array:23 [
  "pii" => "S1695403300774571"
  "issn" => "16954033"
  "doi" => "10.1016/S1695-4033(00)77457-1"
  "estado" => "S300"
  "fechaPublicacion" => "2000-09-01"
  "aid" => "77457"
  "copyright" => "Asociación Española de Pediatría"
  "copyrightAnyo" => "2000"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "sco"
  "cita" => "An Pediatr (Barc). 2000;53:277-9"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 4199
    "formatos" => array:3 [
      "EPUB" => 92
      "HTML" => 3448
      "PDF" => 659
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1695403300774583"
    "issn" => "16954033"
    "doi" => "10.1016/S1695-4033(00)77458-3"
    "estado" => "S300"
    "fechaPublicacion" => "2000-09-01"
    "aid" => "77458"
    "copyright" => "Asociación Española de Pediatría"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "sco"
    "cita" => "An Pediatr (Barc). 2000;53:280-2"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 5597
      "formatos" => array:3 [
        "EPUB" => 78
        "HTML" => 4802
        "PDF" => 717
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Meningitis como primera y única manifestación de brucelosis"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "280"
          "paginaFinal" => "282"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Meningitis As The First And Only Manifestation Of Brucellosis"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "H. González García, J.E. Fernández Alonso, M. de Paz García, C. Ramos Sánchez, B. Aguirre Gervás"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "H."
              "apellidos" => "González García"
            ]
            1 => array:2 [
              "nombre" => "J.E."
              "apellidos" => "Fernández Alonso"
            ]
            2 => array:2 [
              "nombre" => "M."
              "apellidos" => "de Paz García"
            ]
            3 => array:2 [
              "nombre" => "C."
              "apellidos" => "Ramos Sánchez"
            ]
            4 => array:2 [
              "nombre" => "B."
              "apellidos" => "Aguirre Gervás"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403300774583?idApp=UINPBA00005H"
    "url" => "/16954033/0000005300000003/v1_201307051516/S1695403300774583/v1_201307051516/es/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S169540330077456X"
    "issn" => "16954033"
    "doi" => "10.1016/S1695-4033(00)77456-X"
    "estado" => "S300"
    "fechaPublicacion" => "2000-09-01"
    "aid" => "77456"
    "copyright" => "Asociación Española de Pediatría"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "sco"
    "cita" => "An Pediatr (Barc). 2000;53:273-6"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 6410
      "formatos" => array:3 [
        "EPUB" => 83
        "HTML" => 5189
        "PDF" => 1138
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Alternativa a la aortopexia en el tratamiento de la traqueomalacia grave"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "273"
          "paginaFinal" => "276"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "An Alternative To Aortopexy In The Treatment Of Severe Tracheomalacia"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "R. Sánchez Martín, J.A. Matute Cárdenas, G. Barrientos Fernández, R. Romero Ruiz, M.A. García-Casillas, J. Vázquez Estévez"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "R."
              "apellidos" => "Sánchez Martín"
            ]
            1 => array:2 [
              "nombre" => "J.A."
              "apellidos" => "Matute Cárdenas"
            ]
            2 => array:2 [
              "nombre" => "G."
              "apellidos" => "Barrientos Fernández"
            ]
            3 => array:2 [
              "nombre" => "R."
              "apellidos" => "Romero Ruiz"
            ]
            4 => array:2 [
              "nombre" => "M.A."
              "apellidos" => "García-Casillas"
            ]
            5 => array:2 [
              "nombre" => "J."
              "apellidos" => "Vázquez Estévez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S169540330077456X?idApp=UINPBA00005H"
    "url" => "/16954033/0000005300000003/v1_201307051516/S169540330077456X/v1_201307051516/es/main.assets"
  ]
  "es" => array:14 [
    "idiomaDefecto" => true
    "titulo" => "Adenoma de paratiroides en la edad preescolar"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "277"
        "paginaFinal" => "279"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "E. García García, M.D. López Moreno, M.I. Valenzuela Serrano, J.P. López Siguero"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "E."
