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We summarised the epidemiological&#44; clinical and laboratory characteristics of these cases and compared them with those from previous years&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Fifteen new cases were diagnosed in the period under study&#46; The mean age at diagnosis was 10 years&#44; and one patient had onset at the atypically early age of 19 months&#46; In previous years&#44; the outpatient clinics of the HUCA had managed 23 patients with a median age of 11 years&#44; the youngest of whom was 2 years old&#46; The increase in the incidence of IBD was of approximately 650&#37;&#44; from 2 per 100&#44;000 to 2 per 10&#44;000 inhabitants per year&#46; In 2016&#44; 46&#46;7&#37; of new cases were diagnosed in male patients compared to 74&#37; in the group of cases diagnosed in previous years &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;03&#41;&#46; In 2016&#44; most of the patients that received the diagnosis resided in an urban area &#40;66&#46;6&#37;&#41;&#44; and Oviedo and Gij&#243;n were the cities where the incidence increased most&#44; while in previous year&#44; the distribution of cases was more dispersed throughout the entire region of Asturias&#46; In 2016&#44; Crohn disease &#40;CD&#41; accounted for 66&#46;7&#37; of the cases&#44; and the most frequent presenting symptoms were bloody stools and abdominal pain&#46; In previous years&#44; the distribution of diagnostic categories was more even&#44; with 52&#46;2&#37; of cases of CD&#44; 43&#46;5&#37; of ulcerative colitis &#40;UC&#41; and 4&#46;3&#37; of indeterminate colitis &#40;IC&#41;&#46; In 2016&#44; only one patient had a family history of IBD&#44; while 46&#46;7&#37; had underlying diseases &#40;57&#37; asthma&#47;allergy&#41;&#46; The body weight was within the normal range in 73&#46;3&#37; of patients &#40;body mass index between the 15th and the 85th percentiles&#41;&#44; 1 patient was obese and 1 malnourished at the time of diagnosis&#46; Eighty percent of patients had faecal calprotectin levels of 1000<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;g or greater&#44; while only 5 patients had an erythrocyte sedimentation rate of more than 20<span class="elsevierStyleHsp" style=""></span>mm&#47;h and 3 a C-reactive protein level of more than 5<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#46; Also&#44; 26&#46;7&#37; tested positive for anti-<span class="elsevierStyleItalic">Saccharomyces cerevisiae</span> or anti-neutrophil cytoplasmic antibodies&#46; Only one patient had an albumin level of less than 30<span class="elsevierStyleHsp" style=""></span>g&#47;L&#46; Thrombocytosis was present in 73&#46;4&#37; of cases&#46; Except for one episode of severe colitis &#40;Paediatric Ulcerative Colitis Activity Index &#91;PUCAI&#93;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>65 points&#41; in the child aged 19 months&#44; activity index scores in all patients &#40;PUCAI and Paediatric Crohn&#39;s Disease Activity Index &#91;PCDAI&#93;&#41; reflected mild disease at the time of diagnosis&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The causes of this increase in incidence have yet to be determined&#46; The aetiology of IBD is multifactorial&#44; and it is hypothesised that it results from the interaction of genetic vulnerability&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> various environmental factors and the intestinal microbiota&#46; When IBD is diagnosed in children aged less than 6 years&#44; it is considered very-early-onset IBD &#40;VEOIBD&#41;&#46; Furthermore&#44; diagnosis in children aged less than 2 years requires ruling out monogenic forms of IBD&#44; as these children exhibit more disseminated inflammation&#44; higher rates of treatment resistance and rapid disease progression&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> In our patient aged 19 months&#44; we ruled out immunodeficiencies that could present with an IBD-like phenotype &#40;primary immunodeficiencies&#44; autoinflammatory diseases&#44; &#8230;&#41;&#46; However&#44; we cannot rule out a genetic basis in this case&#44; as a genetic investigation was not performed in this patient as part of the initial evaluation due to the presenting phenotype and the very favourable response to standard treatment&#46; There are numerous articles in the literature on the influence of environmental factors in IBD&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> There is an evidence of an association with diets rich in animal protein and additives&#44; the excessive use of antibiotics and the increase in environmental pollution&#44; among others&#44; but the pathophysiology that underlies this association is not understood&#46; We do know that antibiotic use can lead to dysbiosis in the intestinal microbiota&#44; which in turn is associated with