Original Article
Cryptogenic West syndrome: Clinical profile, response to treatment and prognostic factors
Síndrome de West criptogénico: perfil clínico, respuesta al tratamiento y factores pronósticos
María Calderón Romero
, Elena Arce Portillo, Mercedes López Lobato, Beatriz Muñoz Cabello, Bárbara Blanco Martínez, Marcos Madruga Garrido, Olga Alonso Luego
Corresponding author
Servicio de Neuropediatría, Hospitales Universitarios Virgen del Rocío, Sevilla, Spain
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class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Elena" "apellidos" => "Arce Portillo" ] 2 => array:2 [ "nombre" => "Mercedes" "apellidos" => "López Lobato" ] 3 => array:2 [ "nombre" => "Beatriz" "apellidos" => "Muñoz Cabello" ] 4 => array:2 [ "nombre" => "Bárbara" "apellidos" => "Blanco Martínez" ] 5 => array:2 [ "nombre" => "Marcos" "apellidos" => "Madruga Garrido" ] 6 => array:2 [ "nombre" => "Olga" "apellidos" => "Alonso Luego" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Neuropediatría, Hospitales Universitarios Virgen del Rocío, Sevilla, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Síndrome de West criptogénico: perfil clínico, respuesta al tratamiento y factores pronósticos" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 448 "Ancho" => 2299 "Tamanyo" => 60452 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Treatment protocol used in our unit and implemented in the series of patients with cryptogenic West syndrome.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">West syndrome (WS) is an age-dependent epileptic encephalopathy characterised by the triad of (1) infantile spasms, usually clustered; (2) evidence of hypsarrhythmia in the electroencephalogram (EEG), with tracings showing a chaotic, multifocal and bilateral pattern of high-amplitude waves; and (3) regression of psychomotor development, although the latter may be absent.<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">1,2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Its estimated incidence ranges from 2 to 4 in 10<span class="elsevierStyleHsp" style=""></span>000 individuals depending on the series, and therefore it is the most frequent form of epilepsy in the first year of life outside of neonatal and febrile seizures.<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">1,3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Due to the numerous underlying causes and the variability in neurologic development in these patients, it is often categorised into different diagnostic groups. The most common classification continues to be the one proposed by the International League Against Epilepsy (ILAE), which categorises infantile spasms as symptomatic or cryptogenic.<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">4</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The symptomatic category corresponds to patients with an obvious underlying cause and/or a history of developmental delay or epileptic seizures prior to the onset of spasms, and accounts for approximately 80% of all patients with WS. Patients in whom an underlying condition is suspected but has not been identified after the aetiological investigation are categorised as having cryptogenic WS and account for the remaining 20% of cases. In the cryptogenic group, patients have normal psychomotor development at onset that goes on to deteriorate progressively in most cases. However, in a minority of cases, approximately 5% of patients with infantile spasms, the outcomes are favourable, with full resolution of the spasms and normal psychomotor development, which has led some authors to consider it a separate aetiological group labelled <span class="elsevierStyleItalic">idiopathic</span>,<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">5</span></a> although this category has yet to be adopted by the ILAE. This aetiological category is based on disease outcomes, so it can only be applied through the followup of patients.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Since developmental delays present at diagnosis could be explained by both the underlying disease and the epileptic encephalopathy itself (spasms that were not detected previously or presence of hypsarrhythmia prior to onset), some authors propose abandoning the distinction between symptomatic and cryptogenic WS in favour of a classification based on the development preceding onset. In the United Kingdom Infantile Spasms Study (UKISS), 61% of patients had proven aetiology, 33% had no identified aetiology, and 6% had not been fully investigated.<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">4</span></a> A recent study of the ILAE proposes replacing these terms with 3 new aetiologic groups: genetic, structural-metabolic and unknown.<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">6</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">When it comes to the aetiological diagnosis of WS, neuroimaging is the method that offers the highest yield. The underlying cause is identified in 70% of the patients after an adequate history-taking and physical examination and magnetic resonance imaging of the head.