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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Eosinophilic gastroenteritis &#40;EGE&#41; is a rare type of gastroenteritis characterised by eosinophilic inflammation in different segments of the GI tract in the absence of known causes for eosinophilia &#40;parasitic infestation&#44; drug toxicity&#44; malignancy&#44; inflammatory bowel disease or hypereosinophilic syndrome&#44; among others&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The clinical manifestations of EGE are nonspecific and vary based on the location and the depth of eosinophilic infiltration in the layers of the gastrointestinal tract&#44; and may include chronic abdominal pain&#44; vomiting&#44; upper or lower gastrointestinal bleeding&#44; diarrhoea and&#47;or ascites&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> Its aetiology and pathophysiology is not understood&#44; although they seem to be involve hypersensitivity mechanisms&#44; and the antigen involved most frequently in infants is cow&#39;s milk protein &#40;CMP&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">3&#44;4</span></a> The diagnosis is confirmed by histological examination&#44; and at present there is no established threshold for the definition of eosinophilia in the gastrointestinal tract&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">2&#44;4&#44;5</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Eosinophilic gastroenteritis is rare in infants and its presentation can vary widely&#44; so diagnosis requires a high level of suspicion&#46; In patients that present with upper gastrointestinal bleeding&#44; the disease may range from mild forms that are well tolerated to severe forms leading to anaemia or haemodynamic instability that may require transfusions&#46; We present the cases of two infants with eosinophilic gastroenteritis and gastritis managed in our hospital&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Case 1&#58; infant aged 4 months&#44; previously healthy&#44; who in the context of acute gastroenteritis had three episodes of vomiting with presence of coagulated blood in the vomit&#46; He had not received ibuprofen and had been fed infant formula since age 1 month&#46; At the time of evaluation&#44; he was in good general health with normal vital signs&#46; He had several eczematous lesions in the trunk and retroauricular area&#46; The complete blood count revealed a haemoglobin concentration of 11&#46;2<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#44; a white blood cell count of 18<span class="elsevierStyleHsp" style=""></span>800<span class="elsevierStyleHsp" style=""></span>cells&#47;mm<span class="elsevierStyleSup">3</span> &#40;18&#46;9&#37; neutrophils&#44; 56&#46;4&#37; lymphocytes&#44; 22&#46;8&#37; monocytes&#44; 1&#46;8&#37; eosinophils&#44; 0&#46;1&#37; basophils&#41; and a platelet count of 283<span class="elsevierStyleHsp" style=""></span>000&#47;mm<span class="elsevierStyleSup">3</span>&#46; The abdominal ultrasound findings were normal&#46; Fresh blood was found on gastric suction&#44; and oesophagogastroduodenoscopy revealed erosions in the antral mucosa and diffuse fibrin-coated lesions in the gastric body and a pale duodenal mucosa&#46; Histological examination &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; revealed a significant although heterogeneous eosinophilic component in the duodenal mucosa &#40;&#62;20 eosinophils&#47;high power field &#91;HPF&#93; with focal involvement&#41; and a mixed inflammatory cellular infiltrate in the gastric mucosa that included abundant eosinophils &#40;25&#8211;30 eosinophils&#47;HPF&#41;&#46; The infant was managed by switching to elemental formula&#44; to which he showed a favourable response&#46; Allergen-specific IgE testing detected low titres of antibodies against CMP &#40;casein&#44; 0&#46;44<span class="elsevierStyleHsp" style=""></span>kIU&#47;L&#59; &#946;-lactoglobulin&#44; 0&#46;24<span class="elsevierStyleHsp" style=""></span>kIU&#47;L&#44; &#945;-lactalbumin&#44; 0&#46;12<span class="elsevierStyleHsp" style=""></span>kIU&#47;L&#41;&#46; Followup&#58; from age 12 months&#44; CMP was progressively reintroduced in the diet without negative repercussions&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Case 2&#58; infant aged 2 months&#44; previously healthy&#44; who had three episodes of vomiting with fresh blood and a darker-than-normal bowel movement the day before evaluation&#46; She presented with urticarial-like lesions in the lower extremities that had developed 24<span class="elsevierStyleHsp" style=""></span>h earlier&#44; which she had also exhibited transiently at age 1 month&#46; The patient had been formula-fed from birth&#46; She was in good general health at the time of physical examination&#44; whose salient findings were a