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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Necrotising enterocolitis &#40;NEC&#41;&#44; first described by Siebold in 1825&#44;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">1</span></a> is the most common gastrointestinal emergency occurring in neonatal intensive care units &#40;NICUs&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">2</span></a> with an estimated incidence of 0&#46;3&#8211;3 cases per 1&#44;000 live births&#46;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">3&#44;4</span></a> Its aetiology is not well understood&#44; although it is hypothesised that it is related to decreased perfusion and ischaemia of the intestinal wall &#40;particularly in immature intestines&#41;&#44; leading to disruption of the intestinal barrier and enabling bacterial passage and activation of inflammatory mediators&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">5</span></a> The main risk factors for the development of this disease are preterm birth&#44; perinatal asphyxia&#44; early enteral feeding in preterm newborns&#44; congenital heart defects and umbilical catheterization&#44; among others&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Necrotising enterocolitis should not be confused with focal intestinal perforation&#44; which is less frequent and affects up to 2&#37; of extremely low birth weight infants&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">3</span></a> Other differential features of focal intestinal perforation are&#58; lack of systemic involvement&#44; absence of intestinal pneumatosis&#44; earlier onset&#44; lower birth weight and extreme prematurity&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Necrotising enterocolitis is classified according to the staging criteria proposed by Bell et al&#46; as stage I &#40;suspected&#41;&#44; <span class="elsevierStyleSmallCaps">ii</span> &#40;proven&#41; or <span class="elsevierStyleSmallCaps">iii</span> &#40;advanced&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">6</span></a> a system that was later modified by Walsh and Kliegman in 1986&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">7</span></a> In this modified scheme&#44; stages are further subdivided into A or B depending on the radiographic findings&#58; stage I<span class="elsevierStyleSmallCaps">A</span> or B &#40;normal or intestinal dilation&#41;&#44; stage IIA &#40;ileus&#44; pneumatosis intestinalis&#41; or IIB &#40;portal venous gas&#41;&#44; stage IIIA &#40;ascites&#41; or IIIB &#40;pneumoperitoneum&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">5&#44;6</span></a> Another classification scheme was published in the <span class="elsevierStyleItalic">Vermont Oxford Network Manual of Operations</span> that described the clinical and radiographic findings required to establish the diagnosis of NEC&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">8</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">There is widespread agreement that surgical intervention is necessary in patients with NEC that have developed intestinal gangrene&#44; whose presence is evident if it leads to perforation and pneumoperitoneum&#44; which is not always the case&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">9</span></a> Free air in the abdominal cavity is the only radiographic feature universally accepted as an indication for surgical intervention in NEC&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">10</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The aim of this study was to analyse the cases of NEC treated with surgery to establish the reasons that led to performance of surgery&#44; to determine whether pneumoperitoneum had been present in all patients with bowel perforation&#44; and to assess patient outcomes based on whether pneumoperitoneum had or had not been present before surgery&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">To this end&#44; we compared the radiographic findings &#40;whether pneumoperitoneum was present or absent&#41; with the surgical findings and the outcomes in a group of patients with NEC that underwent surgical intervention&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Sample and methods</span><p id="par0035" class="elsevierStylePara elsevierViewall">We conducted a retrospective study in a cohort of newborns with NEC that underwent surgery between January 2006 and December 2015&#46; We divided these patients into 2 groups for comparison based on the preoperative presence or absence of pneumoperitoneum &#40;P&#43;&#47;P&#8211;&#41;&#46; We compared both groups based on the surgical findings&#44; which included the length of resected bowel and the presence or absence of NEC <span class="elsevierStyleItalic">totalis</span> &#40;involvement of 3 or more bowel segments&#41;&#46; We also compared other variables related to morbidity and mortality&#58; duration of symptoms from onset to the day of surgery&#44; days of intubation&#44; days of total parenteral nutrition&#44; days from surgery at initiation of enteral feeding&#44; length of stay in days&#44; and mortality&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">In addition&#44; we assessed interrater reliability&#44; using the kappa statistic to compare the interpretation of the preoperatory findings made a posteriori by an expert paediatric radiologist masked to the symptoms to the preoperatory assessment made jointly by the neonatologist and the on-call paediatric surgeon&#46; A <span class="elsevierStyleItalic">kappa</span> value of 0 signifies a total absence of interrater agreement&#44; while a value of 1 signifies perfect agreement&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">4</span></a> We assessed the level of agreement applying the criteria proposed by Landis and Koch&#58; <span class="elsevierStyleItalic">k</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;20 &#40;very poor&#41;&#44; 0&#46;21<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">k</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;40 &#40;poor&#41;&#44; 0&#46;41<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">k</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;60 &#40;fair&#41;&#44; 0&#46;61<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">k</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;80 &#40;good&#41;&#44; and 0&#46;81<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">k</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>1&#46;00 &#40;excellent&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">11</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">To compare qualitative variables&#44; we used the chi square test or the Fisher exact test as appropriate&#46; We compared quantitative variables by means of the nonparametric Mann&#8211;Whitney <span class="elsevierStyleItalic">U</span> test&#46; We assessed survival using the Kaplan&#8211;Meier method&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">We set the alpha level to define statistical significance at 0&#46;05&#46; The statistical analysis was performed with the software SPSS version 23&#46;0&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Results</span><p id="par0055" class="elsevierStylePara elsevierViewall">In the 10 years under study&#44; 53 patients with NEC underwent surgical intervention&#46; They had been born at a median of 28<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>6 weeks&#8217; gestation &#40;range&#44; 23&#8211;41 weeks&#41; with a mean birth weight of 1229<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>581<span class="elsevierStyleHsp" style=""></span>g &#40;range&#44; 590&#8211;3087<span class="elsevierStyleHsp" style=""></span>g&#41;&#44; with 94&#46;3&#37; being born with a low birth weight &#40;50 newborns with weight &#60;2500<span class="elsevierStyleHsp" style=""></span>g&#41;&#44; 73&#46;6&#37; with a very low birth weight &#40;39 newborns with weight &#60;1500<span class="elsevierStyleHsp" style=""></span>g&#41; and 50&#46;9&#37; with an extremely low birth weight &#40;27 newborns with weight &#60;1000<span class="elsevierStyleHsp" style=""></span>g&#41;&#46; We estimated an incidence of surgical NEC of 7 newborns per 10&#44;000 live births&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">In this cohort&#44; 51&#37; of patients were female &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>27&#41; and 94&#46;3&#37; had been born preterm &#40;born before 37 weeks&#8217; gestation&#44; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>50&#41;&#44; with 77&#46;4&#37; born very or extremely preterm &#40;born before 32 weeks&#8217; gestation&#44; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>41&#41;&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The mean age at the time of surgery was 19<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>14 days &#40;range&#44; 2&#8211;63 