Inmunogenicidad de la vacuna antineumocócica de 23 polisacáridos en niños con enfermedad renal crónica
Immunogenicity of the 23-valent pneumococcal vaccine in children with chronic renal disease
M.J. Rodrigo Anoroa, L. Callís Braconsb, M.J. Cruz Carmonaa, J. de Gracia Roldánc, M. Miravitlles Fernándezc
a Laboratorio de Bioquímica. Hospitals Vall d'Hebron
c Servicio de Neumología. Hospitals Vall d'Hebron
b Servicio de Nefrología Pediátrica. Hospital Materno-infantil Vall d‘Hebron. Universitat Autònoma de Barcelona
M. Campins Martí, N. Pinart Pons
Servicio de Medicina Preventiva
Leído
10342
Vecesse ha leído el artículo
2261
Total PDF
8081
Total HTML
Compartir estadísticas
array:23 [ "pii" => "S1695403300773267" "issn" => "16954033" "doi" => "10.1016/S1695-4033(00)77326-7" "estado" => "S300" "fechaPublicacion" => "2000-03-01" "aid" => "77326" "copyright" => "Asociación Española de Pediatría" "copyrightAnyo" => "2000" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "An Pediatr (Barc). 2000;52:220-4" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 5810 "formatos" => array:3 [ "EPUB" => 84 "HTML" => 5316 "PDF" => 410 ] ] "itemSiguiente" => array:18 [ "pii" => "S1695403300773279" "issn" => "16954033" "doi" => "10.1016/S1695-4033(00)77327-9" "estado" => "S300" "fechaPublicacion" => "2000-03-01" "aid" => "77327" "copyright" => "Asociación Española de Pediatría" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "An Pediatr (Barc). 2000;52:225-31" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3614 "formatos" => array:3 [ "EPUB" => 66 "HTML" => 3142 "PDF" => 406 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Pautas hospitalarias respecto a la lactancia materna en el centro-norte de España" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "225" "paginaFinal" => "231" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Maternity Protocols About Breastfeeding In The North-Center Of Spain" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "L. Barriuso Lapresa, F. Sánchez-Valverde Visus, C. Romero Ibarra, J.C. Vitoria Comerzana" "autores" => array:4 [ 0 => array:2 [ "nombre" => "L." "apellidos" => "Barriuso Lapresa" ] 1 => array:2 [ "nombre" => "F." "apellidos" => "Sánchez-Valverde Visus" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Romero Ibarra" ] 3 => array:2 [ "nombre" => "J.C." "apellidos" => "Vitoria Comerzana" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403300773279?idApp=UINPBA00005H" "url" => "/16954033/0000005200000003/v1_201307051451/S1695403300773279/v1_201307051451/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1695403300773255" "issn" => "16954033" "doi" => "10.1016/S1695-4033(00)77325-5" "estado" => "S300" "fechaPublicacion" => "2000-03-01" "aid" => "77325" "copyright" => "Asociación Española de Pediatría" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "An Pediatr (Barc). 2000;52:212-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 5500 "formatos" => array:3 [ "EPUB" => 76 "HTML" => 4975 "PDF" => 449 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Empleo racional de los antibióticos en pediatría: impacto de la aplicación de un test rápido de detección de estreptococo beta-hemolítico del grupo A en la faringoamigdalitis aguda" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "212" "paginaFinal" => "219" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Rational use of antibiotics in pediatrics: impact of a rapid test for detection of B-hemolytic group a streptococci in acute pharyngotonsillitis" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "C. Contessotto Spadetto, M. Cámara Simón, M.J. Avilés Inglés, J.M. Ojeda Escuriet, I. Cascales Barceló, F. Rodríguez Sánchez" "autores" => array:6 [ 0 => array:2 [ "nombre" => "C." "apellidos" => "Contessotto Spadetto" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Cámara Simón" ] 2 => array:2 [ "nombre" => "M.J." "apellidos" => "Avilés Inglés" ] 3 => array:2 [ "nombre" => "J.M." "apellidos" => "Ojeda Escuriet" ] 4 => array:2 [ "nombre" => "I." "apellidos" => "Cascales Barceló" ] 5 => array:2 [ "nombre" => "F." "apellidos" => "Rodríguez Sánchez" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403300773255?idApp=UINPBA00005H" "url" => "/16954033/0000005200000003/v1_201307051451/S1695403300773255/v1_201307051451/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Inmunogenicidad