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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El SOFD constituye un grupo heterog&#233;neo de alteraciones gen&#233;ticas que tienen en com&#250;n anomal&#237;as faciales&#44; orales y digitales con distintos patrones de herencia mendeliana&#46; Se han descrito&#44; al menos 9 formas cl&#237;nicas de este s&#237;ndrome &#40;I-IX&#41;&#44; habi&#233;ndose comunicado 2 casos de SOFD asociados a agenesia hipofisaria&#46;</p> <span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">1&#46; Describir el caso de un paciente afectado de sOFD&#44; en el que se asocian agenesia hipofisaria y panhipopituitarismo&#46; 2&#46; Analizar si la asociaci&#243;n de agenesia hipofisaria a SOFD representa una nueva variante cl&#237;nica de este s&#237;ndrome&#46;</p> <span class="elsevierStyleSectionTitle">Paciente</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Var&#243;n de 11 meses de edad&#44; remitido por talla baja&#46; Presentaba un s&#237;ndrome malformativo con anomal&#237;as orales &#40;paladar ojival&#44; lengua lobulada&#44; hamartoma sublingual&#44; frenillos laterales&#41;&#44; faciales &#40;nariz peque&#241;a con ra&#237;z hundida&#44; alas nasales hipopl&#225;sicas&#44; macizo facial hipopl&#225;sico&#44; frente abombada&#44; orejas de implantaci&#243;n baja&#44; estenosis de coanas&#41; y digitales &#40;poli y clinodactilia en manos y pies&#41;&#44; t&#237;picas del SOFD&#46; Otros hallazgos cl&#237;nicos&#58; micropene&#44; criptorquidia bilateral&#44; escroto hipopl&#225;sico&#44; incisivo maxilar &#250;nico y obesidad&#44; Datos auxol&#243;gicos&#58; talla&#44; 60&#44;6 cm &#40;-5&#44;9 DE&#41;&#59; peso&#44; 7&#44;9 kg &#40;-2 DE&#41;&#59; IMC&#44; 21&#44;35 &#40;&#43;2&#44;2 DE&#41;&#59; PC&#44; 42&#44;5 cm &#40;-4&#44;3 DE&#41;&#59; velocidad de crecimiento&#44; 5&#44;8 cm&#47;a&#241;o para 16 meses &#40;-3&#44;8 DE&#41;&#46; Pruebas complementarias&#58; cariotipo 46&#44; XY&#59; los estudios hormonales demuestran la existencia de una deficiencia combinada de GH&#44; TSH y&#44; posiblemente&#44; de gonadotrofinas&#59; RMN craneal&#44; silla turca aplanada&#44; sin que se identifique par&#233;nquima hipofisario&#44; con tallo hipofisario adelgazado&#46; Actualmente el paciente se encuentra en tratamiento con levotiroxina s&#243;dica y hormona de crecimiento&#46;</p> <span class="elsevierStyleSectionTitle">Resumen</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Las manifestaciones cl&#237;nicas del paciente son sugerentes de un SOFD tipo II&#44; asociado a agenesia hipofisaria&#46;</p> <span class="elsevierStyleSectionTitle">Conclusi&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La asociaci&#243;n infrecuente de agenesia hipofisaria y panhipopituitarismo&#44; as&#237; como la descripci&#243;n previa de 2 hermanos con SOFD y agenesia hipofisaria sugiere la posibilidad de que se trate de una nueva variante de SOFD&#46;</p>"
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        "resumen" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Oral-facial digital syndrome &#40;OFDS&#41; consists of a group of heterogeneous genetic disorders with different patterns of inheritance&#46; These disorders share facial&#44; oral and digital abnormalities&#46; At least 11 types of this syndromehave been described &#40;I-IX&#41; and the association between OFDS type II and absent pituitary has recently been reported in the case of two brothers&#46;</p> <span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">1&#46; To describe the case of patients with OFDS associated with the absence of the hypophysis and panhypopituitarism&#46; 2&#46; To analyse whether the association between the agenesis of the hypophysis with OFDS represents a new type of this syndrome&#46;</p> <span class="elsevierStyleSectionTitle">Patient</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">An 11-month-old male infant presented with a malformation syndrome with oral &#40;Gothic palate&#44; lobulated tongue with lateral frenulae and hamartomas&#41; facial &#40;a small nose with flattened nasal root and hypoplastic nostrils&#44; small facial skeleton&#44; high forehead&#44; low-implanted ears&#44; stenosis of the choana&#41; and digital malformations &#40;polyand clinodactyl hands and feet&#41; typical of OFDS&#46; In addition to these findings&#44; at the age of 11 months he had growth retardation &#40;length 5&#46;9 SD&#41;&#44; obesity&#44; mild psychomotor delay&#44; a single upper incisor&#44; micropenis and undescended testes&#46; Endocrinologic studies