days&#41;&#44; and the mean weight was 1474<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>669<span class="elsevierStyleHsp" style=""></span>g &#40;range&#44; 650&#8211;3750<span class="elsevierStyleHsp" style=""></span>g&#41;&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">The sensitivity of abdominal radiography for the diagnosis of pneumoperitoneum is 54&#46;5&#37;&#44; while the specificity is 92&#46;3&#37;&#46; In 36&#37; of patients &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>19&#41;&#44; surgery was performed due to the presence of pneumoperitoneum&#44; while in the remaining patients &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>34&#41; it was performed for other reasons &#40;clinical deterioration&#44; metabolic derangement or intestinal obstruction&#41; &#40;Fig 1&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">When we analysed the two groups defined by the presence or absence of pneumoperitoneum &#40;P&#43;&#47;P&#8211;&#41;&#44; we found a shorter duration of symptoms from onset to surgery in the P&#43; group&#44; with a mean of 2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;7 days &#40;range&#44; 1&#8211;3 days&#41; compared to 7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8 days in the P&#8211; group &#40;range&#44; 3&#8211;10 days&#41;&#44; and also a shorter length of stay&#44; which was of 79<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>28 days in the P&#43; group &#40;60&#8211;98&#41; compared to 127<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>43 days in the P&#8211; group &#40;103&#8211;150&#41; &#40;excluding deceased patients&#41;&#44; differences that were statistically significant &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;008 and <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;003&#44; respectively&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; The differences remained significant when we adjusted the analysis for weight&#58; in the group with birth weights of more than 1000<span class="elsevierStyleHsp" style=""></span>g &#40;&#43;1000<span class="elsevierStyleHsp" style=""></span>g&#41;&#44; the mean length of stay was 58<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10 days in P&#43; newborns &#40;range&#44; 48&#8211;69&#41; compared to 89<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15 days in the P&#8211; group &#40;range&#44; 71&#8211;107&#41; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;005&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; We also found differences in the group with birth weight of less than 1000<span class="elsevierStyleHsp" style=""></span>g&#44; although they were not statistically significant&#58; mean of 107<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20 days &#40;range&#44; 78&#8211;135&#41; in the P&#43; group vs&#46; 146<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>43 days &#40;range&#44; 116&#8211;175&#41; in the P&#8211; group &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;064&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">When we analysed mortality&#44; we did not find statistically significant differences between the two groups&#46; The overall mortality was 41&#46;5&#37;&#44; corresponding to 10 newborns in the P&#43; group &#40;45&#37;&#41; and 12 of the P&#8211; group &#40;55&#37;&#41;&#46; We also found no statistically significant differences in any of the other variables under study &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">The <span class="elsevierStyleItalic">kappa</span> statistic was 0&#46;7&#44; which corresponds to a good correlation based on the criteria proposed by Landis and Koch&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Discussion</span><p id="par0090" class="elsevierStylePara elsevierViewall">Necrotising enterocolitis is one of the main causes of morbidity and mortality in newborns&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">12</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">Most cases of NEC occur in preterm newborns&#46; The mean gestational age at birth in our cohort was 28<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>6 weeks &#40;range&#44; 23&#8211;41&#41;&#44; which was consistent with previous studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">13&#44;14</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">The mean birth weight in our cohort was 1229<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>581<span class="elsevierStyleHsp" style=""></span>g&#44; with a range of 590&#8211;3087<span class="elsevierStyleHsp" style=""></span>g&#44; which was similar to the findings reported in the literature&#44;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">15</span></a> although there seems to be a declining trend in the mean birth weight of patients with surgical NEC&#44; as suggested by other authors&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">9</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">The mean age at the time of surgery in our study was 19 days &#40;range&#44; 2&#8211;63&#41;&#44; which was similar to the one reported in a study conducted in 2002<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">16</span></a> and another study we found in the reviewed literature&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">13</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">When medical treatment fails &#40;including antibiotherapy&#44; discontinuation of enteral feeding and supportive care&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">17</span></a> the decision to perform surgery is based on radiographic findings and clinical manifestations suggestive of metabolic derangement&#46;<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">2&#44;8</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">In patients with suspected NEC&#44; a radiological evaluation can confirm the staging as proven or advanced&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">18</span></a> Extraluminal air &#40;free air&#41; is a sign of advanced NEC<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">8</span></a> and the sole radiologic finding that is universally accepted as an indication for surgical intervention&#44;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">19</span></a> as it is direct evidence of perforation&#46; Some authors consider metabolic derangement a sufficient indication for surgery and have established a series of laboratory criteria and thresholds to determine the appropriateness of intervention&#44; even in the absence of pneumoperitoneum&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">3</span></a> We ought to highlight the importance of obtaining the two radiographic images &#40;antero-posterior view and horizontal beam view with the patient in the supine position&#41; within 48<span class="elsevierStyleHsp" style=""></span>h from onset&#44; as most perforations develop in that time interval&#44;<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">10&#44;12</span></a> something that we corroborated in our results&#44; as we found that a mean of 2 days elapsed from the onset of symptoms to evidence of pneumoperitoneum&#44; with a range of 1&#8211;3 days&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Pneumoperitoneum is not always present and is found in 50&#8211;75&#37; of patients with intestinal perforation due to NEC&#44;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">20</span></a> with other authors reporting its presence in as few as 12&#8211;50&#37; of these patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">18&#44;21</span></a> Thus&#44; the sensitivity of this radiographic finding is much lower than expected&#46; In our study&#44; its sensitivity was 54&#46;5&#37;&#46; There are several possible explanations for the absence of pneumoperitoneum in cases of intestinal perforation&#58; &#40;1&#41; perforation of the jejunum or ileus&#44; which may not contain air&#59; &#40;2&#41; early closure of perforation&#59; &#40;3&#41; retroperitoneal perforation&#59; &#40;4&#41; small amount of gas due to effective suction through a nasogastric tube&#59; &#40;5&#41; lack of an optimal radiographic view showing the pneumoperitoneum&#44; and &#40;6&#41; perforation occurring after obtaining the radiograph and before surgery&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">1</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">This radiographic feature is not always easy to identify&#44; and there are several radiographic signs that help detect its presence&#58; Rigler&#39;s sign &#40;gas on both sides of the intestinal wall&#41;&#44; the falciform ligament sign &#40;gas outlining the falciform ligament&#41;&#44; the football sign &#40;gas outlining the peritoneal cavity&#41;&#44; the inverted-V sign &#40;gas outlining the medial umbilical folds&#41; and right-upper-quadrant gas sign &#40;localised gas in this