was read the article
array:25 [ "pii" => "S2341287920300624" "issn" => "23412879" "doi" => "10.1016/j.anpede.2019.05.014" "estado" => "S300" "fechaPublicacion" => "2020-05-01" "aid" => "2675" "copyright" => "Asociación Española de Pediatría" "copyrightAnyo" => "2020" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "An Pediatr (Barc). 2020;92:297-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "es" => array:20 [ "pii" => "S1695403319302061" "issn" => "16954033" "doi" => "10.1016/j.anpedi.2019.05.015" "estado" => "S300" "fechaPublicacion" => "2020-05-01" "aid" => "2675" "copyright" => "Asociación Española de Pediatría" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "An Pediatr (Barc). 2020;92:297-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1428 "formatos" => array:3 [ "EPUB" => 53 "HTML" => 1199 "PDF" => 176 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">CARTA CIENTÍFICA</span>" "titulo" => "Granuloma aséptico facial idiopático: características clinicopatológicas y ecográficas" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "297" "paginaFinal" => "299" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Idiopathic facial aseptic granuloma: Clinical, pathological, and ultrasound characteristics" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1036 "Ancho" => 1250 "Tamanyo" => 221004 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A) Imagen clínica del caso 2. B) Imagen clínica del caso 6. Se observa un chalación en el párpado inferior derecho. C) Estudio histológico de la lesión de la mejilla derecha del caso 6. Se observa un infiltrado linfoplasmocitario en la dermis, con presencia de granulomas con histiocitos y células gigantes multinucleadas. D) Ecografía de la lesión en la mejilla derecha (caso 6). Se aprecia una estructura hipoecogénica con un borde posterior abollonado.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Alexandre Docampo Simón, María José Sánchez-Pujol, Luca Schneller-Pavelescu, Laura Berbegal, Isabel Betlloch Mas" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Alexandre" "apellidos" => "Docampo Simón" ] 1 => array:2 [ "nombre" => "María José" "apellidos" => "Sánchez-Pujol" ] 2 => array:2 [ "nombre" => "Luca" "apellidos" => "Schneller-Pavelescu" ] 3 => array:2 [ "nombre" => "Laura" "apellidos" => "Berbegal" ] 4 => array:2 [ "nombre" => "Isabel" "apellidos" => "Betlloch Mas" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2341287920300624" "doi" => "10.1016/j.anpede.2019.05.014" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2341287920300624?idApp=UINPBA00005H" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403319302061?idApp=UINPBA00005H" "url" => "/16954033/0000009200000005/v1_202005210647/S1695403319302061/v1_202005210647/es/main.assets" ] ] "itemSiguiente" => array:18 [ "pii" => "S2341287920300612" "issn" => "23412879" "doi" => "10.1016/j.anpede.2019.06.011" "estado" => "S300" "fechaPublicacion" => "2020-05-01" "aid" => "2682" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "An Pediatr (Barc). 2020;92:299-300" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>" "titulo" => "Controlled asystole donation in the paediatric patient" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "299" "paginaFinal" => "300" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Donación en asistolia controlada en el paciente pediátrico" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Laura Butragueño Laiseca, Milagros Sancho González, Jesús López-Herce Cid, Santiago Mencía Bartolomé" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Laura" "apellidos" => "Butragueño Laiseca" ] 1 => array:2 [ "nombre" => "Milagros" "apellidos" => "Sancho González" ] 2 => array:2 [ "nombre" => "Jesús" "apellidos" => "López-Herce Cid" ] 3 => array:2 [ "nombre" => "Santiago" "apellidos" => "Mencía Bartolomé" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S1695403319302462" "doi" => "10.1016/j.anpedi.2019.06.006" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403319302462?idApp=UINPBA00005H" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2341287920300612?idApp=UINPBA00005H" "url" => "/23412879/0000009200000005/v1_202005210725/S2341287920300612/v1_202005210725/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S2341287920300570" "issn" => "23412879" "doi" => "10.1016/j.anpede.2019.05.013" "estado" => "S300" "fechaPublicacion" => "2020-05-01" "aid" => "2673" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "An Pediatr (Barc). 