Tratamiento con insulina Lispro (Lys B28, Pro B29) en adolescentes y jóvenes con diabetes mellitus tipo 1
Insulin lispro (Lys B28, Pro B29) treatment in adolescents with type 1 diabetes
Unidad de Endocrinología Pediátrica. Servicio de Pediatría. Hospital Ramón y Cajal. Madrid.
Leído
9052
Vecesse ha leído el artículo
2311
Total PDF
6741
Total HTML
Compartir estadísticas
array:23 [ "pii" => "S169540330077353X" "issn" => "16954033" "doi" => "10.1016/S1695-4033(00)77353-X" "estado" => "S300" "fechaPublicacion" => "2000-04-01" "aid" => "77353" "copyright" => "Asociación Española de Pediatría" "copyrightAnyo" => "2000" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "An Pediatr (Barc). 2000;52:334-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3894 "formatos" => array:3 [ "EPUB" => 74 "HTML" => 3330 "PDF" => 490 ] ] "itemSiguiente" => array:18 [ "pii" => "S1695403300773541" "issn" => "16954033" "doi" => "10.1016/S1695-4033(00)77354-1" "estado" => "S300" "fechaPublicacion" => "2000-04-01" "aid" => "77354" "copyright" => "Asociación Española de Pediatría" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "An Pediatr (Barc). 2000;52:339-45" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2316 "formatos" => array:3 [ "EPUB" => 70 "HTML" => 1766 "PDF" => 480 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Eficacia del tratamiento hemodinámico guiado por el pH intramucoso gástrico en niños críticamente enfermos" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "339" "paginaFinal" => "345" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Effectiveness of hemodynamic treatment guided by gastric intramucosalph monitoring" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "C. Calvo Rey, F. Ruza Tarrío, M.A. Delgado Domínguez, J. López-Herce Cid, P. Dorao Martínez-Romillo" "autores" => array:5 [ 0 => array:2 [ "nombre" => "C." "apellidos" => "Calvo Rey" ] 1 => array:2 [ "nombre" => "F." "apellidos" => "Ruza Tarrío" ] 2 => array:2 [ "nombre" => "M.A." "apellidos" => "Delgado Domínguez" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "López-Herce Cid" ] 4 => array:2 [ "nombre" => "P." "apellidos" => "Dorao Martínez-Romillo" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403300773541?idApp=UINPBA00005H" "url" => "/16954033/0000005200000004/v1_201307051457/S1695403300773541/v1_201307051457/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1695403300773528" "issn" => "16954033" "doi" => "10.1016/S1695-4033(00)77352-8" "estado" => "S300" "fechaPublicacion" => "2000-04-01" "aid" => "77352" "copyright" => "Asociación Española de Pediatría" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "An Pediatr (Barc). 2000;52:327-33" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 5071 "formatos" => array:3 [ "EPUB" => 78 "HTML" => 3414 "PDF" => 1579 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Pico de flujo espiratorio en escolares de 4 a 15 años de edad. Comparación de tres modelos de medidor" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "327" "paginaFinal" => "333" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Peak espiratory flow rate in school-children 4-15 years old. Comparison between three different devices" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "V. Hernando Sastre, L. García-Marcos, J. Gómez García, U. Faura Martínez, J. Rubio Pérez, M.D. Navarro Ortiz, J.A. Hernández Dólera" "autores" => array:7 [ 0 => array:2 [ "nombre" => "V." "apellidos" => "Hernando Sastre" ] 1 => array:2 [ "nombre" => "L." "apellidos" => "García-Marcos" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Gómez García" ] 3 => array:2 [ "nombre" => "U." "apellidos" => "Faura Martínez" ] 4 => array:2 [ "nombre" => "J." "apellidos" => "Rubio Pérez" ] 5 => array:2 [ "nombre" => "M.D." "apellidos" => "Navarro Ortiz" ] 6 => array:2 [ "nombre" => "J.A." "apellidos" => "Hernández Dólera" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403300773528?idApp=UINPBA00005H" "url" => "/16954033/0000005200000004/v1_201307051457/S1695403300773528/v1_201307051457/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Tratamiento con insulina Lispro (Lys B28, Pro B29) en adolescentes y jóvenes con diabetes mellitus tipo 1" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "334" "paginaFinal" => "338" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M.J. Tuset Castellano, I. Martínez Badás, M. Alonso Blanco, R. Barrio Castellanos" "autores" => array:4 [ 0 => array:3 [ "nombre" => "M.J." "apellidos" => "Tuset Castellano" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "I." "apellidos" => "Martínez Badás" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Alonso Blanco" ] 3 => array:2 [ "nombre" => "R." "apellidos" => "Barrio Castellanos" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Unidad de Endocrinología Pediátrica. Servicio de Pediatría. Hospital Ramón y Cajal. Madrid." ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Pedro Rico 17, 12 B. 28029 Madrid." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Insulin lispro (Lys B28, Pro B29) treatment in adolescents with type 1 diabetes" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1999-09-30" "fechaAceptado" => "2000-01-31" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec186289" "palabras" => array:4 [ 0 => "Diabetes tipo 1" 1 => "Insulina Lispro" 2 => "Niños" 3 => "Adolescencia" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec186290" "palabras" => array:4 [ 0 => "Type-1 diabetes" 1 => "Lispro insulin" 2 => "Childhood" 3 => "Teenager" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El análogo de la insulina humana Lispro (Lys B28, ProB29) remeda mejor el perfil de la respuesta normal de la insulina pancreática ante la ingestión por lo que puede ser una alternativa en el tratamiento clásico de la diabetes tipo 1 en la infancia. El objetivo ha sido analizar la respuesta a una pauta de tratamiento insulínico con este análogo, tras un año de seguimiento.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Veinte pacientes diabéticos puberales, 9 varones y 11mujeres, con una edad media de 15,6 años (desviación estándar [DE], ± 4,5) y un tiempo medio de evolución de la enfermedad de 8,3 años (± 4,3), cambiaron su tratamiento intensivo clásico, mezcla de insulina regular (HR) e insulina NPH (Humulina NPH) por una nueva pauta con insulina Lispro e insulina NPH en 3 o 4 dosis. Todos los pacientes habían recibido educación diabetológica y se realizaban 4 o más glucemias capilares al día y autocontrol. Analizamos los 6 meses previos (grupo A) y los 12 meses posteriores al cambio de tratamiento (grupo B) y comparamos la cantidad de insulina (U/kg/día), la proporción de insulina rápida e intermedia en cada dosis, las modificaciones en la dieta, el grado de control metabóli-co valorado mediante la media de las Ab A1c realizadascada 2 meses, la presencia de hipoglucemias graves y elgrado de satisfacción de los pacientes con el tratamiento.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">El número de dosis administradas, así como la cantidad de insulina al día, fue igual en ambos grupos (3,7 [± 0,6] dosis/día; 0,9 [± 0,2] U/kg/día).</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">En la pauta con Lispro disminuyó la proporción de insulina rápida/insulina intermedia. Esta diferencia fue estadísticamente significativa en la dosis antes del desayu-no (clásico, 65,4 ± 30% frente a Lispro, 47,1 ± 19,6%), y en la dosis antes de la comida (clásico, 58,1 ± 29,3% frente a Lispro, 39 ± 12,8%). La mayoría de los pacientes no precisaron la ingestión de media mañana y merienda. No hu-bo modificaciones en el índice de masa corporal.</p><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Aunque el control metabólico mejoró ligeramente (clásico, -X Hb A1c = 7 ± 1,2 frente a Lispro -X Hb A1c = 6,6 ±1,1), la diferencia no fue estadísticamente significativa. Tres pacientes tuvieron un episodio de hipoglucemia grave en los primeros 6 meses de tratamiento con la nueva pauta. Todos estuvieron satisfechos con la nueva insulina.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La terapia intensiva con insulina Lispro en combinación con dosis adecuadas de insulina basal (NPH) puede ser una buena alternativa en el tratamiento de pacientes diabéticos adolescentes.