quadrant&#44; in the subhepatic space&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">22</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">Some critically ill infants require mechanical ventilation&#44; which may cause pneumothorax or pneumomediastinum and therefore pneumoperitoneum&#46; In these patients&#44; it is important to perform a correct differential diagnosis of gastrointestinal perforation and medical pneumoperitoneum to avoid unnecessary surgical procedures&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">23</span></a> We found one such patient in this study&#46; As we mentioned before&#44; pneumoperitoneum was the indication for surgery in 39&#37; of cases&#44; a proportion that was similar to those reported in other studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">24&#44;25</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">In the past&#44; there was widespread agreement that the prognosis of patients with NEC worsened once intestinal perforation occurred&#44;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">1&#44;10&#44;26</span></a> although the published evidence is not completely concordant on this aspect&#46;<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">24&#44;27</span></a> As Grosfeld et al&#46; already stated in 1991&#44; early diagnosis&#44; advances in neonatal intensive care and prompt surgical intervention when indicated have improved survival in patients with NEC&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">28</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">In our study&#44; we found that even adjusting for weight&#44; radiographic evidence of pneumoperitoneum was not in and of itself associated to poorer outcomes&#44; but rather the opposite&#46; This was probably due to the association of pneumoperitoneum with a shorter duration of symptoms before surgery compared to patients without pneumoperitoneum&#46; In many cases&#44; the decision to perform surgery in preterm infants with manifestations suggestive of NEC is delayed for days while the patient receives more aggressive medical treatment&#44; precisely because there are no radiographic findings that clearly &#8220;invite&#8221; the surgeon to intervene&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Considering the low sensitivity of abdominal radiography found in our study&#44; relying on the detection of free abdominal air as the sole definitive indication for surgery should by now be considered obsolete or risky&#46; Other authors also recommend against waiting for stage IIIB NEC to operate&#44; given that it may not always be detected radiographically&#44; as long as the patient develops metabolic derangement or infection despite adequate medical treatment&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">In our study&#44; 10 patients in the pneumoperitoneum group &#40;45&#37;&#41; and 12 in the group without pneumoperitoneum &#40;55&#37;&#41; died&#46; The overall mortality was 41&#46;5&#37;&#44; a proportion that was similar to those reported in other case series&#44; which range between 55&#37; and 83&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">5&#44;13</span></a></p><p id="par0155" class="elsevierStylePara elsevierViewall">The kappa statistic found in this study revealed a very good interrater reliability &#40;0&#46;7&#41;&#46; Nevertheless&#44; to decrease both false-negative and false-positive interpretation&#44; it is recommended that an experienced radiologist always review the radiographs of patients with suspected NEC&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">29</span></a></p><p id="par0160" class="elsevierStylePara elsevierViewall">The authors of a study conducted in 2002 estimated the sensitivity and specificity of pneumoperitoneum at 52&#37; and 92&#37;&#44; respectively&#44;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">30</span></a> which are practically the same as the estimates obtained in our study&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">The limitations of this study include its retrospective design and the small sample size&#44; and a prospective study would be necessary to collect more reliable information regarding patient outcomes that would allow drawing firmer conclusions&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conclusion</span><p id="par0170" class="elsevierStylePara elsevierViewall">Given that there is no specific clinical&#44; radiologic or laboratory finding to establish the need for surgery and that &#40;as occurred in 39&#37; of the patients in our study&#41; perforation may be present in the absence of pneumoperitoneum&#44; the decision to operate must be based on the collection of clinical and radiologic features of the patient&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">We have not found other articles comparing the outcomes of patients that underwent surgery for NEC based on the presence or absence of pneumoperitoneum&#44; so we believe that our study contributes relevant information to our understanding of the outcomes of NEC&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">The presence of pneumoperitoneum in cases of NEC is not associated with a less favourable outcome&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflicts of interest</span><p id="par0185" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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              "titulo" => "M&#233;todo"
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              "titulo" => "Resultados"
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              "titulo" => "Conclusiones"
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          "titulo" => "Introduction"
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          "titulo" => "Conflicts of interest"
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          "titulo" => "References"
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    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2017-07-11"
    "fechaAceptado" => "2017-11-13"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1033003"
          "palabras" => array:4 [
            0 => "Necrotising enterocolitis"
            1 => "Pneumoperitoneum"
            2 => "Intestinal perforation"
            3 => "Mortality"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec1033002"
          "palabras" => array:4 [
            0 => "Enterocolitis necrosante"
            1 => "Neumoperitoneo"
            2 => "Perforaci&#243;n intestinal"
            3 => "Mortalidad"
          ]
        ]
      ]
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    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Surgical intervention in necrotising enterocolitis &#40;NEC&#41; is correct when there is intestinal gangrene&#46; This is evident when gangrene produces perforation and pneumoperitoneum&#44; with this being the only universally accepted radiological indication for the surgical intervention of NEC&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To perform an analysis on patients with surgically managed NEC&#44; including determining how the decision to intervene is reached&#44; the outcomes&#44; and if patients with perforation had a pneumoperitoneum&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Retrospective review of neonates with surgical NEC over a period of 10<span class="elsevierStyleHsp" style=""></span>years &#40;2006&#8211;2015&#41;&#46; An analysis was made of pre-surgical X-ray findings&#44; which were compared with surgical ones&#44; in addition to the morbidity and mortality&#44; depending on the presence &#40;N&#43;&#41; or absence &#40;N&#8722;&#41; of pneumoperitoneum&#46; An evaluation was also made of the interobserver concordance with a paediatric radiologist blinded to the clinical reason using the <span class="elsevierStyleItalic">kappa</span> agreement index&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">A total of 53 neonates were included in the study&#46; Surgical treatment was indicated after observing pneumoperitoneum in 36&#37;&#46; In the remaining neonates&#44; the surgical decision was made after noting a clinical and metabolic deterioration with classical X-ray findings&#46; Intestinal perforation was observed in 39&#37; of the N&#8722; neonates&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">There were no statistical differences between either group on analysing the excised intestinal length&#44; days of intubation&#44; starting of enteral nutrition&#44; and the mortality rate&#46; Comparisons in terms of duration of symptoms and total hospital stay were statistically significant &#40;7 vs&#46; 2 days&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;008&#59; 127 vs&#46; 79 days&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;003&#44; respectively&#41;&#44; with both being more favourable in the N&#43; group&#46; These differences remained when the groups were adjusted by birthweight&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusions</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Surgical indication has to be done on an ensemble of clinical and radiological evidence&#44; as 39&#37; of the neonates in the N&#8722; groups were perforated&#46;</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">In our study&#44; the presence of a pneumoperitoneum did not correlate with a worse prognosis&#46;</p></span>"
