Aplasia cutis congénita en un recién nacido: revisión etiopatogénica y actitud diagnóstica
Aplasia cutis congenita in a newborn: Etiopathogenic review and diagnostic attitude
M. Moros Peña*, M. Labay Matías, F. Valle Sánchez, T. Valero Adán, J. Martín-Calama Valero, M. Muñoz Albillos
Servicio de Pediatría. Hospital General de Teruel Obispo Polanco. Teruel
Leído
41648
Vecesse ha leído el artículo
23779
Total PDF
17869
Total HTML
Compartir estadísticas
array:23 [ "pii" => "S1695403300773796" "issn" => "16954033" "doi" => "10.1016/S1695-4033(00)77379-6" "estado" => "S300" "fechaPublicacion" => "2000-05-01" "aid" => "77379" "copyright" => "Asociación Española de Pediatría" "copyrightAnyo" => "2000" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "An Pediatr (Barc). 2000;52:453-6" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 29528 "formatos" => array:3 [ "EPUB" => 84 "HTML" => 14080 "PDF" => 15364 ] ] "itemSiguiente" => array:18 [ "pii" => "S1695403300773802" "issn" => "16954033" "doi" => "10.1016/S1695-4033(00)77380-2" "estado" => "S300" "fechaPublicacion" => "2000-05-01" "aid" => "77380" "copyright" => "Asociación Española de Pediatría" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "An Pediatr (Barc). 2000;52:457-63" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 8109 "formatos" => array:3 [ "EPUB" => 56 "HTML" => 7310 "PDF" => 743 ] ] "es" => array:7 [ "idiomaDefecto" => true "titulo" => "Recomendaciones de reanimación cardiopulmonar básica, avanzada y neonatal. Estabilización posresucitación y transporte" "tienePdf" => "es" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "457" "paginaFinal" => "463" ] ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. López-Herce Cid, A. Carrillo Álvarez, C. Calvo Macías" "autores" => array:4 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "López-Herce Cid" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Carrillo Álvarez" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Calvo Macías" ] 3 => array:1 [ "colaborador" => "Grupo Español de Reanimación Cardiopulmonar Pediátrica y Neonatal" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403300773802?idApp=UINPBA00005H" "url" => "/16954033/0000005200000005/v1_201307051502/S1695403300773802/v1_201307051502/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1695403300773784" "issn" => "16954033" "doi" => "10.1016/S1695-4033(00)77378-4" "estado" => "S300" "fechaPublicacion" => "2000-05-01" "aid" => "77378" "copyright" => "Asociación Española de Pediatría" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "An Pediatr (Barc). 2000;52:447-52" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3199 "formatos" => array:3 [ "EPUB" => 84 "HTML" => 2520 "PDF" => 595 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Presión arterial en la infancia y la adolescencia. Estudio de su relación con variables de crecimiento y maduración" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "447" "paginaFinal" => "452" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Blood pressure in childhood and adolescence and its relationship with growth and maturation variables" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.J. Díaz Martín, C. Rey Galán, M. Antón Gamero, M. Pumarada Prieto, R. Gutiérrez Martínez, S. Málaga Guerrero" "autores" => array:6 [ 0 => array:2 [ "nombre" => "J.J." "apellidos" => "Díaz Martín" ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Rey Galán" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Antón Gamero" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "Pumarada Prieto" ] 4 => array:2 [ "nombre" => "R." "apellidos" => "Gutiérrez Martínez" ] 5 => array:2 [ "nombre" => "S." "apellidos" => "Málaga Guerrero" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403300773784?idApp=UINPBA00005H" "url" => "/16954033/0000005200000005/v1_201307051502/S1695403300773784/v1_201307051502/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Aplasia