de la vacuna antineumocócica de 23 polisacáridos en niños con enfermedad renal crónica" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "220" "paginaFinal" => "224" ] ] "autores" => array:2 [ 0 => array:3 [ "autoresLista" => "M.J. Rodrigo Anoro, L. Callís Bracons, M.J. Cruz Carmona, J. de Gracia Roldán, M. Miravitlles Fernández" "autores" => array:5 [ 0 => array:3 [ "nombre" => "M.J." "apellidos" => "Rodrigo Anoro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "L." "apellidos" => "Callís Bracons" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "M.J." "apellidos" => "Cruz Carmona" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "J." "apellidos" => "de Gracia Roldán" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 4 => array:3 [ "nombre" => "M." "apellidos" => "Miravitlles Fernández" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Laboratorio de Bioquímica. Hospitals Vall d'Hebron" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Neumología. Hospitals Vall d'Hebron" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 2 => array:3 [ "entidad" => "Servicio de Nefrología Pediátrica. Hospital Materno-infantil Vall d‘Hebron. Universitat Autònoma de Barcelona" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 1 => array:3 [ "autoresLista" => "M. Campins Martí, N. Pinart Pons" "autores" => array:2 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Campins Martí" ] 1 => array:2 [ "nombre" => "N." "apellidos" => "Pinart Pons" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Medicina Preventiva" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Immunogenicity of the 23-valent pneumococcal vaccine in children with chronic renal disease" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1999-09-30" "fechaAceptado" => "2000-01-31" "PalabrasClave" => array:1 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec186240" "palabras" => array:5 [ 0 => "Enfermedad neumocócica" 1 => "Vacuna antineumocócica de 23 polisacáridos" 2 => "Insuficiencia renal crónica" 3 => "Síndrome nefrótico" 4 => "Niños" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Estudiar la inmunogenicidad de la vacuna antineumocócica de 23 polisacáridos en niños con diversos tipos de enfermedad renal crónica y en los afectados de síndrome nefrótico, y compararla con la obtenida en niños sanos.</p> <span class="elsevierStyleSectionTitle">Métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se han incluido en el estudio 150 niños mayores de 2 años: 113 con enfermedad renal (26 con síndrome nefrótico, 23 con reflujo vesicoureteral grado III-IV, 16 con insuficiencia renal crónica, 6 con trasplante renal, 6 en hemodiálisis y 36 con otras enfermedades renales) (grupo 1) y 37 sanos (grupo 2), a los que se administró una dosis de vacuna. Se ha determinado la concentración de IgG total específica frente a neumococo antes de la vacunación y a los 30 días de la misma por el método ELISA. Se comparan los resultados obtenidos entre los dos grupos de niños, así como la respuesta observada entre el subgrupo de niños con enfermedades renales en las que la vacuna está indicada (síndrome nefrótico, insuficiencia renal crónica, trasplante renal y terapia con hemodiálisis) (grupo 3) y los niños sanos.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">El 87,3% de los niños duplicaron las concentraciones de anticuerpos al mes de la vacunación, no observándose diferencias significativas entre los tres grupos. Se consideró que la vacuna fue inmunógena en el 78,4% de los niños sanos, en el 77,9% de los del grupo 1 y en el 72,5% de los del grupo 3 (p = 0,533). Los niños con trasplante renal y los sometidos a hemodiálisis presentaron una respuest amenor.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La vacuna antineumocócica de 23 polisacáridos es inmunógena en niños mayores de 2 años con insuficiencia renal crónica, síndrome nefrótico, sometidos a trasplante renal o a hemodiálisis. Hay que destacar la importancia de aumentar la cobertura vacunal en este grupo de enfermos de alto riesgo de enfermedad neumocócica invasiva.