        "secciones" => array:5 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Introduction"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Objective"
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          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Methods"
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            "identificador" => "abst0020"
            "titulo" => "Results"
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            "identificador" => "abst0025"
            "titulo" => "Conclusions"
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      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Introducci&#243;n</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La intervenci&#243;n quir&#250;rgica en las enterocolitis necrosantes &#40;EN&#41; es precisa cuando existe gangrena intestinal&#44; hecho evidente cuando produce perforaci&#243;n y neumoperitoneo&#44; siendo este la &#250;nica indicaci&#243;n radiol&#243;gica aceptada universalmente para la intervenci&#243;n quir&#250;rgica&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Objetivo</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Analizar a los pacientes intervenidos de EN&#44; saber por qu&#233; se les intervino&#44; c&#243;mo evolucionan y si los pacientes perforados presentan neumoperitoneo&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">M&#233;todo</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Estudio retrospectivo de una cohorte de reci&#233;n nacidos con EN intervenidos durante un periodo de 10 a&#241;os &#40;2006-2015&#41;&#46; Se analizan los hallazgos radiol&#243;gicos preoperatorios y se correlacionan con los quir&#250;rgicos y con la morbimortalidad&#44; dependiendo de la presencia de neumoperitoneo &#40;N&#43;&#41; o no &#40;N&#8211;&#41;&#46; Se evalu&#243; la concordancia interobservador con radi&#243;logo pedi&#225;trico enmascarado a la cl&#237;nica mediante el &#237;ndice de acuerdo <span class="elsevierStyleItalic">kappa</span>&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Resultados</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Se analiz&#243; a 53 pacientes&#46; El 36&#37; se intervino tras la visualizaci&#243;n de neumoperitoneo&#59; en el resto&#44; la indicaci&#243;n fue deterioro cl&#237;nico y metab&#243;lico&#44; junto con hallazgos radiol&#243;gicos asociados&#46; En el 39&#37; del grupo N&#8211; se objetiv&#243; perforaci&#243;n&#46;</p><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">No se encontraron diferencias significativas en ambos grupos con respecto a longitud intestinal resecada&#44; d&#237;as de intubaci&#243;n&#44; d&#237;a de inicio de nutrici&#243;n enteral y mortalidad&#46; La comparaci&#243;n entre duraci&#243;n de s&#237;ntomas y estancia hospitalaria total en ambos grupos &#40;N&#8211;&#47;N&#43;&#41; fue significativa &#40;7 vs&#46; 2 d&#237;as&#44; p &#61; 0&#44;008&#59; 127 vs&#46; 79 d&#237;as&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;003 respectivamente&#41;&#44; siendo m&#225;s favorable en el grupo N&#43;&#46; Estas diferencias se mantuvieron al ajustar por peso&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conclusiones</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">La indicaci&#243;n quir&#250;rgica ha de basarse en un conjunto de datos cl&#237;nicos y radiol&#243;gicos&#44; ya que el 39&#37; de los pacientes sin neumoperitoneo presentaron perforaci&#243;n&#46;</p><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">En nuestro estudio la presencia de neumoperitoneo no se correlaciona con peor pron&#243;stico&#46;</p></span>"
        "secciones" => array:5 [
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            "identificador" => "abst0030"
            "titulo" => "Introducci&#243;n"
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            "titulo" => "Objetivo"
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            "identificador" => "abst0040"
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            "titulo" => "Resultados"
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            "titulo" => "Conclusiones"
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    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Villamil V&#44; Fern&#225;ndez-Ibieta M&#44; Gilabert Ubeda MA&#44; Aranda Garc&#237;a MJ&#44; Ruiz Pruneda R&#44; S&#225;nchez Morote JM&#44; et al&#46; Correlaci&#243;n entre el neumoperitoneo y los hallazgos quir&#250;rgicos y morbimortalidad en reci&#233;n nacidos con enterocolitis necrosante&#46; An Pediatr &#40;Barc&#41;&#46; 2018&#59;89&#58;205&#8211;210&#46;</p>"
      ]
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          "en" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Indications for surgery in newborns with necrotising enterocolitis&#46; The absolute frequency is presented in parentheses&#46; NEC&#44; necrotising enterocolitis&#46;</p>"
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          "leyenda" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Data expressed as means and <span class="elsevierStyleItalic">p</span> values&#46;</p><p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">EF&#44; enteral feeding&#46;</p><p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">Statistically significant results are presented in boldface&#46;</p>"
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                  <table border="0" frame="\n
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                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variables&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">P&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">P&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Duration of symptoms in days &#40;mean</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#177;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">0&#46;008</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Days of intubation &#40;mean</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#177;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Days post-surgery at initiation of EF &#40;mean</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#177;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Length of stay in days &#40;mean</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#177;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">79<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">127<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>43&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">0&#46;003</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Length of stay in &#8805;1000<span class="elsevierStyleHsp" style=""></span>g&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">89<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Length of stay in ¿1000<span class="elsevierStyleHsp" style=""></span>g&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">107<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">146<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>43&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">20<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;21&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10 &#40;45&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12 &#40;55&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Mortality in &#8805;1000<span class="elsevierStyleHsp" style=""></span>g&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7 &#40;54&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6 &#40;46&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Mortality in ¿1000<span class="elsevierStyleHsp" style=""></span>g&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;40&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6 &#40;60&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "en" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Statistical analysis of quantitative data in the two groups compared in the study&#46;</p>"
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Original Article
Correlation between pneumoperitoneum and surgical findings and morbidity and mortality in newborns with necrotising enterocolitis
Correlación entre el neumoperitoneo y los hallazgos quirúrgicos y morbimortalidad en recién nacidos con enterocolitis necrosante
Vanesa Villamila,
Corresponding author
vanesa_villamil@yahoo.com.ar

Corresponding author.
