Scientific Letter
Newborn screening for congenital hypothyroidism: a 13-year observational study
Cribado neonatal de hipotiroidismo congénito: estudio observacional de 13 años
Read
7599
Timeswas read the article
2259
Total PDF
5340
Total HTML
Share statistics
array:25 [ "pii" => "S2341287919301498" "issn" => "23412879" "doi" => "10.1016/j.anpede.2019.06.005" "estado" => "S300" "fechaPublicacion" => "2020-07-01" "aid" => "2698" "copyright" => "Asociación Española de Pediatría" "copyrightAnyo" => "2020" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "An Pediatr (Barc). 2020;93:50-2" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 624 "formatos" => array:3 [ "EPUB" => 17 "HTML" => 494 "PDF" => 113 ] ] "Traduccion" => array:1 [ "es" => array:20 [ "pii" => "S1695403319302632" "issn" => "16954033" "doi" => "10.1016/j.anpedi.2019.06.015" "estado" => "S300" "fechaPublicacion" => "2020-07-01" "aid" => "2698" "copyright" => "Asociación Española de Pediatría" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "An Pediatr (Barc). 2020;93:50-2" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 740 "formatos" => array:3 [ "EPUB" => 37 "HTML" => 530 "PDF" => 173 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">CARTA CIENTÍFICA</span>" "titulo" => "Cribado neonatal de hipotiroidismo congénito: estudio observacional de 13 años" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "50" "paginaFinal" => "52" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Newborn screening for congenital hypothyroidism: A 13-year observational study" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1213 "Ancho" => 2508 "Tamanyo" => 215231 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Resultados generales del estudio.</p> <p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Entre enero del 2006 y diciembre del 2009 se empleó un punto de corte de 8,5 mU/l. En este período, se diagnosticaron 5 casos de HC y 9 de hipertiroxinemia con pruebas adicionales. El nivel de TSH en el cribado neonatal en estos casos había estado entre 8,5 y 9,0 mU/l.</p> <p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">HC: hipotiroidismo congénito; TSH: tirotropina; TSHn: tirotropina en cribado neonatal; T4l: tiroxina libre.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Yanni Zhang, Yuqi Yang, Hongmei Mu, Jun Chen, Jiang Jian" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Yanni" "apellidos" => "Zhang" ] 1 => array:2 [ "nombre" => "Yuqi" "apellidos" => "Yang" ] 2 => array:2 [ "nombre" => "Hongmei" "apellidos" => "Mu" ] 3 => array:2 [ "nombre" => "Jun" "apellidos" => "Chen" ] 4 => array:2 [ "nombre" => "Jiang" "apellidos" => "Jian" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2341287919301498" "doi" => "10.1016/j.anpede.2019.06.005" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2341287919301498?idApp=UINPBA00005H" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403319302632?idApp=UINPBA00005H" "url" => "/16954033/0000009300000001/v1_202007120738/S1695403319302632/v1_202007120738/es/main.assets" ] ] "itemSiguiente" => array:20 [ "pii" => "S2341287920300855" "issn" => "23412879" "doi" => "10.1016/j.anpede.2019.07.008" "estado" => "S300" "fechaPublicacion" => "2020-07-01" "aid" => "2696" "copyright" => "Asociación Española de Pediatría" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "An Pediatr (Barc). 2020;93:52-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific letter</span>" "titulo" => "Adhesive sutures using cyanoacrylate in pleural drains of premature infants" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "52" "paginaFinal" => "54" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Suturas adhesivas mediante cianoacrilato en drenajes pleurales de prematuros" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 955 "Ancho" => 1800 "Tamanyo" => 161222 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A-E) Caso 2-B: A) Right-sided chest drain. B) Removal of drain and closure with liquid tissue adhesive. C) 24 h after closure. D) 48 h after closure. E and F) Case 1: E) 1 week after closure. F) 30 days after closure.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Inmaculada Lara-Cantón, Pilar Sáenz-González, Ana García-Robles, Maria Dolores Lorena Mocholí-Tomás, Álvaro Solaz-García" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Inmaculada" "apellidos" => "Lara-Cantón" ] 1 => array:2 [ "nombre" => "Pilar" "apellidos" => "Sáenz-González" ] 2 => array:2 [ "nombre" => "Ana" "apellidos" => "García-Robles" ] 3 => array:2 [ "nombre" => "Maria Dolores Lorena" "apellidos" => "Mocholí-Tomás" ] 4 => array:2 [ "nombre" => "Álvaro" "apellidos" => "Solaz-García" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S1695403319302619" "doi" => "10.1016/j.anpedi.2019.07.005" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403319302619?idApp=UINPBA00005H" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2341287920300855?idApp=UINPBA00005H" "url" => "/23412879/0000009300000001/v1_202007160923/S2341287920300855/v1_202007160923/en/main.assets" ] "itemAnterior" => array:20 [ "pii" => "S2341287919301796" "issn" => "23412879" "doi" => "10.1016/j.anpede.2019.06.006" "estado" => "S300" "fechaPublicacion" => "2020-07-01" "aid" => "2700" "copyright" => "Asociación Española de Pediatría" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "An Pediatr (Barc). 