Profilaxis de la anemia de la prematuridad con eritropoyetina. Estudio caso-control
Prophylaxis of anemia of prematurity with erythropoietin. case control study
M.J. de la Torre Aguilar*, F.J. Gascón Jiménez, M. Zapatero Martínez, J. Guzmán Cabañas, D. Huertas Muñoz, D. Ruiz González, P. Jaraba Caballero
Departamento de Pediatría. Unidad de Neonatología. Hospital Universitario Reina Sofía
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Zapatero Martínez, J. Guzmán Cabañas, D. Huertas Muñoz, D. Ruiz González, P. Jaraba Caballero" "autores" => array:7 [ 0 => array:3 [ "nombre" => "M.J." "apellidos" => "de la Torre Aguilar" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "F.J." "apellidos" => "Gascón Jiménez" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Zapatero Martínez" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Guzmán Cabañas" ] 4 => array:2 [ "nombre" => "D." "apellidos" => "Huertas Muñoz" ] 5 => array:2 [ "nombre" => "D." "apellidos" => "Ruiz González" ] 6 => array:2 [ "nombre" => "P." "apellidos" => "Jaraba Caballero" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Departamento de Pediatría. Unidad de Neonatología. Hospital Universitario Reina Sofía" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Juan Molina, 3, 1.o 3. 14005 Córdoba" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Prophylaxis of anemia of prematurity with erythropoietin. case control study" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2000-02-29" "fechaAceptado" => "2000-06-30" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec186426" "palabras" => array:2 [ 0 => "Eritropoyetina" 1 => "Anemia de la prematuridad" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec186427" "palabras" => array:2 [ 0 => "Erythropoietin" 1 => "Anemia of prematurity" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Determinar la eficacia del tratamiento con eritropoyetina humana recombinante (rH-EPO) en la profilaxis de la anemia del prematuro.</p> <span class="elsevierStyleSectionTitle">Pacientes y método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio de casos y controles, no aleatorizado, retrospectivo de 108 pretérminos de peso < 1.500 gramos y edad gestacional < 34 semanas. Se excluyeron a los prematuros afectados de enfermedad hemolítica o hemorrágica y/o fallecimiento durante los primeros días de vida. Fueron tratados 54 pacientes con rH-EPO (250 U/kg, subcutánea, 3 veces por semana) durante 6 semanas. Se añadió sulfato ferroso oral (4-6 mg/kg/día) y un complejo polivitamínico.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Entre ambos grupos no existen diferencias significativas en cuanto a: edad gestacional, peso, ferritina, hemoglobina y hematócrito al ingreso, número de extracciones y días con ventilación mecánica. El número de transfusiones por niño en el grupo sin rH-EPO fue de 1,46 ± 1,38, frente a 0,69 ± 1,19 en el tratado (p < 0,002). Un 63% de los niños tratados no precisaron ser transfundidos frente a un 29% del grupo control (p < 0,001). La hemoglobina media más baja alcanzada fue de 8,72 ± 2,62 g/dl en el grupo sin tratamiento, frente a una hemoglobina de 9,7 ± 2,08 g/dl en el que sí lo recibió.