IBD&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> The SPIRIT study<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> &#40;a multicentre study conducted between 1996 and 2009&#41; found that the incidence of CD had tripled&#44; the incidence of UC doubled&#44; and a north-south gradient in the incidence of IBD&#46; There is evidence of an association between vitamin D deficiency and IBD&#44;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> which could partly explain the presence of this north-south gradient&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The increased incidence of IBD observed in our region in 2016 has the characteristics of an epidemic&#46; Although we found no differences in the age at onset or disease severity&#44; we did find a significant increase in the incidence of IBD in female patients&#46; Performance of epidemiological studies would be useful to try to determine the underlying causes of this phenomenon&#46;</p></span>"
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                            0 => "W&#46; Venema"
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                            4 => "E&#46; Festen"
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Scientific Letter
2016: Inflammatory bowel disease epidemic in Asturias
2016: epidemia de enfermedad inflamatoria intestinal en Asturias
Alicia Isabel Pascual Pérez
Corresponding author
Aliciapascual13@gmail.com

Corresponding author.
, Juan José Díaz Martín, Santiago Jiménez Treviño, Carlos Bousoño García
Sección de Gastroenterología, Hepatología y Nutrición Pediátrica, Área de Gestión Clínica de Pediatría, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain
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            "entidad" => "Secci&#243;n de Gastroenterolog&#237;a&#44; Hepatolog&#237;a y Nutrici&#243;n Pedi&#225;trica&#44; &#193;rea de Gesti&#243;n Cl&#237;nica de Pediatr&#237;a&#44; Hospital Universitario Central de Asturias&#44; Oviedo&#44; Asturias&#44; Spain"
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        "titulo" => "2016&#58; epidemia de enfermedad inflamatoria intestinal en Asturias"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The term epidemic refers to the occurrence of a number of cases of a specific disease that exceeds the expected incidence in a given geographical area&#46; The Hospital Universitario Central de Asturias &#40;HUCA&#41; is the regional referral centre for inflammatory bowel disease &#40;IBD&#41; for the paediatric population of the Autonomous Community of Asturias&#44; Spain&#46; Historically&#44; the department of paediatric gastroenterology diagnosed an average of 2 new cases of IBD each year&#46; However&#44; in year 2016 the department diagnosed 15 new cases&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">With the aim of finding an explanation to this striking increase in incidence&#44; we reviewed the health records of children &#40;aged 0&#8211;14 years&#41; that received a diagnosis of IBD in the paediatric gastroenterology outpatient clinics of the HUCA between December 2015 and January 2017&#46; We summarised the epidemiological&#44; clinical and laboratory characteristics of these cases and compared them with those from previous years&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Fifteen new cases were diagnosed in the period under study&#46; The mean age at diagnosis was 10 years&#44; and one patient had onset at the atypically early age of 19 months&#46; In previous years&#44; the outpatient clinics of the HUCA had managed 23 patients with a median age of 11 years&#44; the youngest of whom was 2 years old&#46; The increase in the incidence of IBD was of approximately 650&#37;&#44; from 2 per 100&#44;000 to 2 per 10&#44;000 inhabitants per year&#46; In 2016&#44; 46&#46;7&#37; of new cases were diagnosed in male patients compared to 74&#37; in the group of cases diagnosed in previous years &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;03&#41;&#46; In 2016&#44; most of the patients that received the diagnosis resided in an urban area &#40;66&#46;6&#37;&#41;&#44; and Oviedo and Gij&#243;n were the cities where the incidence increased most&#44; while in previous year&#44; the distribution of cases was more dispersed throughout the entire region of Asturias&#46; In 2016&#44; Crohn disease &#40;CD&#41; accounted for 66&#46;7&#37; of the cases&#44; and the most frequent presenting symptoms were bloody stools and abdominal pain&#46; In previous years&#44; the distribution of diagnostic categories was more even&#44; with 52&#46;2&#37; of cases of CD&#44; 43&#46;5&#37; of ulcerative colitis &#40;UC&#41; and 4&#46;3&#37; of indeterminate colitis &#40;IC&#41;&#46; In 2016&#44; only one patient had a family history of IBD&#44; while 46&#46;7&#37; had underlying diseases &#40;57&#37; asthma&#47;allergy&#41;&#46; The body weight was within the normal