<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">7</span></a> Several studies have evaluated the yield of other diagnostic tests, such as genetic and metabolic investigations.<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">6,8,9</span></a> They conclude that in children without an aetiological diagnosis after the initial investigation, a cost-efficient strategy would be performance of microarray-based comparative genomic hybridisation (aCGH) followed by an epilepsy gene panel and a general metabolic study (lactate, pyruvate, amino acids and organic acids in urine) in those patients in which the results of aCGH are inconclusive. It is estimated that this approach achieves aetiological diagnosis in an additional 10%–15% of cases. The study conducted by the National Infantile Spasms Consortium of the United States found that performance of aCGH resulted in an aetiological diagnosis in 11% of the patients that did not previously have one, the epilepsy gene panel in 31% of those patients, and the metabolic study in 4.5%.</p><p id="par0035" class="elsevierStylePara elsevierViewall">Advances in diagnostic techniques and the interest in the underlying cause on account of its prognostic value have led to a decrease in the frequency of cryptogenic cases with an associated increase in symptomatic cases.</p><p id="par0040" class="elsevierStylePara elsevierViewall">Infantile spasms are refractory to most anticonvulsant drugs, and only 2 drugs have clearly proven efficacious in WS, vigabatrin (VGB) and adrenocorticotropic hormone (ACTH). At present, as the most recent Cochrane review emphasises, the existing evidence is insufficient to determine the superiority of either drug for use as first-line treatment. Some studies have shown that ACTH therapy is more effective in controlling the spasms in the short-term, although its superiority in the long term has yet to be demonstrated.<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">10–12</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">There are numerous studies and reviews that focus on WS overall, with particular emphasis on the symptomatic form on account of its higher prevalence. However, few studies have specifically analysed the cryptogenic form, and consequently it is less well understood and its prognosis unclear.</p><p id="par0050" class="elsevierStylePara elsevierViewall">The aim of this study was to define the profile of cryptogenic WS in our region, exploring the clinical characteristics of the cases, the diagnostic tests performed and the subsequent outcomes. Based on these data, we identified potential prognostic factors for the purpose of improving outcomes and counselling families.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Patients and methods</span><p id="par0055" class="elsevierStylePara elsevierViewall">We conducted a retrospective observational study by reviewing the electronic health records of 16 patients. The statistical analysis was solely descriptive, and we did not apply any inferential methods. The inclusion criteria were: cryptogenic aetiology (understood as normal psychomotor development prior to diagnosis), no focal signs in the neurologic evaluation at diagnosis, no history of seizures prior to onset of spasms (excluding neonatal and febrile seizures), normal neuroimaging findings and lack of an attributable aetiology; diagnosis made in the 2000–2015 period; and treatment and followup in our hospital. The mean duration of followup was 6.6 years, with a minimum of 2 years and a maximum 15 years. There were no losses to followup.</p><p id="par0060" class="elsevierStylePara elsevierViewall">We created a data collection form that included the following variables: sex, age at onset, history (obstetric, personal and family), psychomotor development at onset, epileptic seizures prior to onset of spasms, type of spasms, EEG abnormalities, delay in treatment initiation, initial treatment, response to initial treatment, persistence of spasms/hypsarrhythmia, received treatments, adverse events, relapse, psychomotor development during followup, development of other forms of epilepsy, seizure-free time and development of neurologic disease.</p><p id="par0065" class="elsevierStylePara elsevierViewall">In adherence with the treatment protocol of our hospital, all patients received escalating doses of VGB (up to 200<span class="elsevierStyleHsp" style=""></span>mg/kg/day) as first-line treatment. If VGB monotherapy proved ineffective after 2 weeks (persistence of spasms and/or hypsarrhythmia), we added a daily dose of ACTH for 14 days that was tapered off over an additional 5 weeks.</p><p id="par0070" class="elsevierStylePara elsevierViewall">We defined unfavourable outcome as the subsequent development of other forms of epilepsy and/or the development of moderate to severe cognitive impairment based on a neuropsychiatric evaluation.