, María Fernández-Ibietaa, María Amparo Gilabert Ubedab, María Josefa Aranda Garcíaa, Ramón Ruiz Prunedaa, Juana María Sánchez Morotea, José Ignacio Ruiz Jiméneza
a Servicio de Cirugía Pediátrica, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain
b Servicio de Radiología, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain
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leading to disruption of the intestinal barrier and enabling bacterial passage and activation of inflammatory mediators&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">5</span></a> The main risk factors for the development of this disease are preterm birth&#44; perinatal asphyxia&#44; early enteral feeding in preterm newborns&#44; congenital heart defects and umbilical catheterization&#44; among others&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Necrotising enterocolitis should not be confused with focal intestinal perforation&#44; which is less frequent and affects up to 2&#37; of extremely low birth weight infants&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">3</span></a> Other differential features of focal intestinal perforation are&#58; lack of systemic involvement&#44; absence of intestinal pneumatosis&#44; earlier onset&#44; lower birth weight and extreme prematurity&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Necrotising enterocolitis is classified according to the staging criteria proposed by Bell et al&#46; as stage I &#40;suspected&#41;&#44; <span class="elsevierStyleSmallCaps">ii</span> &#40;proven&#41; or <span class="elsevierStyleSmallCaps">iii</span> &#40;advanced&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">6</span></a> a system that was later modified by Walsh and Kliegman in 1986&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">7</span></a> In this modified scheme&#44; stages are further subdivided into A or B depending on the radiographic findings&#58; stage I<span class="elsevierStyleSmallCaps">A</span> or B &#40;normal or intestinal dilation&#41;&#44; stage IIA &#40;ileus&#44; pneumatosis intestinalis&#41; or IIB &#40;portal venous gas&#41;&#44; stage IIIA &#40;ascites&#41; or IIIB &#40;pneumoperitoneum&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">5&#44;6</span></a> Another classification scheme was published in the <span class="elsevierStyleItalic">Vermont Oxford Network Manual of Operations</span> that described the clinical and radiographic findings required to establish the diagnosis of NEC&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">8</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">There is widespread agreement that surgical intervention is necessary in patients with NEC that have developed intestinal gangrene&#44; whose presence is evident if it leads to perforation and pneumoperitoneum&#44; which is not always the case&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">9</span></a> Free air in the abdominal cavity is the only radiographic feature universally accepted as an indication for surgical intervention in NEC&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">10</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The aim of this study was to analyse the cases of NEC treated with surgery to establish the reasons that led to performance of surgery&#44; to determine whether pneumoperitoneum had been present in all patients with bowel perforation&#44; and to assess patient outcomes based on whether pneumoperitoneum had or had not been present before surgery&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">To this end&#44; we compared the radiographic findings &#40;whether pneumoperitoneum was present or absent&#41; with the surgical findings and the outcomes in a group of patients with NEC that underwent surgical intervention&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Sample and methods</span><p id="par0035" class="elsevierStylePara elsevierViewall">We conducted a retrospective study in a cohort of newborns with NEC that underwent surgery between January 2006 and December 2015&#46; We divided these patients into 2 groups for comparison based on the preoperative presence or absence of pneumoperitoneum &#40;P&#43;&#47;P&#8211;&#41;&#46; We compared both groups based on the surgical findings&#44; which included the length of resected bowel and the presence or absence of NEC <span class="elsevierStyleItalic">totalis</span> &#40;involvement of 3 or more bowel segments&#41;&#46; We also compared other variables related to morbidity and mortality&#58; duration of symptoms from onset to the day of surgery&#44; days of intubation&#44; days of total parenteral nutrition&#44; days from surgery at initiation of enteral feeding&#44; length of stay in days&#44; and mortality&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">In addition&#44; we assessed interrater reliability&#44; using the kappa statistic to compare the interpretation of the preoperatory findings made a posteriori by an expert paediatric radiologist masked to the symptoms to the preoperatory assessment made jointly by the neonatologist and the on-call paediatric surgeon&#46; A <span class="elsevierStyleItalic">kappa</span> value of 0 signifies a total absence of interrater agreement&#44; while a value of 1 signifies perfect agreement&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">4</span></a> We assessed the level of agreement applying the criteria proposed by Landis and Koch&#58; <span class="elsevierStyleItalic">k</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;20 &#40;very poor&#41;&#44; 0&#46;21<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">k</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;40 &#40;poor&#41;&#44; 0&#46;41<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">k</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;60 &#40;fair&#41;&#44; 0&#46;61<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">k</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;80 &#40;good&#41;&#44; and 0&#46;81<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">k</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>1&#46;00 &#40;excellent&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">11</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">To compare qualitative variables&#44; we used the chi square test or the Fisher exact test as appropriate&#46; We compared quantitative variables by means of the nonparametric Mann&#8211;Whitney <span class="elsevierStyleItalic">U</span> test&#46; We assessed survival using the Kaplan&#8211;Meier method&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">We set the alpha level to define statistical significance at 0&#46;05&#46; The statistical analysis was performed with the software SPSS version 23&#46;0&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Results</span><p id="par0055" class="elsevierStylePara elsevierViewall">In the 10 years under study&#44; 53 patients with NEC underwent surgical intervention&#46; They had been born at a median of 28<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>6 weeks&#8217; gestation &#40;range&#44; 23&#8211;41 weeks&#41; with a mean birth weight of 1229<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>581<span class="elsevierStyleHsp" style=""></span>g &#40;range&#44; 590&#8211;3087<span class="elsevierStyleHsp" style=""></span>g&#41;&#44; with 94&#46;3&#37; being born with a low birth weight &#40;50 newborns with weight &#60;2500<span class="elsevierStyleHsp" style=""></span>g&#41;&#44; 73&#46;6&#37; with a very low birth weight &#40;39 newborns with weight &#60;1500<span class="elsevierStyleHsp" style=""></span>g&#41; and 50&#46;9&#37; with an extremely low birth weight &#40;27 newborns with weight &#60;1000<span class="elsevierStyleHsp" style=""></span>g&#41;&#46; We estimated an incidence of surgical NEC of 7 newborns per 10&#44;000 live births&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">In this cohort&#44; 51&#37; of patients were female &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>27&#41; and 94&#46;3&#37; had been born preterm &#40;born before 37 weeks&#8217; gestation&#44; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>50&#41;&#44; with 77&#46;4&#37; born very or extremely preterm &#40;born before 32 weeks&#8217; gestation&#44; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>41&#41;&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The mean age at the time of surgery was 19<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>14 days &#40;range&#44; 2&#8211;63 days&#41;&#44; and the mean weight was 1474<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>669<span class="elsevierStyleHsp" style=""></span>g &#40;range&#44; 650&#8211;3750<span class="elsevierStyleHsp" style=""></span>g&#41;&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">The sensitivity of abdominal radiography for the diagnosis of pneumoperitoneum is 54&#46;5&#37;&#44; while the