            "apellidos" => "García García"
            "email" => array:1 [
              0 => "emigaga@santandersupernet.com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "M&#46;D&#46;"
            "apellidos" => "L&#243;pez Moreno"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "M&#46;I&#46;"
            "apellidos" => "Valenzuela Serrano"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "J&#46;P&#46;"
            "apellidos" => "L&#243;pez Siguero"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Unidad de Endocrinolog&#237;a Pedi&#225;trica&#46; Complejo Hospitalario Carlos Haya&#46; M&#225;laga"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Anatom&#237;a Patol&#243;gica&#46; Complejo Hospitalario Carlos Haya&#46; M&#225;laga"
            "etiqueta" => "<span class="elsevierStyleSup">c</span>"
            "identificador" => "aff0015"
          ]
          2 => array:3 [
            "entidad" => "Servicio de Pediatr&#237;a&#46; Hospital de la Axarqu&#237;a&#46; V&#233;lez-M&#225;laga"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#42;"
            "correspondencia" => "Correspondencia&#58; Unidad de Endocrinolog&#237;a Pedi&#225;trica&#46; Hospital Materno-Infantil&#46; Av&#46; Arroyo de los &#193;ngeles&#44; s&#47;n&#46; 29011 M&#225;laga&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Parathyroid Adenoma In Pre-School Age Children"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2000-04-30"
    "fechaAceptado" => "2000-05-31"
    "PalabrasClave" => array:2 [
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec186437"
          "palabras" => array:4 [
            0 => "Hipercalcemia"
            1 => "Hiperparatiroidismo"
            2 => "Neoplasias de paratiroides"
            3 => "Ni&#241;o"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec186436"
          "palabras" => array:4 [
            0 => "Hypercalcemia"
            1 => "Hyperparathyroidism"
            2 => "Parathyroid neoplasms"
            3 => "Child"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:1 [
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El hiperparatiroidismo primario es una entidad rara en la infancia&#46; La forma neonatal se produce por hiperplasia de las gl&#225;ndulas paratiroides&#46; En el resto de edades pedi&#225;tricas las formas espor&#225;dicas se deben principalmente a adenomas y las familiares a hiperplasia&#46; Los adenomas se presentan generalmente en adolescentes&#46; En el caso que se describe&#44; un adenoma de paratiroides fue extirpado en una ni&#241;a de 11 a&#241;os con antecedente de hipercalcemia espor&#225;dica desde los 5&#44;5 a&#241;os de edad&#44; descubierta en una anal&#237;tica y sin presentar s&#237;ntomas ni complicaciones debidas a ella&#46; Los estudios de imagen preoperatorios&#44; entre ellos la gammagraf&#237;a con <span class="elsevierStyleSup">99m</span>Tc-sestabimi&#44; localizaron la lesi&#243;n y la intervenci&#243;n normaliz&#243; la calcemia&#46; El adenoma de paratiroides se presenta tambi&#233;n en la edad preescolar y su diag&#243;stico puede demorarse por la ausencia de s&#237;ntomas&#46;</p>"
      ]
      "en" => array:1 [
        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Primary hyperparathyroidism in children is rare&#46; The neonatal form involves hyperplasia of the parathyroid glands&#46; In older children sporadic forms are usually due to an adenoma and familial forms are generally due to hyperplasia&#46; Adenoma usually presents in adolescents&#46; In the case presented herein&#44; a parathyroid adenoma was excised from an 11-year-old girl with a history of sporadic hypercalcemia from the age of 5&#46;5 years&#46; The disease was discovered in serum chemistry and the patient presented no symptoms or conditions associated with hypercalcemia&#46; Diagnosis was by preoperative imaging studies including <span class="elsevierStyleSup">99m</span>Tc-sestabimi and surgical intervention stabilized calcium levels&#46; Parathyroid adenoma occurs in pre-school age children and its diagnosis may be delayed because of the absence of symptoms&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:15 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Primary hyperparathyroidism in children"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46; Levard"
                            1 => "J&#46; Gaudelus"
                            2 => "C&#46; Cessans"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Chir"
                        "fecha" => "1992"
                        "volumen" => "46"
                        "paginaInicial" => "653"
                        "paginaFinal" => "658"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1456700"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "L&#8217;hyperparathyro&#239;die primitive chez l&#8217;enfant"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "L&#46; David"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "P&#233;diatrie"
                        "fecha" => "1993"
                        "volumen" => "48"
                        "paginaInicial" => "431"
                        "paginaFinal" => "434"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8247641"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Primary hyperparathyroidism&#46; A personal experience with 242 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "T&#46;R&#46; Kelly"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Surg"