range in 73&#46;3&#37; of patients &#40;body mass index between the 15th and the 85th percentiles&#41;&#44; 1 patient was obese and 1 malnourished at the time of diagnosis&#46; Eighty percent of patients had faecal calprotectin levels of 1000<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;g or greater&#44; while only 5 patients had an erythrocyte sedimentation rate of more than 20<span class="elsevierStyleHsp" style=""></span>mm&#47;h and 3 a C-reactive protein level of more than 5<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#46; Also&#44; 26&#46;7&#37; tested positive for anti-<span class="elsevierStyleItalic">Saccharomyces cerevisiae</span> or anti-neutrophil cytoplasmic antibodies&#46; Only one patient had an albumin level of less than 30<span class="elsevierStyleHsp" style=""></span>g&#47;L&#46; Thrombocytosis was present in 73&#46;4&#37; of cases&#46; Except for one episode of severe colitis &#40;Paediatric Ulcerative Colitis Activity Index &#91;PUCAI&#93;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>65 points&#41; in the child aged 19 months&#44; activity index scores in all patients &#40;PUCAI and Paediatric Crohn&#39;s Disease Activity Index &#91;PCDAI&#93;&#41; reflected mild disease at the time of diagnosis&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The causes of this increase in incidence have yet to be determined&#46; The aetiology of IBD is multifactorial&#44; and it is hypothesised that it results from the interaction of genetic vulnerability&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> various environmental factors and the intestinal microbiota&#46; When IBD is diagnosed in children aged less than 6 years&#44; it is considered very-early-onset IBD &#40;VEOIBD&#41;&#46; Furthermore&#44; diagnosis in children aged less than 2 years requires ruling out monogenic forms of IBD&#44; as these children exhibit more disseminated inflammation&#44; higher rates of treatment resistance and rapid disease progression&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> In our patient aged 19 months&#44; we ruled out immunodeficiencies that could present with an IBD-like phenotype &#40;primary immunodeficiencies&#44; autoinflammatory diseases&#44; &#8230;&#41;&#46; However&#44; we cannot rule out a genetic basis in this case&#44; as a genetic investigation was not performed in this patient as part of the initial evaluation due to the presenting phenotype and the very favourable response to standard treatment&#46; There are numerous articles in the literature on the influence of environmental factors in IBD&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> There is an evidence of an association with diets rich in animal protein and additives&#44; the excessive use of antibiotics and the increase in environmental pollution&#44; among others&#44; but the pathophysiology that underlies this association is not understood&#46; We do know that antibiotic use can lead to dysbiosis in the intestinal microbiota&#44; which in turn is associated with IBD&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> The SPIRIT study<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> &#40;a multicentre study conducted between 1996 and 2009&#41; found that the incidence of CD had tripled&#44; the incidence of UC doubled&#44; and a north-south gradient in the incidence of IBD&#46; There is evidence of an association between vitamin D deficiency and IBD&#44;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> which could partly explain the presence of this north-south gradient&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The increased incidence of IBD observed in our region in 2016 has the characteristics of an epidemic&#46; Although we found no differences in the age at onset or disease severity&#44; we did find a significant increase in the incidence of IBD in female patients&#46; Performance of epidemiological studies would be useful to try to determine the underlying causes of this phenomenon&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Pascual P&#233;rez AI&#44; D&#237;az Mart&#237;n JJ&#44; Jim&#233;nez Trevi&#241;o S&#44; Bouso&#241;o Garc&#237;a C&#46; 2016&#58; epidemia de enfermedad inflamatoria intestinal en Asturias&#46; An Pediatr &#40;Barc&#41;&#46; 2018&#59;89&#58;183&#8211;184&#46;</p>"
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      "titulo" => "References"
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        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:6 [
            0 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The genetic background of inflammatory bowel disease&#58; from correlation to causality"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "W&#46; Venema"
                            1 => "M&#46; Voskuil"
                            2 => "G&#46; Dijkstra"
                            3 => "R&#46; Weersma"