showed combined GH&#44; TSH&#44; LH and FSH deficiency&#46; Cranial magnetic resonance imaging showed a smooth sella turcica&#44; lacking the pituitary gland&#44; and the absence of the normal sign of neurohypophysis&#46; Replacement therapy with GH and 1-thyroxine was started&#46;</p> <span class="elsevierStyleSectionTitle">Summary</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">We report a patient with the clinical characteristics of OFDS type II&#44; associated with the absence of hypophysis and panhypopituitarism&#46;</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">The infrequent association of agenesis of the pituitary gland and panhypopituitarism with OFDS&#44; and the previous report of two brothers with this syndrome and the same association&#44; suggests that this is a new type of OFDS&#46;</p>"
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                        "paginaFinal" => "105"
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                        "paginaFinal" => "556"
                      ]
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                        "tituloSerie" => "Am J Med Genet"
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                        "volumen" => "57"
                        "paginaInicial" => "22"
                        "paginaFinal" => "26"
                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7645593"
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                        "paginaFinal" => "800"
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Síndrome orofaciodigital asociado a agenesia hipofisaria
Oral-facial-digital syndrome associated with agenesis of the pituitary gland
M. Buño, J. Pozo, M.T. Muñoz, M. Espejo, J. Argente*
Departamento de Pediatría. Universidad Autónoma de Madrid. Sección de Endocrinología Pediátrica. Hospital Niño Jesús. Madrid.
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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El SOFD constituye un grupo heterog&#233;neo de alteraciones gen&#233;ticas que tienen en com&#250;n anomal&#237;as faciales&#44; orales y digitales con distintos patrones de herencia mendeliana&#46; Se han descrito&#44; al menos 9 formas cl&#237;nicas de este s&#237;ndrome &#40;I-IX&#41;&#44; habi&#233;ndose comunicado 2 casos de SOFD asociados a agenesia hipofisaria&#46;</p> <span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">1&#46; Describir el caso de un paciente afectado de sOFD&#44; en el que se asocian agenesia hipofisaria y panhipopituitarismo&#46; 2&#46; Analizar si la asociaci&#243;n de agenesia hipofisaria a SOFD representa una nueva variante cl&#237;nica de este s&#237;ndrome&#46;</p> <span class="elsevierStyleSectionTitle">Paciente</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Var&#243;n de 11 meses de edad&#44; remitido por talla baja&#46; Presentaba un s&#237;ndrome malformativo con anomal&#237;as orales &#40;paladar ojival&#44; lengua lobulada&#44; hamartoma sublingual&#44; frenillos laterales&#41;&#44; faciales &#40;nariz peque&#241;a con ra&#237;z hundida&#44; alas nasales hipopl&#225;sicas&#44; macizo facial hipopl&#225;sico&#44; frente abombada&#44; orejas de implantaci&#243;n baja&#44; estenosis de coanas&#41; y digitales &#40;poli y clinodactilia en manos y pies&#41;&#44; t&#237;picas del SOFD&#46; Otros hallazgos cl&#237;nicos&#58; micropene&#44; criptorquidia bilateral&#44; escroto hipopl&#225;sico&#44; incisivo maxilar &#250;nico y obesidad&#44; Datos auxol&#243;gicos&#58; talla&#44; 60&#44;6 cm &#40;-5&#44;9 DE&#41;&#59; peso&#44; 7&#44;9 kg &#40;-2 DE&#41;&#59; IMC&#44; 21&#44;35 &#40;&#43;2&#44;2 DE&#41;&#59; PC&#44; 42&#44;5 cm &#40;-4&#44;3 DE&#41;&#59; velocidad de crecimiento&#44; 5&#44;8 cm&#47;a&#241;o para 16 meses &#40;-3&#44;8 DE&#41;&#46; Pruebas complementarias&#58; cariotipo 46&#44; XY&#59; los estudios hormonales demuestran la existencia de una deficiencia combinada de GH&#44; TSH y&#44; posiblemente&#44; de gonadotrofinas&#59; RMN craneal&#44; silla turca aplanada&#44; sin que se identifique par&#233;nquima hipofisario&#44; con tallo hipofisario adelgazado&#46; Actualmente el paciente se encuentra en tratamiento con levotiroxina s&#243;dica y hormona de crecimiento&#46;</p> <span class="elsevierStyleSectionTitle">Resumen</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Las manifestaciones cl&#237;nicas del paciente son sugerentes de un SOFD tipo II&#44; asociado a agenesia hipofisaria&#46;</p> <span class="elsevierStyleSectionTitle">Conclusi&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La asociaci&#243;n infrecuente de agenesia hipofisaria y panhipopituitarismo&#44; as&#237; como la descripci&#243;n previa de 2 hermanos con SOFD y agenesia hipofisaria sugiere la posibilidad de que se trate de una nueva variante de SOFD&#46;</p>"