2020;93:49-50" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 666 "formatos" => array:3 [ "EPUB" => 16 "HTML" => 601 "PDF" => 49 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>" "titulo" => "GIANOTTI-CROSTI SYNDROME-LIKE REACTION SECONDARY TO MOLLUSCUM CONTAGIOSUM" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "49" "paginaFinal" => "50" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "SÍNDROME GIANOTTI-CROSTI LIKE SECUNDARIO A MOLLUSCUM CONTAGIOSUM" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 838 "Ancho" => 1750 "Tamanyo" => 149658 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">1- Patient 3. 10-year-old male with Gianotti-Crosti syndrome-like reaction to molluscum contagiosum. (1a) Inflamed MC lesions in the thigh. (1b) Inflammatory oedematous red papules on the elbows. (1c) Pink papules on the knees, Koebner response secondary to scratching.</p> <p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">2- Patient 1. 8-year-old female with Gianotti-Crosti syndrome-like reaction to molluscum contagiosum. (2a) Inflamed MC in the cervical area. (2b-c) Oedematous pink to red papules on the elbows and knees.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Andrea Estébanez, Esmeralda Silva, Santiago Guillen, Alejandro García, Jose M. Martín" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Andrea" "apellidos" => "Estébanez" ] 1 => array:2 [ "nombre" => "Esmeralda" "apellidos" => "Silva" ] 2 => array:2 [ "nombre" => "Santiago" "apellidos" => "Guillen" ] 3 => array:2 [ "nombre" => "Alejandro" "apellidos" => "García" ] 4 => array:2 [ "nombre" => "Jose M." "apellidos" => "Martín" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S1695403319302693" "doi" => "10.1016/j.anpedi.2019.06.016" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403319302693?idApp=UINPBA00005H" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2341287919301796?idApp=UINPBA00005H" "url" => "/23412879/0000009300000001/v1_202007160923/S2341287919301796/v1_202007160923/en/main.assets" ] "en" => array:18 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>" "titulo" => "Newborn screening for congenital hypothyroidism: a 13-year observational study" "tieneTextoCompleto" => true "saludo" => "Dear Editor:" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "50" "paginaFinal" => "52" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Yanni Zhang, Yuqi Yang, Mu Hongmei, Jun Chen, Jiang Jian" "autores" => array:5 [ 0 => array:3 [ "nombre" => "Yanni" "apellidos" => "Zhang" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "Yuqi" "apellidos" => "Yang" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Mu" "apellidos" => "Hongmei" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Jun" "apellidos" => "Chen" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:4 [ "nombre" => "Jiang" "apellidos" => "Jian" "email" => array:1 [ 0 => "ybcz0519@163.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Hospital Materno-Infantil de Ankang, Ankang, Shaanxi, China" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Hospital Materno-Infantil de Changzhou, Universidad Médica de Nanjing, Changzhou, Jiangsu, China" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Cribado neonatal de hipotiroidismo congénito: estudio observacional de 13 años" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1262 "Ancho" => 2508 "Tamanyo" => 199403 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">General results of the study.</p> <p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Note: *From Jan 2006 to Dec 2009, we used the cutoff as 8.5 mIU/L. During the period, 5 cases of CH and 9 of hyperthyroxinemia were diagnosed with additional recall. Their NTSH were between 8.5 and 9.0.</p> <p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">CH, congenital hypothyroidism; FT4, free thyroxine; NTSH, neonatal thyroid stimulating hormone level; TSH, thyroid stimulating hormone level.</p> <p id="spar0020" class="elsevierStyleSimplePara elsevierViewall"> .</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Newborn screening is an important method for the early detection and treatment of congenital defects, and it plays a key role in improving children's health.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Many countries consider newborn screening an important national public health programme, and screening for certain diseases is widespread. Newborn screening for detection of congenital hypothyroidism (CH) is performed worldwide since the 1970s and has proven useful for the detection of this disease. We conducted a retrospective study in which we analysed the clinical data corresponding to CH screening for the past 13 years, focusing on the distribution of the results, the optimal cut-off points for definition of positive results, possible associated factors, etc.