Densidad mineral ósea en la diabetes mellitus infantojuvenil
Bone mineral density in type 1 diabetes mellitus
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Madrid" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Medicina Preventiva (Unidad de Investigación Clinicoepidemiológica) Hospital Clínico San Carlos. Madrid" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Medicina Interna (Unidad de Osteopatías Metabólicas). Hospital Clínico San Carlos. Madrid" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Aláantara, 18, 1<span class="elsevierStyleSup">°</span>. 28006 Madrid." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Bone mineral density in type 1 diabetes mellitus" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1999-10-31" "fechaAceptado" => "2000-04-30" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec186361" "palabras" => array:4 [ 0 => "Densidad mineral ósea" 1 => "Densitometría de doble energía de rayos X" 2 => "Diabetes tipo 1" 3 => "Niños" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec186362" "palabras" => array:4 [ 0 => "Bone mineral density" 1 => "Dual-energy X-ray absorptiometry" 2 => "Type 1 diabetes mellitus" 3 => "Children" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Determinar la densidad mineral ósea (DMO) en hueso axial y apendicular en un grupo de niños y adolescentes con diabetes tipo 1 y relacionarla con parámetros de control metabólico y con el tiempo de evolución de la enfermedad</p> <span class="elsevierStyleSectionTitle">Pacientes y método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se realizó una densitometría de columna lumbar (L 1-L 4) y de antebrazo mediante el densitómetro de doble energía de rayos X Hologic QDR;1000 a 246 niños y adolescentes sanos (111 varones y 135 mujeres, de 2,8 a 20,8 años) y a 45 diabéticos (18 varones y 27 mujeres, de 5,2 a 19,4 años). Los resultados se expresaron en forma de media y desviación estándar. Las diferencias entre ambas poblaciones se determinaron mediante el t-test y análisis de la variancia. La relación entre DMO y el resto de las variables se midió mediante el coeficiente de correlación de Pearson y el coeficiente de correlación parcial. Se definió significación estadística a un valor de p < 0,05.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La DMO aumenta desde la infancia a la vida adulta en ambas poblaciones. La DMO de los pacientes diabéticos fue inferior a la del grupo no diabético, tanto en la columna lumbar como en el antebrazo, sobre todo durante el brote puberal. Las diferencias de masa ósea más llamativas se encontraron en el hueso trabecular de la pobla-ción masculina. No se encontró ninguna relación estadísticamente significativa entre la DMO de las diferentes regiones analizadas y los parámetros de control metabólico (hemoglobina glucosilada media, dosis de insulina) o el tiempo de evolución de la enfermedad (p > 0,05).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La diabetes tipo 1 debe considerarse una población de riesgo de padecer osteoporosis en la vida adulta. El diagnóstico debe establecerse a partir de criterios densitomé-tricos, ya que en este estudio el grado de control metabólico o el tiempo de evolución de la enfermedad no per-mitieron predecir qué grupo de diabéticos va a estar os-teopénico.