                        "fecha" => "1980"
                        "volumen" => "140"
                        "paginaInicial" => "632"
                        "paginaFinal" => "635"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7435821"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Primary hyperparathyroidism in children&#44; adolescents&#44; and young adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Allo"
                            1 => "N&#46;W&#46; Thompson"
                            2 => "J&#46;K&#46; Harness"
                            3 => "R&#46;H&#46; Nishiyama"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "World J Surg"
                        "fecha" => "1982"
                        "volumen" => "6"
                        "paginaInicial" => "771"
                        "paginaFinal" => "776"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7180010"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Microsatellite instability in sporadic parathyroid adenoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Sarquis"
                            1 => "E&#46; Friedman"
                            2 => "W&#46;L&#46; Boson"
                            3 => "R&#46;S&#46; G&#243;mez"
                            4 => "A&#46;F&#46; Dias"
                            5 => "L&#46; De Marco"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jcem.85.1.6370"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "2000"
                        "volumen" => "85"
                        "paginaInicial" => "250"
                        "paginaFinal" => "252"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10634395"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Primary hyperparathyroidism in children"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "H&#46; Mannix"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Surg"
                        "fecha" => "1997"
                        "volumen" => "129"
                        "paginaInicial" => "528"
                        "paginaFinal" => "531"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1130592"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical profile of primary hyperparathyroidism in adolescents and young adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "K&#46;C&#46; Loh"
                            1 => "Q&#46;Y&#46; Duh"
                            2 => "D&#46; Shoback"
                            3 => "L&#46; Gee"
                            4 => "A&#46; Siperstein"
                            5 => "O&#46;H&#46; Clark"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clin Endocrinol &#40;Oxf&#41;"
                        "fecha" => "1998"
                        "volumen" => "48"
                        "paginaInicial" => "435"
                        "paginaFinal" => "443"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Familial hyperparathyroidism caused by solitary adenomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Allo"
                            1 => "N&#46;W&#46; Thompson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Surgery"
                        "fecha" => "1982"
                        "volumen" => "92"
                        "paginaInicial" => "486"
                        "paginaFinal" => "490"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7112400"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Primary hyperparathyroidism in children&#58; patient report and review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46; Damiani"
                            1 => "C&#46;H&#46; Aguiar"
                            2 => "V&#46;S&#46; Bueno"
                            3 => "F&#46;L&#46; Montenegro"
                            4 => "V&#46;H&#46; Koch"
                            5 => "A&#46;M&#46; Cocozza"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pediatr Endocrinol Metab"
                        "fecha" => "1998"
                        "volumen" => "11"
                        "paginaInicial" => "83"
                        "paginaFinal" => "86"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9642634"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Primary hyperparathyroidism in children&#58; report of a case and a brief review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46;B&#46; Huang"
                            1 => "S&#46;C&#46; Huang"
                            2 => "F&#46;F&#46; Chou"
                            3 => "W&#46;J&#46; Chen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Formos Med Assoc"
                        "fecha" => "1993"
                        "volumen" => "92"
                        "paginaInicial" => "1095"
                        "paginaFinal" => "1098"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7911360"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sporadic primary hyperparathyroidism in young patients&#58; a separate disease entity&#945;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "C&#46;R&#46; Harman"
                            1 => "J&#46;A&#46; Van Heerden"
                            2 => "D&#46;R&#46; Farley"
                            3 => "C&#46;S&#46; Grant"
                            4 => "G&#46;B&#46; Thompson"
                            5 => "K&#46; Curlee"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Surg"
                        "fecha" => "1999"