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      "en" => array:1 [
        "resumen" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Oral-facial digital syndrome &#40;OFDS&#41; consists of a group of heterogeneous genetic disorders with different patterns of inheritance&#46; These disorders share facial&#44; oral and digital abnormalities&#46; At least 11 types of this syndromehave been described &#40;I-IX&#41; and the association between OFDS type II and absent pituitary has recently been reported in the case of two brothers&#46;</p> <span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">1&#46; To describe the case of patients with OFDS associated with the absence of the hypophysis and panhypopituitarism&#46; 2&#46; To analyse whether the association between the agenesis of the hypophysis with OFDS represents a new type of this syndrome&#46;</p> <span class="elsevierStyleSectionTitle">Patient</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">An 11-month-old male infant presented with a malformation syndrome with oral &#40;Gothic palate&#44; lobulated tongue with lateral frenulae and hamartomas&#41; facial &#40;a small nose with flattened nasal root and hypoplastic nostrils&#44; small facial skeleton&#44; high forehead&#44; low-implanted ears&#44; stenosis of the choana&#41; and digital malformations &#40;polyand clinodactyl hands and feet&#41; typical of OFDS&#46; In addition to these findings&#44; at the age of 11 months he had growth retardation &#40;length 5&#46;9 SD&#41;&#44; obesity&#44; mild psychomotor delay&#44; a single upper incisor&#44; micropenis and undescended testes&#46; Endocrinologic studies showed combined GH&#44; TSH&#44; LH and FSH deficiency&#46; Cranial magnetic resonance imaging showed a smooth sella turcica&#44; lacking the pituitary gland&#44; and the absence of the normal sign of neurohypophysis&#46; Replacement therapy with GH and 1-thyroxine was started&#46;</p> <span class="elsevierStyleSectionTitle">Summary</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">We report a patient with the clinical characteristics of OFDS type II&#44; associated with the absence of hypophysis and panhypopituitarism&#46;</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">The infrequent association of agenesis of the pituitary gland and panhypopituitarism with OFDS&#44; and the previous report of two brothers with this syndrome and the same association&#44; suggests that this is a new type of OFDS&#46;</p>"
      ]
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            0 => array:3 [
              "identificador" => "bib0005"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hypertrophied frenuli&#44; oligophrenia&#44; familial trembling and anomalies of the hand&#58; reportof four cases in one family and a form frustr in another&#46;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46;J&#46; Gorlin"
                            1 => "V&#46;E&#46; Anderson"
                            2 => "C&#46;R&#46; Scott"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM196103092641004"
                      "Revista" => array:6 [
                        "tituloSerie" => "New Engl J Med"
                        "fecha" => "1961"
                        "volumen" => "264"
                        "paginaInicial" => "486"
                        "paginaFinal" => "489"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13707262"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral-facial-digital syndromes&#44; 1992&#46;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "H&#46;V&#46; Toriello"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Dysmorph"
                        "fecha" => "1993"
                        "volumen" => "2"
                        "paginaInicial" => "95"
                        "paginaFinal" => "105"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8281288"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "On lumping and splitting&#58;a fetus with clinical findings of the oral-facial-digital syndrometype IV&#44; the hydrolethalus syndome&#44; and the Pallister-Hall syndrome&#46;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; M&#252;nke"
                            1 => "E&#46;D&#46; Ruchelli"
                            2 => "L&#46;B&#46; Rorke"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Med Genet"
