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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Analizar los factores que influyen en la respuesta antit&#233;rmica del ibuprofeno&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Ni&#241;os de entre 1 y 10 a&#241;os que acudieron al servicio de urgencias con temperatura superior a 38 &#176;C&#46; Se les administr&#243; una dosis de 7 mg&#47;kg de ibuprofeno&#44; anot&#225;ndose despu&#233;s la temperatura a los 30&#44; 60&#44; 90&#44; 120&#44; 180 y 240 min&#46; Se analiz&#243; la influencia de la edad&#44; sexo&#44; peso&#44; superficie corporal&#44; entidad nosol&#243;gica&#44; administraci&#243;n previa de antit&#233;rmicos y asociaci&#243;n de medidas f&#237;sicas sobre la evoluci&#243;n de la temperatura&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se estudiaron 384 ni&#241;os&#44; con temperatura corporal comprendida entre 38 y 42 &#176;C &#40;39&#44;1 6 0&#44;6 &#176;C&#41;&#44; en el 77&#44;8&#37; la fiebre duraba m&#225;s de 6 h y el 59&#44;5&#37; hab&#237;an recibido al menos un antit&#233;rmico&#46; El 93&#44;5&#37; de los ni&#241;os redujeron su temperatura hasta 37&#44;5 &#176;C o menos&#44; alcanz&#225;ndose dicha temperatura en el 80&#44;2&#37; de los ni&#241;os entre 1 y 2 horas despu&#233;s del tratamiento&#46; El 95&#37; de los pacientes alcanz&#243; un descenso de la temperatura corporal de al menos 1 &#176;C&#46; La temperatura inicial m&#225;s alta &#40;odds ratio &#91;OR&#93; 0&#44;008&#59; intervalo de confianza &#91;IC&#93; 95&#37;&#44; 0-0&#44;14&#41; y la mayor superficie corporal &#40;OR&#44; 0&#44;004&#59; IC 95&#37;&#44; 0-0&#44;89&#41; facilitan la consecuci&#243;n de dicho objetivo&#44; mientras que la mayor edad la dificulta &#40;OR&#44; 1&#44;67&#59; IC 95&#37;&#44; 1&#44;03-2&#44;7&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El ibuprofeno es un f&#225;rmaco muy eficaz en el tratamiento de la fiebre infantil y la magnitud de su efecto antit&#233;rmico guarda cierta relaci&#243;n con la edad&#44; el grado de temperatura inicial y la superficie corporal&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To assess the factors influencing the antipyretic activity of ibuprofen in children&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Children aged between 1 and 10 years attending the emergency department with a temperature of 38 &#176;C were given one dose of ibuprofen &#40;7 mg&#47;kg&#41;&#46; Temperature was recorded before and 30&#44; 60&#44; 90&#44; 120&#44; 180 and 240 min after ibuprofen administration&#46; The influence of age&#44; sex&#44; weight&#44; body surface&#44; nosologic entity&#44; previous antipyretic administration&#44; and the association between physical measurements and temperature evolution were assessed&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">A total of 384 children were studied&#46; Baseline temperatures were between 38 &#176;C and 42 &#176;C &#40;mean&#58; 39&#46;1 6 0&#46;6&#41;&#46; Most of the patients &#40;77&#46;8&#37;&#41; had been feverish for more than 6 hours and 59&#46;5&#37; had received antipyretic treatment&#46; In 93&#46;5&#37; of the children temperature was lowered to 37&#46;5 &#176;C or less&#46; In 80&#46;2&#37; of the children this temperature was reached 1-2 hours after treatment&#46; In 95&#37; of ther children a decrease of at least 1 &#176;C was achieved&#46; Older age &#40;OR 1&#46;67&#59; 95&#37; CI&#58; 1&#46;03-2&#46;7&#41;&#44; smaller body surface &#40;OR 0&#46;004&#59; 95&#37; CI 0-0&#46;89&#41; and lower baseline temperature &#40;OR 0&#46;008&#59; 95&#37; CI 0-0&#46;14&#41; were associated with a smaller antipyretic response &#40;decrease in body temperature lower than 1 &#176;C&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Ibuprofen is effective in the treatment of fever in children&#46; Its effectiveness is related to age&#44; the degree of fever and body surface&#46;</p>"
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Vol. 53. Núm. 5.
Páginas 431-435 (noviembre 2000)
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Vol. 53. Núm. 5.
Páginas 431-435 (noviembre 2000)
Acceso a texto completo
Análisis de los factores pronósticos de la respuesta antipirética del ibuprofeno
Analysis of prognostic factors for the antipyretic response to ibuprofen
Visitas
7242
F. Martinón Sáncheza, J. Antelo Cortizasb, R. Morales Redondoc, E. Moreno Carreterod,
Autor para correspondencia
emilio.moreno@knoll-ag.de