specificity is 92&#46;3&#37;&#46; In 36&#37; of patients &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>19&#41;&#44; surgery was performed due to the presence of pneumoperitoneum&#44; while in the remaining patients &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>34&#41; it was performed for other reasons &#40;clinical deterioration&#44; metabolic derangement or intestinal obstruction&#41; &#40;Fig 1&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">When we analysed the two groups defined by the presence or absence of pneumoperitoneum &#40;P&#43;&#47;P&#8211;&#41;&#44; we found a shorter duration of symptoms from onset to surgery in the P&#43; group&#44; with a mean of 2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;7 days &#40;range&#44; 1&#8211;3 days&#41; compared to 7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8 days in the P&#8211; group &#40;range&#44; 3&#8211;10 days&#41;&#44; and also a shorter length of stay&#44; which was of 79<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>28 days in the P&#43; group &#40;60&#8211;98&#41; compared to 127<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>43 days in the P&#8211; group &#40;103&#8211;150&#41; &#40;excluding deceased patients&#41;&#44; differences that were statistically significant &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;008 and <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;003&#44; respectively&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; The differences remained significant when we adjusted the analysis for weight&#58; in the group with birth weights of more than 1000<span class="elsevierStyleHsp" style=""></span>g &#40;&#43;1000<span class="elsevierStyleHsp" style=""></span>g&#41;&#44; the mean length of stay was 58<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10 days in P&#43; newborns &#40;range&#44; 48&#8211;69&#41; compared to 89<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15 days in the P&#8211; group &#40;range&#44; 71&#8211;107&#41; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;005&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; We also found differences in the group with birth weight of less than 1000<span class="elsevierStyleHsp" style=""></span>g&#44; although they were not statistically significant&#58; mean of 107<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20 days &#40;range&#44; 78&#8211;135&#41; in the P&#43; group vs&#46; 146<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>43 days &#40;range&#44; 116&#8211;175&#41; in the P&#8211; group &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;064&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">When we analysed mortality&#44; we did not find statistically significant differences between the two groups&#46; The overall mortality was 41&#46;5&#37;&#44; corresponding to 10 newborns in the P&#43; group &#40;45&#37;&#41; and 12 of the P&#8211; group &#40;55&#37;&#41;&#46; We also found no statistically significant differences in any of the other variables under study &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">The <span class="elsevierStyleItalic">kappa</span> statistic was 0&#46;7&#44; which corresponds to a good correlation based on the criteria proposed by Landis and Koch&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Discussion</span><p id="par0090" class="elsevierStylePara elsevierViewall">Necrotising enterocolitis is one of the main causes of morbidity and mortality in newborns&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">12</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">Most cases of NEC occur in preterm newborns&#46; The mean gestational age at birth in our cohort was 28<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>6 weeks &#40;range&#44; 23&#8211;41&#41;&#44; which was consistent with previous studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">13&#44;14</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">The mean birth weight in our cohort was 1229<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>581<span class="elsevierStyleHsp" style=""></span>g&#44; with a range of 590&#8211;3087<span class="elsevierStyleHsp" style=""></span>g&#44; which was similar to the findings reported in the literature&#44;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">15</span></a> although there seems to be a declining trend in the mean birth weight of patients with surgical NEC&#44; as suggested by other authors&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">9</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">The mean age at the time of surgery in our study was 19 days &#40;range&#44; 2&#8211;63&#41;&#44; which was similar to the one reported in a study conducted in 2002<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">16</span></a> and another study we found in the reviewed literature&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">13</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">When medical treatment fails &#40;including antibiotherapy&#44; discontinuation of enteral feeding and supportive care&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">17</span></a> the decision to perform surgery is based on radiographic findings and clinical manifestations suggestive of metabolic derangement&#46;<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">2&#44;8</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">In patients with suspected NEC&#44; a radiological evaluation can confirm the staging as proven or advanced&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">18</span></a> Extraluminal air &#40;free air&#41; is a sign of advanced NEC<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">8</span></a> and the sole radiologic finding that is universally accepted as an indication for surgical intervention&#44;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">19</span></a> as it is direct evidence of perforation&#46; Some authors consider metabolic derangement a sufficient indication for surgery and have established a series of laboratory criteria and thresholds to determine the appropriateness of intervention&#44; even in the absence of pneumoperitoneum&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">3</span></a> We ought to highlight the importance of obtaining the two radiographic images &#40;antero-posterior view and horizontal beam view with the patient in the supine position&#41; within 48<span class="elsevierStyleHsp" style=""></span>h from onset&#44; as most perforations develop in that time interval&#44;<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">10&#44;12</span></a> something that we corroborated in our results&#44; as we found that a mean of 2 days elapsed from the onset of symptoms to evidence of pneumoperitoneum&#44; with a range of 1&#8211;3 days&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Pneumoperitoneum is not always present and is found in 50&#8211;75&#37; of patients with intestinal perforation due to NEC&#44;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">20</span></a> with other authors reporting its presence in as few as 12&#8211;50&#37; of these patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">18&#44;21</span></a> Thus&#44; the sensitivity of this radiographic finding is much lower than expected&#46; In our study&#44; its sensitivity was 54&#46;5&#37;&#46; There are several possible explanations for the absence of pneumoperitoneum in cases of intestinal perforation&#58; &#40;1&#41; perforation of the jejunum or ileus&#44; which may not contain air&#59; &#40;2&#41; early closure of perforation&#59; &#40;3&#41; retroperitoneal perforation&#59; &#40;4&#41; small amount of gas due to effective suction through a nasogastric tube&#59; &#40;5&#41; lack of an optimal radiographic view showing the pneumoperitoneum&#44; and &#40;6&#41; perforation occurring after obtaining the radiograph and before surgery&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">1</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">This radiographic feature is not always easy to identify&#44; and there are several radiographic signs that help detect its presence&#58; Rigler&#39;s sign &#40;gas on both sides of the intestinal wall&#41;&#44; the falciform ligament sign &#40;gas outlining the falciform ligament&#41;&#44; the football sign &#40;gas outlining the peritoneal cavity&#41;&#44; the inverted-V sign &#40;gas outlining the medial umbilical folds&#41; and right-upper-quadrant gas sign &#40;localised gas in this quadrant&#44; in the subhepatic space&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">22</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">Some critically ill infants require mechanical ventilation&#44; which may cause pneumothorax or pneumomediastinum and therefore pneumoperitoneum&#46; In these patients&#44; it is important to perform a correct differential diagnosis of gastrointestinal