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Results</span><p id="par0075" class="elsevierStylePara elsevierViewall">We studied a total of 16 patients, and there were no losses during the followup period.</p><p id="par0080" class="elsevierStylePara elsevierViewall">When it came to sex, we found a predominance of the male sex, as 11 out of the 16 patients (69%) were male. The age at onset ranged between 1.5 and 10 months, with a predominance of patients in the 5–7 months group (50%). The mean age at presentation of spasms was 6 months.</p><p id="par0085" class="elsevierStylePara elsevierViewall">As for the medical history, 6 of the 16 patients had a family history of epilepsy of some form, all of them benign idiopathic forms in first- or second-degree relatives, and 2 had a personal history of seizures prior to onset of spasms (neonatal seizures in one and febrile seizures in the other).</p><p id="par0090" class="elsevierStylePara elsevierViewall">The most frequent type of spasms were extensor spasms (50%), followed by flexor spasms (43%) and mixed spasms (7%). Only 4 of the patients had mild developmental delay at onset of spasms.</p><p id="par0095" class="elsevierStylePara elsevierViewall">The time elapsed between onset of spasms and initiation of treatment was less than 1 week in 50% of patients. Per the treatment protocol of the department, all patients received VGB as initial therapy (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall">The response to VGB was favourable in 5 of the 16 patients, with resolution of the spasms in the first week of treatment and normalisation of EEG features in 2 weeks. Patients that had not improved after 15 days of VGB received ACTH as second-line treatment. All of the 11 patients treated with ACTH had a favourable response, achieving control of hypsarrhythmia.</p><p id="par0105" class="elsevierStylePara elsevierViewall">There were adverse events in 32% of patients, most of them associated with use of ACTH. Of the 16 patients treated with VGB, only 1 suffered an adverse reaction, an acute encephalopathy that improved a few hours after discontinuing the drug. Of the 11 patients treated with ACTH, 4 developed high blood pressure requiring antihypertensive therapy; 2 of them also had echocardiographic abnormalities indicative of septal hypertrophy, although this state was transient and resolved after completion of ACTH therapy.</p><p id="par0110" class="elsevierStylePara elsevierViewall">The outcome was unfavourable in 7 of the 16 patients (43.7%), all of who developed other forms of epilepsy. Five of them also had moderate or severe cognitive impairment, which was associated with a pervasive developmental disorder in 2. The mean time they remained seizure-free until the development of another form of epilepsy was 10 months, and secondary epilepsy developed within 2 years of diagnosis in all. Other patients exhibited milder impairment in the long term: language disorder, attention-deficit hyperactivity disorder and mild cognitive impairment, and while we have included these data in the analysis of outcomes, we did not include these patients in the unfavourable outcome group because these problems did not have a significant impact on their everyday functioning. None of the patients experienced a relapse (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0115" class="elsevierStylePara elsevierViewall">An aetiological diagnosis was eventually achieved in 2 of the 16 patients during the followup. In one, it was biotinidase deficiency, identified when the metabolic evaluation was expanded in this patient due to the presence of persistent dermatitis, and the other a focal cortical dysplasia identified 10 years after diagnosis of spasms; both patients belonged to the unfavourable outcome group. Therefore, the overall outcome of our cryptogenic patients would improve if we were to exclude these 2 patients (who eventually became part of the symptomatic group) from the results, with unfavourable outcomes in only 5 of a total of 14 patients (35.7%).</p><p id="par0120" class="elsevierStylePara elsevierViewall">We made a descriptive analysis of several variables, searching for potential prognostic factors with the purpose of developing working hypotheses for future inferential research. We found a greater probability of developing secondary epilepsy in patients of the male sex (55%) or onset before age 6 months (71%), while early treatment (initiated in the first 2 weeks from onset of spasms) and early control of hypsarrhythmia (in the first 3 weeks) were associated with a decreased probability of developing secondary epilepsy (36% and 33% respectively) (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>).</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Discussion</span><p id="par0125" class="elsevierStylePara elsevierViewall">Our study was consistent with the previous literature as regards the age of onset of spasms, the predominance of the male sex and the distribution of the type of spasms.