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To determine bone mineral density (BMD) at axial and appendicular sites in patients with type 1 diabetes melli-tus and evaluate its relationship with metabolic control and disease duration.</p> <span class="elsevierStyleSectionTitle">Patients and method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">BMD was measured by dual-energy X-ray absorptio-metry (Hologic QDR-1000) in the lumbar spine (L 1-L 4) and at the distal third forearm in 246 healthy non-diabetic children and adolescents (111 boys, 135 girls, aged 2.820.8 years) and in 45 diabetic patients (18 boys, 27 girls, aged 5.2-19.4 years). The results were expressed as the mean and standard deviation. The differences were tested by analysis of variance or Student's t-test, as appropriate. The relationship between BMD and the remaining variables was studied by simple Pearson's coefficient and partial correlation coefficient. Significance was defined as p < 0.05.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">BMD increased progressively from infancy to adulthood in both populations. Lumbar spine and forearm BMD were significantly lower in diabetic patients than in the healthy non-diabetic children, mainly during pubertal spurt. The greatest differences were found in males and in the trabecular bone. No relationship was found between metabolic control (mean glycosylated hemoglobin, insulin requirement) and duration of diabetes and the BMD in any region studied (p > 0.05).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Pediatric patients with type 1 diabetes mellitus appear to constitute a population at risk of osteoporosis in adulthood. Diagnosis of osteopenia diagnosis should be established according to densitometric criteria. In this study, metabolic control parameters and duration of diabetes did not enable predetermination of diabetic patients at risk of osteoporosis in adulthood.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:30 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 10 | 15 | 25 |
| 2024 Octubre | 67 | 49 | 116 |
| 2024 Septiembre | 55 | 47 | 102 |
| 2024 Agosto | 70 | 84 | 154 |
| 2024 Julio | 38 | 45 | 83 |
| 2024 Junio | 45 | 39 | 84 |
| 2024 Mayo | 60 | 34 | 94 |
| 2024 Abril | 29 | 33 | 62 |
| 2024 Marzo | 52 | 41 | 93 |
| 2024 Febrero | 49 | 44 | 93 |
| 2024 Enero | 29 | 30 | 59 |
| 2023 Diciembre | 31 | 24 | 55 |
| 2023 Noviembre | 38 | 32 | 70 |
| 2023 Octubre | 40 | 23 | 63 |
| 2023 Septiembre | 37 | 21 | 58 |
| 2023 Agosto | 24 | 18 | 42 |
| 2023 Julio | 29 | 27 | 56 |
| 2023 Junio | 29 | 24 | 53 |
| 2023 Mayo | 35 | 15 | 50 |
| 2023 Abril | 27 | 26 | 53 |
| 2023 Marzo | 25 | 52 | 77 |
| 2023 Febrero | 22 | 18 | 40 |
| 2023 Enero | 24 | 20 | 44 |
| 2022 Diciembre | 27 | 22 | 49 |
| 2022 Noviembre | 48 | 30 | 78 |
| 2022 Octubre | 32 | 33 | 65 |
| 2022 Septiembre | 56 | 30 | 86 |
| 2022 Agosto | 65 | 50 | 115 |
| 2022 Julio | 46 | 38 | 84 |
| 2022 Junio | 40 | 39 | 79 |
| 2022 Mayo | 53 | 30 | 83 |
| 2022 Abril | 41 | 43 | 84 |
| 2022 Marzo | 33 | 50 | 83 |
| 2022 Febrero | 23 | 32 | 55 |
| 2022 Enero | 40 | 45 | 85 |
| 2021 Diciembre | 44 | 53 | 97 |
| 2021 Noviembre | 30 | 42 | 72 |