marked paleness of the skin and mucosae and a red and swollen exanthema in the lower extremities that was spreading to the upper limbs&#46; Auscultation of heart sounds revealed tachycardia&#44; with 165 beats per minute&#44; and a mild systolic murmur&#46; The findings of the complete blood count were&#58; haemoglobin concentration of 6&#46;5<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#44; white blood cell count of 16<span class="elsevierStyleHsp" style=""></span>700<span class="elsevierStyleHsp" style=""></span>cells&#47;mm<span class="elsevierStyleSup">3</span> &#40;24&#46;2&#37; neutrophils&#44; 61&#46;3&#37; lymphocytes&#44; 13&#46;5&#37; monocytes&#44; 0&#46;7&#37; eosinophils&#44; 0&#46;3&#37; basophils&#41; and 338<span class="elsevierStyleHsp" style=""></span>000<span class="elsevierStyleHsp" style=""></span>platelets&#47;mm<span class="elsevierStyleSup">3</span>&#44; with normal features in the peripheral blood smear&#46; The results of the blood chemistry and coagulation panel were normal&#44; and haematuria was not detected in the urine test strip&#46; The patient underwent gastric lavage and suction&#44; and blood was not found in the recovered contents&#46; Since the loss of blood had caused haemodynamic instability&#44; the patient received a transfusion of packed red blood cells&#44; which led to improvement of symptoms and laboratory parameters&#46; Oesophagogastroduodenoscopy revealed diffuse erythema and multiple fibrinous lesions in the gastric mucosa and a normal duodenal mucosa&#46; Biopsy examination revealed superficial gastritis and a mixed inflammatory cell infiltrate with a predominance of eosinophils&#44; with up to 30 eosinophils&#47;HPF &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The patient was switched to an exclusive diet of elemental formula&#44; with resolution of symptoms&#46; Allergen-specific IgE testing detected antibodies against CMP &#40;casein&#44; 1&#46;24<span class="elsevierStyleHsp" style=""></span>kIU&#47;L&#59; &#946;-lactoglobulin&#44; 2&#46;82<span class="elsevierStyleHsp" style=""></span>kIU&#47;L&#59; &#945;-lactalbumin&#44; 0&#46;14<span class="elsevierStyleHsp" style=""></span>kIU&#47;L&#59; cow&#39;s milk&#44; 3&#46;69<span class="elsevierStyleHsp" style=""></span>kIU&#47;L&#41;&#46; Followup&#58; the patient is still keeping a CMP-free diet&#44; which is well tolerated&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">The two patients whose cases we present here had onset during infancy with upper gastrointestinal bleeding and a different degree of haemodynamic impact&#44; and received final diagnoses of eosinophilic gastroenteritis and eosinophilic gastritis&#44; respectively&#46; Recently&#44; Choi et al&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> published a study assessing the clinical&#44; endoscopic and histologic features and the response to treatment of 13 children with a histological diagnosis of EGE&#46; They found that the most prevalent symptom at onset in the infant group &#40;8 patients&#41; 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Scientific Letter
Hematemesis as debut of eosinophilic gastroenteritis in infants
Hematemesis como debut de gastroenteritis eosinofílica en lactantes
María Soriano-Ramos
Corresponding author
sorianoramosmaria@gmail.com

Corresponding author.
, Enrique Salcedo Lobato, Yolanda Rodríguez Gil, Enrique Medina Benítez, Pedro Urruzuno Tellería
Departamento de Pediatría, Hospital Universitario 12 de Octubre, Madrid, Spain
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    "titulo" => "Hematemesis as debut of eosinophilic gastroenteritis in infants"
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">High-magnification microscopic view of gastric mucosa revealing erosive gastritis with a significant eosinophil component in the inflammatory infiltrate &#40;&#62;30<span class="elsevierStyleHsp" style=""></span>cells&#47;HPF&#41;&#46; HE stain&#46; 400&#215; magnification&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Eosinophilic gastroenteritis &#40;EGE&#41; is a rare type of gastroenteritis characterised by eosinophilic inflammation in different segments of the GI tract in the absence of known causes for eosinophilia &#40;parasitic infestation&#44; drug toxicity&#44; malignancy&#44; inflammatory bowel disease or hypereosinophilic syndrome&#44; among others&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The clinical manifestations of EGE are nonspecific and vary based on the location and the depth of eosinophilic infiltration in the layers of the gastrointestinal tract&#44; and may include chronic abdominal pain&#44; vomiting&#44; upper or lower gastrointestinal bleeding&#44; diarrhoea and&#47;or ascites&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> Its aetiology and pathophysiology is not understood&#44; although