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An
Pediatr
(Barc).
2014;
81(5)
:297---302
www.analesdepediatria.org
ORIGINAL
ARTICLE
Eye
and
systemic
manifestations
of
Mobius
syndrome

,

A.M.
Borbolla
Pertierra
,
P.
Acevedo
González,
V.
Bosch
Canto,
J.C.
Ordaz
Favila,
J.C.
Juárez
Echenique
Servicio
de
Oftalmología
Pediátrica,
Instituto
Nacional
de
Pediatría,
México
Distrito
Federal,
Mexico
Received
23
June
2013;
accepted
10
October
2013
Available
online
23
October
2014
KEYWORDS
Mobius
syndrome;
Facial
palsy;
Esotropia;
Abortion
inducing
agents;
Epicanthus;
Entropion
Abstract
Introduction:
Mobius
syndrome
is
characterised
by
damage
in
the
nucleus
of
the
sixth
and
seventh
cranial
nerves,
with
subsequent
facial
palsy
and
abduction
limitation
of
the
eyes.
The
aim
of
this
article
is
to
describe
the
ophthalmological
findings
of
the
Mobius
syndrome
in
Mexican
children.
Patients
and
methods:
A
cross-sectional,
retrospective,
observational
and
descriptive
study
was
conducted.
A
review
was
made
of
the
clinical
charts
of
patients
with
Mobius
syndrome
who
were
seen
in
the
National
Institute
of
Pediatrics
in
Mexico,
between
the
years
2000
and
2010.
Results:
A
total
of
64
charts
were
reviewed.
The
most
important
findings
were
eye
abduction
limitation
(100%),
facial
palsy
(100%),
esotropia
(54%),
epicanthus
(51.5%),
entropion
(22%),
and
history
of
use
of
abortion
inducers
in
the
mother
in
the
first
trimester
of
pregnancy
(28%).
We
also
found
exotropia
and
hypertropia
in
some
cases.
Conclusions:
Mobius
syndrome
has
a
wide
spectrum
of
ophthalmological
manifestations
that
are
important
to
detect
early
in
order
to
improve
function
and
aesthetics.
©
2013
Asociación
Espa
̃
nola
de
Pediatría.
Published
by
Elsevier
España,
S.L.U.
All
rights
reserved.
PALABRAS
CLAVE
Síndrome
de
Möebius;
Endotropia;
Parálisis
facial;
Agentes
abortivos;
Manifestaciones
oculares
y
sistémicas
del
síndrome
de
Möebius
Resumen
Introducción:
El
síndrome
de
Möebius
es
una
enfermedad
caracterizada
por
lesión
en
los
núcleos
del
sexto
y
séptimo
nervios
craneales,
produciendo
parálisis
facial
y
limitación
a
la
abducción

Please
cite
this
article
as:
Borbolla
Pertierra
AM,
Acevedo
González
P,
Bosch
Canto
V,
Ordaz
Favila
JC,
Juárez
Echenique
JC.
Manifestac-
iones
oculares
y
sistémicas
del
síndrome
de
Möebius.
An
Pediatr
(Barc).
2014;81:297---302.

Previous
presentations:
This
study
was
presented
at
the
2nd
World
Congress
of
Pediatric
Ophthalmology
and
Strabismus;
September
7---9,
2012,
Milan,
Italy;
and
at
the
Congreso
Mexicano
de
Oftalmología;
June
9---13,
2003,
Guadalajara,
Jalisco,
Mexico.
Corresponding
author.
E-mail
address:
ambp09@gmail.com
(A.M.
Borbolla
Pertierra).
2341-2879/©
2013
Asociación
Espa
̃
nola
de
Pediatría.
Published
by
Elsevier
España,
S.L.U.
All
rights
reserved.