Información del artículo
En los últimos años se ha producido un aumento significativo en la prevalencia de resistencias de los principales patógenos respiratorios a la mayoría de los antibióticos utilizados en el ámbito extrahospitalario que ha comprometido en muchos casos el tratamiento empírico de algunas infecciones respiratorias, siendo de especial interés el progresivo aumento de las tasas de resistencia deStreptococcus pneumoniae a macrólidos y penicilina y deS. pyogenes a macrólidos
Varios estudios han confirmado la asociación entre consumo de antibióticos y desarrollo de resistencia en S. pneumoniae y S. pyogenes. Sin embargo, ni todos los antibióticos tienen la misma capacidad de selección de resistencias, ni todos se ven afectados de la misma manera
El objetivo del tratamiento antimicrobiano en las infecciones del tracto respiratorio es la erradicación bacteriológica. Los parámetros farmacodinámicos pueden utilizarse para predecir la erradicación bacteriológica de los antimicrobianos
Palabras clave:
Erradicación
Infección respiratoria
S. pneumoniae
S. pyogenes
Farmacodinámica
During the last few years, increasing antibiotic resistance amongst the major respiratory pathogens in the community has compromised the choice of empirical therapy for some respiratory tract infections. Of special interest has been the progressive increase in the resistance rates of Streptococcus pneumoniaeto macrolides and penicillin, and of S. pyogenes to macrolides
Several studies have confirmed the association between community use of certain antibiotics and the development of resistance inS. pneumoniae and S. pyogenes. Nevertheless, not all the antibiotics have the same ability to select resistance and not all microorganisms are affected in the same way
The aim of antimicrobial therapy in respiratory tract infections is bacterial eradication. Pharmacokinetic and pharmacodynamics can be used to predict bacteriological eradication with antimicrobial therapy
Keywords:
Eradication
Respiratory tract infection
S. pneumoniae
S. pyogenes
Pharmacodynamics
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