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To study the immunogenicity of the 23-valent pneumoccal vaccine in children with chronic renal diseaseand in those with nephrotic syndrome, and to compare it with the response in healthy children.</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">The vaccine was administered to 150 children aged 2-18 years: 113 with renal diseases (26 with nephrotic syndrome, 23 with severe grades of vesicoureteral reflux, 16with chronic renal insufficiency, 6 renal transplant recipients, 6 requiring dialysis and 36 with other renal diseases) (group 1) and 37 healthy (group 2). Specific IgG antibodies concentrations were measured by ELISA before and 30 days after vaccination. The results obtained in both groups were compared. We compared too the response observed between the subgroup of children with renal diseases in which pneumococcal vaccine is indicated (nephrotic syndrome, chronic renal insufficiency, renal transplant and those requiring dialysis (group 3) and healthy children.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">87.3% of children showed a 2-fold increase in antibody concentrations after vaccination. No significant differences were observed between the three groups. We considered that the vaccine was immunogenic in 78.4% of healthy children, in 77.9% of group 1 children and in 72.5% of those in the group 3 (p = 0,533). A lower responsewas observed in children with a kidney transplant and in those requiring dialysis.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">These results suggest that 23-valent pneumococcal vaccine is immunogenic in children with chronic renal diseases or nephrotic syndrome and may protect these patients from invasive pneumococcal disease. The importance of improved vaccine coverage is emphasized.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:23 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiologie de la colonisation nasopharyngée par Streptococcus pneumoniae et Haemophilus influenzae dans une collectivité fermée de jeunes enfants." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "F. Moulin" 1 => "L. Armand-Lefèvre" 2 => "I. Le Thomas" 3 => "A. Comeau" 4 => "J. Raymond" 5 => "D. Gendrel" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Pédiatr" "fecha" => "1999" "volumen" => "6" "numero" => "Supl 3" "paginaInicial" => "620" "paginaFinal" => "624" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevention of pneumococcal disease. Recommendations of the Advisory Committee on Immunization Practices" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "CDC" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Mmwr" "fecha" => "1997" "volumen" => "46" "paginaInicial" => "1" "paginaFinal" => "24" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9427216" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vacunas antineumocócicas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M. Campins" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:2 [ "titulo" => "Vacunas" "serieFecha" => "1998" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A controlled evaluation of the protective efficacy of pneumococcal vaccine for patients at high risk of pneumococcal infections" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "E.D. Shapiro" 1 => "J.D. Clemens" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Intern Med" "fecha" => "1984" "volumen" => "101" "paginaInicial" => "325" "paginaFinal" => "330" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6380367" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efficacy of pneumococcal vaccine in highrisk patients: results of a Veterans Administration cooperative study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.S. Simberkoff" 1 => "A.P. Cross" 2 => "M. Al-Ibrahim" 3 => "A.L. Baltch" 4 => "P.J. Geiseler" 5 => "J. Nadler" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM198611203152104" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1986" "volumen" => "315" "paginaInicial" => "1318" "paginaFinal" => "1327" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3534568" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inefficacy of pneumococcal vaccine in a high-risk population" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "H.L. Forrester" 1 => "D.W. Jahnigen" 2 => "F.M. LaForce" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Med" "fecha" => "1987" "volumen" => "83" "paginaInicial" => "425" "paginaFinal" => "430" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3661581" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The protective efficacy of polivalent pneumococcal polysaccharide vaccine" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E.D. Shapiro" 1 => "A.T. Berg" 2 => "R. Austrian" 3 => "D. Schroeder" 4 => "V. Parcells" 5 => "A. Margolis" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199111213252101" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1991" "volumen" => "325" "paginaInicial" => "1453" "paginaFinal" => "1460" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1944423" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Preventing pneumococcal bacteremia in patients at risk: results of a matched case-control study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "B.M. Farr" 1 => "B.L. Johnston" 2 => "D.K. Cobb" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Intern Med" "fecha" => "1995" "volumen" => "155" "paginaInicial" => "2336" "paginaFinal" => "2340" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7487259" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efficacy of pneumococcal vaccination in adults" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.J. Fine" 1 => "M.A. Smith" 2 => "C.A. Carson" 3 => "F. Meffe" 4 => "S.S. Stanley" 5 => "L.A. Weissfeld" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Intern Med" "fecha" => "1994" "volumen" => "154" "paginaInicial" => "2666" "paginaFinal" => "2677" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7993150" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Etiology of bacterial sepsis in nephrotic children: 1963-1967" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C.M. Wilfert" 1 => "S.L. Katz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Pediatrics" "fecha" => "1968" "volumen" => "42" "paginaInicial" => "840" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5685368" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunogenicity and safety of a 23-valent pneumococcal polysaccharide vaccine in healthy children and in children at increased risk of pneumococcal infection" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H.J. Lee" 1 => "J.H. Kang" 2 => "J. Henrichsen" 3 => "H.B. Konradsen" 4 => "S.H. Jang" 5 => "H.Y. Shin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Vaccine" "fecha" => "1995" "volumen" => "13" "paginaInicial" => "1533" "paginaFinal" => "1538" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8578838" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pneumococcal polysaccharide vaccine in children with chronic renal disease: a prospective study of antibody response and duration" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S.L. Furth" 1 => "A.M. Neu" 2 => "B. Case" 3 => "H.M. Lederma" 4 => "M. Steinhoff" 5 => "B. Fivush" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Pediatr" "fecha" => "1996" "volumen" => "128" "paginaInicial" => "99" "paginaFinal" => "101" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8551427" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Serum antibody response to pneumococcal vaccine in children with nephrotic syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.S. Spika" 1 => "N.A. Halsey" 2 => "A.J. Fish" 3 => "G.M. Lum" 4 => "B.A. Lauer" 5 => "G. Schiffman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatrics" "fecha" => "1982" "volumen" => "69" "paginaInicial" => "219" "paginaFinal" => "223" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7058096" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Assessment of the antibody response to pneumococcal vaccine in high-risk populations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S.H. Landesman" 1 => "G. Schiffman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Infect Dis" "fecha" => "1981" "numero" => "Supl 3" "paginaInicial" => "184" "paginaFinal" => "196" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Characterization of specific immunoglobulin G (IgG) and its subclasses (IgG1 and IgG2) against the 23-valent pneumococcal vaccine in a healthy adult population: proposal for response