cutis congénita en un recién nacido: revisión etiopatogénica y actitud diagnóstica" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "453" "paginaFinal" => "456" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M. Moros Peña, M. Labay Matías, F. Valle Sánchez, T. Valero Adán, J. Martín-Calama Valero, M. Muñoz Albillos" "autores" => array:6 [ 0 => array:3 [ "nombre" => "M." "apellidos" => "Moros Peña" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Labay Matías" ] 2 => array:2 [ "nombre" => "F." "apellidos" => "Valle Sánchez" ] 3 => array:2 [ "nombre" => "T." "apellidos" => "Valero Adán" ] 4 => array:2 [ "nombre" => "J." "apellidos" => "Martín-Calama Valero" ] 5 => array:2 [ "nombre" => "M." "apellidos" => "Muñoz Albillos" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Pediatría. Hospital General de Teruel Obispo Polanco. Teruel" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: General Sueiro, 21, 4.° D. 50008 Zaragoza." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Aplasia cutis congenita in a newborn: Etiopathogenic review and diagnostic attitude" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1999-10-31" "fechaAceptado" => "2000-02-29" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec186322" "palabras" => array:3 [ 0 => "Aplasia cutis congénita" 1 => "Recién nacido" 2 => "Piel" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec186321" "palabras" => array:3 [ 0 => "Aplasia cutis congenita" 1 => "Newborn" 2 => "Skin" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La aplasia cutis congénita es una rara alteración caracterizada por la ausencia congénita de epidermis, dermis y, en ocasiones, de los tejidos subyacentes. Fue descrita por primera vez por Cordon en 1767 y desde entonces se han referido unos 500 casos, con una incidencia estimada de 3 de cada 10.000 recién nacidos. Las lesiones pueden afectar a cualquier región corporal, aunque la localización más frecuente es en el cuero cabelludo. En aproximadamente un 20% de los casos se encuentra un defecto óseo del cráneo subyacente. La aplasia cutis congénita puede presentarse aislada o asociada a otras malformaciones. No hay una teoría etiopatogénica uniforme y los grandes defectos del cuero cabelludo plantean un dilema terapéutico. Presentamos un recién nacido con un extenso defecto de cuero cabelludo localizado en la línea media del vértex sin otras malformaciones asociadas. No existían antecedentes familiares de interés. Las radiografías de cráneo y extremidades, el análisis cromosómico y las ecografías cerebral y abdominal fueron normales. Se emplearon dos pautas terapéuticas: un tratamiento conservador, consistente en curas locales diarias con antisépticos para permitir la epitelización, mejoró las condiciones para el tratamiento quirúrgico secundario, cerrando el defecto a los 30 días de vida con colgajos rotacionales locales. El postoperatorio cursó sin incidencias y se consiguió un excelente resultado estético.</p>" ] "en" => array:1 [ "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Aplasia cutis congenita is a rare condition characterized by the congenital absence of epidermis, dermis and, in some cases, subcutaneous tissues. It was first described by Cordon in 1767 and more than 500 cases have been reported since, with an estimate incidence of 3 in 10,000 births. The lesions may occur on any body surface although localised agenesis of the scalp is the most frequent pattern. In approximately 20% of cases underlying bone defects are also found. Aplasia cutis congenita occurs as an isolated defect or with other associated anomalies. There is no unifying theory for the pathogenesis and large scalp defects present a management dilemma. We report a newborn with a large scalp defect in the mid line retiesradiographs, chromosome analysis, cerebral and abdominal sonography were normal. Two methods of treatment were used: a conservative approach consisting of daily antiseptic dressing to allow scalp epithelialization improved conditions for secondary surgery at 30 The postoperative course was uneventful and an excellent cosmetic result was achieved.