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    "titulo" => "El neumococo: ¿un germen nuevo en el recién nacido?"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Revisar las caracter&#237;sticas cl&#237;nicas y sensibilidad antibi&#243;-tica de las sepsis por Streptococcus pneumoniae en nues-tra unidad neonatal&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio retrospectivo de las sepsis por S&#46; pneumo-niae recogidas en nuestra base de datos en los &#250;ltimos 12 a&#241;os&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se han identificado un total de 8casos de infecci&#243;n por S&#46; pneumoniae&#46; La edad gestacional oscil&#243; entre las 30 y las 38 semanas &#40;mediana&#44; 34semanas&#41; y el rango de peso al nacimiento fue entre 1&#46;680 y 4&#46;460 g &#40;mediana&#44; 2&#46;480 g&#41;&#46; En 7 casos se identificaron factores de riesgo de infecci&#243;n&#46; Aunque en 4casos la presentaci&#243;n curs&#243; con grave afecta-ci&#243;n hemodin&#225;mica y en otro con meningitis&#44; todos evolu-cionaron hacia la curaci&#243;n&#46; Se encontr&#243; resistencia a peni-cilina en 3episodios&#46;</p> <span class="elsevierStyleSectionTitle">Conclusi&#243;n</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El S&#46; pneumoniae es un germen causante de infecciones graves en el reci&#233;n nacido&#46; El creciente n&#250;mero de resis-tencias al tratamiento con penicilina y derivados hace que nos planteemos la necesidad de conocer la epidemiolog&#237;a local en cuanto a la proporci&#243;n de madres portadoras y su relaci&#243;n con la infecci&#243;n neonatal&#44; para elaborar estra-tegias de prevenci&#243;n y tratamiento&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetive</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To study the clinical characteristics and susceptibility to antimicrobial agents of Streptococcus pneumoniaeinvasi-ve infection in our neonatal unit&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Data from newborns with Streptococcus pneumonia invasive infection in the last 12years were retrospecti-vely collected&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Eight cases of invasive infection were identified&#46; Gesta-tional age ranged from 30 to 38weeks &#40;median&#58; 34weeks&#41; and birth weight ranged from 1&#44;680 g to 4&#44;460 g &#40;median&#58; 2&#44;480g&#41;&#46; Risk factors related to infection were identified in 7 patients&#46; Although infection manifested as shock in 4 patients and meningitis in 1&#44; evolution was favorable in all patients&#46; Penicillin resistance was found in 3 pa-tients&#46;</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Streptococcus pneumoniae produces serious disease in neonates&#46; Because of the increasing prevalence of pe-nicillin-resistant pneumococci&#44; the relationship between the percentage of mothers colonized withpneumococci and neonatal infection should be determined to develop new prevention and treatment strategies in newborn in-fants&#46;</p>"
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              "referencia" => array:1 [
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                    0 => array:2 [
                      "titulo" => "Invasive Antibiotic-resistant Streptococcus pneumoniae in children in Madrid"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;T&#46; Ramos"
                            1 => "J&#46; Saavedra"
                            2 => "J&#46; Ruiz-Contreras"
                            3 => "J&#46; Bravo"
                            4 => "F&#46; Sanz"
                            5 => "A&#46; Noriega"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Pediatr Infect Dis"
                        "fecha" => "1998"
                        "volumen" => "17"
                        "paginaInicial" => "252"
                        "paginaFinal" => "255"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Streptococcus pneumoniae invasive disease in the neonatal period&#58; an increasing problem&#945;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;M&#46; Simpson"
                            1 => "J&#46;S&#46; Patel"
                            2 => "P&#46; Ispahani"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Pediatr"
                        "fecha" => "1995"
                        "volumen" => "154"
                        "paginaInicial" => "563"
                        "paginaFinal" => "566"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7556324"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neonatal Streptococcus pneumoniae infection&#58; case reports and review of the literature"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; G&#243;mez"
                            1 => "S&#46; Alter"
                            2 => "M&#46;L&#46; Kumar"
                            3 => "S&#46; Murphy"
                            4 => "M&#46;H&#46; Rathore"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Pediatr Infect Dis"
                        "fecha" => "1999"
                        "volumen" => "18"
                        "paginaInicial" => "1014"