                        "fecha" => "1991"
                        "volumen" => "41"
                        "paginaInicial" => "518"
                        "paginaFinal" => "556"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Absent pituitary glandin two brothers with an oral-facial-digital syndrome reesemblingOFDS II and VI&#58; a new type of OFDS&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "V&#46; Shashi"
                            1 => "P&#46; Clark"
                            2 => "A&#46; Rogol"
                            3 => "W&#46; Wilson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/ajmg.1320570107"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med Genet"
                        "fecha" => "1995"
                        "volumen" => "57"
                        "paginaInicial" => "22"
                        "paginaFinal" => "26"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7645593"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intrauterinegrowth as estimated from liveborn birth weight data at 24 to42 weeks gestation&#46;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "I&#46; Lubchenco"
                            1 => "C&#46; Hansman"
                            2 => "M&#46; Dressler"
                            3 => "E&#46; Boyd"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatrics"
                        "fecha" => "1963"
                        "volumen" => "32"
                        "paginaInicial" => "793"
                        "paginaFinal" => "800"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14075621"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Hern&#225;ndez"
                            1 => "J&#46; Castellet"
                            2 => "J&#46;L&#46; Narvaiza"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "1988"
                        "editorial" => "Garsi"
                        "editorialLocalizacion" => "Madrid"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A hereditary lethal syndrome in man&#46; Avh Norske Videnskad&#46;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "O&#46;L&#46; Mohr"
                          ]
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Oslo"
                        "fecha" => "1941"
                        "volumen" => "14"
                        "paginaInicial" => "1"
                        "paginaFinal" => "18"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genetic and clinical heterogeneity in the oral-facial-digital syndromes&#46;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;L&#46; Rimoin"
                            1 => "M&#46;T&#46; Edgerton"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pediat"
                        "fecha" => "1967"
                        "volumen" => "71"
                        "paginaInicial" => "94"
                        "paginaFinal" => "102"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5293864"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The orofaciodigital &#40;OFD&#41; syndromes&#46;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46; Baraitser"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Med Genet"
                        "fecha" => "1986"
                        "volumen" => "23"
                        "paginaInicial" => "116"
                        "paginaFinal" => "119"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3712388"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Mohr syndrome&#58; are there two variants&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46; Haumont"
                            1 => "S&#46; Pelc"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Genet"
                        "fecha" => "1983"
                        "volumen" => "24"
                        "paginaInicial" => "41"
                        "paginaFinal" => "46"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6352094"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oro-facial-digital syndrome II &#40;carta&#41;&#46;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "Y&#46; Guillerot"
                            1 => "L&#46; Koulicher"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Genet"
                        "fecha" => "1988"
                        "volumen" => "33"
                        "paginaInicial" => "141"
                        "paginaFinal" => "142"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3359665"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Central nervous system malformations and early end-stage disease in oro-facio-digital syndrome type I &#58; a review&#46;"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46; Odent"