2020;92:286-96" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Holistic approach of the care of the infant with hypoxic-ischaemic encephalopathy in Spain" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "286" "paginaFinal" => "296" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Atención integral del neonato con encefalopatía hipóxico-isquémica en España" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1038 "Ancho" => 1580 "Tamanyo" => 59366 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Quality of the care delivered to newborns with HIE managed with therapeutic hypothermia in the 57 hospitals that offer therapeutic hypothermia in Spain. We assigned 1 point if the hospital answered “nearly always” to questions regarding management during hypothermia (items 1–9, 12–19, 22–23), prognosis (items 84, 88, 90, 95, 97–103, 106), post-discharge followup (items 107, 108, 111–119), and current knowledge (items 58–66). For items 95–106, with answers given on a scale of 1 to 5, we assigned a score of 1 if the answer given was 5. For each hospital, we calculated the total score in absolute terms by adding the scores of all the items, and also the total score as a percentage of the maximum possible score. Each boxplot shows the total scores calculated as a percentage of the maximum possible score for all hospitals for each of the dimensions under study.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Juan Arnaez, Nuria Herranz-Rubia, Alfredo Garcia-Alix" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Juan" "apellidos" => "Arnaez" ] 1 => array:2 [ "nombre" => "Nuria" "apellidos" => "Herranz-Rubia" ] 2 => array:2 [ "nombre" => "Alfredo" "apellidos" => "Garcia-Alix" ] 3 => array:1 [ "colaborador" => "Grupo de Trabajo ESP-EHI" ] 4 => array:1 [ "colaborador" => "Grupo de Trabajo ESP-EHI. Unidades de Neonatología. Hospitales terciarios, España" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S1695403319302048" "doi" => "10.1016/j.anpedi.2019.05.013" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403319302048?idApp=UINPBA00005H" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2341287920300570?idApp=UINPBA00005H" "url" => "/23412879/0000009200000005/v1_202005210725/S2341287920300570/v1_202005210725/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>" "titulo" => "Idiopathic facial aseptic granuloma: Clinical, pathological, and ultrasound characteristics" "tieneTextoCompleto" => true "saludo" => "<span class="elsevierStyleItalic">Dear Editor</span>," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "297" "paginaFinal" => "299" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Alexandre Docampo Simón, María José Sánchez-Pujol, Luca Schneller-Pavelescu, Laura Berbegal, Isabel Betlloch Mas" "autores" => array:5 [ 0 => array:4 [ "nombre" => "Alexandre" "apellidos" => "Docampo Simón" "email" => array:1 [ 0 => "docamposimon@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "María José" "apellidos" => "Sánchez-Pujol" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Luca" "apellidos" => "Schneller-Pavelescu" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Laura" "apellidos" => "Berbegal" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "Isabel" "apellidos" => "Betlloch Mas" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital General Universitario de Alicante, Alicante, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital de Denia, Denia, Alicante, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital General Universitario de Alicante, Instituto de investigación ISABIAL, Alicante, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Granuloma aséptico facial idiopático: características clinicopatológicas y ecográficas en 7 casos" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1036 "Ancho" => 1250 "Tamanyo" => 221429 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Clinical image of case 2. (B) Clinical image of case 6 showing a chalazion in the right lower eyelid. (C) Histological examination of the lesion in the right cheek of case 6, showing a cutaneous infiltrate of lymphocytes and plasma cells with granulomas composed of histocytes and multinucleate giant cells. (D) Ultrasound of lesion in the right cheek (case 6) showing a hypoechoic structure with a rolled posterior edge.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Idiopathic facial aseptic granuloma (IFAG) is a recently described disease that affects the paediatric age group.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> It is characterised by the development of one or more nodules in the cheeks and the differential diagnosis must include other facial nodules acquired in childhood, including pilomatrixomas, dermoid cysts, bacterial infection by <span class="elsevierStyleItalic">Leishmania</span> or mycobacteria and vascular malformations. For this reason, it is probably underdiagnosed.</p><p id="par0010" class="elsevierStylePara elsevierViewall">We conducted a retrospective observational study of all cases of IFAG diagnosed in our hospital over a 12-year period. <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> summarises the characteristics of these cases. The mean age of the patients was 3 years. Three of the patients had multiple lesions. Five of the patients received oral antibiotherapy: 2 amoxicillin–clavulanic acid, 1 cefuroxime, 1 clarithromycin and 1 amoxicillin–clavulanic acid followed by azithromycin with no clear evidence of improvement. The disease tended to resolve spontaneously by a mean of 13 months. Two patients underwent surgical removal of the lesions. None of the patients experienced complications or recurrence during the follow-up.