Letter to the Editor
Dispersible fixed-dose combinations of antituberculous drugs... Finally available!!
Combinaciones de dosis fija dispersables de antituberculosos... ¡Al fin disponibles!
a Malalties Infeccioses i Resposta Inflamatòria Sistèmica en Pediatria, Servei d’ Infectologia Pediàtrica, Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Déu, Barcelona, Spain
b Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública, Madrid, Spain
c Departament de Cirurgia i Especialitats Medicoquirúrgiques, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain
d Servei de Farmàcia, Hospital Sant Joan de Déu, Barcelona, Spain
e Medicamentos en Situaciones Especiales, Agencia Española de Medicamentos y Productos Sanitarios, Madrid, Spain
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Finally available!!" "tieneTextoCompleto" => true "saludo" => "Dear Editor:" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "70" "paginaFinal" => "71" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Antoni Noguera-Julian, Cristina Latre, Ángeles Flores" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Antoni" "apellidos" => "Noguera-Julian" "email" => array:1 [ 0 => "ton@hsjdbcn.es" ] "referencia" => array:4 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 3 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Cristina" "apellidos" => "Latre" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 2 => array:3 [ "nombre" => "Ángeles" "apellidos" => "Flores" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] ] ] "afiliaciones" => array:5 [ 0 => array:3 [ "entidad" => "Malalties Infeccioses i Resposta Inflamatòria Sistèmica en Pediatria, Servei d’ Infectologia Pediàtrica, Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Déu, Barcelona, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública, Madrid, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Departament de Cirurgia i Especialitats Medicoquirúrgiques, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Servei de Farmàcia, Hospital Sant Joan de Déu, Barcelona, Spain" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Medicamentos en Situaciones Especiales, Agencia Española de Medicamentos y Productos Sanitarios, Madrid, Spain" "etiqueta" => "e" "identificador" => "aff0025" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Combinaciones de dosis fija dispersables de antituberculosos... ¡Al fin disponibles!" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2448 "Ancho" => 2925 "Tamanyo" => 592869 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0070" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The provinces highlighted in the map are those that have requested at least one of the dispersible formulations for treatment of at least one patient as of April 11, 2024.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">In June 2023, the working groups of the Spanish societies of paediatric pulmonology and infectious diseases (Sociedad Española de Neumología Pediátrica and Sociedad Española de Infectología Pediátrica) published the Update on the Diagnosis and Treatment of Tuberculosis.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> This document insists on the importance of adequate adherence to tuberculosis (TB) treatment, although it also highlighted that the formulations of first-line oral TB drugs currently marketed in Spain were not suitable for young children. In fact, only one oral solution of rifampicin is available. This is a problem shared by all countries in the European Union that forces paediatricians to resort to solutions that are not contemplated in the summary of product characteristics, such as crushing tablets, mixing them with food or using combinations of fixed-dose formulations developed for use in adults.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Since August 2023, after a long process of marketing authorization and importing with the collaboration of the Agencia Española de Medicamentos y Productos Sanitarios (AEMPS, Spanish Agency of Medicines and Medical Devices), dispersible fixed-dose combination formulations are available in tablet form for isoniazid (50 mg)-rifampicin (75 mg)-pyrazinamide (150 mg; HRZ) and isoniazid (50 mg)-rifampicin (75 mg; HR).<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Dispersible tablets are also available for monotherapy with isoniazid (100 mg) and ethambutol (100 mg). These formulations readily dissolve in water, have pleasant organoleptic properties and are administered in doses based on body weight ranges (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>), according to the recommendations for the dose per kg of body weight in young children. They also have a shelf life of 2 years and a reasonable price. They are useful for treatment of TB disease (HRZ tablets ± ethambutol tablets in the intensive phase; HR tablets in the maintenance phase), TB infection (HR tablets for 3 months or isoniazid as monotherapy for 6–9 months), and for primary chemoprophylaxis in young children after contact with an adult with active disease (isoniazid as monotherapy). Once dissolved in water, they must be administered immediately, although these tablets can also be taken whole. Although they were developed with young children in mind, in rare cases they may be useful for older patients with swallowing problems or when medication needs to be administered via a feeding tube.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Since they became available in 2015, dispersible tablets have made possible the treatment of more than one million of children with TB in over 120 low-income countries worldwide. In Spain, any paediatrician can order them through a hospital pharmacy as a foreign drug after presenting an individual clinical report through the “Medication in Special Situations” procedure of the AEMPS.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> As of April 2024, 8 months after the first import, 25 out of 50 Spanish provinces (50%) and the autonomous city of Ceuta have requested at least one of the dispersible tables for treatment of at least 1 patient (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). We do not know why half of the country has yet to use them. Our aim in writing this letter is to spread the news about these novel formulations to all paediatricians in Spain and highlight how they can facilitate the treatment of TB in paediatric patients, so that the maximum possible number of children can benefit from them.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0020" class="elsevierStylePara elsevierViewall">This study was partially funded by the <span class="elsevierStyleGrantSponsor" id="gs0005">Instituto de Salud Carlos III, Ministry of Economy and Competitiveness of Spain</span> (PI22/00766) and a grant of the <span class="elsevierStyleGrantSponsor" id="gs0010">Sociedad Española de Neumología y Cirugía Torácica</span> (169-2022).</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflicts of interest</span><p id="par0025" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Funding" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Conflicts of interest" ] 2 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2448 "Ancho" => 2925 "Tamanyo" => 592869 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0070" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The provinces highlighted in the map are those that have requested at least one of the dispersible formulations for treatment of at least one patient as of April 11, 2024.</p>" ] ] 1 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0075" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Weight \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">H50-R75-Z150 tablets \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">H50-R75 tablets \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4–7 kg \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8–11 kg \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12–15 kg \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16–24 kg \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3598418.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Daily dose of dispersible fixed-dose combination tablets by body weight range recommended by the World Health Organization.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:4 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Actualización del diagnóstico y tratamiento de la tuberculosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F. 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Ritz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/13993003.01196-2021" "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2021" "volumen" => "58" "paginaInicial" => "2101196" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/34049946" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0735109714015630" "estado" => "S300" "issn" => "07351097" ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Availability of paediatric dispersible fixed-dose combinations of tuberculosis drugs in Spain" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Noguera-Julian" 1 => "C. Latre" 2 => "Á. Flores" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/13993003.00104-2024" "Revista" => array:5 [ "tituloSerie" => "Eur Respir J" "fecha" => "2024" "volumen" => "63" "paginaInicial" => "2400104" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/38575168" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Agencia Española de Medicamentos y Productos Sanitarios. Medicamentos en situaciones especiales. Madrid, Spain. [Accessed 15 April 2024]. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 October | 90 | 49 | 139 |
| 2024 September | 97 | 40 | 137 |
| 2024 August | 109 | 64 | 173 |
| 2024 July | 354 | 66 | 420 |
| 2024 June | 139 | 47 | 186 |