</p><p id="par0010" class="elsevierStylePara elsevierViewall">A signed informed consent form was obtained for screening of each newborn. The dried blood spot (DBS) samples were collected from the infants on 903 filter paper at 72 h post birth. The level of thyroid stimulating hormone (TSH) in the samples was measured by means of time-resolved fluoroimmunoassay (TRFIA). In case of a positive result, serum levels of TSH and free thyroxine (FT4) were measured by electrochemical immunoassay (ECIA).</p><p id="par0015" class="elsevierStylePara elsevierViewall">The study includes a total of 437,342 newborn infants for whom consent was given to perform screening. <a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a> shows the overall results of the study. A total of 192 infants ultimately received a diagnosis of CH, corresponding to 105 boys and 87 girls. The incidence of CH was of 1 case per 2278 births, which was consistent with the average reported for China.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> At the same time, this diverged slightly from the incidence in other countries.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">In the group of infants with CH, the median level of TSH was 46.10 mIU/L (interquartile range [IQR], 17.90–120.00), compared to 2.39 mIU/L in infants with normal test results. In the subsequent serologic tests, the median serum level of TSH was 75.0 mIU/L (IQR, 75.00–75.00) and the median level of FT4 was 5.14 pmol/L (IQR, 2.83–8.39). The cut-off value used for detection of CH between January 2006 and December 2009 was 8.5 mIU/L. During the period under study, an additional 5 cases of CH were diagnosed, and the serum TSH levels in these infants were 8.58, 8.82, 8.86, 8.87 and 8.95 mIU/L. Screening for CH has been widespread for many years and is proven to be effective. However, a growing number of experts is trying to determine the optimal TSH threshold that should be used to differentiate infants with CH from otherwise healthy newborns and minimise the frequency of false positive results. In order to optimise the TSH threshold, we plotted receiver operating characteristic (ROC) curves and calculated the corresponding areas under the curve (AUCs) with the data of our 430 thousand patients. The AUC for detection of CH was 0.996 applying a cutoff of 9.0 mIU/L. The corresponding sensitivity, specificity, precision, positive predictive value (PPV) and negative predictive value (NPV) were 96.89%, 99.13%, 99.13%, 4.70% and 99.99%, respectively. The optimal cut-off value in our study was 8.58 mIU/L, as it yielded the best combination of sensitivity (99.48%) and specificity (97.70%). Similar studies have been carried out in other countries, corroborating that optimization of the TSH threshold can improve the effectiveness of CH screening.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,4</span></a> We also believe that it is necessary to adjust the TSH threshold for local populations through the analysis of retrospective data.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Evidence from various studies suggests that CH is associated with multiple factors. The season of birth season is one of factors that have attracted the attention of researchers. <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> showed the data of the association between the screening indicators and the season of birth. We found that the newborn screening programme of CH achieved the best results in the fourth trimester of the year, with an AUC greater than 0.99 and a precision of more than 95%. This was similar to the results reported by Khanjani et al.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Several authors have identified different factors that may be involved in the association between the prevalence of CH and the season of birth, such as viral infection, differences in climate, living conditions, or the differences in iodine levels that exist between geographical areas.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">In conclusion, our analysis of a large clinical sample confirmed that the incidence of CH was reliable and the newborn screening programme was effective. However, the yield of screening programmes can still be improved by adjusting the TSH thresholds applied in local screening programmes and correcting for possible confounding factors, such as the season.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0035" class="elsevierStylePara elsevierViewall">This study was supported by grants from the <span class="elsevierStyleGrantSponsor" id="gs0005">Key Research and Development Plan Project of Jiangsu Province</span> (<span class="elsevierStyleGrantNumber" refid="gs0005">BE2017650</span>), the <span class="elsevierStyleGrantSponsor" id="gs0010">Changzhou Science and Technology Support Project</span> (Social Development <span class="elsevierStyleGrantNumber" refid="gs0010">CE20175021</span>), and the <span class="elsevierStyleGrantSponsor" id="gs0015">Jiangsu Mother and Child Health Research Project</span> (<span class="elsevierStyleGrantNumber" refid="gs0015">F201671</span>).