                        "volumen" => "134"
                        "paginaInicial" => "651"
                        "paginaFinal" => "655"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10367876"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Estudio isot&#243;pico con <span class="elsevierStyleSup">99m</span>Tc-sestamibi doble fase en la localizaci&#243;n de lesiones de las gl&#225;ndulas paratiroides"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Berna"
                            1 => "J&#46; Piera"
                            2 => "J&#46; Rodriguez-Espinosa"
                            3 => "A&#46; Caixas"
                            4 => "M&#46; Puig-Domingo"
                            5 => "J&#46; Farrerons"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;"
                        "fecha" => "1999"
                        "volumen" => "112"
                        "paginaInicial" => "201"
                        "paginaFinal" => "205"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hyperparathyroidism in high-risk surgical patients&#58; evaluation with double-phase technetium-99m sestamibi imaging"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "V&#46;S&#46; Lee"
                            1 => "R&#46;H&#46; Wilkinson"
                            2 => "G&#46;S&#46; Leight"
                            3 => "A&#46;C&#46; Coogan"
                            4 => "R&#46;E&#46; Coleman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1148/radiology.197.3.7480730"
                      "Revista" => array:6 [
                        "tituloSerie" => "Radiology"
                        "fecha" => "1995"
                        "volumen" => "197"
                        "paginaInicial" => "627"
                        "paginaFinal" => "633"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7480730"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Parathyroid localization&#58; inability to predict multiple gland involvement"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "K&#46;S&#46; Heller"
                            1 => "J&#46;N&#46; Attie"
                            2 => "S&#46; Dubner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Surg"
                        "fecha" => "1993"
                        "volumen" => "166"
                        "paginaInicial" => "357"
                        "paginaFinal" => "359"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8214292"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Primary hyperparathyroidism&#58; preoperative localization using technetiumsestamibi scanning"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "B&#46;K&#46; Mitchell"
                            1 => "B&#46;K&#46; Kinder"
                            2 => "E&#46; Cornelius"
                            3 => "A&#46;F&#46; Stewart"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jcem.80.1.7829642"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "1995"
                        "volumen" => "80"
                        "paginaInicial" => "7"
                        "paginaFinal" => "9"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7829642"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/16954033/0000005300000003/v1_201307051516/S1695403300774571/v1_201307051516/es/main.assets"
  "Apartado" => array:4 [
    "identificador" => "14441"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Notas cl&#237;nicas"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/16954033/0000005300000003/v1_201307051516/S1695403300774571/v1_201307051516/es/main.pdf?idApp=UINPBA00005H&text.app=https://analesdepediatria.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403300774571?idApp=UINPBA00005H"
]
Compartir
Información de la revista
Vol. 53. Núm. 3.
Páginas 277-279 (septiembre 2000)
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Vol. 53. Núm. 3.
Páginas 277-279 (septiembre 2000)
Acceso a texto completo
Adenoma de paratiroides en la edad preescolar
Parathyroid Adenoma In Pre-School Age Children
Visitas
8437
E. García Garcíaa,
Autor para correspondencia
emigaga@santandersupernet.com

Correspondencia: Unidad de Endocrinología Pediátrica. Hospital Materno-Infantil. Av. Arroyo de los Ángeles, s/n. 29011 Málaga.
, M.D. López Morenob, M.I. Valenzuela Serranoc, J.P. López Sigueroa
a Unidad de Endocrinología Pediátrica. Complejo Hospitalario Carlos Haya. Málaga
c Servicio de Anatomía Patológica. Complejo Hospitalario Carlos Haya. Málaga
b Servicio de Pediatría. Hospital de la Axarquía. Vélez-Málaga
Este artículo ha recibido
Información del artículo

El hiperparatiroidismo primario es una entidad rara en la infancia. La forma neonatal se produce por hiperplasia de las glándulas paratiroides. En el resto de edades pediátricas las formas esporádicas se deben principalmente a adenomas y las familiares a hiperplasia. Los adenomas se presentan generalmente en adolescentes. En el caso que se describe, un adenoma de paratiroides fue extirpado en una niña de 11 años con antecedente de hipercalcemia esporádica desde los 5,5 años de edad, descubierta en una analítica y sin presentar síntomas ni complicaciones debidas a ella. Los estudios de imagen preoperatorios, entre ellos la gammagrafía con 99mTc-sestabimi, localizaron la lesión y la intervención normalizó la calcemia. El adenoma de paratiroides se presenta también en la edad preescolar y su diagóstico puede demorarse por la ausencia de síntomas.