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The histological examination revealed a granulomatous reaction of the dermis, with lymphocyte and plasma cells and negative results of staining for detection of microorganisms (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>C). In one of the cases, the examination found remnants of an epidermoid cyst.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The ultrasound scan revealed hypoechoic oval structures in the dermis with the longest diameter parallel to the skin surface. There were no calcium deposits. The posterior edge was even except in 1 case in which it exhibited mildly rolled edges (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>D). The posterior hypodermis was hyperechoic. The presence of peripheral fluid was variable, and there was no fluid within the lesion in any case.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Idiopathic facial aseptic granuloma is characterised by the development of a painless, hard red or purple nodule in the cheek.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> It has a characteristic location: in 2/3 of cases, it is located within a triangle with vertices at the earlobe, the external corner of the eye and the mouth corner. There is usually a single lesion, although some patients may have more than 1. It tends to regress spontaneously in a mean of 11 months.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> All patients in our case series fit these clinical characteristics and course of disease.</p><p id="par0030" class="elsevierStylePara elsevierViewall">The mean age at onset is 46 months, with a range of 8 months to 13 years.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1,2</span></a> It is more frequent in female patients, although this was not the case in our series.</p><p id="par0035" class="elsevierStylePara elsevierViewall">The pathogenesis of IFAG has yet to be determined. One of the current hypotheses is that it could belong in the spectrum of granulomatous rosacea in children.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> The concomitant presence of chalazions (commonly associated with rosacea), described in up to 2/3 of patients at the time of diagnosis of IFAG, the subsequent development of rosacea lesions in a large number of patients, the detection of perifollicular histocyte infiltration in the histological examination, typical of granulomatous rosacea, or the response to antibiotic agents used for treatment of rosacea are some of the features that suggest an association with granulomatous rosacea.<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">3–5</span></a> In our case series, one patient developed perioral rosacea papules and another patient had a chalazion.</p><p id="par0040" class="elsevierStylePara elsevierViewall">The possibility of an infectious aetiology seems to have been excluded, at least when it comes to known pathogens.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">A third hypothesis suggests the development of a granulomatous reaction in response to an embryonal remnant.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> This possibility is supported by a case where the histological examination revealed remnants of an epidermoid cyst,<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> which we also found in one of our patients.</p><p id="par0050" class="elsevierStylePara elsevierViewall">Lastly, other proposed aetiologies include a persisting reaction to an insect bite or traumatic injury.</p><p id="par0055" class="elsevierStylePara elsevierViewall">The histological presentation of IFAG is characterised by a cutaneous inflammatory granulomatous infiltrate composed mainly of lymphocytes, histocytes, neutrophils and multinucleated foreign body giant cells in the absence of calcification or ghost cells.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">The ultrasound examination of skin lesions reveals hypoechoic oval structures in the dermis with posterior hyperechogenicity with no calcification.<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2,4</span></a> Patients with acute inflammation present with perilesional fluid, which disappears as the lesion resolves. In most cases of IFAG, there is no fluid within the lesion.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">When it comes to treatment, the previous literature describes improvement with long courses (2–3 months) of oral clarithromycin or doxycycline and topical metronidazole or ivermectin.