                            1 => "B&#46; Le Marec"
                            2 => "A&#46; Toutain"
                            3 => "A&#46; David"
                            4 => "J&#46; Vigneron"
                            5 => "C&#46; Tr&#233;guier"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med Genet"
                        "fecha" => "1998"
                        "volumen" => "75"
                        "paginaInicial" => "389"
                        "paginaFinal" => "394"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9482645"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            12 => array:3 [
              "identificador" => "bib0065"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Abnormalities of the cerebellum in oro-facial-digitalsyndrome II &#40;Mohr syndrome&#41;&#46;"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
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                            2 => "S&#46; J&#242;zviak"
                            3 => "S&#46; Kjartansson"
                            4 => "B&#46; Str&#246;mberg"
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Genet"
                        "fecha" => "1990"
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                        "paginaInicial" => "69"
                        "paginaFinal" => "73"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2387087"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0070"
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                    0 => array:2 [
                      "titulo" => "Oral-facial-digital syndrometype VI&#58; further clinical delineation&#46;"
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                          "etal" => false
                          "autores" => array:3 [
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                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Med Genet"
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                        "paginaInicial" => "360"
                        "paginaFinal" => "369"
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                      "titulo" => "Absent pituitary gland and hypoplais of the cerebellar vermis associated with partial opthalmoplegia and postaxial polydactily&#58;a variant of orofaciodigital syndrome VI or a new syndrome&#63;"
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                        0 => array:2 [
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                            3 => "W&#46; Shather"
                            4 => "M&#46; Nork"
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                    ]
                  ]
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                      "Revista" => array:6 [
                        "tituloSerie" => "J Med Genet"
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                        "paginaFinal" => "166"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10051020"
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Información del artículo
ISSN: 16954033
Idioma original: Español
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2018 Diciembre 15 15 30
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2018 Octubre 27 27 54
2018 Septiembre 18 8 26
2018 Junio 1 0 1
2018 Mayo 3 0 3
2018 Abril 6 0 6
2018 Marzo 5 0 5
2018 Febrero 3 0 3
2018 Enero 4 0 4
2017 Diciembre 4 0 4
2017 Noviembre 6 0 6
2017 Octubre 7 0 7
2017 Septiembre 7 0 7
2017 Agosto 3 0 3
2017 Julio 11 1 12
2017 Junio 8 50 58
2017 Mayo 14 16 30
2017 Abril 17 22 39
2017 Marzo 14 30 44
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2016 Diciembre 24 16 40
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2016 Octubre 34 29 63
2016 Septiembre 36 16 52
2016 Agosto 50 33 83
2016 Julio 33 34 67
2015 Diciembre 2 0 2
2015 Agosto 2 0 2
2015 Julio 7 0 7
2015 Junio 5 0 5
2015 Mayo 16 0 16
2015 Abril 13 0 13
2015 Marzo 13 0 13
2015 Febrero 8 0 8
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2014 Diciembre 12 1 13
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2013 Julio 3 8 11
2013 Junio 2 6 8
2013 Mayo 3 6 9
2013 Abril 4 7 11
2013 Marzo 4 6 10
2013 Febrero 15 3 18
2013 Enero 13 3 16
2012 Diciembre 19 4 23
2012 Noviembre 19 6 25
2012 Octubre 3 1 4
2012 Septiembre 1 1 2
2012 Julio 1 0 1
2000 Marzo 6122 0 6122
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