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Biblografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:24 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Extrait d'une lettre au sujet de trois enfants de la même mère nés avec partie des extrémités dénuée de peau" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M. Cordon" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Méd Chir Pharm" "fecha" => "1767" "volumen" => "26" "paginaInicial" => "556" "paginaFinal" => "557" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Case of congenital ulcer on the cranium of a fetus, terminating in fatal hemorrhage on the 18th day after birth" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "W. Campbell" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Med Sci" "fecha" => "1826" "volumen" => "1826" "paginaInicial" => "2" "paginaFinal" => "82" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Gorlin RJ, Cohen MM, Levin LS. Syndromes of head and neck (3.<span class="elsevierStyleSup">a</span> ed.). Nueva York: Oxford University Press, 1990; 417–419" ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aplasia cutis como efecto teratógeno del metimazol" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J. Díez Delgado" 1 => "M.J. Belmonte" 2 => "M.D. Calvo" 3 => "E. López-Candel" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "An Esp Pediatr" "fecha" => "1999" "volumen" => "51" "paginaInicial" => "290" "paginaFinal" => "292" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10575754" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Congenital defects of the scalp. III. Studies in the pathology of development" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "N.W. Ingalls" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Am J Obstet Gynecol" "fecha" => "1933" "volumen" => "25" "paginaInicial" => "861" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aplasia congénita de cutis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.K. Arrate" 1 => "M. Ugidos" 2 => "S. García Rodrigo" 3 => "J. De Gárate" 4 => "S. González Tanago" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "An Esp Pediatr" "fecha" => "1980" "volumen" => "13" "paginaInicial" => "423" "paginaFinal" => "428" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7406366" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aplasia cutis congenita of the scalp with large underlying skull defect: a case report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "N. Leboucq" 1 => "P. Montoya y Martínez" 2 => "F. Montoya-Vigo" 3 => "P. Castan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neuroradiology" "fecha" => "1994" "volumen" => "36" "paginaInicial" => "480" "paginaFinal" => "482" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7991097" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aplasia cutis congenita and associated disorders: an update" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.E.J.W. Evers" 1 => "P.M. Steijlen" 2 => "B.C.J. Hamel" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Genet" "fecha" => "1995" "volumen" => "47" "paginaInicial" => "295" "paginaFinal" => "301" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7554362" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hereditary deformities in man due to arrested development" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "F.H. Adams" 1 => "C.P. Oliver" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Hered" "fecha" => "1945" "volumen" => "39" "paginaInicial" => "3" "paginaFinal" => "7" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aplasia