they seem to be involve hypersensitivity mechanisms&#44; and the antigen involved most frequently in infants is cow&#39;s milk protein &#40;CMP&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">3&#44;4</span></a> The diagnosis is confirmed by histological examination&#44; and at present there is no established threshold for the definition of eosinophilia in the gastrointestinal tract&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">2&#44;4&#44;5</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Eosinophilic gastroenteritis is rare in infants and its presentation can vary widely&#44; so diagnosis requires a high level of suspicion&#46; In patients that present with upper gastrointestinal bleeding&#44; the disease may range from mild forms that are well tolerated to severe forms leading to anaemia or haemodynamic instability that may require transfusions&#46; We present the cases of two infants with eosinophilic gastroenteritis and gastritis managed in our hospital&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Case 1&#58; infant aged 4 months&#44; previously healthy&#44; who in the context of acute gastroenteritis had three episodes of vomiting with presence of coagulated blood in the vomit&#46; He had not received ibuprofen and had been fed infant formula since age 1 month&#46; At the time of evaluation&#44; he was in good general health with normal vital signs&#46; He had several eczematous lesions in the trunk and retroauricular area&#46; The complete blood count revealed a haemoglobin concentration of 11&#46;2<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#44; a white blood cell count of 18<span class="elsevierStyleHsp" style=""></span>800<span class="elsevierStyleHsp" style=""></span>cells&#47;mm<span class="elsevierStyleSup">3</span> &#40;18&#46;9&#37; neutrophils&#44; 56&#46;4&#37; lymphocytes&#44; 22&#46;8&#37; monocytes&#44; 1&#46;8&#37; eosinophils&#44; 0&#46;1&#37; basophils&#41; and a platelet count of 283<span class="elsevierStyleHsp" style=""></span>000&#47;mm<span class="elsevierStyleSup">3</span>&#46; The abdominal ultrasound findings were normal&#46; Fresh blood was found on gastric suction&#44; and oesophagogastroduodenoscopy revealed erosions in the antral mucosa and diffuse fibrin-coated lesions in the gastric body and a pale duodenal mucosa&#46; Histological examination &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; revealed a significant although heterogeneous eosinophilic component in the duodenal mucosa &#40;&#62;20 eosinophils&#47;high power field &#91;HPF&#93; with focal involvement&#41; and a mixed inflammatory cellular infiltrate in the gastric mucosa that included abundant eosinophils &#40;25&#8211;30 eosinophils&#47;HPF&#41;&#46; The infant was managed by switching to elemental formula&#44; to which he showed a favourable response&#46; Allergen-specific IgE testing detected low titres of antibodies against CMP &#40;casein&#44; 0&#46;44<span class="elsevierStyleHsp" style=""></span>kIU&#47;L&#59; &#946;-lactoglobulin&#44; 0&#46;24<span class="elsevierStyleHsp" style=""></span>kIU&#47;L&#44; &#945;-lactalbumin&#44; 0&#46;12<span class="elsevierStyleHsp" style=""></span>kIU&#47;L&#41;&#46; Followup&#58; from age 12 months&#44; CMP was progressively reintroduced in the diet without negative repercussions&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Case 2&#58; infant aged 2 months&#44; previously healthy&#44; who had three episodes of vomiting with fresh blood and a darker-than-normal bowel movement the day before evaluation&#46; She presented with urticarial-like lesions in the lower extremities that had developed 24<span class="elsevierStyleHsp" style=""></span>h earlier&#44; which she had also exhibited transiently at age 1 month&#46; The patient had been formula-fed from birth&#46; She was in good general health at the time of physical examination&#44; whose salient findings were a marked paleness of the skin and mucosae and a red and swollen exanthema in the lower extremities that was spreading to the upper limbs&#46; Auscultation of heart sounds revealed tachycardia&#44; with 165 beats per minute&#44; and a mild systolic murmur&#46; The findings of the complete blood count were&#58; haemoglobin concentration of 6&#46;5<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#44; white blood cell count of 16<span class="elsevierStyleHsp" style=""></span>700<span class="elsevierStyleHsp" style=""></span>cells&#47;mm<span class="elsevierStyleSup">3</span> &#40;24&#46;2&#37; neutrophils&#44; 61&#46;3&#37; lymphocytes&#44; 13&#46;5&#37; monocytes&#44; 0&#46;7&#37; eosinophils&#44; 0&#46;3&#37; basophils&#41; and 338<span class="elsevierStyleHsp" style=""></span>000<span class="elsevierStyleHsp" style=""></span>platelets&#47;mm<span class="elsevierStyleSup">3</span>&#44; with normal features in the peripheral