<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">3,5</span></a> Amoxicillin–clavulanic acid, azithromycin, erythromycin and cefalexin have proven ineffective.</p><p id="par0070" class="elsevierStylePara elsevierViewall">The aim of this study was to bring attention to a disease that is probably underdiagnosed. Since this disease resolves spontaneously and is located in an area that has an aesthetic impact, the use of invasive diagnostic tests must be justified, and ultrasonography is an important non-invasive tool in its differential diagnosis. In the future, additional descriptions of IFAG cases will probably help elucidate the aetiology and optimal management of this disease.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Docampo Simón A, Sánchez-Pujol MJ, Schneller-Pavelescu L, Berbegal L, Betlloch Mas I. Granuloma aséptico facial idiopático: características clinicopatológicas y ecográficas. An Pediatr (Barc). 2020;92:297–9.</p>" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1036 "Ancho" => 1250 "Tamanyo" => 221429 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Clinical image of case 2. (B) Clinical image of case 6 showing a chalazion in the right lower eyelid. (C) Histological examination of the lesion in the right cheek of case 6, showing a cutaneous infiltrate of lymphocytes and plasma cells with granulomas composed of histocytes and multinucleate giant cells. (D) Ultrasound of lesion in the right cheek (case 6) showing a hypoechoic structure with a rolled posterior edge.</p>" ] ] 1 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Case \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Sex \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Age \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Clinical features \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Histological examination \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Ultrasound \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Time to resolution \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Male \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Indurated nodule in right cheek \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Surgical removal \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Male \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 months \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Several papules in left cheek. Plaque with central crust \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15 months \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Male \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Soft nodule in left cheek \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15 months \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Male \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Nodule in left cheekPerioral pink papulesEpisodes of facial erythema \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 months \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Male \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 months \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Purulent papule in left cheek \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14 months \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Female \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Nodule in right cheekBleedingPapule in left cheekChalazion \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Surgical removal \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Female \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Nodule in left cheek \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Ongoing \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2294237.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Patient characteristics.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:6 [ 0 => array:3 [ "identificador" => "bib0035" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Idiopathic aseptic facial granuloma (pyodermite froide du visage): a pediatric entity?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S. Roul" 1 => "C. Léauté-Labrèze" 2 => "F. Boralevi" 3 => "P. Bioulac-Sage" 4 => "J. Maleville" 5 => "A. Taïeb" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "2001" "volumen" => "137" "paginaInicial" => "1253" "paginaFinal" => "1255" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11559236" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0040" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Idiopathic facial aseptic granuloma: a multicentre prospective study of 30 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F. Boralevi" 1 => "C. Léauté-Labrèze" 2 => "S. Lepreux" 3 => "S. Barbarot" 4 => "J. Mazereeuw-Hautier" 5 => "C. Eschard" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2006.07741.