cutis congenita: a clinical review and proposal for classification" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "I.J. Frieden" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1986" "volumen" => "14" "paginaInicial" => "646" "paginaFinal" => "660" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3514708" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aplasia cutis congenita: a report of 12 new families and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "V.P. Sybert" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatr Dermatol" "fecha" => "1985" "volumen" => "3" "paginaInicial" => "1" "paginaFinal" => "14" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3906608" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical aspects of congenital skin defects" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "U. Demmel" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Pediatr" "fecha" => "1975" "volumen" => "121" "paginaInicial" => "21" "paginaFinal" => "50" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/765133" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intrauterine herpes simplex infection resembling mechanobullous disease in a newborn infant" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "H.H. Harris" 1 => "E. Foucar" 2 => "R. Andersen" 3 => "T.L. Ray" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1986" "volumen" => "15" "paginaInicial" => "1148" "paginaFinal" => "1155" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3534027" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aplasia cutis congenita of the scalp in five successive generations of one family [carta]" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "F. Fullana" 1 => "M. González" 2 => "M. No" 3 => "O. Huc" 4 => "V. González-Mestre" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Plast Reconstr Surg" "fecha" => "1995" "volumen" => "95" "paginaInicial" => "214" "paginaFinal" => "215" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7809261" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Origin of scalp vertex aplasia cutis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.J. Stephan" 1 => "D.W. Smith" 2 => "J.W. Ponzi" 3 => "E.R. Aldan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Pediatrics" "fecha" => "1982" "volumen" => "101" "paginaInicial" => "850" "paginaFinal" => "853" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Methimazole in animal feed and congenital aplasia cutis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.L. Martínez-Frías" 1 => "A. Cerreijo" 2 => "E. Rodríguez-Pinilla" 3 => "M. Urioste" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1992" "volumen" => "339" "paginaInicial" => "742" "paginaFinal" => "743" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1347607" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Congenitalmal formation of the scalp and cranium after failed first trimester abortion attempt with misoprostol" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "W. Fonseca" 1 => "A.J.C. Alencar" 2 => "R.M.M. Pereira" 3 => "C. Misago" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Dysmorphol" "fecha" => "1993" "volumen" => "2" "paginaInicial" => "76" "paginaFinal" => "80" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8298743" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aplasia cutiscongenita with fetus papyraceus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R.K. Joshi" 1 => "M.A. Majeed-Saidan" 2 => "A. Abanmi" 3 => "D. Diab" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1991" "volumen" => "6" "paginaInicial" => "1083" "paginaFinal" => "1085" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Congenital absence of skin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.L. Levin" 1 => "K.S. Nolan" 2 => "N.B. Esterly" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1980" "volumen" => "2" "paginaInicial" => "203" "paginaFinal" => "206" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7364976" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aplasia cutis congenita: a cutaneous marker of occult spinaldysraphism" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.C. Higginbottom" 1 => "K.L. Jones" 2 => "H.E. James" 3 => "D.A. Bruce" 4 => "L. Chut" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Pediatr" "fecha" => "1980" "volumen" => "96" "paginaInicial" => "687" "paginaFinal" => "689" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6987360" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aplasia cutis congenita of the scalp in an infant exposedto valproic acid in utero" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Hubert" 1 => "D. Bonneau" 2 => "D. Couet" 3 => "M. Berthier" 4 => "D. Oriot" 5 => "M. Larrègue" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Paediatr" "fecha" => "1994" "volumen" => "83" "paginaInicial" => "789" "paginaFinal" => "790" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7949818" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aplasia cutis congenita, elevated alpha-fetoprotein and a distinct amniotic fluid acetylcholinesterase electrophoretic band" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Y. Dror" 1 => "Z. Gelman-Kohan" 2 => "Z. Hagai" 3 => "A. Juster-Reicher" 4 => "R.N. Cohen" 5 => "B. Mogilner" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1055/s-2007-994576" "Revista" => array:6 [ "tituloSerie" => "Am J Perinatol" "fecha" => "1992" "volumen" => "11" "paginaInicial" => "149" "paginaFinal" => "152" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7515237" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aplasia cutis congenita of the scalp" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "L.A. Sargent" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Pediatr Surg" "fecha" => "1990" "volumen" => "25" "paginaInicial" => "1211" "paginaFinal" => "1213" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2286881" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aplasia cutiscongenita: Failed conservative treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D.A. Ross" 1 => "S.W.S. Laurie" 2 => "C.J. Coombs" 3 => "K.L. Mutimer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Plast Reconstr Surg" "fecha" => "1995" "volumen" => "95" "paginaInicial" => "124" "paginaFinal" => "129" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7809224" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/16954033/0000005200000005/v1_201307051502/S1695403300773796/v1_201307051502/es/main.assets" "Apartado" => array:4 [ "identificador" => "14234" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Medicina fetal y neonatología" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/16954033/0000005200000005/v1_201307051502/S1695403300773796/v1_201307051502/es/main.pdf?idApp=UINPBA00005H&text.app=https://analesdepediatria.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403300773796?idApp=UINPBA00005H" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 8 | 25 | 33 |
| 2024 Octubre | 93 | 96 | 189 |
| 2024 Septiembre | 115 | 73 | 188 |
| 2024 Agosto | 106 | 141 | 247 |
| 2024 Julio | 107 | 147 | 254 |
| 2024 Junio | 98 | 101 | 199 |
| 2024 Mayo | 108 | 117 | 225 |
| 2024 Abril | 104 | 130 | 234 |
| 2024 Marzo | 91 | 111 | 202 |
| 2024 Febrero | 101 | 94 | 195 |
| 2024 Enero | 66 | 113 | 179 |
| 2023 Diciembre | 85 | 95 | 180 |
| 2023 Noviembre | 74 | 118 | 192 |
| 2023 Octubre | 80 | 104 | 184 |
| 2023 Septiembre | 51 | 72 | 123 |
| 2023 Agosto | 57 | 69 | 126 |
| 2023 Julio | 61 | 109 | 170 |
| 2023 Junio | 54 | 93 | 147 |
| 2023 Mayo | 63 | 124 | 187 |
| 2023 Abril | 45 | 97 | 142 |
| 2023 Marzo | 62 | 128 | 190 |
| 2023 Febrero | 33 | 87 | 120 |
| 2023 Enero | 34 | 135 | 169 |
| 2022 Diciembre | 34 | 103 | 137 |
| 2022 Noviembre | 60 | 134 | 194 |