perforation and medical pneumoperitoneum to avoid unnecessary surgical procedures&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">23</span></a> We found one such patient in this study&#46; As we mentioned before&#44; pneumoperitoneum was the indication for surgery in 39&#37; of cases&#44; a proportion that was similar to those reported in other studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">24&#44;25</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">In the past&#44; there was widespread agreement that the prognosis of patients with NEC worsened once intestinal perforation occurred&#44;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">1&#44;10&#44;26</span></a> although the published evidence is not completely concordant on this aspect&#46;<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">24&#44;27</span></a> As Grosfeld et al&#46; already stated in 1991&#44; early diagnosis&#44; advances in neonatal intensive care and prompt surgical intervention when indicated have improved survival in patients with NEC&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">28</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">In our study&#44; we found that even adjusting for weight&#44; radiographic evidence of pneumoperitoneum was not in and of itself associated to poorer outcomes&#44; but rather the opposite&#46; This was probably due to the association of pneumoperitoneum with a shorter duration of symptoms before surgery compared to patients without pneumoperitoneum&#46; In many cases&#44; the decision to perform surgery in preterm infants with manifestations suggestive of NEC is delayed for days while the patient receives more aggressive medical treatment&#44; precisely because there are no radiographic findings that clearly &#8220;invite&#8221; the surgeon to intervene&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Considering the low sensitivity of abdominal radiography found in our study&#44; relying on the detection of free abdominal air as the sole definitive indication for surgery should by now be considered obsolete or risky&#46; Other authors also recommend against waiting for stage IIIB NEC to operate&#44; given that it may not always be detected radiographically&#44; as long as the patient develops metabolic derangement or infection despite adequate medical treatment&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">In our study&#44; 10 patients in the pneumoperitoneum group &#40;45&#37;&#41; and 12 in the group without pneumoperitoneum &#40;55&#37;&#41; died&#46; The overall mortality was 41&#46;5&#37;&#44; a proportion that was similar to those reported in other case series&#44; which range between 55&#37; and 83&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">5&#44;13</span></a></p><p id="par0155" class="elsevierStylePara elsevierViewall">The kappa statistic found in this study revealed a very good interrater reliability &#40;0&#46;7&#41;&#46; Nevertheless&#44; to decrease both false-negative and false-positive interpretation&#44; it is recommended that an experienced radiologist always review the radiographs of patients with suspected NEC&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">29</span></a></p><p id="par0160" class="elsevierStylePara elsevierViewall">The authors of a study conducted in 2002 estimated the sensitivity and specificity of pneumoperitoneum at 52&#37; and 92&#37;&#44; respectively&#44;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">30</span></a> which are practically the same as the estimates obtained in our study&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">The limitations of this study include its retrospective design and the small sample size&#44; and a prospective study would be necessary to collect more reliable information regarding patient outcomes that would allow drawing firmer conclusions&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conclusion</span><p id="par0170" class="elsevierStylePara elsevierViewall">Given that there is no specific clinical&#44; radiologic or laboratory finding to establish the need for surgery and that &#40;as occurred in 39&#37; of the patients in our study&#41; perforation may be present in the absence of pneumoperitoneum&#44; the decision to operate must be based on the collection of clinical and radiologic features of the patient&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">We have not found other articles comparing the outcomes of patients that underwent surgery for NEC based on the presence or absence of pneumoperitoneum&#44; so we believe that our study contributes relevant information to our understanding of the outcomes of NEC&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">The presence of pneumoperitoneum in cases of NEC is not associated with a less favourable outcome&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflicts of interest</span><p id="par0185" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Surgical intervention in necrotising enterocolitis &#40;NEC&#41; is correct when there is intestinal gangrene&#46; This is evident when gangrene produces perforation and pneumoperitoneum&#44; with this being the only universally accepted radiological indication for the surgical intervention of NEC&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To perform an analysis on patients with surgically managed NEC&#44; including determining how the decision to intervene is reached&#44; the outcomes&#44; and if patients with perforation had a pneumoperitoneum&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Retrospective review of neonates with surgical NEC over a period of 10<span class="elsevierStyleHsp" style=""></span>years &#40;2006&#8211;2015&#41;&#46; An analysis was made of pre-surgical X-ray findings&#44; which were compared with surgical ones&#44; in addition to the morbidity and mortality&#44; depending on the presence &#40;N&#43;&#41; or absence &#40;N&#8722;&#41; of pneumoperitoneum&#46; An evaluation was also made of the interobserver concordance with a paediatric radiologist blinded to the clinical reason using the <span class="elsevierStyleItalic">kappa</span> agreement index&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">A total of 53 neonates were included in the study&#46; Surgical treatment was indicated after observing pneumoperitoneum in 36&#37;&#46; In the remaining neonates&#44; the surgical decision was made after noting a clinical and metabolic deterioration with classical X-ray findings&#46; Intestinal perforation was observed in 39&#37; of the N&#8722; neonates&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">There were no statistical differences between either group on analysing the excised intestinal length&#44; days of intubation&#44; starting of enteral nutrition&#44; and the mortality rate&#46; Comparisons in terms of duration of symptoms and total hospital stay were statistically significant &#40;7 vs&#46; 2 days&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;008&#59; 127 vs&#46; 79 days&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;003&#44; respectively&#41;&#44; with both being more favourable in the N&#43; group&#46; These differences remained when the groups were adjusted by birthweight&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusions</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Surgical indication has to be done on an ensemble of clinical and radiological evidence&#44; as 39&#37; of the neonates in the N&#8722; groups were perforated&#46;</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">In our study&#44; the presence of a pneumoperitoneum did not correlate with a worse prognosis&#46;</p></span>"
        "secciones" => array:5 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Introduction"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Objective"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Methods"
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          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Results"
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          4 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Conclusions"