| 2021 Octubre | 30 | 49 | 79 |
| 2021 Septiembre | 50 | 43 | 93 |
| 2021 Agosto | 12 | 28 | 40 |
| 2021 Julio | 23 | 36 | 59 |
| 2021 Junio | 34 | 40 | 74 |
| 2021 Mayo | 19 | 31 | 50 |
| 2021 Abril | 86 | 103 | 189 |
| 2021 Marzo | 78 | 29 | 107 |
| 2021 Febrero | 58 | 34 | 92 |
| 2021 Enero | 45 | 17 | 62 |
| 2020 Diciembre | 18 | 32 | 50 |
| 2020 Noviembre | 27 | 18 | 45 |
| 2020 Octubre | 25 | 7 | 32 |
| 2020 Septiembre | 11 | 6 | 17 |
| 2020 Agosto | 23 | 11 | 34 |
| 2020 Julio | 20 | 14 | 34 |
| 2020 Junio | 21 | 15 | 36 |
| 2020 Mayo | 33 | 13 | 46 |
| 2020 Abril | 24 | 10 | 34 |
| 2020 Marzo | 21 | 5 | 26 |
| 2020 Febrero | 15 | 12 | 27 |
| 2020 Enero | 20 | 16 | 36 |
| 2019 Diciembre | 24 | 19 | 43 |
| 2019 Noviembre | 18 | 6 | 24 |
| 2019 Octubre | 21 | 10 | 31 |
| 2019 Septiembre | 18 | 19 | 37 |
| 2019 Agosto | 13 | 13 | 26 |
| 2019 Julio | 28 | 25 | 53 |
| 2019 Junio | 34 | 31 | 65 |
| 2019 Mayo | 40 | 41 | 81 |
| 2019 Abril | 44 | 35 | 79 |
| 2019 Marzo | 17 | 13 | 30 |
| 2019 Febrero | 14 | 16 | 30 |
| 2019 Enero | 12 | 7 | 19 |
| 2018 Diciembre | 9 | 19 | 28 |
| 2018 Noviembre | 22 | 9 | 31 |
| 2018 Octubre | 24 | 14 | 38 |
| 2018 Septiembre | 8 | 6 | 14 |
| 2018 Agosto | 1 | 0 | 1 |
| 2018 Mayo | 3 | 0 | 3 |
| 2018 Abril | 14 | 0 | 14 |
| 2018 Marzo | 4 | 0 | 4 |
| 2018 Febrero | 8 | 0 | 8 |
| 2018 Enero | 6 | 0 | 6 |
| 2017 Diciembre | 10 | 0 | 10 |
| 2017 Noviembre | 12 | 0 | 12 |
| 2017 Octubre | 9 | 0 | 9 |
| 2017 Septiembre | 10 | 0 | 10 |
| 2017 Agosto | 7 | 0 | 7 |
| 2017 Julio | 11 | 0 | 11 |
| 2017 Junio | 21 | 7 | 28 |
| 2017 Mayo | 19 | 14 | 33 |
| 2017 Abril | 21 | 2 | 23 |
| 2017 Marzo | 17 | 3 | 20 |
| 2017 Febrero | 12 | 6 | 18 |
| 2017 Enero | 21 | 4 | 25 |
| 2016 Diciembre | 21 | 8 | 29 |
| 2016 Noviembre | 30 | 3 | 33 |
| 2016 Octubre | 33 | 6 | 39 |
| 2016 Septiembre | 42 | 2 | 44 |
| 2016 Agosto | 19 | 5 | 24 |
| 2016 Julio | 7 | 4 | 11 |
| 2016 Junio | 1 | 0 | 1 |
| 2016 Abril | 1 | 0 | 1 |
| 2016 Marzo | 1 | 0 | 1 |
| 2016 Febrero | 3 | 0 | 3 |
| 2016 Enero | 2 | 0 | 2 |
| 2015 Diciembre | 3 | 0 | 3 |
| 2015 Octubre | 1 | 0 | 1 |
| 2015 Septiembre | 1 | 0 | 1 |
| 2015 Julio | 16 | 0 | 16 |
| 2015 Junio | 18 | 0 | 18 |
| 2015 Mayo | 16 | 0 | 16 |
| 2015 Abril | 20 | 0 | 20 |
| 2015 Marzo | 11 | 0 | 11 |
| 2015 Febrero | 8 | 0 | 8 |
| 2015 Enero | 11 | 0 | 11 |
| 2014 Diciembre | 15 | 1 | 16 |
| 2014 Noviembre | 12 | 0 | 12 |
| 2014 Octubre | 17 | 0 | 17 |
| 2014 Septiembre | 9 | 2 | 11 |
| 2014 Agosto | 9 | 2 | 11 |
| 2014 Julio | 13 | 1 | 14 |
| 2014 Junio | 16 | 1 | 17 |
| 2014 Mayo | 33 | 4 | 37 |
| 2014 Abril | 18 | 1 | 19 |
| 2014 Marzo | 18 | 5 | 23 |
| 2014 Febrero | 15 | 7 | 22 |
| 2014 Enero | 17 | 6 | 23 |
| 2013 Diciembre | 17 | 7 | 24 |
| 2013 Noviembre | 8 | 4 | 12 |
| 2013 Octubre | 39 | 4 | 43 |
| 2013 Septiembre | 18 | 7 | 25 |
| 2013 Agosto | 16 | 5 | 21 |
| 2013 Julio | 7 | 2 | 9 |
| 2013 Junio | 3 | 3 | 6 |
| 2013 Mayo | 7 | 4 | 11 |
| 2013 Abril | 7 | 2 | 9 |
| 2013 Marzo | 11 | 5 | 16 |
| 2013 Febrero | 30 | 3 | 33 |
| 2013 Enero | 28 | 3 | 31 |
| 2012 Diciembre | 23 | 2 | 25 |
| 2012 Noviembre | 11 | 5 | 16 |
| 2012 Octubre | 15 | 2 | 17 |
| 2012 Septiembre | 2 | 1 | 3 |
| 2000 Mayo | 759 | 0 | 759 |
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