                        "paginaFinal" => "1018"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0020"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Infecci&#243;n neonatal precoz por neumococo"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46; L&#243;pez de Heredia"
                            1 => "A&#46; Cotero"
                            2 => "C&#46; Castro"
                            3 => "R&#46; Jaquotot"
                            4 => "C&#46; Guti&#233;rrez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "An Esp Pediatr"
                        "fecha" => "1981"
                        "volumen" => "14"
                        "paginaInicial" => "416"
                        "paginaFinal" => "420"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7294530"
                            "web" => "Medline"
                          ]
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                    ]
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                ]
              ]
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              "identificador" => "bib0025"
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                    0 => array:2 [
                      "titulo" => "Prevention of perinatal group B streptococcal disease&#58; a public health perspective"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Schuchat"
                            1 => "C&#46; Whitney"
                            2 => "K&#46; Zangwill"
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "MMWR Marb Mortal Wkly Rep"
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                        "volumen" => "45"
                        "paginaInicial" => "1"
                        "paginaFinal" => "24"
                      ]
                    ]
                  ]
                ]
              ]
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                  "contribucion" => array:1 [
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                      "titulo" => "American Academy of Pediatrics&#44; COID&#47;COFN&#46; Revised guidelines for prevention of early-onset group B streptococcal &#40;GBS&#41; infection"
                    ]
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                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatrics"
                        "fecha" => "1997"
                        "volumen" => "99"
                        "paginaInicial" => "489"
                        "paginaFinal" => "496"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9041310"
                            "web" => "Medline"
                          ]
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                  ]
                ]
              ]
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              "identificador" => "bib0035"
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                      "titulo" => "Group B Streptococcal Disease in the era of intrapartum antibiotic prophylaxis"
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                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46;J&#46; Schrag"
                            1 => "S&#46; Zywicki"
                            2 => "M&#46;M&#46; Farley"
                            3 => "A&#46;L&#46; Reingold"
                            4 => "L&#46;H&#46; Harrison"
                            5 => "L&#46;B&#46; Lebkowitz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2000"
                        "volumen" => "6"
                        "paginaInicial" => "15"
                        "paginaFinal" => "20"
                      ]
                    ]
                  ]
                ]
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              "identificador" => "bib0040"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Risk factors and opportunities for prevention of early-onset neontal sepsis&#58; a multicenter case-control study"
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                          "etal" => false
                          "autores" => array:6 [
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                            1 => "S&#46;S&#46; Zywicki"
                            2 => "M&#46;J&#46; Dinsmoor"
                            3 => "B&#46; Mercer"
                            4 => "J&#46; Romaguera"
                            5 => "M&#46;J&#46; O&#39;Sullivan"
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                        "paginaFinal" => "26"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10617699"
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                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Pathol"
                        "fecha" => "1975"
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                        "paginaInicial" => "731"
                        "paginaFinal" => "735"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1100681"
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Vol. 54. Núm. 4.
Páginas 390-393 (abril 2001)
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Vol. 54. Núm. 4.
Páginas 390-393 (abril 2001)
Acceso a texto completo
El neumococo: ¿un germen nuevo en el recién nacido?
Pneumococci: A new microorganism in the newborn?
Visitas
7361
C. de Alba Romeroa,
Autor para correspondencia
calba@hdoc.insalud.es