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La a dministración profiláctica de rH-EPO muestra una tendencia a disminuir el número de transfusiones en los prematuros de bajo peso, siendo claramente eficaz en los pretérminos estables con un peso superior a 1.000 gramos.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To evaluate the effectiveness of recombinant human erythropoietin (rH-EPO) in the prophylactic treatment of anemia of prematurity.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We performed a non-randomised, retrospective case control study of 108 premature babies with birth weights of less than 1500 grams and gestational age of less than 34 weeks. Infants with hemolytic or hemorrhagic disease and those who died in the first days of life were excluded. Fifty-four patients were treated with rHEPO (250 U/kg subcutaneously, 3 times a week) for 6 weeks. A ferrous sulfate supplement was also administered orally (4-6 mg/kg/day) with a multivitamin complex.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">There were no differences between groups in gestational age, birth weight, ferritin levels, hematocrit and hemoglobin on admission, amount of blood sampled and days with ventilatory support. The number of transfusions per patient were 1.46 ± 1.38 in control group versus 0.69 ± 1.19 in rH-EPO-treated infants (p < 0.002). Sixty-three percent of infants in the treated group did not require blood transfusions compared with only 29.7% in the nontreated group (p < 0.001). The lowest mean hemoglobin was 8.72 ± 2.62 gr/dl in the control group versus 9.70 ± 2.08 gr/dl in the rH-EPO group.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Prophylactic treatment with rH-EPO was effective in reducing the number of transfusions, mainly in stable newborn infants with a birth weight greater than 1000 grams.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:32 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of recombinant human erythropoietin in infants with the anemia of prematurity: a pilot study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D.S. Halpérin" 1 => "P. Wacker" 2 => "G. Lacourt" 3 => "M. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 3 | 12 | 15 |
| 2024 Octubre | 39 | 56 | 95 |
| 2024 Septiembre | 49 | 63 | 112 |
| 2024 Agosto | 84 | 101 | 185 |
| 2024 Julio | 52 | 44 | 96 |
| 2024 Junio | 44 | 43 | 87 |
| 2024 Mayo | 62 | 39 | 101 |
| 2024 Abril | 54 | 39 | 93 |
| 2024 Marzo | 46 | 46 | 92 |
| 2024 Febrero | 37 | 45 | 82 |
| 2024 Enero | 49 | 30 | 79 |
| 2023 Diciembre | 42 | 20 | 62 |
| 2023 Noviembre | 29 | 26 | 55 |
| 2023 Octubre | 34 | 24 | 58 |
| 2023 Septiembre | 24 | 21 | 45 |
| 2023 Agosto | 21 | 24 | 45 |
| 2023 Julio | 22 | 29 | 51 |
| 2023 Junio | 30 | 33 | 63 |
| 2023 Mayo | 37 | 31 | 68 |
| 2023 Abril | 21 | 24 | 45 |
| 2023 Marzo | 18 | 29 | 47 |
| 2023 Febrero | 26 | 15 | 41 |
| 2023 Enero | 21 | 22 | 43 |
| 2022 Diciembre | 23 | 22 | 45 |
| 2022 Noviembre | 48 | 29 | 77 |
| 2022 Octubre | 35 | 52 | 87 |
| 2022 Septiembre | 54 | 29 | 83 |
| 2022 Agosto | 50 | 56 | 106 |
| 2022 Julio | 40 | 49 | 89 |
| 2022 Junio | 27 | 31 | 58 |
| 2022 Mayo | 22 | 40 | 62 |
| 2022 Abril | 43 | 39 | 82 |
| 2022 Marzo | 43 | 51 | 94 |
| 2022 Febrero | 28 | 36 | 64 |
| 2022 Enero | 25 | 45 | 70 |
| 2021 Diciembre | 32 | 37 | 69 |
| 2021 Noviembre | 25 | 51 | 76 |
| 2021 Octubre | 36 | 70 | 106 |
| 2021 Septiembre | 29 | 59 | 88 |
