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        "resumen" => "<span class="elsevierStyleSectionTitle">Antecedentes</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La trombosis venosa cerebral es un hallazgo neuropatol&#243;gico infrecuente dentro del per&#237;odo neonatal&#46; Es una patolog&#237;a poco descrita hasta el momento en el reci&#233;n nacido&#44; pero gracias al desarrollo de nuevas t&#233;cnicas deneuroimagen&#44; como la angiorresonancia&#44; el n&#250;mero decasos descritos en la literatura es cada vez mayor&#46;</p> <span class="elsevierStyleSectionTitle">Caso cl&#237;nico</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Reci&#233;n nacido pret&#233;rmino de 35 semanas de gestaci&#243;n con enfermedad hip&#243;xicoisqu&#233;mica grave con afectaci&#243;n multiorg&#225;nica&#46; En su Segundo d&#237;a de vida presenta hemorragia pulmonar grave secundaria a coagulopat&#237;a de consumo&#46; Al tercer d&#237;a de vida presenta convulsions cl&#243;nicas generalizadas que precisan tratamiento con diazepam en infusi&#243;n continua&#46; Se practica angiorresonancia que muestra oclusi&#243;n de los senos venosos longitudinal y lateral derecho&#46; Se practica estudio de hemostasia&#44;detect&#225;ndose mutaci&#243;n heterocigota R506Q para el factor V de coagulaci&#243;n&#46;</p> <span class="elsevierStyleSectionTitle">Comentarios</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La trombosis venosa cerebral se presenta cl&#237;nicamente con depresi&#243;n neurol&#243;gica y convulsiones de manifesta ci&#243;n precoz&#46; El seno longitudinal es el vaso m&#225;s frecuentemente implicado&#44; afect&#225;ndose en el 80&#37; de los casos&#46; Etiol&#243;gicamente la trombosis venosa cerebral se ha relacionado con aquellas situaciones cl&#237;nicas en las que se produce un incremento de la viscosidad sangu&#237;nea&#44; que act&#250;an como factores de riesgo que precipitan la formaci&#243;n de trombos&#46; Sin embargo&#44; varios estudios demuestran la presencia de alteraciones cong&#233;nitas en el sistema fibrinol&#237;tico tales como defectos de antitrombina III&#44; prote&#237;nas C y S y factor V de Leiden&#46; Este &#250;ltimo se encuentra con una elevada prevalencia en los sujetos con fen&#243;menos tromb&#243;ticos&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Cerebral venous thrombosis is an inusual disease in neonatal age&#46; Increasing reports of this disorder had described since magnetic resonance angiography is used&#46;</p> <span class="elsevierStyleSectionTitle">Case report</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Newborn of apropriate seze for gestational age was delivered at 35 weeks of gestation&#46; Refered a severe hipoxic-is-quemic disease with multisistemic afectation&#46; The second day of life presented disseminated intravascular coagulation with pulmonary bleeding&#46; The third day&#44; the infant developed seizures that required treatment with diazepam in continuous perfussion&#46; MR angiography visualized superior sagital and transvers sinus thrombosis&#46; Coagulation study detected factor V Leiden&#46;</p> <span class="elsevierStyleSectionTitle">Comments</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Frecuently venous cerebral thrombosis is presenting with lethargy and seizures&#46; The most common vessels involved are sagital and transvers sinus&#46; It is described in association with exogenous risk factors that increasing blood hyperviscosity and additional inhered coagulation dissorders such as defects on antihrombina III&#44; protein C and S and activate protein C resistance&#46; The last defect has a hight prevalence in subjects with trombosis events&#46;</p>"
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Trombosis cerebral neonatal y déficit de factor V de Leiden
Neonatal cerebral thombosis and deficit of factor v leiden
E. Moliner Calderón*, E. López Bernal, G. Ginovart Galiana, J. Nadal Amat, J. Cubells Riero
Unidad de Neonatología. Servicio de Pediatría. Facultad de Medicina. Universidad Autónoma de Barcelona.Hospital de la Santa Creu i Sant Pau. Barcelona.