Palabras clave:
Hipercalcemia
Hiperparatiroidismo
Neoplasias de paratiroides
Niño

Primary hyperparathyroidism in children is rare. The neonatal form involves hyperplasia of the parathyroid glands. In older children sporadic forms are usually due to an adenoma and familial forms are generally due to hyperplasia. Adenoma usually presents in adolescents. In the case presented herein, a parathyroid adenoma was excised from an 11-year-old girl with a history of sporadic hypercalcemia from the age of 5.5 years. The disease was discovered in serum chemistry and the patient presented no symptoms or conditions associated with hypercalcemia. Diagnosis was by preoperative imaging studies including 99mTc-sestabimi and surgical intervention stabilized calcium levels. Parathyroid adenoma occurs in pre-school age children and its diagnosis may be delayed because of the absence of symptoms.

Key words:
Hypercalcemia
Hyperparathyroidism
Parathyroid neoplasms
Child
El Texto completo está disponible en PDF
Bibliografía
[1.]
G. Levard, J. Gaudelus, C. Cessans.
Primary hyperparathyroidism in children.
Ann Chir, 46 (1992), pp. 653-658
[2.]
L. David.
L’hyperparathyroïdie primitive chez l’enfant.
Pédiatrie, 48 (1993), pp. 431-434
[3.]
T.R. Kelly.
Primary hyperparathyroidism. A personal experience with 242 cases.
Am J Surg, 140 (1980), pp. 632-635
[4.]
M. Allo, N.W. Thompson, J.K. Harness, R.H. Nishiyama.
Primary hyperparathyroidism in children, adolescents, and young adults.
World J Surg, 6 (1982), pp. 771-776
[5.]
M. Sarquis, E. Friedman, W.L. Boson, R.S. Gómez, A.F. Dias, L. De Marco.
Microsatellite instability in sporadic parathyroid adenoma.
J Clin Endocrinol Metab, 85 (2000), pp. 250-252
[6.]
H. Mannix.
Primary hyperparathyroidism in children.
Am J Surg, 129 (1997), pp. 528-531
[7.]
K.C. Loh, Q.Y. Duh, D. Shoback, L. Gee, A. Siperstein, O.H. Clark.
Clinical profile of primary hyperparathyroidism in adolescents and young adults.
Clin Endocrinol (Oxf), 48 (1998), pp. 435-443
[8.]
M. Allo, N.W. Thompson.
Familial hyperparathyroidism caused by solitary adenomas.
Surgery, 92 (1982), pp. 486-490
[9.]
D. Damiani, C.H. Aguiar, V.S. Bueno, F.L. Montenegro, V.H. Koch, A.M. Cocozza, et al.
Primary hyperparathyroidism in children: patient report and review of the literature.
J Pediatr Endocrinol Metab, 11 (1998), pp. 83-86
[10.]
C.B. Huang, S.C. Huang, F.F. Chou, W.J. Chen.
Primary hyperparathyroidism in children: report of a case and a brief review of the literature.
J Formos Med Assoc, 92 (1993), pp. 1095-1098
[11.]
C.R. Harman, J.A. Van Heerden, D.R. Farley, C.S. Grant, G.B. Thompson, K. Curlee.
Sporadic primary hyperparathyroidism in young patients: a separate disease entityα.
Arch Surg, 134 (1999), pp. 651-655
[12.]
L. Berna, J. Piera, J. Rodriguez-Espinosa, A. Caixas, M. Puig-Domingo, J. Farrerons, et al.
Estudio isotópico con 99mTc-sestamibi doble fase en la localización de lesiones de las glándulas paratiroides.
Med Clin (Barc), 112 (1999), pp. 201-205
[13.]
V.S. Lee, R.H. Wilkinson, G.S. Leight, A.C. Coogan, R.E. Coleman.
Hyperparathyroidism in high-risk surgical patients: evaluation with double-phase technetium-99m sestamibi imaging.
Radiology, 197 (1995), pp. 627-633
[14.]
K.S. Heller, J.N. Attie, S. Dubner.
Parathyroid localization: inability to predict multiple gland involvement.
Am J Surg, 166 (1993), pp. 357-359
[15.]
B.K. Mitchell, B.K. Kinder, E. Cornelius, A.F. Stewart.
Primary hyperparathyroidism: preoperative localization using technetiumsestamibi scanning.
J Clin Endocrinol Metab, 80 (1995), pp. 7-9
Copyright © 2000. Asociación Española de Pediatría
Descargar PDF
Idiomas
Anales de Pediatría
Opciones de artículo
Herramientas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?