</p><p id="par0130" class="elsevierStylePara elsevierViewall">When we analysed the cryptogenic subgroup in particular, our study did find a higher proportion of patients with a family history of epilepsy. In previous studies on WS, the overall proportion of patients with a family history of epilepsy ranged between 15% and 25%,<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">1,3</span></a> while in our series of cryptogenic cases it was as high as 37%. This finding is congruent with the importance of genetic factors in this group of patients, something that has already been noted in previous reviews that found an association between WS of unknown aetiology with other idiopathic forms of epilepsy, such as childhood absence epilepsy.<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">5</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">Several studies have found a clear relationship between early initiation of treatment and favourable outcomes, mainly in cryptogenic cases.<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">9,13–17</span></a> In our study, 50% of patients were referred to our hospital early, and treatment was initiated in the first week since onset of spasms. In 5 patients, treatment was initiated more than 2 weeks after onset, and 3 of them (60%) had unfavourable outcomes with subsequent development of other forms of epilepsy, which also represented a worse outcome relative to the overall outcomes of WS of any type. However, of the 11 patients that started treatment within 2 weeks of onset, only 4 (36%) developed secondary epilepsy.</p><p id="par0140" class="elsevierStylePara elsevierViewall">Since Chiron et al.<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">18</span></a> demonstrated the efficacy of VGB for control of spasms, numerous authors have compared VGB with ACTH and observed a similar response in the long term, although with a lower rate of adverse events.<a class="elsevierStyleCrossRefs" href="#bib0205"><span class="elsevierStyleSup">11,12,19</span></a> As we already mentioned, the treatment protocol of our department, based on the European survey study conducted by Aicardi,<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">20–22</span></a> uses VGB monotherapy as first-line treatment and reserves ACTH therapy for patients that did not respond to the initial treatment.</p><p id="par0145" class="elsevierStylePara elsevierViewall">In our study, we defined a favourable response to initial therapy as resolution of spasms and normalisation of the EEG in the first 2 weeks of treatment as long as the improvement persisted for at least one month. Initial therapy with VGB achieved a favourable response in 30% of the patients with cryptogenic WS in our study, a proportion that was lower than the 50%–70% reported in other case series.<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">1,19,23</span></a> Of the patients that responded well to initial treatment with VGB monotherapy, 60% remained free of seizures during the subsequent followup, a percentage that was similar to the percentage we found in the long-term followup of patients treated with VGB and ACTH. Therefore, while the response to initial treatment with VGB was less favourable than expected, long-term outcomes were favourable in the 56% of patients regardless of treatment, which was consistent with the findings of other studies<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">9,10,14</span></a> (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>).</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0150" class="elsevierStylePara elsevierViewall">GABAergic retinopathy, which causes irreversible peripheral visual field constriction in adults, continues to be the most important adverse effect of treatment with VGB, although it is difficult to identify in the paediatric age group. Different studies have found a direct association with the dose and duration of treatment, and indicated that treatment can be safe if it lasts less than 6 months and at doses not exceeding 200<span class="elsevierStyleHsp" style=""></span>mg/kg/day.<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">15,24,25</span></a> Of the 16 patients we followed up, none experienced this complication, even though most of them received treatment for much longer, for a maximum of 3 years. On the other hand, treatment with ACTH produced moderate adverse effects that required treatment in 36% of cases.</p><p id="par0155" class="elsevierStylePara elsevierViewall">Monitoring of retinal toxicity proved challenging due to the young age and the intellectual disability of some of the patients, although their families did not report any visual problems in their everyday lives during the followup visits. All patients underwent periodic checkups in the ophthalmology department with gross assessment of the visual field (menace response, kinetic perimetry and confrontation visual field testing) that revealed no signs of impairment. Automated perimetry was only performed in 2 patients, both without intellectual disability and once they were of prepubertal age, with results within the normal range in both, which leads us to believe that they did not suffer retinal toxicity or else the latter was reversible.