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1</a>B&#41; and treated with repeated balloon dilations and nebulised budesonide&#44; leaving residual stenosis of 20&#37;&#8211;30&#37; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>C&#41;&#46; The respiratory manifestations improved gradually&#44; and the patient was discharged 60 days after admission without need of oxygen therapy&#46; The outcome at 1 year is satisfactory&#44; with no signs of respiratory distress&#44; although the lung sounds continue to be abnormal with bilateral coarse crackles&#46; The patient experiences acute episodes of infectious bronchitis that are managed with inhaled salbutamol and oral corticosteroids&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">A boy aged 3 years presented with increased work of breathing in the context of febrile acute bronchitis&#46; The salient findings of the physical examination were increased work of breathing with generalized retractions&#44; 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hypertransaminasaemia &#40;gamma-glutamyl transferase 98 U&#47;L&#59; aspartate aminotransferase 16 658 U&#47;L and alanine aminotransferase 7384 U&#47;L&#41;&#44; C-reactive protein level of 3&#46;95<span class="elsevierStyleHsp" style=""></span>mg&#47;dL and severe coagulopathy with a prothrombin time percent activity of 9&#37; and an international normalized ratio of 7&#46;95&#46; The abdominal ultrasound scan found hepatomegaly and gallbladder oedema&#46; These findings&#44; suggestive of acute liver failure&#44; prompted transfer of the patient to a reference centre&#44; where she underwent liver transplantation for management of fulminant hepatic failure&#46; Adenovirus was detected in the bloodstream&#44; leading to diagnosis of acute liver failure due to adenovirus infection in the context of an outbreak of severe acute hepatitis that affected 1010 children from 35 countries across the world in the first half of 2022 and associated with infection by serotype 41&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> During the post-transplantation follow-up&#44; there has been no evidence of complications or acute transplant rejection&#46; The patient remains in treatment with tacrolimus&#44; which she tolerates well&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">We consider that the cases presented are examples of the phenomenon known as &#8220;immunity debt&#8221;&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> which we have been experiencing since 2022 after the lifting of the restrictions imposed to fight SARS-CoV-2 and is characterised by an increase incidence and virulence of classical pathogens due to the reduction in herd immunity resulting from prolonged periods of decreased exposure&#44; as was the case during the recent COVID-19 pandemic&#46;</p></span>"
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Scientific Letter
Severe adenovirus infection: presentation of 3 cases
Infección grave por adenovirus: descripción de 3 casos
Ana Cristina Galindo Garcíaa,
Corresponding author
acgalindog@salud.aragon.es

Corresponding author.
, Inés Teresa Bolsa Ferrera, Paula Casajús Pelegaya, Ruth García Romerob, Carlos Martín de Vicentec
a Servicio de Pediatría, Hospital Universitario Miguel Servet, Zaragoza, Spain
b Unidad de Gastroenterología Pediátrica, Hospital Universitario Miguel Servet, Zaragoza, Spain
c Unidad de Neumología Pediátrica, Hospital Universitario Miguel Servet, Zaragoza, Spain
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Testing by polymerase chain reaction of a throat swab specimen turned out positive for adenovirus and respiratory syncytial virus&#46; After extubation&#44; inspiratory and expiratory rhonchi&#44; bilateral coarse crackles and the need for oxygen therapy persisted for three weeks&#44; prompting performance of a lung CT scan that revealed a bilateral mosaic attenuation pattern compatible with postinfectious bronchiolitis obliterans &#40;PiBO<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#46; Treatment of PiBO was initiated with intravenous high-dose methylprednisolone&#44; azithromycin&#44; montelukast and acetylcysteine&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> As a complication&#44; the patient developed tracheal stenosis of 60&#37;&#8211;70&#37; secondary to intubation&#44; diagnosed by a chest TC scan and flexible bronchoscopy that allowed visualization of tracheal granuloma &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41; and treated with repeated balloon dilations and nebulised budesonide&#44; leaving residual stenosis of 20&#37;&#8211;30&#37; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>C&#41;&#46; The respiratory manifestations