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2007" "volumen" => "156" "paginaInicial" => "705" "paginaFinal" => "708" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17493068" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0045" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Idiopathic facial aseptic granuloma in a 13-year-old boy dramatically improved with oral doxycycline and topical metronidazole: evidence for a link with childhood rosacea" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C. Orion" 1 => "A. Sfecci" 2 => "L. Tisseau" 3 => "L. Darrieux" 4 => "G. Safa" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000447624" "Revista" => array:6 [ "tituloSerie" => "Case Rep Dermatol" "fecha" => "2016" "volumen" => "8" "paginaInicial" => "197" "paginaFinal" => "201" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27920676" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0050" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dramatic efficacy of topical ivermectin in idiopathic facial aseptic granuloma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E. Blind" 1 => "N. Ropars" 2 => "G. Safa" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.annder.2018.07.019" "Revista" => array:6 [ "tituloSerie" => "Ann Dermatol Venereol" "fecha" => "2018" "volumen" => "145" "paginaInicial" => "792" "paginaFinal" => "794" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30197052" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0055" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Should idiopathic facial aseptic granuloma be considered granulomatous rosacea? Report of three pediatric cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "I. Neri" 1 => "B. Raone" 2 => "A. Dondi" 3 => "C. Misciali" 4 => "A. Patrizi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1525-1470.2011.01689.x" "Revista" => array:6 [ "tituloSerie" => "Pediatr Dermatol" "fecha" => "2013" "volumen" => "30" "paginaInicial" => "109" "paginaFinal" => "111" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22340024" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0060" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Idiopathic facial aseptic granuloma: clinical and ultrasound findings in 3 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A.I. Rodríguez-Bandera" 1 => "M. Feito-Rodríguez" 2 => "R. Maseda-Pedrero" 3 => "R. de Lucas-Laguna" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ad.2017.03.024" "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2018" "volumen" => "109" "paginaInicial" => "e1" "paginaFinal" => "e5" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29724431" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/23412879/0000009200000005/v1_202005210725/S2341287920300624/v1_202005210725/en/main.assets" "Apartado" => array:4 [ "identificador" => "38181" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Scientific letters" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/23412879/0000009200000005/v1_202005210725/S2341287920300624/v1_202005210725/en/main.pdf?idApp=UINPBA00005H&text.app=https://analesdepediatria.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2341287920300624?idApp=UINPBA00005H" ]
Year/Month | Html | Total | |
---|---|---|---|
2024 November | 5 | 3 | 8 |
2024 October | 112 | 49 | 161 |
2024 September | 100 | 61 | 161 |
2024 August | 129 | 86 | 215 |
2024 July | 144 | 39 | 183 |
2024 June | 106 | 67 | 173 |
2024 May | 144 | 41 | 185 |
2024 April | 90 | 45 | 135 |
2024 March | 89 | 25 | 114 |
2024 February | 154 | 33 | 187 |
2024 January | 134 | 28 | 162 |
2023 December | 174 | 46 | 220 |
2023 November | 216 | 39 | 255 |
2023 October | 130 | 45 | 175 |
2023 September | 117 | 25 | 142 |
2023 August | 147 | 27 | 174 |
2023 July | 161 | 58 | 219 |
2023 June | 108 | 34 | 142 |
2023 May | 163 | 37 | 200 |
2023 April | 152 | 30 | 182 |
2023 March | 147 | 33 | 180 |
2023 February | 166 | 31 | 197 |
2023 January | 165 | 28 | 193 |
2022 December | 177 | 48 | 225 |
2022 November | 166 | 54 | 220 |
2022 October | 174 | 57 | 231 |
2022 September | 178 | 47 | 225 |
2022 August | 183 | 56 | 239 |
2022 July | 123 | 45 | 168 |
2022 June | 108 | 41 | 149 |
2022 May | 132 | 44 | 176 |
2022 April | 114 | 54 | 168 |
2022 March | 152 | 58 | 210 |
2022 February | 170 | 44 | 214 |
2022 January | 188 | 36 | 224 |
2021 December | 179 | 42 | 221 |
2021 November | 170 | 41 | 211 |
2021 October | 241 | 75 | 316 |
2021 September | 189 | 40 | 229 |
2021 August | 173 | 39 | 212 |
2021 July | 222 | 35 | 257 |
2021 June | 186 | 42 | 228 |
2021 May | 251 | 49 | 300 |
2021 April | 520 | 74 | 594 |
2021 March | 789 | 46 | 835 |
2021 February | 230 | 30 | 260 |
2021 January | 278 | 22 | 300 |
2020 December | 194 | 20 | 214 |
2020 November | 122 | 25 | 147 |
2020 October | 116 | 10 | 126 |
2020 September | 158 | 37 | 195 |
2020 August | 146 | 38 | 184 |
2020 July | 141 | 38 | 179 |
2020 June | 64 | 30 | 94 |
2020 May | 71 | 30 | 101 |
2020 April | 1 | 0 | 1 |