Correspondencia: Dr. E. Moreno Carretero. Departamento Médico. Laboratorios Knoll, S.A. Avda. de Burgos, 91. 28050 Madrid.
, R. Domínguez Granadosd
a Servicios de Pediatría. Hospital Nuestra Señora del Cristal. Orense
b Hospital Xeral Cíes. Vigo. Pontevedra
c Hospital Xeral Calde Lugo. Lugo
d Departamento Médico. Laboratorios Knoll, S.A. Madrid
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Bibliografía
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Estadísticas
Abstract
Objetivo

Analizar los factores que influyen en la respuesta antitérmica del ibuprofeno.

Pacientes y métodos

Niños de entre 1 y 10 años que acudieron al servicio de urgencias con temperatura superior a 38 °C. Se les administró una dosis de 7 mg/kg de ibuprofeno, anotándose después la temperatura a los 30, 60, 90, 120, 180 y 240 min. Se analizó la influencia de la edad, sexo, peso, superficie corporal, entidad nosológica, administración previa de antitérmicos y asociación de medidas físicas sobre la evolución de la temperatura.

Resultados

Se estudiaron 384 niños, con temperatura corporal comprendida entre 38 y 42 °C (39,1 6 0,6 °C), en el 77,8% la fiebre duraba más de 6 h y el 59,5% habían recibido al menos un antitérmico. El 93,5% de los niños redujeron su temperatura hasta 37,5 °C o menos, alcanzándose dicha temperatura en el 80,2% de los niños entre 1 y 2 horas después del tratamiento. El 95% de los pacientes alcanzó un descenso de la temperatura corporal de al menos 1 °C. La temperatura inicial más alta (odds ratio [OR] 0,008; intervalo de confianza [IC] 95%, 0-0,14) y la mayor superficie corporal (OR, 0,004; IC 95%, 0-0,89) facilitan la consecución de dicho objetivo, mientras que la mayor edad la dificulta (OR, 1,67; IC 95%, 1,03-2,7).

Conclusiones

El ibuprofeno es un fármaco muy eficaz en el tratamiento de la fiebre infantil y la magnitud de su efecto antitérmico guarda cierta relación con la edad, el grado de temperatura inicial y la superficie corporal.

Key words:
Fever
Ibuprofen
Prognostic factors
Resumen
Objectives

To assess the factors influencing the antipyretic activity of ibuprofen in children.

Methods

Children aged between 1 and 10 years attending the emergency department with a temperature of 38 °C were given one dose of ibuprofen (7 mg/kg). Temperature was recorded before and 30, 60, 90, 120, 180 and 240 min after ibuprofen administration. The influence of age, sex, weight, body surface, nosologic entity, previous antipyretic administration, and the association between physical measurements and temperature evolution were assessed.

Results

A total of 384 children were studied. Baseline temperatures were between 38 °C and 42 °C (mean: 39.1 6 0.6). Most of the patients (77.8%) had been feverish for more than 6 hours and 59.5% had received antipyretic treatment. In 93.5% of the children temperature was lowered to 37.5 °C or less. In 80.2% of the children this temperature was reached 1-2 hours after treatment. In 95% of ther children a decrease of at least 1 °C was achieved. Older age (OR 1.67; 95% CI: 1.03-2.7), smaller body surface (OR 0.004; 95% CI 0-0.89) and lower baseline temperature (OR 0.008; 95% CI 0-0.14) were associated with a smaller antipyretic response (decrease in body temperature lower than 1 °C).

Conclusions

Ibuprofen is effective in the treatment of fever in children. Its effectiveness is related to age, the degree of fever and body surface.

Palabras clave:
Fiebre
Ibuprofeno
Factores pronósticos
El Texto completo está disponible en PDF
Bibliografía
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Trabajo financiado por Laboratorios Knoll, S.A. (estudio BR2106).

Copyright © 2000. Asociación Española de Pediatría
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