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      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Introducci&#243;n</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La intervenci&#243;n quir&#250;rgica en las enterocolitis necrosantes &#40;EN&#41; es precisa cuando existe gangrena intestinal&#44; hecho evidente cuando produce perforaci&#243;n y neumoperitoneo&#44; siendo este la &#250;nica indicaci&#243;n radiol&#243;gica aceptada universalmente para la intervenci&#243;n quir&#250;rgica&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Objetivo</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Analizar a los pacientes intervenidos de EN&#44; saber por qu&#233; se les intervino&#44; c&#243;mo evolucionan y si los pacientes perforados presentan neumoperitoneo&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">M&#233;todo</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Estudio retrospectivo de una cohorte de reci&#233;n nacidos con EN intervenidos durante un periodo de 10 a&#241;os &#40;2006-2015&#41;&#46; Se analizan los hallazgos radiol&#243;gicos preoperatorios y se correlacionan con los quir&#250;rgicos y con la morbimortalidad&#44; dependiendo de la presencia de neumoperitoneo &#40;N&#43;&#41; o no &#40;N&#8211;&#41;&#46; Se evalu&#243; la concordancia interobservador con radi&#243;logo pedi&#225;trico enmascarado a la cl&#237;nica mediante el &#237;ndice de acuerdo <span class="elsevierStyleItalic">kappa</span>&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Resultados</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Se analiz&#243; a 53 pacientes&#46; El 36&#37; se intervino tras la visualizaci&#243;n de neumoperitoneo&#59; en el resto&#44; la indicaci&#243;n fue deterioro cl&#237;nico y metab&#243;lico&#44; junto con hallazgos radiol&#243;gicos asociados&#46; En el 39&#37; del grupo N&#8211; se objetiv&#243; perforaci&#243;n&#46;</p><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">No se encontraron diferencias significativas en ambos grupos con respecto a longitud intestinal resecada&#44; d&#237;as de intubaci&#243;n&#44; d&#237;a de inicio de nutrici&#243;n enteral y mortalidad&#46; La comparaci&#243;n entre duraci&#243;n de s&#237;ntomas y estancia hospitalaria total en ambos grupos &#40;N&#8211;&#47;N&#43;&#41; fue significativa &#40;7 vs&#46; 2 d&#237;as&#44; p &#61; 0&#44;008&#59; 127 vs&#46; 79 d&#237;as&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;003 respectivamente&#41;&#44; siendo m&#225;s favorable en el grupo N&#43;&#46; Estas diferencias se mantuvieron al ajustar por peso&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conclusiones</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">La indicaci&#243;n quir&#250;rgica ha de basarse en un conjunto de datos cl&#237;nicos y radiol&#243;gicos&#44; ya que el 39&#37; de los pacientes sin neumoperitoneo presentaron perforaci&#243;n&#46;</p><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">En nuestro estudio la presencia de neumoperitoneo no se correlaciona con peor pron&#243;stico&#46;</p></span>"
        "secciones" => array:5 [
          0 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Introducci&#243;n"
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          1 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Objetivo"
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          2 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "M&#233;todo"
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          3 => array:2 [
            "identificador" => "abst0045"
            "titulo" => "Resultados"
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          4 => array:2 [
            "identificador" => "abst0050"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Villamil V&#44; Fern&#225;ndez-Ibieta M&#44; Gilabert Ubeda MA&#44; Aranda Garc&#237;a MJ&#44; Ruiz Pruneda R&#44; S&#225;nchez Morote JM&#44; et al&#46; Correlaci&#243;n entre el neumoperitoneo y los hallazgos quir&#250;rgicos y morbimortalidad en reci&#233;n nacidos con enterocolitis necrosante&#46; An Pediatr &#40;Barc&#41;&#46; 2018&#59;89&#58;205&#8211;210&#46;</p>"
      ]
    ]
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        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
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        "figura" => array:1 [
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        "descripcion" => array:1 [
          "en" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Indications for surgery in newborns with necrotising enterocolitis&#46; The absolute frequency is presented in parentheses&#46; NEC&#44; necrotising enterocolitis&#46;</p>"
        ]
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      1 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
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            "identificador" => "at1"
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          "leyenda" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Data expressed as means and <span class="elsevierStyleItalic">p</span> values&#46;</p><p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">EF&#44; enteral feeding&#46;</p><p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">Statistically significant results are presented in boldface&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variables&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">P&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">P&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Duration of symptoms in days &#40;mean</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#177;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">0&#46;008</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Days of intubation &#40;mean</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#177;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Days post-surgery at initiation of EF &#40;mean</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#177;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Length of stay in days &#40;mean</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#177;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">79<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">127<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>43&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">0&#46;003</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Length of stay in &#8805;1000<span class="elsevierStyleHsp" style=""></span>g&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">58<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">89<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">0&#46;005</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Length of stay in ¿1000<span class="elsevierStyleHsp" style=""></span>g&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">107<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">146<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>43&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;064&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Resected length of bowel in cm &#40;mean</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#177;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">20<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Mortality &#40;n &#8211; &#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10 &#40;45&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12 &#40;55&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Mortality in &#8805;1000<span class="elsevierStyleHsp" style=""></span>g&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7 &#40;54&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6 &#40;46&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Mortality in ¿1000<span class="elsevierStyleHsp" style=""></span>g&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;40&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6 &#40;60&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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        "descripcion" => array:1 [
          "en" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Statistical analysis of quantitative data in the two groups compared in the study&#46;</p>"
        ]
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    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:30 [
            0 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Indications for operation in acute necrotizing enterocolitis of the neonate"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;M&#46; Kosloske"
                            1 => "L&#46;A&#46; Papile"
                            2 => "J&#46; Burstein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Surgery"
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                        "volumen" => "87"
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                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6966078"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prospective evaluation of the impact of sonography on the management and surgical intervention of neonates with necrotizing enterocolitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
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                            0 => "A&#46; Yikilmaz"
                            1 => "N&#46;J&#46; Hall"
                            2 => "A&#46; Daneman"
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                            5 => "R&#46; Moineddin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00383-014-3613-8"
                      "Revista" => array:7 [
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