                            4 => "E&#46; Festen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/path.4817"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pathol"
                        "fecha" => "2017"
                        "volumen" => "241"
                        "paginaInicial" => "146"
                        "paginaFinal" => "158"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27785786"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Phenotypic and genotypic characterisation of inflammatory bowel disease presenting before the age of 2 years"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Kammermeier"
                            1 => "R&#46; Dziubak"
                            2 => "M&#46; Pescarin"
                            3 => "S&#46; Drury"
                            4 => "H&#46; Godwin"
                            5 => "K&#46; Reeve"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ecco-jcc/jjw118"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Crohns Colitis"
                        "fecha" => "2017"
                        "volumen" => "11"
                        "paginaInicial" => "60"
                        "paginaFinal" => "69"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27302973"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "European Crohn&#39;s and colitis organisation topical review on environmental factors in IBD"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Maaser"
                            1 => "E&#46; Langholz"
                            2 => "A&#46; Gordon"
                            3 => "J&#46; Burisch"
                            4 => "P&#46; Ellul"
                            5 => "V&#46; Hern&#225;ndez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ecco-jcc/jjw223"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Crohns Colitis"
                        "fecha" => "2017"
                        "volumen" => "11"
                        "paginaInicial" => "905"
                        "paginaFinal" => "920"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28039310"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The association between the gut microbiota and the inflammatory bowel disease activity&#58; a systematic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Prosberg"
                            1 => "F&#46; Bentsen"
                            2 => "I&#46; Vind"
                            3 => "A&#46;M&#46; Petersen"
                            4 => "L&#46;L&#46; Gluud"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1080/00365521.2016.1216587"
                      "Revista" => array:6 [
                        "tituloSerie" => "Scand J Gastroenterol"
                        "fecha" => "2016"
                        "volumen" => "51"
                        "paginaInicial" => "1407"
                        "paginaFinal" => "1415"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27687331"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increasing incidence of pediatric inflammatory bowel disease in Spain &#40;1996&#8211;2009&#41;&#58; the SPIRIT Registry"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46; Mart&#237;n de Carpi"
                            1 => "A&#46; Rodr&#237;guez"
                            2 => "E&#46; Ramos"
                            3 => "S&#46; Jim&#233;nez"
                            4 => "M&#46;J&#46; Mart&#237;nez-G&#243;mez"
                            5 => "E&#46; Medina"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/ibd.22980"
                      "Revista" => array:6 [
                        "tituloSerie" => "Inflamm Bowel Dis"
                        "fecha" => "2013"
                        "volumen" => "19"
                        "paginaInicial" => "73"
                        "paginaFinal" => "80"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22535573"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vitamin D deficiency associated with disease activity in patients with inflammatory bowel diseases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Torki"
                            1 => "A&#46; Gholamrezaei"
                            2 => "L&#46; Mirbagher"
                            3 => "M&#46; Danesh"
                            4 => "S&#46; Kheiri"
                            5 => "M&#46; Emami"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s10620-015-3727-4"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dig Dis Sci"
                        "fecha" => "2015"
                        "volumen" => "60"
                        "paginaInicial" => "3085"
                        "paginaFinal" => "3091"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26031421"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
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ISSN: 23412879
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