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We conducted a descriptive analysis of the demographic and clinical characteristics of the sample&#44; the treatment received and the degree of satisfaction and safety perceived by the families&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Direct home-based care was provided by paediatricians in the HAH in coordination with the oncologist in charge of the patient&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The patients in the sample met the criteria for admission to the HAH unit&#58; clinical stability&#44; voluntary participation in the programme and signed informed consent&#46; The families were found to be reliable and had been trained&#44; had telephonic access to the hospital around the clock and lived less than 30&#8239;min away from the hospital&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">We obtained informed consent from families to participate in the satisfaction survey by completing an online form anonymously&#46; The form included questions regarding satisfaction and the safety perceived by respondents&#44; scored on a Likert scale that ranged from 1 &#40;lowest degree&#41; to 5 &#40;highest degree&#41;&#44; and the burden of care they experienced &#40;Appendix B&#41;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Of the total admissions to HAH &#40;634&#41;&#44; 7&#46;4&#37; &#40;47&#41; corresponded to patients with oncological or haematological disease&#59; 8 required admission repeatedly&#44; so the total patients included amounted to 31 &#40;51&#37; male&#41;&#46; The median age was 8 years &#40;IQR&#44; 3&#8211;11&#41;&#44; the mean stay was 7 days &#40;IQR&#44; 5&#8211;12&#41;&#46; A total of 416 hospitalizations were avoided&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The most frequent oncological and blood disorders in the sample were leukaemia and neuroblastoma &#40;76&#46;5&#37;&#41;&#46; The most frequent reason for admission was the need of intravenous antibiotherapy for management of infectious diseases &#40;70&#46;2&#37;&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">The most frequently used drugs delivered intravenously were dinutuximab and teicoplanin &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; In 42&#46;2&#37; &#40;19&#41; of cases&#44; these drugs were administered by the family&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">During the stay in the HAH programme&#44; 21&#46;2&#37; &#40;10&#47;47&#41; of the patients required hospital readmission&#58; 5 due to fever&#44; 4 to modify treatment and 1 due to poor adherence to treatment&#46; There were no events that compromised patient safety&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">We submitted 26 invitations to complete the questionnaire&#44; one per patient&#44; excluding deceased patients and patients currently in relapse &#40;3 cases&#41;&#44; and we were unable to contact 2 of the patients&#46; The response rate was 92&#37; &#40;24&#47;26&#41;&#46; All respondents rated their overall satisfaction with the HAH service at 4 or 5 points&#46; Also&#44; 52&#46;4&#37; expressed that the burden of care turned out to be lower than expected&#44; while 38&#46;1&#37; expressed that it matched expectations&#46; All respondents rated the perceived safety at 4 or 5 points&#46; All would choose the option of HAH again&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">As advantages&#44; respondents highlighted an improvement in family life and caregiving balance and in comfort &#40;19 respondents&#41; as well as the potential avoidance of infection &#40;2 respondents&#41;&#46; As drawbacks&#44; they mentioned the worry associated with not being in a hospital setting &#40;5 respondents&#41; and lack of confidence in managing medical devices &#40;5 respondents&#41;&#44; although this insecurity improved as days went by&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">The main limitations of our study were the small sample size and the use of a questionnaire developed by the researchers due to the lack of a validated scale fitting the needs of the study&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">We conclude that paediatric patients with oncological disease may benefit from admission to HAH units&#44; which can allow a reduction in hospital stays with a high level of satisfaction and perceived safety in the families&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Further studies are required to establish the effectiveness and safety of HAH in this group of patients&#46;</p></span>"
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            "apendice" => "<p id="par0095" class="elsevierStylePara elsevierViewall">The following is Supplementary data to this article&#58;<elsevierMultimedia ident="upi0005"></elsevierMultimedia></p>"
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            "titulo" => "Supplementary data"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Medication administered intravenously&#44; expressed as the count of patients that received a specific drug&#46;</p>"
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          "leyenda" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">CVC&#44; central venous catheter&#46; Data expressed as absolute frequencies and percentages&#46;</p>"
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                  \t\t\t\t">11 &#40;23&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Other &#40;immunodeficiency&#46; brain tumour&#46; germ cell tumour&#46; medulloblastoma&#46; Langerhans cell histiocytosis&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Home intravenous antibiotherapy&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Invasive fungal infection&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">7 &#40;21&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t">2 &#40;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1 &#40;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                      "titulo" => "The European Association for Children in Hospital Charter with Annotations"
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