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The human insulin analogue, Lispro (Lys B28, Pro B29), is more similar to normal pancreatic insulin response to ingestion. Therefore, it could provide an alternative to the classical treatment of type-1 diabetes in childhood. The aim of this study was to analyze the response to insulin treatment with this analogue during 1 year.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">In a study group of twenty puberal diabetic patients (nine male and 11 female) with a mean age of 15.6 years (± SD) and with diabetes of a mean of 8.3 years (± 4.3 SD), classical intensive treatment, a combination of regular in-sulin (HR) and NPH insulin (Humulin NPH) was substituted for a new treatment with Lispro and NPH insulin in 3-4 doses. All patients had received diabetic education and performed at least four blood glucose tests daily and self monitoring. We analyzed the 6 months prior to the change in treatment (Group A) and the 12 months after the change (Group B). The amount of insulin (u/kg/day), thefast/intermediate insulin ratio in each dose, dietary modifications, the level of metabolic control given by the HbA1C average measured every 2 months, severe hypoglycemia and the patient’s level of satisfaction with the new treatment were compared between the two groups.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The number of daily doses, as well as the daily insulin intake, was the same in both groups (3.7 [± 0.6] doses/day; 0.9 [± 0.2] u/kg/day). With Lispro treatment the ratio fast/intermediate insulin was reduced. This reduction was statistically significant for the pre-breakfast dose (Classical = 65.4 ± 30% vs Lispro = 47.1 ± 19.6%), and for the pre-lunch dose (Classical = 58.1 ± 29.3% vs Lispro = 39 ± 12.8%). Most patients did not need neither mid-morning or mid-afternoon doses. There were no modifi-cations in body mass index. Although metabolic control im-proved slightly (Classical X-AbA1c= 7 ± 1.2 vs Lispro X-AbA1c= 6.6 ± 1.1), the difference was not statistically significant. Three patients had a severe hypoglycemic episode in the first 6 months with the new treatment pattern. All of them were satisfied with the new insulin.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Intensive therapy with Lispro insulin combined with appropriate doses of basal insulin (NPH) can provide a good alternative in the treatment of diabetic teenagers.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:21 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Insulin analogues" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Barnett" 1 => "D. Owens" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(96)06032-1" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1997" "volumen" => "349" "paginaInicial" => "47" "paginaFinal" => "51" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8988131" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "(Lys (B28), Pro (B29))-Human insulin. A rapidly absorbed analogue of human insulin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D. Howey" 1 => "R. Bowsher" 2 => "R. Brunelle" 3 => "J. Woodworth" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Diabetes" "fecha" => "1994" "volumen" => "43" "paginaInicial" => "396" "paginaFinal" => "402" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8314011" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparative study of insulin Lispro and regular insulin in prepuberal children with type 1 diabetes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J. Holcombe" 1 => "R. Brunelle" 2 => "S. Zalani" 3 => "L. Deeb" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Diabetes" "fecha" => "1998" "volumen" => "47" "paginaInicial" => "A96" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Use of in-sulin lispro in pediatric patients with IDDM" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Pfützner" 1 => "U. Gudat" 2 => "M.E. Trautmann" 3 => "J. Holcombe" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Diabetologia" "fecha" => "1996" "volumen" => "39" "paginaInicial" => "A222" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pre-meal insulin analogue insulin Lispro vs Humulin CAR. Insulin treatment in young subjects with ty-pe 1 diabetes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S.K. Garg" 1 => "J.A. Carmain" 2 => "K.C. Braddy" 3 => "J.H. Andersen" 4 => "L. Vignati" 5 => "M.K. Jennings" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/(SICI)1096-9136(199601)13:1<47::AID-DIA999>3.0.CO;2-M" "Revista" => array:6 [ "tituloSerie" => "Diabetic Medicine" "fecha" => "1996" "volumen" => "13" "paginaInicial" => "47" "paginaFinal" => "52" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8741812" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The human insulin analogue insulin Lispro" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "V.A. Koivisto" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Med" "fecha" => "1998" "volumen" => "30" "paginaInicial" => "260" "paginaFinal" => "266" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9677011" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of the short-acting insulin analog (Lys (B28), Pro(B29)) on postpandrial blood glucose controlin IDDM" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "E. Torlone" 1 => "S. Pampanelli" 2 => "S. Lalli" 3 => "P. Del Sindaco" 4 => "A. Di Vicenzo" 5 => "A.M. Rambotti" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Diabetes Care" "fecha" => "1996" "volumen" => "19" "paginaInicial" => "945" "paginaFinal" => "952" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8875087" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effectiveness of postprandial humalog in toddlers" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "K.S. Rutledge" 1 => "H.P. Chase" 2 => "J. Klingensmith" 3 => "P. Walravens" 4 => "R. Slover" 5 => "S.K. Garg" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatrics" "fecha" => "1997" "volumen" => "100" "paginaInicial" => "968" "paginaFinal" => "972" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9374566" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Postprandial glycaemia after regular and lispro insulin in children and adolescents with diabetes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "B. Rami" 1 => "E. Schober" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Eu-ropean Journal of Pediatrics" "fecha" => "1997" "volumen" => "156" "paginaInicial" => "838" "paginaFinal" => "840" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term efficacy of humalog in subjects with type 1 diabetes mellitus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S.K. Gag" 1 => "J.H. Anderson" 2 => "S.V. Perry" 3 => "S.K. Garg" 4 => "J.H. Anderson" 5 => "M.K. Jennigs" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Diabetic Medicine" "fecha" => "1999" "volumen" => "16" "paginaInicial" => "384" "paginaFinal" => "387" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10342337" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reduction of post prandial hyperglucemia and frecuency of hypoglucemia in IDDM patients on insulin-analog treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Anderson" 1 => "R.L. Brunelle" 2 => "V.A. Koivisto" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Diabetes" "fecha" => "1997" "volumen" => "46" "paginaInicial" => "265" "paginaFinal" => "270" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9000704" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lispro insulin as premeal therapy in type 1 diabetes: comparison with Humulin R" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.R. Daniels" 1 => "R. Bruce" 2 => "L. McGregor" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "New Zealand Med J" "fecha" => "1997" "volumen" => "110" "paginaInicial" => "435" "paginaFinal" => "438" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9418839" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metabolic efficacy of preprandial administration of Lys (B28), Pro (B29) human insulin analog in IDDM patients. A comparision with human regular insulin during a three-meal test period" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.A. Jacobs" 1 => "E.T. Keulen" 2 => "K. Kanc" 3 => "S. Casteleijn" 4 => "P. Scheffer" 5 => "W. Devillé" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Diabetes Care" "fecha" => "1997" "volumen" => "20" "paginaInicial" => "1279" "paginaFinal" => "1286" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9250454" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673607601512" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prolonged