criteria" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.J. Rodrigo" 1 => "M. Miravitlles" 2 => "M.J. Cruz" 3 => "J. De Gracia" 4 => "M. Vendrell" 5 => "C. Pascual" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin Diag Lab Immunol" "fecha" => "1997" "volumen" => "4" "paginaInicial" => "168" "paginaFinal" => "172" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pneumococcal and influenza vaccination levels among adults 65 years United States, 1994" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "CDC" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Mmwr" "fecha" => "1997" "volumen" => "45" "paginaInicial" => "853" "paginaFinal" => "859" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8927004" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Antibody response to capsular polysaccharide vaccine of Streptococcus pneumoniae in patients with nephrotic syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S.M. Fikrig" 1 => "G. Schiffman" 2 => "J.C. Phillip" 3 => "D.I. Moel" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Infect Dis" "fecha" => "1978" "volumen" => "137" "paginaInicial" => "818" "paginaFinal" => "821" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26723" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Standardization of antibody assays for measuring response to pneumococcal infection and immunization" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G.R. Siber" 1 => "C. Priehs" 2 => "D.W. Madone" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Pediatr Infect Dis J" "fecha" => "1989" "volumen" => "8" "paginaInicial" => "84" "paginaFinal" => "91" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Differential effect of human immunodeficiency virus infection on the IgA and IgG antibody responses to pneumococcal vaccine" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F. Mascart-Lemone" 1 => "M. Gerard" 2 => "M. Libin" 3 => "A. Crusiaux" 4 => "P. Franchioly" 5 => "A. Lambrechts" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Infect Dis" "fecha" => "1995" "volumen" => "172" "paginaInicial" => "1253" "paginaFinal" => "1260" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7594661" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C. Frasch" 1 => "D. Goldblatt" 2 => "G. Carlone" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "1996" "editorial" => "CDC" "editorialLocalizacion" => "Atlanta" ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bacterial polysaccharide immune globulin for prophylaxis of acute otitis media in high-risk children" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P.A. Shurin" 1 => "J.M. Rehmus" 2 => "C.E. Johnson" 3 => "C.D. Marchant" 4 => "S.A. Carlin" 5 => "D.M. Super" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Pediatr" "fecha" => "1993" "volumen" => "123" "paginaInicial" => "801" "paginaFinal" => "810" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8229496" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Antibody deficiency: IgG subclass deficiency and vaccine nonresponder states" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R.L. Wasserman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Pediatr Infect Dis" "fecha" => "1990" "volumen" => "9" "paginaInicial" => "424" "paginaFinal" => "433" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Revaccination of renal transplant and hemodialysis recipients with pneumococcal vaccine" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C.C. Linnermann" 1 => "M.R. First" 2 => "G. Schiffman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Intern Med" "fecha" => "1986" "volumen" => "146" "paginaInicial" => "1554" "paginaFinal" => "1556" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3524494" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/16954033/0000005200000003/v1_201307051451/S1695403300773267/v1_201307051451/es/main.assets" "Apartado" => array:4 [ "identificador" => "14282" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Originales" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/16954033/0000005200000003/v1_201307051451/S1695403300773267/v1_201307051451/es/main.pdf?idApp=UINPBA00005H&text.app=https://analesdepediatria.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403300773267?idApp=UINPBA00005H" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 5 | 15 | 20 |