</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Funding" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2019-03-13" "fechaAceptado" => "2019-06-17" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Please cite this article as: Zhang Y, Yang Y, Mu H, Chen J, Jian J. Cribado neonatal de hipotiroidismo congénito: estudio observacional de 13 años. An Pediatr (Barc). 2020;93:50–52.</p>" ] ] "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1262 "Ancho" => 2508 "Tamanyo" => 199403 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">General results of the study.</p> <p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Note: *From Jan 2006 to Dec 2009, we used the cutoff as 8.5 mIU/L. During the period, 5 cases of CH and 9 of hyperthyroxinemia were diagnosed with additional recall. Their NTSH were between 8.5 and 9.0.</p> <p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">CH, congenital hypothyroidism; FT4, free thyroxine; NTSH, neonatal thyroid stimulating hormone level; TSH, thyroid stimulating hormone level.</p> <p id="spar0020" class="elsevierStyleSimplePara elsevierViewall"> .</p>" ] ] 1 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:3 [ "leyenda" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">AUC, area under the curve; CH, congenital hypothyroidism; CI, confidence interval; IQR, interquartile range; TSH, thyroid-stimulating hormone.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Months \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Number of newborns \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">CHT \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Prevalence (/10 000) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">TSH median (IQR) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">False positive rate \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">AUC \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">95% CI \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">January–March \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">104 461 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">41 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.92 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.78 (1.68– 4.34) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.34% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.9958 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.9936–0.9981 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">April–June \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">94 226 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">37 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.93 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.29 (1.35– 3.59) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.70% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.9902 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.9763–0.999 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">July–September \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">107 419 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">46 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.28 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.19 (1.29–3.41) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.52% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.9985 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.9977–0.9994 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">October–December \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">130 998 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">69 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5.27 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.60 (1.57– 4.03) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.89% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.9983 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.9974–0.9993 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Total \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">437 103<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">193<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.42 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.47 (1.47– 3.86) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.87% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.9961 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.9930–0.9992 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2341798.png" ] ] ] "notaPie" => array:2 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">The analysis did not include the data of 239 babies who were lost to followup.</p>" ] 1 => array:3 [ "identificador" => "tblfn0010" "etiqueta" => "b" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Screening failed to detect 1 case of CHT.