| 2022 Octubre | 48 | 143 | 191 |
| 2022 Septiembre | 46 | 179 | 225 |
| 2022 Agosto | 64 | 182 | 246 |
| 2022 Julio | 37 | 87 | 124 |
| 2022 Junio | 30 | 103 | 133 |
| 2022 Mayo | 43 | 142 | 185 |
| 2022 Abril | 48 | 169 | 217 |
| 2022 Marzo | 64 | 218 | 282 |
| 2022 Febrero | 48 | 157 | 205 |
| 2022 Enero | 69 | 158 | 227 |
| 2021 Diciembre | 82 | 159 | 241 |
| 2021 Noviembre | 57 | 166 | 223 |
| 2021 Octubre | 70 | 200 | 270 |
| 2021 Septiembre | 34 | 169 | 203 |
| 2021 Agosto | 45 | 146 | 191 |
| 2021 Julio | 41 | 187 | 228 |
| 2021 Junio | 85 | 204 | 289 |
| 2021 Mayo | 122 | 285 | 407 |
| 2021 Abril | 133 | 418 | 551 |
| 2021 Marzo | 95 | 168 | 263 |
| 2021 Febrero | 77 | 155 | 232 |
| 2021 Enero | 68 | 163 | 231 |
| 2020 Diciembre | 61 | 153 | 214 |
| 2020 Noviembre | 97 | 193 | 290 |
| 2020 Octubre | 71 | 137 | 208 |
| 2020 Septiembre | 45 | 191 | 236 |
| 2020 Agosto | 71 | 203 | 274 |
| 2020 Julio | 44 | 182 | 226 |
| 2020 Junio | 47 | 155 | 202 |
| 2020 Mayo | 65 | 161 | 226 |
| 2020 Abril | 33 | 175 | 208 |
| 2020 Marzo | 41 | 218 | 259 |
| 2020 Febrero | 48 | 180 | 228 |
| 2020 Enero | 57 | 150 | 207 |
| 2019 Diciembre | 83 | 226 | 309 |
| 2019 Noviembre | 69 | 205 | 274 |
| 2019 Octubre | 98 | 315 | 413 |
| 2019 Septiembre | 110 | 389 | 499 |
| 2019 Agosto | 46 | 274 | 320 |
| 2019 Julio | 73 | 216 | 289 |
| 2019 Junio | 369 | 311 | 680 |
| 2019 Mayo | 674 | 404 | 1078 |
| 2019 Abril | 773 | 545 | 1318 |
| 2019 Marzo | 553 | 484 | 1037 |
| 2019 Febrero | 405 | 653 | 1058 |
| 2019 Enero | 322 | 641 | 963 |
| 2018 Diciembre | 166 | 518 | 684 |
| 2018 Noviembre | 106 | 959 | 1065 |
| 2018 Octubre | 33 | 655 | 688 |
| 2018 Septiembre | 33 | 726 | 759 |
| 2018 Agosto | 1 | 0 | 1 |
| 2018 Junio | 4 | 0 | 4 |
| 2018 Mayo | 10 | 0 | 10 |
| 2018 Abril | 11 | 8 | 19 |
| 2018 Marzo | 7 | 9 | 16 |
| 2018 Febrero | 13 | 7 | 20 |
| 2018 Enero | 17 | 9 | 26 |
| 2017 Diciembre | 10 | 6 | 16 |
| 2017 Noviembre | 17 | 6 | 23 |
| 2017 Octubre | 15 | 6 | 21 |
| 2017 Septiembre | 20 | 5 | 25 |
| 2017 Agosto | 12 | 7 | 19 |
| 2017 Julio | 23 | 35 | 58 |
| 2017 Junio | 25 | 671 | 696 |
| 2017 Mayo | 25 | 529 | 554 |
| 2017 Abril | 25 | 490 | 515 |
| 2017 Marzo | 22 | 543 | 565 |
| 2017 Febrero | 17 | 438 | 455 |
| 2017 Enero | 27 | 283 | 310 |
| 2016 Diciembre | 32 | 390 | 422 |
| 2016 Noviembre | 65 | 571 | 636 |
| 2016 Octubre | 83 | 602 | 685 |
| 2016 Septiembre | 242 | 953 | 1195 |
| 2016 Agosto | 767 | 1024 | 1791 |
| 2016 Julio | 346 | 796 | 1142 |
| 2016 Junio | 1 | 0 | 1 |
| 2016 Mayo | 3 | 0 | 3 |
| 2016 Abril | 1 | 0 | 1 |
| 2016 Marzo | 3 | 0 | 3 |
| 2016 Febrero | 3 | 0 | 3 |
| 2016 Enero | 1 | 0 | 1 |
| 2015 Diciembre | 3 | 0 | 3 |
| 2015 Noviembre | 2 | 0 | 2 |
| 2015 Octubre | 2 | 0 | 2 |
| 2015 Septiembre | 4 | 0 | 4 |
| 2015 Julio | 12 | 0 | 12 |
| 2015 Junio | 10 | 0 | 10 |
| 2015 Mayo | 10 | 0 | 10 |
| 2015 Abril | 15 | 0 | 15 |
| 2015 Marzo | 24 | 0 | 24 |
| 2015 Febrero | 16 | 0 | 16 |
| 2015 Enero | 17 | 0 | 17 |
| 2014 Diciembre | 13 | 2 | 15 |
| 2014 Noviembre | 10 | 0 | 10 |
| 2014 Octubre | 8 | 1 | 9 |
| 2014 Septiembre | 13 | 3 | 16 |
| 2014 Agosto | 13 | 1 | 14 |
| 2014 Julio | 9 | 1 | 10 |
| 2014 Junio | 24 | 0 | 24 |
| 2014 Mayo | 28 | 2 | 30 |
| 2014 Abril | 17 | 3 | 20 |
| 2014 Marzo | 23 | 28 | 51 |
| 2014 Febrero | 14 | 17 | 31 |
| 2014 Enero | 15 | 22 | 37 |
| 2013 Diciembre | 27 | 17 | 44 |
| 2013 Noviembre | 24 | 14 | 38 |
| 2013 Octubre | 33 | 17 | 50 |
| 2013 Septiembre | 35 | 19 | 54 |
| 2013 Agosto | 25 | 12 | 37 |
| 2013 Julio | 5 | 6 | 11 |
| 2013 Junio | 3 | 3 | 6 |
| 2013 Mayo | 5 | 3 | 8 |
| 2013 Abril | 4 | 4 | 8 |
| 2013 Marzo | 7 | 6 | 13 |
| 2013 Febrero | 22 | 2 | 24 |
| 2013 Enero | 31 | 8 | 39 |
| 2012 Diciembre | 26 | 1 | 27 |
| 2012 Noviembre | 22 | 3 | 25 |
| 2012 Octubre | 20 | 3 | 23 |
| 2012 Septiembre | 7 | 0 | 7 |
| 2000 Abril | 7634 | 0 | 7634 |
Mostrar todo
