen" => "19" "paginaInicial" => "253" "paginaFinal" => "257" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cystic neuroblastoma of infancy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.L. Richards" 1 => "A.E. Gundersen" 2 => "M.S. Williams" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Pediatr Surg" "fecha" => "1995" "volumen" => "30" "paginaInicial" => "1354" "paginaFinal" => "1357" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8523244" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/16954033/0000005400000003/v1_201307051543/S1695403301775170/v1_201307051543/es/main.assets" "Apartado" => array:4 [ "identificador" => "14282" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Originales" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/16954033/0000005400000003/v1_201307051543/S1695403301775170/v1_201307051543/es/main.pdf?idApp=UINPBA00005H&text.app=https://analesdepediatria.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403301775170?idApp=UINPBA00005H" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 7 | 12 | 19 |
| 2024 Octubre | 60 | 85 | 145 |
| 2024 Septiembre | 46 | 64 | 110 |
| 2024 Agosto | 66 | 92 | 158 |
| 2024 Julio | 39 | 63 | 102 |
| 2024 Junio | 63 | 76 | 139 |
| 2024 Mayo | 50 | 88 | 138 |
| 2024 Abril | 42 | 68 | 110 |
| 2024 Marzo | 40 | 83 | 123 |
| 2024 Febrero | 50 | 87 | 137 |
| 2024 Enero | 33 | 64 | 97 |
| 2023 Diciembre | 30 | 52 | 82 |
| 2023 Noviembre | 35 | 53 | 88 |
| 2023 Octubre | 28 | 39 | 67 |
| 2023 Septiembre | 29 | 57 | 86 |
| 2023 Agosto | 34 | 27 | 61 |
| 2023 Julio | 32 | 39 | 71 |
| 2023 Junio | 29 | 32 | 61 |
| 2023 Mayo | 35 | 30 | 65 |
| 2023 Abril | 12 | 16 | 28 |
| 2023 Marzo | 20 | 33 | 53 |
| 2023 Febrero | 16 | 19 | 35 |
| 2023 Enero | 14 | 32 | 46 |
| 2022 Diciembre | 29 | 33 | 62 |
| 2022 Noviembre | 44 | 40 | 84 |
| 2022 Octubre | 35 | 51 | 86 |
| 2022 Septiembre | 37 | 33 | 70 |
| 2022 Agosto | 54 | 49 | 103 |
| 2022 Julio | 44 | 51 | 95 |
| 2022 Junio | 58 | 42 | 100 |
| 2022 Mayo | 26 | 47 | 73 |
| 2022 Abril | 33 | 54 | 87 |
| 2022 Marzo | 25 | 51 | 76 |
| 2022 Febrero | 23 | 30 | 53 |
| 2022 Enero | 30 | 40 | 70 |
| 2021 Diciembre | 22 | 43 | 65 |
| 2021 Noviembre | 22 | 36 | 58 |
| 2021 Octubre | 40 | 50 | 90 |
| 2021 Septiembre | 34 | 47 | 81 |
| 2021 Agosto | 23 | 29 | 52 |
| 2021 Julio | 28 | 28 | 56 |
| 2021 Junio | 32 | 42 | 74 |
| 2021 Mayo | 26 | 33 | 59 |
| 2021 Abril | 63 | 67 | 130 |
| 2021 Marzo | 74 | 45 | 119 |
| 2021 Febrero | 60 | 25 | 85 |
| 2021 Enero | 38 | 23 | 61 |
| 2020 Diciembre | 53 | 23 | 76 |
| 2020 Noviembre | 45 | 19 | 64 |
| 2020 Octubre | 35 | 10 | 45 |
| 2020 Septiembre | 42 | 14 | 56 |
| 2020 Agosto | 20 | 11 | 31 |
| 2020 Julio | 34 | 24 | 58 |
| 2020 Junio | 36 | 13 | 49 |
| 2020 Mayo | 45 | 27 | 72 |
