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marcescens</span> outbreak associated with the use of contaminated chlorhexidine &#40;CHX&#41; antiseptic solution<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> that occurred between August 2014 and January 2015 and comprised 148 cases &#40;86 confirmed&#41; in 10 Autonomous regions&#46; Although most of the affected patients were aged more than 65 years&#44; 8 children were affected in our hospital&#44; between November 22 and December 16&#44; 2014&#46; All developed bacteraemia and had favourable outcomes&#44; except 1 infant who died within 24<span class="elsevierStyleHsp" style=""></span>h from diagnosis &#40;mortality of 12&#46;5&#37;&#41;&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Initially&#44; when we were still unaware of the national scope of the outbreak&#44; we hypothesised that there must be a common source&#47;reservoir of <span class="elsevierStyleItalic">S&#46; marcescens</span>&#44; a fluid medium somewhere in the surgical suite of the hospital&#44; where the first 5 affected patients had been treated&#46; Since culture of the CHX-based antiseptic solutions in the surgical suite was negative and <span class="elsevierStyleItalic">S</span>&#46; <span class="elsevierStyleItalic">marcescens</span> was isolated from a bag of packed red blood cells in a patient that had received a transfusion in the paediatric ICU and not undergone surgery&#44; we considered transfusion another potential route of infection&#44; as all the affected patients had received transfusions prior to the diagnosis of bacteraemia&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">With the investigation underway&#44; when 7 of the 8 cases had been detected&#44; the Spanish Agency of Medicines and Medical Devices issued a recall of skin antiseptic based on CHX in aqueous or alcohol solution that had been distributed in 2014 &#40;lots <span class="elsevierStyleSmallCaps">I</span>-15&#44; <span class="elsevierStyleSmallCaps">I</span>-11&#44; <span class="elsevierStyleSmallCaps">I</span>-28&#44; <span class="elsevierStyleSmallCaps">I</span>-29&#44; <span class="elsevierStyleSmallCaps">I</span>-30&#44; <span class="elsevierStyleSmallCaps">I</span>-33 and <span class="elsevierStyleSmallCaps">I</span>-35&#41;&#44; while the Epidemiological Surveillance System of Andalusia &#40;SVEA&#41; of Andalusia warned us that the use of this antiseptic was probably the cause of the outbreak at our hospital&#46; Having received this warning&#44; we verified that the units affected by the outbreak had been using products from several of the lots included in the recall&#46; Unlike other published studies regarding this outbreak&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> we performed pulsed-field gel electrophoresis for the molecular analysis of isolates from patient samples&#44; those obtained from new samples of CHX solutions removed from use in the hospital &#40;lots <span class="elsevierStyleSmallCaps">I</span>-33 and <span class="elsevierStyleSmallCaps">I</span>-35&#41; and the strain provided by the laboratories that distributed the contaminated antiseptic&#44; and found that all isolates were from a single clone &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The procedures that most likely contributed to the transmission of infection were those whose performance was preceded by the use of this antiseptic&#44; such as disinfection of the skin prior to surgery or catheterisation&#44; and disinfection of 3-way stopcocks before transfusion&#46; This was consistent with the information received in the outbreak report&#44; where the medical procedure associated with the use of the CHX solution was catheterisation in 70&#37; of cases&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The rapid identification and notification of the outbreak&#44; the implementation of preventive measures and molecular testing allowed the control of an outbreak affecting the paediatric age group&#44; a particularly vulnerable population&#46; We ought to highlight that our study evinced the clonal relationship of all isolates from the outbreak with the original contaminant strain&#44; and that cases were restricted to the paediatric population&#44; including one death that could be attributed to infection by <span class="elsevierStyleItalic">S</span>&#46; <span class="elsevierStyleItalic">marcescens</span> out of the 148 patients affected nationwide&#46; It is essential that we improve the communication between Public Health Agencies and health care facilities&#44; as the problem started in 2014 and the outbreak persisted through December of the same year&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a></p></span>"
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        "texto" => "<p id="par0030" class="elsevierStylePara elsevierViewall">We thank the Pediatric Critical Care and Emergency Unit&#44; Department of Pediatrics and Department of Pediatric Surgery of the Pediatric University Hospital Virgen del Roc&#237;o&#44; the Epidemiological Surveillance System of Andalusia and the Regional Blood transfusion center of Seville for their inestimable collaboration in managing the outbreak and their invaluable contributions&#46;</p>"
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Scientific Letter
Implication of a national outbreak of Serratia marcescens associated with a contaminated solution of chlorhexidine in a paediatric hospital
Implicación de un brote nacional de infección por Serratia marcescens asociado a clorhexidina contaminada en un hospital pediátrico
Áurea Morilloa,
Corresponding author
aurea.morillo@gmail.com

Corresponding author.