</p><p id="par0160" class="elsevierStylePara elsevierViewall">Therefore, contrary to the suggestion of other authors that advocate for first-line treatment with ACTH,<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">26</span></a> our study did not find poorer long-term outcomes in patients treated solely with VGB, and the safety profile of this drug was adequate.</p><p id="par0165" class="elsevierStylePara elsevierViewall">The prognosis of cryptogenic WS continues to be bleak. In our study, 44% percent of patients developed another form of epilepsy (in 71% of cases associated with moderate-to-severe cognitive impairment), findings that were pretty congruent with those of other authors.<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">9,10,14</span></a> The incidence of Lennox–Gastaut syndrome was low (1/16), and focal epilepsy was the most frequent outcome. The patient that developed Lennox–Gastaut syndrome did not respond to monotherapy with VGB and required the addition of ACTH, in spite of which the time elapsed from initiation of treatment to resolution of hypsarrhythmia was 3 months and a half. Thus, although treatment was initiated in the first week since onset of the spasms, the persistence of hypsarrhythmia in an immature brain may have contributed to the less favourable outcome.<a class="elsevierStyleCrossRefs" href="#bib0220"><span class="elsevierStyleSup">14,27,28</span></a></p><p id="par0170" class="elsevierStylePara elsevierViewall">Since our study only included patients with a cryptogenic aetiology, it was reasonable to expect better long-term outcomes. However, the proportion of favourable outcomes barely reached 55%, which was probably due to the presence in some cases of an unidentified underlying organic cause that worsened the prognosis independently of the control of hypsarrhythmia. Advances in diagnostic techniques and the increased use of genetic testing will lead to the identification of additional underlying conditions that could account for this epileptic encephalopathy, which a more accurate identification of cryptogenic patients that would be associated with a greater proportion of favourable long-term outcomes.<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">6,29,30</span></a> In our case, due to lack of resources in our hospital during the period under study, genetic testing was limited to karyotype analysis and testing for microdeletion syndromes, without access to gene panels. Nevertheless, metabolic studies and neuroimaging allowed the identification of an underlying cause in 2 of the 16 patients, and excluding these patients from the analysis would increase the proportion of patients with a favourable outcome to 64%, which is closer to our original expectations.</p><p id="par0175" class="elsevierStylePara elsevierViewall">We are aware of the limitations of our study, which is the reason we urge for the performance of additional research on this subject. Some of the methodological aspects that could be improved are the small sample size, the restriction of the analysis to descriptive methods, the limited access to diagnostic techniques that could help discriminate cryptogenic cases more accurately, and the subjective assessment of retinal toxicity.</p><p id="par0180" class="elsevierStylePara elsevierViewall">In conclusion, although our series was limited to cases originally classified as cryptogenic, we found that a considerable percentage had unfavourable outcomes in the long term, which underscores the severity of this disease. An exhaustive aetiological investigation continues to be essential in patients with WS in order to accurately identify patients in the cryptogenic group and be able to make an accurate prognosis. In our study, the factors we identified that may be associated with a favourable prognosis were female sex, onset of spasms after age 6 months, early initiation of treatment and early control of hypsarrhythmia, with the last 2 being particularly relevant, as they are the only factors that are actually modifiable. However, we did not find an association between first-line treatment with VGB monotherapy and a greater probability of developing secondary epilepsy.