Correspondencia: Servicio de Neonatología. Hospital 12 de Octubre. Ctra. de Andalucía, km 5,4. 28041 Madrid
, J.T. Ramos Amadorb, E. Gómez del Castilloa
a Servicio de Neonatología e Hospital 12 de Octubre. Madrid.
b Inmunodeficiencias. Hospital 12 de Octubre. Madrid.
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Bibliografía
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Estadísticas
Objetivo

Revisar las características clínicas y sensibilidad antibió-tica de las sepsis por Streptococcus pneumoniae en nues-tra unidad neonatal.

Métodos

Estudio retrospectivo de las sepsis por S. pneumo-niae recogidas en nuestra base de datos en los últimos 12 años.

Resultados

Se han identificado un total de 8casos de infección por S. pneumoniae. La edad gestacional osciló entre las 30 y las 38 semanas (mediana, 34semanas) y el rango de peso al nacimiento fue entre 1.680 y 4.460 g (mediana, 2.480 g). En 7 casos se identificaron factores de riesgo de infección. Aunque en 4casos la presentación cursó con grave afecta-ción hemodinámica y en otro con meningitis, todos evolu-cionaron hacia la curación. Se encontró resistencia a peni-cilina en 3episodios.

Conclusión

El S. pneumoniae es un germen causante de infecciones graves en el recién nacido. El creciente número de resis-tencias al tratamiento con penicilina y derivados hace que nos planteemos la necesidad de conocer la epidemiología local en cuanto a la proporción de madres portadoras y su relación con la infección neonatal, para elaborar estra-tegias de prevención y tratamiento.

Palabras clave:
Neumococo
Recién nacido
Resistencia antibiótica
Objetive

To study the clinical characteristics and susceptibility to antimicrobial agents of Streptococcus pneumoniaeinvasi-ve infection in our neonatal unit.

Methods

Data from newborns with Streptococcus pneumonia invasive infection in the last 12years were retrospecti-vely collected.

Results

Eight cases of invasive infection were identified. Gesta-tional age ranged from 30 to 38weeks (median: 34weeks) and birth weight ranged from 1,680 g to 4,460 g (median: 2,480g). Risk factors related to infection were identified in 7 patients. Although infection manifested as shock in 4 patients and meningitis in 1, evolution was favorable in all patients. Penicillin resistance was found in 3 pa-tients.

Conclusion

Streptococcus pneumoniae produces serious disease in neonates. Because of the increasing prevalence of pe-nicillin-resistant pneumococci, the relationship between the percentage of mothers colonized withpneumococci and neonatal infection should be determined to develop new prevention and treatment strategies in newborn in-fants.

Key words:
Pneumococci
Newborn
Drug-resistance
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Bibliografía
[1.]
J.T. Ramos, J. Saavedra, J. Ruiz-Contreras, J. Bravo, F. Sanz, A. Noriega.
Invasive Antibiotic-resistant Streptococcus pneumoniae in children in Madrid.
Pediatr Infect Dis, 17 (1998), pp. 252-255
[2.]
J.M. Simpson, J.S. Patel, P. Ispahani.
Streptococcus pneumoniae invasive disease in the neonatal period: an increasing problemα.
Eur J Pediatr, 154 (1995), pp. 563-566
[3.]
M. Gómez, S. Alter, M.L. Kumar, S. Murphy, M.H. Rathore.
Neonatal Streptococcus pneumoniae infection: case reports and review of the literature.
Pediatr Infect Dis, 18 (1999), pp. 1014-1018
[4.]
J. López de Heredia, A. Cotero, C. Castro, R. Jaquotot, C. Gutiérrez.
Infección neonatal precoz por neumococo.
An Esp Pediatr, 14 (1981), pp. 416-420
[5.]
A. Schuchat, C. Whitney, K. Zangwill.
Prevention of perinatal group B streptococcal disease: a public health perspective.
MMWR Marb Mortal Wkly Rep, 45 (1996), pp. 1-24
[6.]
American Academy of Pediatrics, COID/COFN. Revised guidelines for prevention of early-onset group B streptococcal (GBS) infection.
Pediatrics, 99 (1997), pp. 489-496
[7.]
S.J. Schrag, S. Zywicki, M.M. Farley, A.L. Reingold, L.H. Harrison, L.B. Lebkowitz.
Group B Streptococcal Disease in the era of intrapartum antibiotic prophylaxis.
N Engl J Med, 6 (2000), pp. 15-20
[8.]
A. Schuchat, S.S. Zywicki, M.J. Dinsmoor, B. Mercer, J. Romaguera, M.J. O'Sullivan.
Risk factors and opportunities for prevention of early-onset neontal sepsis: a multicenter case-control study.
Pediatrics, 105 (2000), pp. 21-26
[9.]
J. De Louvois, R. Hurley, V.C. Stanley.
Microbial flora of the lower genital tract during pregnancy: relationship to morbidity.
J Clin Pathol, 28 (1975), pp. 731-735
[10.]
C.A. White, F.P. Koontz.
Bacterial flora of the cervix during pregnancy.
Obstet Gynaecol, 32 (1968), pp. 402-407
[11.]
H. Westh, L. Skibsted, B. Korner.
Streptococcus pneumoniae infections of the female genital tract and the newborn child.
Rev Inf Dis, 12 (1990), pp. 416-421
[12.]
X. Saez-llorens, M.S. Ah-Chu, E. Castano, L. Carter, A. Torres, M. Suarez.
Intrapartum prophylaxis with ceftriaxone rates of bacterial colonization and early-onset infection in newborns.
Clin Infect Dis, 21 (1995), pp. 876-880
Copyright © 2001. Asociación Española de Pediatría
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