, María José Torresb, María Teresa Alonso Salasc, Manuel Condea, Javier Aznara,b,d
a Unidad Clínica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen del Rocío, Sevilla, Spain
b Departamento de Microbiología, Universidad de Sevilla, Sevilla, Spain
c Unidad Clínica de Cuidados Críticos y Urgencias Pediátricas, Hospital Universitario Virgen del Rocío, Sevilla, Spain
d Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío, CSIC Universidad de Sevilla, Sevilla, Spain
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marcescens</span> outbreak associated with the use of contaminated chlorhexidine &#40;CHX&#41; antiseptic solution<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> that occurred between August 2014 and January 2015 and comprised 148 cases &#40;86 confirmed&#41; in 10 Autonomous regions&#46; Although most of the affected patients were aged more than 65 years&#44; 8 children were affected in our hospital&#44; between November 22 and December 16&#44; 2014&#46; All developed bacteraemia and had favourable outcomes&#44; except 1 infant who died within 24<span class="elsevierStyleHsp" style=""></span>h from diagnosis &#40;mortality of 12&#46;5&#37;&#41;&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Initially&#44; when we were still unaware of the national scope of the outbreak&#44; we hypothesised that there must be a common source&#47;reservoir of <span class="elsevierStyleItalic">S&#46; marcescens</span>&#44; a fluid medium somewhere in the surgical suite of the hospital&#44; where the first 5 affected patients had been treated&#46; Since culture of the CHX-based antiseptic solutions in the surgical suite was negative and <span class="elsevierStyleItalic">S</span>&#46; <span class="elsevierStyleItalic">marcescens</span> was isolated from a bag of packed red blood cells in a patient that had received a transfusion in the paediatric ICU and not undergone surgery&#44; we considered transfusion another potential route of infection&#44; as all the affected patients had received transfusions prior to the diagnosis of bacteraemia&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">With the investigation underway&#44; when 7 of the 8 cases had been detected&#44; the Spanish Agency of Medicines and Medical Devices issued a recall of skin antiseptic based on CHX in aqueous or alcohol solution that had been distributed in 2014 &#40;lots <span class="elsevierStyleSmallCaps">I</span>-15&#44; <span class="elsevierStyleSmallCaps">I</span>-11&#44; <span class="elsevierStyleSmallCaps">I</span>-28&#44; <span class="elsevierStyleSmallCaps">I</span>-29&#44; <span class="elsevierStyleSmallCaps">I</span>-30&#44; <span class="elsevierStyleSmallCaps">I</span>-33 and <span class="elsevierStyleSmallCaps">I</span>-35&#41;&#44; while the Epidemiological Surveillance System of Andalusia &#40;SVEA&#41; of Andalusia warned us that the use of this antiseptic was probably the cause of the outbreak at our hospital&#46; Having received this warning&#44; we verified that the units affected by the outbreak had been using products from several of the lots included in the recall&#46; Unlike other published studies regarding this outbreak&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> we performed pulsed-field gel electrophoresis for the molecular analysis of isolates from patient samples&#44; those obtained from new samples of CHX solutions removed from use in the hospital &#40;lots <span class="elsevierStyleSmallCaps">I</span>-33 and <span class="elsevierStyleSmallCaps">I</span>-35&#41; and the strain provided by the laboratories that distributed the contaminated antiseptic&#44; and found that all isolates were from a single clone &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The procedures that most likely contributed to the transmission of infection were those whose performance was preceded by the use of this antiseptic&#44; such as disinfection of the skin prior to surgery or catheterisation&#44; and disinfection of 3-way stopcocks before transfusion&#46; This was consistent with the information received in the outbreak report&#44; where the medical procedure associated with the use of the CHX solution was catheterisation in 70&#37; of cases&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The rapid identification and notification of the outbreak&#44; the implementation of preventive measures and molecular testing allowed the control of an outbreak affecting the paediatric age group&#44; a particularly vulnerable population&#46; We ought to highlight that our study evinced the clonal relationship of all isolates from the outbreak with the original contaminant strain&#44; and that cases were restricted to the paediatric population&#44; including one death that could be attributed to infection by <span class="elsevierStyleItalic">S</span>&#46; <span class="elsevierStyleItalic">marcescens</span> out of the 148 patients affected nationwide&#46; It is essential that we improve the communication between Public Health Agencies and health care facilities&#44; as the problem started in 2014 and the outbreak persisted through December of the same year&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a></p></span>"
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Article information
ISSN: 23412879
Original language: English
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Idiomas
Anales de Pediatría (English Edition)
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