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflicts of interest</span><p id="par0185" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:3 [ "identificador" => "xres1077237" "titulo" => "Abstract" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Objectives" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Patients and methods" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Results" ] 4 => array:2 [ "identificador" => "abst0025" "titulo" => "Conclusions" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1023269" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1077238" "titulo" => "Resumen" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0030" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0035" "titulo" => "Objetivos" ] 2 => array:2 [ "identificador" => "abst0040" "titulo" => "Pacientes y métodos" ] 3 => array:2 [ "identificador" => "abst0045" "titulo" => "Resultados" ] 4 => array:2 [ "identificador" => "abst0050" "titulo" => "Conclusiones" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1023268" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Patients and methods" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0025" "titulo" => "Conflicts of interest" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2017-05-19" "fechaAceptado" => "2017-10-25" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1023269" "palabras" => array:6 [ 0 => "West syndrome" 1 => "Infantile spasms" 2 => "Cryptogenic" 3 => "Aetiology" 4 => "Vigabatrin" 5 => "Prognostic factors" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1023268" "palabras" => array:6 [ 0 => "Síndrome de West" 1 => "Espasmos infantiles" 2 => "Criptogénico" 3 => "Etiología" 4 => "Vigabatrina" 5 => "Factores pronósticos" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">West syndrome (WS) is an age-dependent epileptic encephalopathy in which the prognosis varies according to the, not always identified, underlying origin.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objectives</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To define the profile of cryptogenic (a least studied isolated sub-group) WS, in Spain. To study its outcome, response to different treatments, and to establish prognostic factors.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Patients and methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The study included a review of the medical records of 16 patients diagnosed with cryptogenic WS during the period, 2000–2015. The mean follow-up time was 6.6 years, with a minimum of 2 years.</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The large majority (11/16) were male. The mean age at onset was 6 months, and 6/16 had a family history of idiopathic epilepsy. The first line treatment with vigabatrin had an electrical–clinical response in 5/16 patients, with the remaining cases responding to adrenocorticotropic hormone (ACTH). Almost half (44%) of the patients progressed to other types of epilepsy, with no difference between those treated with vigabatrin or ACTH. A greater number of adverse effects were obtained with ACTH, with no retinal involvement being observed with vigabatrin. The aetiological cause was found in 2/16. Being female, late onset, and early control of the hypsarrhythmia, were factors of a good prognosis.</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The overall prognosis of cryptogenic WS was more serious than expected. Although the incidence of Lennox–Gastaut syndrome was low, the progression to focal epilepsy was the most common, with it appearing within the first 2 years of the diagnosis. The initial response to vigabatrin was lower than expected, but the long-term result was comparable to ACTH.</p></span>" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Objectives" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Patients and methods" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Results" ] 4 => array:2 [ "identificador" => "abst0025" "titulo" => "Conclusions" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Introducción</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">El síndrome de West (SW) es una encefalopatía epiléptica dependiente de la edad con pronóstico variable según la etiología subyacente, no siempre identificada.</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Objetivos</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Definir el perfil del SW criptogénico en nuestro medio, subgrupo menos estudiado de forma aislada. Estudiar su evolución, respuesta a los distintos tratamientos y establecer factores pronósticos.</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Pacientes y métodos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Revisión de historias clínicas de 16 pacientes diagnosticados de SW criptogénico durante el período 2000-2015. El tiempo de seguimiento medio fue 6,6 años y mínimo de 2 años.</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">11 de 16 fueron varones, la edad media de inicio fue de 6 meses y 6/16 presentaban antecedente familiar de epilepsia idiopática. El tratamiento de primera línea con vigabatrina tuvo respuesta electroclínica en 5/16 pacientes, respondiendo los casos restantes a hormona adrenocorticotropa (ACTH). El 44% de los pacientes evolucionaron a otras epilepsias, sin diferencia entre los tratados con vigabatrina o ACTH. Se obtuvo un mayor número de efectos adversos con la ACTH, no se evidenció afectación retiniana con la vigabatrina. Durante el seguimiento se llegó a la causa etiológica en 2/16. El sexo femenino, el comienzo tardío y el control precoz de la hipsarritmia resultaron factores de buen pronóstico.