improved gradually&#44; and the patient was discharged 60 days after admission without need of oxygen therapy&#46; The outcome at 1 year is satisfactory&#44; with no signs of respiratory distress&#44; although the lung sounds continue to be abnormal with bilateral coarse crackles&#46; The patient experiences acute episodes of infectious bronchitis that are managed with inhaled salbutamol and oral corticosteroids&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">A boy aged 3 years presented with increased work of breathing in the context of febrile acute bronchitis&#46; The salient findings of the physical examination were increased work of breathing with generalized retractions&#44; tachypnoea with 70 bmp&#44; bilateral expiratory wheezing with hypoventilation in the left hemithorax and an SaO<span class="elsevierStyleInf">2</span> of 84&#37;&#46; The plain chest radiograph showed complete opacification of the left hemithorax with tracheal shift toward the involved lung and hyperinflation of the contralateral lung&#44; all of which was compatible with complete atelectasis of the left lung &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>A&#41;&#46; A few hours later&#44; a flexible bronchoscopy examination revealed mucus plugging in the left main bronchus occluding the entire bronchial lumen&#46; Aspiration achieved full clearance of the plugging&#44; with removal of bronchial casts &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>B&#41;&#44; and full re-expansion of the left lung with rapid improvement of the respiratory symptoms&#46; Testing of a bronchoalveolar lavage sample detected adenovirus&#44; confirming the diagnosis of plastic bronchitis secondary to adenovirus infection&#44; an association that is rare in our region&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a> The patient was then discharged&#44; at which time the physical examination was normal&#44; and has since experienced recurrent episodes of mild bronchitis&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">A girl aged 2 years presented with malaise&#44; vomiting and high fever of 4 days&#8217; duration&#46; The physical examination evinced poor general health&#44; palpable hepatomegaly of 2&#8211;3 finger widths and a Glasgow score of 12&#8211;13 points&#46; The blood glucose level as 26<span class="elsevierStyleHsp" style=""></span>mg&#47;dL with a ketone body concentration of 1&#46;3<span class="elsevierStyleHsp" style=""></span>mg&#47;dL and metabolic acidosis with a lactate level of 11&#46;7<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#46; Further blood tests revealed an ammonia level of 528<span class="elsevierStyleHsp" style=""></span>&#956;mol&#47;L&#44; hypertransaminasaemia &#40;gamma-glutamyl transferase 98 U&#47;L&#59; aspartate aminotransferase 16 658 U&#47;L and alanine aminotransferase 7384 U&#47;L&#41;&#44; C-reactive protein level of 3&#46;95<span class="elsevierStyleHsp" style=""></span>mg&#47;dL and severe coagulopathy with a prothrombin time percent activity of 9&#37; and an international normalized ratio of 7&#46;95&#46; The abdominal ultrasound scan found hepatomegaly and gallbladder oedema&#46; These findings&#44; suggestive of acute liver failure&#44; prompted transfer of the patient to a reference centre&#44; where she underwent liver transplantation for management of fulminant hepatic failure&#46; Adenovirus was detected in the bloodstream&#44; leading to diagnosis of acute liver failure due to adenovirus infection in the context of an outbreak of severe acute hepatitis that affected 1010 children from 35 countries across the world in the first half of 2022 and associated with infection by serotype 41&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> During the post-transplantation follow-up&#44; there has been no evidence of complications or acute transplant rejection&#46; The patient remains in treatment with tacrolimus&#44; which she tolerates well&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">We consider that the cases presented are examples of the phenomenon known as &#8220;immunity debt&#8221;&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> which we have been experiencing since 2022 after the lifting of the restrictions imposed to fight SARS-CoV-2 and is characterised by an increase incidence and virulence of classical pathogens due to the reduction in herd immunity resulting from prolonged periods of decreased exposure&#44; as was the case during the recent COVID-19 pandemic&#46;</p></span>"
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Article information
ISSN: 23412879
Original language: English
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Anales de Pediatría (English Edition)