| 2024 Octubre | 64 | 59 | 123 |
| 2024 Septiembre | 54 | 39 | 93 |
| 2024 Agosto | 78 | 76 | 154 |
| 2024 Julio | 59 | 43 | 102 |
| 2024 Junio | 83 | 47 | 130 |
| 2024 Mayo | 83 | 43 | 126 |
| 2024 Abril | 64 | 34 | 98 |
| 2024 Marzo | 39 | 53 | 92 |
| 2024 Febrero | 44 | 42 | 86 |
| 2024 Enero | 54 | 31 | 85 |
| 2023 Diciembre | 33 | 25 | 58 |
| 2023 Noviembre | 39 | 25 | 64 |
| 2023 Octubre | 37 | 33 | 70 |
| 2023 Septiembre | 25 | 28 | 53 |
| 2023 Agosto | 34 | 28 | 62 |
| 2023 Julio | 43 | 46 | 89 |
| 2023 Junio | 69 | 24 | 93 |
| 2023 Mayo | 74 | 21 | 95 |
| 2023 Abril | 29 | 16 | 45 |
| 2023 Marzo | 75 | 25 | 100 |
| 2023 Febrero | 39 | 20 | 59 |
| 2023 Enero | 34 | 27 | 61 |
| 2022 Diciembre | 61 | 14 | 75 |
| 2022 Noviembre | 61 | 34 | 95 |
| 2022 Octubre | 42 | 38 | 80 |
| 2022 Septiembre | 72 | 27 | 99 |
| 2022 Agosto | 59 | 52 | 111 |
| 2022 Julio | 35 | 38 | 73 |
| 2022 Junio | 49 | 33 | 82 |
| 2022 Mayo | 31 | 34 | 65 |
| 2022 Abril | 54 | 41 | 95 |
| 2022 Marzo | 42 | 42 | 84 |
| 2022 Febrero | 41 | 31 | 72 |
| 2022 Enero | 61 | 37 | 98 |
| 2021 Diciembre | 38 | 56 | 94 |
| 2021 Noviembre | 55 | 50 | 105 |
| 2021 Octubre | 62 | 55 | 117 |
| 2021 Septiembre | 27 | 48 | 75 |
| 2021 Agosto | 51 | 27 | 78 |
| 2021 Julio | 27 | 38 | 65 |
| 2021 Junio | 25 | 48 | 73 |
| 2021 Mayo | 21 | 21 | 42 |
| 2021 Abril | 64 | 100 | 164 |
| 2021 Marzo | 69 | 30 | 99 |
| 2021 Febrero | 83 | 12 | 95 |
| 2021 Enero | 56 | 15 | 71 |
| 2020 Diciembre | 36 | 19 | 55 |
| 2020 Noviembre | 26 | 14 | 40 |
| 2020 Octubre | 56 | 11 | 67 |
| 2020 Septiembre | 50 | 8 | 58 |
| 2020 Agosto | 32 | 11 | 43 |
| 2020 Julio | 25 | 12 | 37 |
| 2020 Junio | 39 | 12 | 51 |
| 2020 Mayo | 46 | 18 | 64 |
| 2020 Abril | 46 | 12 | 58 |
| 2020 Marzo | 46 | 10 | 56 |
| 2020 Febrero | 34 | 9 | 43 |
| 2020 Enero | 35 | 12 | 47 |
| 2019 Diciembre | 39 | 20 | 59 |
| 2019 Noviembre | 33 | 6 | 39 |
| 2019 Octubre | 28 | 6 | 34 |
| 2019 Septiembre | 31 | 14 | 45 |
| 2019 Agosto | 30 | 10 | 40 |
| 2019 Julio | 34 | 30 | 64 |
| 2019 Junio | 40 | 33 | 73 |
| 2019 Mayo | 37 | 65 | 102 |
| 2019 Abril | 17 | 36 | 53 |
| 2019 Marzo | 18 | 14 | 32 |
| 2019 Febrero | 22 | 16 | 38 |
| 2019 Enero | 19 | 16 | 35 |
| 2018 Diciembre | 17 | 15 | 32 |
| 2018 Noviembre | 27 | 13 | 40 |
| 2018 Octubre | 38 | 18 | 56 |
| 2018 Septiembre | 13 | 4 | 17 |
| 2018 Junio | 1 | 0 | 1 |
| 2018 Mayo | 3 | 0 | 3 |
| 2018 Abril | 10 | 0 | 10 |
| 2018 Marzo | 7 | 0 | 7 |
| 2018 Febrero | 6 | 0 | 6 |
| 2018 Enero | 7 | 0 | 7 |
| 2017 Diciembre | 4 | 0 | 4 |
| 2017 Noviembre | 9 | 0 | 9 |
| 2017 Octubre | 9 | 0 | 9 |
| 2017 Septiembre | 9 | 0 | 9 |
| 2017 Agosto | 6 | 0 | 6 |
| 2017 Julio | 7 | 0 | 7 |
| 2017 Junio | 17 | 4 | 21 |
| 2017 Mayo | 19 | 8 | 27 |
| 2017 Abril | 14 | 3 | 17 |
| 2017 Marzo | 15 | 14 | 29 |
| 2017 Febrero | 10 | 2 | 12 |
| 2017 Enero | 10 | 1 | 11 |
| 2016 Diciembre | 26 | 6 | 32 |
| 2016 Noviembre | 54 | 9 | 63 |
| 2016 Octubre | 54 | 8 | 62 |
| 2016 Septiembre | 43 | 4 | 47 |
| 2016 Agosto | 37 | 7 | 44 |
| 2016 Julio | 23 | 10 | 33 |
| 2016 Mayo | 1 | 0 | 1 |
| 2015 Diciembre | 2 | 0 | 2 |
| 2015 Julio | 10 | 0 | 10 |
| 2015 Junio | 5 | 0 | 5 |
| 2015 Mayo | 11 | 0 | 11 |
| 2015 Abril | 7 | 0 | 7 |
| 2015 Marzo | 3 | 0 | 3 |
| 2015 Febrero | 2 | 0 | 2 |
| 2015 Enero | 4 | 0 | 4 |
| 2014 Diciembre | 5 | 0 | 5 |
| 2014 Noviembre | 4 | 0 | 4 |
| 2014 Octubre | 7 | 0 | 7 |
| 2014 Septiembre | 4 | 0 | 4 |
| 2014 Agosto | 7 | 0 | 7 |
| 2014 Julio | 9 | 0 | 9 |
| 2014 Junio | 10 | 0 | 10 |
| 2014 Mayo | 12 | 0 | 12 |
| 2014 Abril | 16 | 0 | 16 |
| 2014 Marzo | 11 | 0 | 11 |
| 2014 Febrero | 12 | 0 | 12 |
| 2014 Enero | 10 | 0 | 10 |
| 2013 Diciembre | 21 | 0 | 21 |
| 2013 Noviembre | 13 | 0 | 13 |
| 2013 Octubre | 12 | 0 | 12 |
| 2013 Septiembre | 15 | 0 | 15 |
| 2013 Agosto | 11 | 0 | 11 |
| 2013 Julio | 5 | 0 | 5 |
| 2013 Junio | 3 | 0 | 3 |
| 2013 Mayo | 3 | 0 | 3 |
| 2013 Abril | 2 | 0 | 2 |
| 2013 Marzo | 5 | 0 | 5 |
| 2013 Febrero | 13 | 0 | 13 |
| 2013 Enero | 6 | 0 | 6 |
| 2012 Diciembre | 7 | 0 | 7 |
| 2012 Noviembre | 3 | 0 | 3 |
| 2012 Octubre | 2 | 0 | 2 |
| 2012 Septiembre | 6 | 0 | 6 |
| 2012 Agosto | 3 | 0 | 3 |
| 2000 Marzo | 4141 | 0 | 4141 |
Mostrar todo