</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">El pronóstico global del SW criptogénico resultó más grave de los esperado. Aunque la incidencia de síndrome de Lennox-Gastaut fue baja, la epilepsia focal resultó la evolución más frecuente apareciendo en los 2 primeros años del diagnóstico. La respuesta inicial a vigabatrina fue menor a la esperada, pero el resultado a largo plazo resultó superponible a la ACTH.</p></span>" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0030" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0035" "titulo" => "Objetivos" ] 2 => array:2 [ "identificador" => "abst0040" "titulo" => "Pacientes y métodos" ] 3 => array:2 [ "identificador" => "abst0045" "titulo" => "Resultados" ] 4 => array:2 [ "identificador" => "abst0050" "titulo" => "Conclusiones" ] ] ] ] "NotaPie" => array:2 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Calderón Romero M, Arce Portillo E, López Lobato M, Muñoz Cabello B, Blanco Martínez B, Madruga Garrido M, et al. Síndrome de West criptogénico: perfil clínico, respuesta al tratamiento y factores pronósticos. An Pediatr (Barc). 2018;89:176–182.</p>" ] 1 => array:2 [ "etiqueta" => "☆☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Previous presentation: Partial results of this study were presented in poster format at the <span class="elsevierStyleSmallCaps">XXXIX</span> Meeting of the Sociedad Espanola de Neurología Pediátrica, May19–21, 2016; Toledo, Spain.</p>" ] ] "multimedia" => array:4 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 448 "Ancho" => 2299 "Tamanyo" => 60452 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Treatment protocol used in our unit and implemented in the series of patients with cryptogenic West syndrome.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1230 "Ancho" => 2333 "Tamanyo" => 182606 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Comparison of the initial long-term response to the 2 treatment regimens. Patients treated with vigabatrin monotherapy and patients treated with a combination of vigabatrin and ACTH.</p>" ] ] 2 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">ADHD, attention-deficit hyperactivity disorder; <span class="elsevierStyleItalic">n</span>, absolute frequency.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Poor outcome</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>7 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Secondary epilepsy</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">7/7 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Focal epilepsy \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Generalised epilepsy \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Lennox–Gastaut syndrome \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Refractory epilepsy \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Moderate/severe cognitive impairment</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">5/7 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Associated with epilepsy \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">5 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Pervasive developmental disorder \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Aetiological diagnosis found</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2/7 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Minor impairment</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">ADHD</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Language disorder</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Mild cognitive impairment</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1838779.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Outcomes.</p>" ] ] 3 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">ACTH, adrenocorticotropic hormone; FHx, family history; <span class="elsevierStyleItalic">n</span>, absolute frequency; VGB, vigabatrin.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Factor \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Secondary epilepsy</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Male sex (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>11) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">55% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">6/11 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Female sex (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">20% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1/5 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Onset before age 6 months (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">71% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">5/7 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Onset after age 6 months (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">22% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2/9 