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        "resumen" => "<span class="elsevierStyleSectionTitle">Antecedentes</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La trombosis venosa cerebral es un hallazgo neuropatol&#243;gico infrecuente dentro del per&#237;odo neonatal&#46; Es una patolog&#237;a poco descrita hasta el momento en el reci&#233;n nacido&#44; pero gracias al desarrollo de nuevas t&#233;cnicas deneuroimagen&#44; como la angiorresonancia&#44; el n&#250;mero decasos descritos en la literatura es cada vez mayor&#46;</p> <span class="elsevierStyleSectionTitle">Caso cl&#237;nico</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Reci&#233;n nacido pret&#233;rmino de 35 semanas de gestaci&#243;n con enfermedad hip&#243;xicoisqu&#233;mica grave con afectaci&#243;n multiorg&#225;nica&#46; En su Segundo d&#237;a de vida presenta hemorragia pulmonar grave secundaria a coagulopat&#237;a de consumo&#46; Al tercer d&#237;a de vida presenta convulsions cl&#243;nicas generalizadas que precisan tratamiento con diazepam en infusi&#243;n continua&#46; Se practica angiorresonancia que muestra oclusi&#243;n de los senos venosos longitudinal y lateral derecho&#46; Se practica estudio de hemostasia&#44;detect&#225;ndose mutaci&#243;n heterocigota R506Q para el factor V de coagulaci&#243;n&#46;</p> <span class="elsevierStyleSectionTitle">Comentarios</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La trombosis venosa cerebral se presenta cl&#237;nicamente con depresi&#243;n neurol&#243;gica y convulsiones de manifesta ci&#243;n precoz&#46; El seno longitudinal es el vaso m&#225;s frecuentemente implicado&#44; afect&#225;ndose en el 80&#37; de los casos&#46; Etiol&#243;gicamente la trombosis venosa cerebral se ha relacionado con aquellas situaciones cl&#237;nicas en las que se produce un incremento de la viscosidad sangu&#237;nea&#44; que act&#250;an como factores de riesgo que precipitan la formaci&#243;n de trombos&#46; Sin embargo&#44; varios estudios demuestran la presencia de alteraciones cong&#233;nitas en el sistema fibrinol&#237;tico tales como defectos de antitrombina III&#44; prote&#237;nas C y S y factor V de Leiden&#46; Este &#250;ltimo se encuentra con una elevada prevalencia en los sujetos con fen&#243;menos tromb&#243;ticos&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Cerebral venous thrombosis is an inusual disease in neonatal age&#46; Increasing reports of this disorder had described since magnetic resonance angiography is used&#46;</p> <span class="elsevierStyleSectionTitle">Case report</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Newborn of apropriate seze for gestational age was delivered at 35 weeks of gestation&#46; Refered a severe hipoxic-is-quemic disease with multisistemic afectation&#46; The second day of life presented disseminated intravascular coagulation with pulmonary bleeding&#46; The third day&#44; the infant developed seizures that required treatment with diazepam in continuous perfussion&#46; MR angiography visualized superior sagital and transvers sinus thrombosis&#46; Coagulation study detected factor V Leiden&#46;</p> <span class="elsevierStyleSectionTitle">Comments</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Frecuently venous cerebral thrombosis is presenting with lethargy and seizures&#46; The most common vessels involved are sagital and transvers sinus&#46; It is described in association with exogenous risk factors that increasing blood hyperviscosity and additional inhered coagulation dissorders such as defects on antihrombina III&#44; protein C and S and activate protein C resistance&#46; The last defect has a hight prevalence in subjects with trombosis events&#46;</p>"
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Información del artículo
ISSN: 16954033
Idioma original: Español
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2012 Diciembre 4 0 4
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2012 Septiembre 5 0 5
2012 Agosto 2 0 2
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