| 2020 Abril | 23 | 14 | 37 |
| 2020 Marzo | 33 | 22 | 55 |
| 2020 Febrero | 42 | 21 | 63 |
| 2020 Enero | 54 | 22 | 76 |
| 2019 Diciembre | 77 | 24 | 101 |
| 2019 Noviembre | 21 | 19 | 40 |
| 2019 Octubre | 32 | 24 | 56 |
| 2019 Septiembre | 30 | 33 | 63 |
| 2019 Agosto | 38 | 22 | 60 |
| 2019 Julio | 34 | 27 | 61 |
| 2019 Junio | 42 | 32 | 74 |
| 2019 Mayo | 52 | 47 | 99 |
| 2019 Abril | 52 | 45 | 97 |
| 2019 Marzo | 35 | 25 | 60 |
| 2019 Febrero | 25 | 18 | 43 |
| 2019 Enero | 24 | 14 | 38 |
| 2018 Diciembre | 27 | 25 | 52 |
| 2018 Noviembre | 38 | 19 | 57 |
| 2018 Octubre | 49 | 23 | 72 |
| 2018 Septiembre | 22 | 10 | 32 |
| 2018 Agosto | 1 | 0 | 1 |
| 2018 Junio | 1 | 0 | 1 |
| 2018 Mayo | 6 | 0 | 6 |
| 2018 Abril | 7 | 0 | 7 |
| 2018 Marzo | 12 | 0 | 12 |
| 2018 Febrero | 4 | 0 | 4 |
| 2018 Enero | 9 | 0 | 9 |
| 2017 Diciembre | 5 | 0 | 5 |
| 2017 Noviembre | 17 | 0 | 17 |
| 2017 Octubre | 9 | 0 | 9 |
| 2017 Septiembre | 9 | 0 | 9 |
| 2017 Agosto | 15 | 0 | 15 |
| 2017 Julio | 12 | 1 | 13 |
| 2017 Junio | 16 | 26 | 42 |
| 2017 Mayo | 21 | 22 | 43 |
| 2017 Abril | 13 | 21 | 34 |
| 2017 Marzo | 16 | 28 | 44 |
| 2017 Febrero | 9 | 29 | 38 |
| 2017 Enero | 12 | 12 | 24 |
| 2016 Diciembre | 24 | 19 | 43 |
| 2016 Noviembre | 34 | 18 | 52 |
| 2016 Octubre | 30 | 25 | 55 |
| 2016 Septiembre | 45 | 26 | 71 |
| 2016 Agosto | 34 | 18 | 52 |
| 2016 Julio | 19 | 18 | 37 |
| 2016 Junio | 1 | 0 | 1 |
| 2016 Mayo | 3 | 0 | 3 |
| 2016 Abril | 2 | 0 | 2 |
| 2016 Marzo | 6 | 0 | 6 |
| 2016 Febrero | 1 | 0 | 1 |
| 2016 Enero | 2 | 0 | 2 |
| 2015 Diciembre | 4 | 0 | 4 |
| 2015 Octubre | 4 | 0 | 4 |
| 2015 Septiembre | 1 | 13 | 14 |
| 2015 Agosto | 1 | 0 | 1 |
| 2015 Julio | 8 | 21 | 29 |
| 2015 Junio | 7 | 0 | 7 |
| 2015 Mayo | 14 | 3 | 17 |
| 2015 Abril | 16 | 5 | 21 |
| 2015 Marzo | 15 | 2 | 17 |
| 2015 Febrero | 8 | 7 | 15 |
| 2015 Enero | 13 | 1 | 14 |
| 2014 Diciembre | 15 | 3 | 18 |
| 2014 Noviembre | 11 | 1 | 12 |
| 2014 Octubre | 21 | 2 | 23 |
| 2014 Septiembre | 16 | 2 | 18 |
| 2014 Agosto | 20 | 1 | 21 |
| 2014 Julio | 29 | 2 | 31 |
| 2014 Junio | 56 | 0 | 56 |
| 2014 Mayo | 60 | 2 | 62 |
| 2014 Abril | 66 | 3 | 69 |
| 2014 Marzo | 60 | 11 | 71 |
| 2014 Febrero | 44 | 5 | 49 |
| 2014 Enero | 38 | 7 | 45 |
| 2013 Diciembre | 57 | 9 | 66 |
| 2013 Noviembre | 60 | 4 | 64 |
| 2013 Octubre | 58 | 7 | 65 |
| 2013 Septiembre | 38 | 7 | 45 |
| 2013 Agosto | 53 | 7 | 60 |
| 2013 Julio | 36 | 6 | 42 |
| 2013 Junio | 2 | 2 | 4 |
| 2013 Mayo | 3 | 3 | 6 |
| 2013 Abril | 4 | 1 | 5 |
| 2013 Marzo | 8 | 4 | 12 |
| 2013 Febrero | 19 | 2 | 21 |
| 2013 Enero | 6 | 2 | 8 |
| 2012 Diciembre | 1 | 1 | 2 |
| 2012 Noviembre | 1 | 3 | 4 |
| 2012 Septiembre | 0 | 2 | 2 |
| 2001 Marzo | 3195 | 0 | 3195 |
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