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">With FHx of epilepsy (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">33% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2/6 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Without FHx of epilepsy (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>10) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">50% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">5/10 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Treatment with VGB in monotherapy (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">40% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2/5 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Treatment with VGB and ACTH (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>11) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">45% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">5/11 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Delay in treatment<span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>2 weeks (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">60% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">3/5 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Delay in treatment<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>2 weeks (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>11) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">36% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">4/11 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Persistence of hypsarrhythmia<span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>3 weeks (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">75% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">3/4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Persistence of hypsarrhythmia<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>3 weeks \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">33% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">4/11 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1838780.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Potential prognostic factors.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:30 [ 0 => array:3 [ "identificador" => "bib0155" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Síndrome de West: etiología, opciones terapéuticas, evolución clínica y factores pronósticos" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 22 | 8 | 30 |
| 2024 October | 119 | 37 | 156 |
| 2024 September | 111 | 27 | 138 |
| 2024 August | 131 | 65 | 196 |
| 2024 July | 133 | 35 | 168 |
| 2024 June | 121 | 31 | 152 |
| 2024 May | 159 | 27 | 186 |
| 2024 April | 126 | 41 | 167 |
| 2024 March | 112 | 26 | 138 |
| 2024 February | 105 | 27 | 132 |
| 2024 January | 106 | 22 | 128 |
| 2023 December | 142 | 25 | 167 |
| 2023 November | 157 | 26 | 183 |
| 2023 October | 169 | 26 | 195 |
| 2023 September | 123 | 26 | 149 |
| 2023 August | 119 | 34 | 153 |
| 2023 July | 126 | 53 | 179 |
| 2023 June | 140 | 39 | 179 |
| 2023 May | 144 | 31 | 175 |
| 2023 April | 107 | 37 | 144 |
| 2023 March | 105 | 29 | 134 |
| 2023 February | 122 | 20 | 142 |
| 2023 January | 104 | 31 | 135 |
| 2022 December | 110 | 35 | 145 |
| 2022 November | 131 | 50 | 181 |
| 2022 October | 128 | 42 | 170 |
| 2022 September | 125 | 33 | 158 |
| 2022 August | 103 | 52 | 155 |
| 2022 July | 103 | 58 | 161 |
| 2022 June | 96 | 40 | 136 |
| 2022 May | 128 | 51 | 179 |
| 2022 April | 176 | 48 | 224 |
| 2022 March | 225 | 68 | 293 |
| 2022 February | 234 | 31 | 265 |
| 2022 January | 184 | 50 | 234 |
| 2021 December | 136 | 48 | 184 |
| 2021 November | 145 | 54 | 199 |
| 2021 October | 143 | 76 | 219 |
| 2021 September | 142 | 45 | 187 |
| 2021 August | 144 | 57 | 201 |
| 2021 July | 126 | 45 | 171 |
| 2021 June | 125 | 47 | 172 |
| 2021 May | 135 | 55 | 190 |
| 2021 April | 408 | 132 | 540 |
| 2021 March | 250 | 64 | 314 |
| 2021 February | 116 | 40 | 156 |
| 2021 January | 120 | 23 | 143 |
| 2020 December | 116 | 32 | 148 |
| 2020 November | 119 | 28 | 147 |
| 2020 October | 116 | 43 | 159 |
| 2020 September | 118 | 58 | 176 |
| 2020 August | 135 | 52 | 187 |
| 2020 July | 106 | 51 | 157 |
| 2020 June | 107 | 24 | 131 |
| 2020 May | 88 | 34 | 122 |
| 2020 April | 78 | 27 | 105 |
| 2020 March | 82 | 25 | 107 |
| 2020 February | 102 | 19 | 121 |
| 2020 January | 112 | 28 | 140 |
| 2019 December | 134 | 33 | 167 |
| 2019 November | 113 | 36 | 149 |
| 2019 October | 123 | 31 | 154 |
| 2019 September | 163 | 31 | 194 |
| 2019 August | 143 | 35 | 178 |
| 2019 July | 103 | 36 | 139 |
| 2019 June | 135 | 34 | 169 |
| 2019 May | 128 | 66 | 194 |
| 2019 April | 95 | 46 | 141 |
| 2019 March | 64 | 36 | 100 |
| 2019 February | 54 | 25 | 79 |
| 2019 January | 51 | 27 | 78 |
| 2018 December | 59 | 29 | 88 |
| 2018 November | 86 | 44 | 130 |
| 2018 October | 98 | 54 | 152 |
| 2018 September | 144 | 84 | 228 |
| 2018 August | 0 | 2 | 2 |
| 2018 July | 0 | 3 | 3 |
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