blood smear&#46; The results of the blood chemistry and coagulation panel were normal&#44; and haematuria was not detected in the urine test strip&#46; The patient underwent gastric lavage and suction&#44; and blood was not found in the recovered contents&#46; Since the loss of blood had caused haemodynamic instability&#44; the patient received a transfusion of packed red blood cells&#44; which led to improvement of symptoms and laboratory parameters&#46; Oesophagogastroduodenoscopy revealed diffuse erythema and multiple fibrinous lesions in the gastric mucosa and a normal duodenal mucosa&#46; Biopsy examination revealed superficial gastritis and a mixed inflammatory cell infiltrate with a predominance of eosinophils&#44; with up to 30 eosinophils&#47;HPF &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The patient was switched to an exclusive diet of elemental formula&#44; with resolution of symptoms&#46; Allergen-specific IgE testing detected antibodies against CMP &#40;casein&#44; 1&#46;24<span class="elsevierStyleHsp" style=""></span>kIU&#47;L&#59; &#946;-lactoglobulin&#44; 2&#46;82<span class="elsevierStyleHsp" style=""></span>kIU&#47;L&#59; &#945;-lactalbumin&#44; 0&#46;14<span class="elsevierStyleHsp" style=""></span>kIU&#47;L&#59; cow&#39;s milk&#44; 3&#46;69<span class="elsevierStyleHsp" style=""></span>kIU&#47;L&#41;&#46; Followup&#58; the patient is still keeping a CMP-free diet&#44; which is well tolerated&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">The two patients whose cases we present here had onset during infancy with upper gastrointestinal bleeding and a different degree of haemodynamic impact&#44; and received final diagnoses of eosinophilic gastroenteritis and eosinophilic gastritis&#44; respectively&#46; Recently&#44; Choi et al&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> published a study assessing the clinical&#44; endoscopic and histologic features and the response to treatment of 13 children with a histological diagnosis of EGE&#46; They found that the most prevalent symptom at onset in the infant group &#40;8 patients&#41; was haematemesis &#40;7 patients&#44; 87&#46;5&#37;&#41;&#44; followed by melena &#40;2 patients&#44; 25&#37;&#41;&#46; In contrast&#44; recurrent abdominal pain was the predominant symptom in the group of children aged more than 1 year &#40;60&#37;&#41;&#46; Furthermore&#44; CMP was the allergen most frequently suspected to be involved based on the clinical manifestations&#44; suspected in 76&#46;9&#37; of patients&#44; and all infants in this study responded favourably to switching from cow&#39;s milk to extensively hydrolysed&#47;elemental formula&#46; These findings are consistent with the outcomes of the two patients managed in our hospital&#44; although it is important to keep in mind that absence of peripheral eosinophilia or negative results of specific IgE assays are not sufficient to exclude a diagnosis of EGE&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#44;2</span></a></p></span>"
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Article information
ISSN: 23412879
Original language: English
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2024 June 60 39 99
2024 May 42 62 104
2024 April 48 31 79
2024 March 60 23 83
2024 February 43 43 86
2024 January 49 27 76
2023 December 69 21 90
2023 November 48 27 75
2023 October 47 23 70
2023 September 46 22 68
2023 August 47 17 64
2023 July 58 34 92
2023 June 60 26 86
2023 May 73 22 95
2023 April 65 24 89
2023 March 83 21 104
2023 February 60 19 79
2023 January 43 21 64
2022 December 65 21 86
2022 November 72 37 109
2022 October 58 40 98
2022 September 43 47 90
2022 August 53 49 102
2022 July 44 43 87
2022 June 42 33 75
2022 May 42 48 90
2022 April 54 46 100
2022 March 60 56 116
2022 February 48 34 82
2022 January 81 48 129
2021 December 53 43 96
2021 November 64 43 107
2021 October 86 86 172
2021 September 45 43 88
2021 August 52 41 93
2021 July 58 36 94
2021 June 53 51 104
2021 May 72 46 118
2021 April 152 53 205
2021 March 78 30 108
2021 February 64 22 86
2021 January 56 24 80
2020 December 61 16 77
2020 November 66 14 80
2020 October 49 20 69
2020 September 64 22 86
2020 August 39 9 48
2020 July 51 14 65
2020 June 59 11 70
2020 May 44 19 63
2020 April 41 15 56
2020 March 39 21 60
2020 February 38 10 48
2020 January 50 16 66
2019 December 59 23 82
2019 November 53 24 77
2019 October 50 15 65
2019 September 32 17 49
2019 August 49 21 70
2019 July 49 26 75
2019 June 33 23 56
2019 May 53 27 80
2019 April 78 33 111
2019 March 48 25 73
2019 February 51 22 73
2019 January 35 14 49
2018 December 56 24 80
2018 November 58 31 89
2018 October 59 13 72
2018 September 44 13 57
2018 August 3 0 3
2018 July 4 1 5
2018 May 0 7 7
2018 April 0 3 3
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¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?