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Association between screening indicators and season.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neonatal screening programs" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "B. Keskinkılıç" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.clinbiochem.2014.05.009" "Revista" => array:5 [ "tituloSerie" => "Clin Biochem" "fecha" => "2014" "volumen" => "47" "paginaInicial" => "692" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24845716" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The status of neonatal screening in China" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K. Zhong" 1 => "W. Wang" 2 => "F. He" 3 => "Z. Wang" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Med Screen" "fecha" => "2013" "volumen" => "2016" "numero" => "23" "paginaInicial" => "59" "paginaFinal" => "61" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Detecting congenital hypothyroidism with newborn screening: the relevance of thyroid-stimulating hormone cutoff values" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.M. Silvestrin" 1 => "C. Leone" 2 => "Cr Leone" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Pediatr (Rio J)" "fecha" => "2017" "volumen" => "93" "paginaInicial" => "274" "paginaFinal" => "280" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluation of the revised New Zealand national newborn screening protocol for congenital hypothyroidism" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "N.L. Heather" 1 => "P.L. Hofman" 2 => "M. de Hora" 3 => "J. Carll" 4 => "J.G. Derraik" 5 => "D. Webster" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin Endocrinol (Oxf)" "fecha" => "2017" "volumen" => "86" "paginaInicial" => "431" "paginaFinal" => "437" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of season and climate in the incidence of congenital hypothyroidism in Kerman province, Southeastern Iran" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "N. Khanjani" 1 => "A. Ahmadzadeh" 2 => "B. Bakhtiari" 3 => "F. Madadizadeh" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1515/jpem-2016-0010" "Revista" => array:6 [ "tituloSerie" => "J Pediatr Endocrinol Metab" "fecha" => "2017" "volumen" => "30" "paginaInicial" => "149" "paginaFinal" => "157" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27941171" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/23412879/0000009300000001/v1_202007160923/S2341287919301498/v1_202007160923/en/main.assets" "Apartado" => array:4 [ "identificador" => "38181" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Scientific letters" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/23412879/0000009300000001/v1_202007160923/S2341287919301498/v1_202007160923/en/main.pdf?idApp=UINPBA00005H&text.app=https://analesdepediatria.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2341287919301498?idApp=UINPBA00005H" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 21 | 16 | 37 |
| 2024 October | 97 | 56 | 153 |
| 2024 September | 98 | 41 | 139 |
| 2024 August | 129 | 61 | 190 |
| 2024 July | 123 | 30 | 153 |
| 2024 June | 118 | 22 | 140 |
| 2024 May | 81 | 43 | 124 |
| 2024 April | 61 | 34 | 95 |
| 2024 March | 76 | 41 | 117 |
| 2024 February | 86 | 37 | 123 |
| 2024 January | 91 | 35 | 126 |
| 2023 December | 88 | 33 | 121 |
| 2023 November | 113 | 64 | 177 |
| 2023 October | 107 | 42 | 149 |
| 2023 September | 142 | 31 | 173 |
| 2023 August | 53 | 19 | 72 |
| 2023 July | 55 | 39 | 94 |
| 2023 June | 40 | 33 | 73 |
| 2023 May | 63 | 25 | 88 |
| 2023 April | 39 | 33 | 72 |
| 2023 March | 62 | 29 | 91 |
| 2023 February | 55 | 24 | 79 |
| 2023 January | 57 | 22 | 79 |
| 2022 December | 90 | 31 | 121 |
| 2022 November | 99 | 53 | 152 |
| 2022 October | 98 | 49 | 147 |
| 2022 September | 76 | 33 | 109 |
| 2022 August | 79 | 47 | 126 |
| 2022 July | 86 | 55 | 141 |
| 2022 June | 61 | 35 | 96 |
| 2022 May | 74 | 34 | 108 |
| 2022 April | 63 | 42 | 105 |
| 2022 March | 88 | 50 | 138 |
| 2022 February | 79 | 36 | 115 |
| 2022 January | 96 | 32 | 128 |
| 2021 December | 80 | 47 | 127 |
| 2021 November | 90 | 37 | 127 |
| 2021 October | 161 | 75 | 236 |
| 2021 September | 90 | 52 | 142 |
| 2021 August | 116 | 44 | 160 |
| 2021 July | 68 | 28 | 96 |
| 2021 June | 73 | 41 | 114 |
| 2021 May | 91 | 57 | 148 |
| 2021 April | 168 | 82 | 250 |
| 2021 March | 106 | 48 | 154 |
| 2021 February | 52 | 30 | 82 |
| 2021 January | 67 | 27 | 94 |
| 2020 December | 90 | 32 | 122 |
| 2020 November | 86 | 22 | 108 |
| 2020 October | 63 | 22 | 85 |
| 2020 September | 62 | 31 | 93 |
| 2020 August | 111 | 16 | 127 |
| 2020 July | 145 | 25 | 170 |
| 2020 June | 78 | 20 | 98 |
| 2020 May | 59 | 30 | 89 |
| 2020 April | 46 | 17 | 63 |
| 2020 March | 63 | 37 | 100 |
| 2020 February | 59 | 42 | 101 |
| 2020 January | 52 | 14 | 66 |
| 2019 December | 68 | 21 | 89 |
| 2019 November | 63 | 23 | 86 |
| 2019 October | 64 | 20 | 84 |
| 2019 September | 225 | 12 | 237 |
Show all