| 2021 Agosto | 21 | 26 | 47 |
| 2021 Julio | 36 | 37 | 73 |
| 2021 Junio | 26 | 42 | 68 |
| 2021 Mayo | 18 | 28 | 46 |
| 2021 Abril | 32 | 72 | 104 |
| 2021 Marzo | 54 | 23 | 77 |
| 2021 Febrero | 58 | 27 | 85 |
| 2021 Enero | 36 | 17 | 53 |
| 2020 Diciembre | 47 | 18 | 65 |
| 2020 Noviembre | 21 | 17 | 38 |
| 2020 Octubre | 27 | 11 | 38 |
| 2020 Septiembre | 22 | 10 | 32 |
| 2020 Agosto | 18 | 16 | 34 |
| 2020 Julio | 19 | 17 | 36 |
| 2020 Junio | 35 | 11 | 46 |
| 2020 Mayo | 31 | 17 | 48 |
| 2020 Abril | 26 | 33 | 59 |
| 2020 Marzo | 43 | 21 | 64 |
| 2020 Febrero | 32 | 25 | 57 |
| 2020 Enero | 52 | 20 | 72 |
| 2019 Diciembre | 38 | 15 | 53 |
| 2019 Noviembre | 32 | 5 | 37 |
| 2019 Octubre | 13 | 18 | 31 |
| 2019 Septiembre | 29 | 23 | 52 |
| 2019 Agosto | 37 | 29 | 66 |
| 2019 Julio | 32 | 41 | 73 |
| 2019 Junio | 27 | 43 | 70 |
| 2019 Mayo | 40 | 34 | 74 |
| 2019 Abril | 44 | 77 | 121 |
| 2019 Marzo | 25 | 14 | 39 |
| 2019 Febrero | 28 | 15 | 43 |
| 2019 Enero | 21 | 15 | 36 |
| 2018 Diciembre | 14 | 17 | 31 |
| 2018 Noviembre | 32 | 27 | 59 |
| 2018 Octubre | 42 | 26 | 68 |
| 2018 Septiembre | 34 | 15 | 49 |
| 2018 Agosto | 1 | 0 | 1 |
| 2018 Julio | 1 | 0 | 1 |
| 2018 Mayo | 4 | 0 | 4 |
| 2018 Abril | 34 | 0 | 34 |
| 2018 Marzo | 18 | 0 | 18 |
| 2018 Febrero | 11 | 0 | 11 |
| 2018 Enero | 10 | 0 | 10 |
| 2017 Diciembre | 17 | 1 | 18 |
| 2017 Noviembre | 22 | 0 | 22 |
| 2017 Octubre | 10 | 0 | 10 |
| 2017 Septiembre | 17 | 0 | 17 |
| 2017 Agosto | 16 | 0 | 16 |
| 2017 Julio | 20 | 1 | 21 |
| 2017 Junio | 20 | 13 | 33 |
| 2017 Mayo | 28 | 24 | 52 |
| 2017 Abril | 21 | 4 | 25 |
| 2017 Marzo | 19 | 28 | 47 |
| 2017 Febrero | 12 | 14 | 26 |
| 2017 Enero | 14 | 9 | 23 |
| 2016 Diciembre | 37 | 10 | 47 |
| 2016 Noviembre | 62 | 11 | 73 |
| 2016 Octubre | 63 | 20 | 83 |
| 2016 Septiembre | 72 | 13 | 85 |
| 2016 Agosto | 51 | 17 | 68 |
| 2016 Julio | 26 | 14 | 40 |
| 2016 Junio | 2 | 0 | 2 |
| 2016 Mayo | 3 | 0 | 3 |
| 2016 Febrero | 5 | 0 | 5 |
| 2016 Enero | 1 | 0 | 1 |
| 2015 Diciembre | 2 | 0 | 2 |
| 2015 Noviembre | 1 | 0 | 1 |
| 2015 Octubre | 6 | 0 | 6 |
| 2015 Septiembre | 1 | 0 | 1 |
| 2015 Agosto | 0 | 12 | 12 |
| 2015 Julio | 13 | 0 | 13 |
| 2015 Junio | 16 | 6 | 22 |
| 2015 Mayo | 27 | 0 | 27 |
| 2015 Abril | 18 | 6 | 24 |
| 2015 Marzo | 12 | 0 | 12 |
| 2015 Febrero | 9 | 5 | 14 |
| 2015 Enero | 23 | 1 | 24 |
| 2014 Diciembre | 14 | 1 | 15 |
| 2014 Noviembre | 12 | 1 | 13 |
| 2014 Octubre | 8 | 1 | 9 |
| 2014 Septiembre | 10 | 4 | 14 |
| 2014 Agosto | 12 | 2 | 14 |
| 2014 Julio | 9 | 1 | 10 |
| 2014 Junio | 19 | 3 | 22 |
| 2014 Mayo | 18 | 3 | 21 |
| 2014 Abril | 9 | 1 | 10 |
| 2014 Marzo | 16 | 13 | 29 |
| 2014 Febrero | 13 | 11 | 24 |
| 2014 Enero | 16 | 6 | 22 |
| 2013 Diciembre | 22 | 10 | 32 |
| 2013 Noviembre | 12 | 6 | 18 |
| 2013 Octubre | 18 | 12 | 30 |
| 2013 Septiembre | 25 | 9 | 34 |
| 2013 Agosto | 13 | 6 | 19 |
| 2013 Julio | 13 | 5 | 18 |
| 2013 Junio | 2 | 4 | 6 |
| 2013 Mayo | 8 | 3 | 11 |
| 2013 Abril | 7 | 2 | 9 |
| 2013 Marzo | 10 | 4 | 14 |
| 2013 Febrero | 22 | 2 | 24 |
| 2013 Enero | 10 | 2 | 12 |
| 2012 Diciembre | 7 | 1 | 8 |
| 2012 Noviembre | 7 | 2 | 9 |
| 2012 Octubre | 2 | 2 | 4 |
| 2012 Septiembre | 3 | 0 | 3 |
| 2012 Agosto | 2 | 0 | 2 |
| 2000 Agosto | 3423 | 0 | 3423 |
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