effi-cacy of short acting insulin lispro in combination with human ultralente in insulin dependent diabetes mellitus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Burge" 1 => "D. Waters" 2 => "J. Holcombe" 3 => "D.S. Schade" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Clin En-docrinol Metab" "fecha" => "1997" "volumen" => "82" "paginaInicial" => "920" "paginaFinal" => "924" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Optimization of evening in-sulin dose in patients using the short acting insulin analog lis-pro" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.B. Ahmed" 1 => "J. Mallias" 2 => "P.D. Home" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Diabetes Care" "fecha" => "1998" "volumen" => "21" "paginaInicial" => "1162" "paginaFinal" => "1166" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9653613" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Optimal provision of daytime NPH" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.B.E. Ahmed" 1 => "P.D. Home" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Diabetes Care" "fecha" => "1998" "volumen" => "21" "paginaInicial" => "1707" "paginaFinal" => "1713" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9773735" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "The DCCT Group. The effect of intensive treatment of diabe-tes on the development and progression of long-term com-plications in insulin dependent diabetes mellitus" ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199309303291401" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1993" "volumen" => "329" "paginaInicial" => "977" "paginaFinal" => "986" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8366922" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparative study of insulin Lispro and regular insulin in 481 adoles-cents with type 1 diabetes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J. Holcombe" 1 => "S. Zalani" 2 => "V. Arora" 3 => "S. Headlee" 4 => "A. Gill" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Diabetes" "fecha" => "1997" "volumen" => "46" "paginaInicial" => "329A" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Insulin Lis-pro (LP) results in less nocturnal hypoglucemia compared with human insulin in adolescents with type 1 diabetes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J. Holcombe" 1 => "S. Zalani" 2 => "V. Arora" 3 => "S. Headlee" 4 => "A. Gill" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Dia-betes" "fecha" => "1997" "volumen" => "46" "paginaInicial" => "103" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lispro or regular insuline for multiple injection therapy in adolescence" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Mohn" 1 => "K.A. Matyka" 2 => "D.A. Harris" 3 => "K.M. Ross" 4 => "J.A. Edge" 5 => "D.B. Dunger" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Diabetes Care" "fecha" => "1999" "volumen" => "22" "paginaInicial" => "27" "paginaFinal" => "32" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10333899" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Health related quality of life results from multinational clinical trials of insulin Lispro" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Kotsanos" 1 => "L. Vignati" 2 => "W. Huster" 3 => "C. Andrejasich" 4 => "M.B. Boggs" 5 => "A.M. Jacobson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Diabetes Care" "fecha" => "1997" "volumen" => "20" "paginaInicial" => "948" "paginaFinal" => "958" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9167105" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/16954033/0000005200000004/v1_201307051457/S169540330077353X/v1_201307051457/es/main.assets" "Apartado" => array:4 [ "identificador" => "14282" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Originales" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/16954033/0000005200000004/v1_201307051457/S169540330077353X/v1_201307051457/es/main.pdf?idApp=UINPBA00005H&text.app=https://analesdepediatria.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S169540330077353X?idApp=UINPBA00005H" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 16 | 11 | 27 |
