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Vol. 60. Núm. 5.
Páginas 459-467 (mayo 2004)
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Vol. 60. Núm. 5.
Páginas 459-467 (mayo 2004)
Acceso a texto completo
¿Cuál es la importancia de la erradicación bacteriana en el tratamiento de la infección respiratoria?
What is the importance of bacterial eradication in the treatment of respiratory tract infections?
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C. Rodrigo Gonzalo de Liria
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crodrigo@ns.hugtip.scs.es

Servicio de Pediatría. Hospital Universitario Germans Trias i Pujol. Ctra. de Canyet, s/n. 08916 Badalona. Barcelona. España
Servicio de Pediatría. Unidad de Enfermedades Infecciosas. Hospital Universitario Germans Trias i Pujol. Universidad Autónoma de Barcelona. España
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En los últimos años se ha producido un aumento significativo en la prevalencia de resistencias de los principales patógenos respiratorios a la mayoría de los antibióticos utilizados en el ámbito extrahospitalario que ha comprometido en muchos casos el tratamiento empírico de algunas infecciones respiratorias, siendo de especial interés el progresivo aumento de las tasas de resistencia deStreptococcus pneumoniae a macrólidos y penicilina y deS. pyogenes a macrólidos

Varios estudios han confirmado la asociación entre consumo de antibióticos y desarrollo de resistencia en S. pneumoniae y S. pyogenes. Sin embargo, ni todos los antibióticos tienen la misma capacidad de selección de resistencias, ni todos se ven afectados de la misma manera

El objetivo del tratamiento antimicrobiano en las infecciones del tracto respiratorio es la erradicación bacteriológica. Los parámetros farmacodinámicos pueden utilizarse para predecir la erradicación bacteriológica de los antimicrobianos

Palabras clave:
Erradicación
Infección respiratoria
S. pneumoniae
S. pyogenes
Farmacodinámica

During the last few years, increasing antibiotic resistance amongst the major respiratory pathogens in the community has compromised the choice of empirical therapy for some respiratory tract infections. Of special interest has been the progressive increase in the resistance rates of Streptococcus pneumoniaeto macrolides and penicillin, and of S. pyogenes to macrolides

Several studies have confirmed the association between community use of certain antibiotics and the development of resistance inS. pneumoniae and S. pyogenes. Nevertheless, not all the antibiotics have the same ability to select resistance and not all microorganisms are affected in the same way

The aim of antimicrobial therapy in respiratory tract infections is bacterial eradication. Pharmacokinetic and pharmacodynamics can be used to predict bacteriological eradication with antimicrobial therapy

Keywords:
Eradication
Respiratory tract infection
S. pneumoniae
S. pyogenes
Pharmacodynamics
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