| 2024 Octubre | 84 | 37 | 121 |
| 2024 Septiembre | 86 | 40 | 126 |
| 2024 Agosto | 96 | 65 | 161 |
| 2024 Julio | 68 | 41 | 109 |
| 2024 Junio | 82 | 33 | 115 |
| 2024 Mayo | 96 | 39 | 135 |
| 2024 Abril | 67 | 40 | 107 |
| 2024 Marzo | 65 | 52 | 117 |
| 2024 Febrero | 58 | 50 | 108 |
| 2024 Enero | 43 | 34 | 77 |
| 2023 Diciembre | 43 | 21 | 64 |
| 2023 Noviembre | 45 | 26 | 71 |
| 2023 Octubre | 45 | 31 | 76 |
| 2023 Septiembre | 34 | 22 | 56 |
| 2023 Agosto | 27 | 22 | 49 |
| 2023 Julio | 67 | 41 | 108 |
| 2023 Junio | 64 | 26 | 90 |
| 2023 Mayo | 76 | 27 | 103 |
| 2023 Abril | 46 | 24 | 70 |
| 2023 Marzo | 49 | 38 | 87 |
| 2023 Febrero | 50 | 29 | 79 |
| 2023 Enero | 45 | 27 | 72 |
| 2022 Diciembre | 76 | 21 | 97 |
| 2022 Noviembre | 75 | 55 | 130 |
| 2022 Octubre | 69 | 39 | 108 |
| 2022 Septiembre | 51 | 42 | 93 |
| 2022 Agosto | 64 | 50 | 114 |
| 2022 Julio | 32 | 36 | 68 |
| 2022 Junio | 40 | 34 | 74 |
| 2022 Mayo | 28 | 37 | 65 |
| 2022 Abril | 46 | 35 | 81 |
| 2022 Marzo | 62 | 57 | 119 |
| 2022 Febrero | 34 | 30 | 64 |
| 2022 Enero | 64 | 41 | 105 |
| 2021 Diciembre | 84 | 41 | 125 |
| 2021 Noviembre | 91 | 48 | 139 |
| 2021 Octubre | 53 | 54 | 107 |
| 2021 Septiembre | 45 | 60 | 105 |
| 2021 Agosto | 48 | 27 | 75 |
| 2021 Julio | 37 | 25 | 62 |
| 2021 Junio | 41 | 36 | 77 |
| 2021 Mayo | 34 | 28 | 62 |
| 2021 Abril | 145 | 44 | 189 |
| 2021 Marzo | 87 | 32 | 119 |
| 2021 Febrero | 78 | 22 | 100 |
| 2021 Enero | 64 | 14 | 78 |
| 2020 Diciembre | 65 | 17 | 82 |
| 2020 Noviembre | 61 | 14 | 75 |
| 2020 Octubre | 54 | 8 | 62 |
| 2020 Septiembre | 28 | 9 | 37 |
| 2020 Agosto | 48 | 8 | 56 |
| 2020 Julio | 61 | 17 | 78 |
| 2020 Junio | 58 | 11 | 69 |
| 2020 Mayo | 57 | 17 | 74 |
| 2020 Abril | 92 | 14 | 106 |
| 2020 Marzo | 75 | 12 | 87 |
| 2020 Febrero | 37 | 21 | 58 |
| 2020 Enero | 39 | 15 | 54 |
| 2019 Diciembre | 39 | 17 | 56 |
| 2019 Noviembre | 15 | 2 | 17 |
| 2019 Octubre | 11 | 11 | 22 |
| 2019 Septiembre | 25 | 15 | 40 |
| 2019 Agosto | 35 | 16 | 51 |
| 2019 Julio | 19 | 30 | 49 |
| 2019 Junio | 40 | 32 | 72 |
| 2019 Mayo | 80 | 34 | 114 |
| 2019 Abril | 78 | 28 | 106 |
| 2019 Marzo | 32 | 15 | 47 |
| 2019 Febrero | 39 | 8 | 47 |
| 2019 Enero | 47 | 11 | 58 |
| 2018 Diciembre | 36 | 15 | 51 |
| 2018 Noviembre | 23 | 12 | 35 |
| 2018 Octubre | 27 | 18 | 45 |
| 2018 Septiembre | 16 | 7 | 23 |
| 2018 Julio | 1 | 0 | 1 |
| 2018 Mayo | 11 | 0 | 11 |
| 2018 Abril | 14 | 0 | 14 |
| 2018 Marzo | 13 | 0 | 13 |
| 2018 Febrero | 17 | 0 | 17 |
| 2018 Enero | 7 | 0 | 7 |
| 2017 Diciembre | 18 | 0 | 18 |
| 2017 Noviembre | 15 | 0 | 15 |
| 2017 Octubre | 13 | 0 | 13 |
| 2017 Septiembre | 13 | 0 | 13 |
| 2017 Agosto | 9 | 0 | 9 |
| 2017 Julio | 8 | 1 | 9 |
| 2017 Junio | 23 | 9 | 32 |
| 2017 Mayo | 22 | 5 | 27 |
| 2017 Abril | 15 | 4 | 19 |
| 2017 Marzo | 9 | 15 | 24 |
| 2017 Febrero | 4 | 0 | 4 |
| 2017 Enero | 12 | 7 | 19 |
| 2016 Diciembre | 8 | 7 | 15 |
| 2016 Noviembre | 27 | 6 | 33 |
| 2016 Octubre | 27 | 8 | 35 |
| 2016 Septiembre | 19 | 13 | 32 |
| 2016 Agosto | 23 | 17 | 40 |
| 2016 Julio | 15 | 16 | 31 |
| 2016 Febrero | 3 | 0 | 3 |
| 2015 Diciembre | 2 | 0 | 2 |
| 2015 Julio | 5 | 0 | 5 |
| 2015 Junio | 7 | 0 | 7 |
| 2015 Mayo | 11 | 0 | 11 |
| 2015 Abril | 10 | 0 | 10 |
| 2015 Marzo | 8 | 0 | 8 |
| 2015 Febrero | 3 | 0 | 3 |
| 2015 Enero | 16 | 0 | 16 |
| 2014 Diciembre | 9 | 1 | 10 |
| 2014 Noviembre | 10 | 0 | 10 |
| 2014 Octubre | 6 | 1 | 7 |
| 2014 Septiembre | 7 | 8 | 15 |
| 2014 Agosto | 12 | 1 | 13 |
| 2014 Julio | 11 | 0 | 11 |
| 2014 Junio | 14 | 1 | 15 |
| 2014 Mayo | 16 | 3 | 19 |
| 2014 Abril | 12 | 2 | 14 |
| 2014 Marzo | 15 | 6 | 21 |
| 2014 Febrero | 6 | 5 | 11 |
| 2014 Enero | 8 | 4 | 12 |
| 2013 Diciembre | 14 | 6 | 20 |
| 2013 Noviembre | 12 | 5 | 17 |
| 2013 Octubre | 19 | 4 | 23 |
| 2013 Septiembre | 17 | 7 | 24 |
| 2013 Agosto | 12 | 5 | 17 |
| 2013 Julio | 4 | 2 | 6 |
| 2013 Junio | 0 | 3 | 3 |
| 2013 Mayo | 2 | 1 | 3 |
| 2013 Abril | 3 | 1 | 4 |
| 2013 Marzo | 6 | 4 | 10 |
| 2013 Febrero | 21 | 9 | 30 |
| 2013 Enero | 13 | 1 | 14 |
| 2012 Diciembre | 14 | 2 | 16 |
| 2012 Noviembre | 11 | 2 | 13 |
| 2012 Octubre | 12 | 0 | 12 |
| 2012 Septiembre | 1 | 1 | 2 |
| 2000 Marzo | 2009 | 0 | 2009 |
Mostrar todo
